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4,4',4'',4'''
1
MCE
2,5
3,6
Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q PMID 1972563
Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'
1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25
4
9,10
CGGK 1253739
MCE
Venturicidin B 33538
KIF20A promotes triple
4
L
5
Fertility Enhancement but Premature Ovarian Failure in esr1
N
(3R)
MCE
MCE
The mechanism of NRF2 regulating cell proliferation and mesenchymal transformation in pulmonary hypertension PMID 38944076
4
脂氧合酶
Temporal Ordering in Endocytic Clathrin
Placental Lactogen/CSH1 蛋白, Human (HEK293, His)
Pasakbumin B 138809
1
Scpep1
[1,1′
2,7
LIV
4'
KAI
18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate PMID 39218234
ULK1 prevents cardiac dysfunction in obesity through autophagy
NGFR Protein, Rabbit (HEK293, His)
1
Guanosine
Camptothecin 7689
Synthesis and antitumor activity of pyrido [2,3
Tetramethyl [4,4'
[1,1 4,1
Stereoselective effects of chiral epoxiconazole on the metabolomic and lipidomic profiling of leek PMID 36413841
Boc
GPX4
SLC52A3 蛋白, Human (sf9, His, MBP, FLAG)
2
(2S,3R,4R)
Semaglutide sodium 2924330
4,7
Ricinus Communis Agglutinin I (Rhodamine) (RCA I (Rhodamine))
MIL
IRMOF
2
4,4'
[1,1' 4',1''
1,4
3,6
5,5′
2,6
Bis
1,5
4,4'
5,5'
5
2,7
5
2
Central administration of interleukin
Indoloprodigiosins from the C
Betulonic acid 4481
Arzoxifene hydrochloride 182133
Burchellin effects on Triatoma infestans and on Trypanosoma cruzi within this vector PMID 11570558
ERα is required for suppressing OCT4
Silevimig
Bleomycin A5 (hydrochloride) 55658
ABCG1 抗体 (YA1841)（ABCG1 Antibody (YA1841)）
Steppogenin
Desmoplakin loss leads to PKC
Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine PMID 18727144
NIR
Taltobulin intermediate
5
Early growth response
5
LncRNA TMEM147
Omeprazole
5
The unusual gradient elution for reversed phase HPLC of a strong chelator as an active drug substance PMID 11248490
1,3
Fmoc
Adhesion of human T cells to antigen
Triphenylene
Spirooxindole
Magnesium 5,10,15,20
4,4'
IL
Recent advances toward the development of Hsp90 C
Effects of alkyl parabens on plant pathogenic fungi PMID 25791450
4,5
tert
4'
CI
Disentangling Organ
Discovery, SAR, and Biological Evaluation of Non
1,3,5
Alisol B 23
Zafirlukast promotes mitochondrial respiration by stimulating mitochondrial biogenesis in human bronchial epithelial cells PMID 33977464
W
Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective PMID 9462667
Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1
Topical delivery of aqueous micellar resolvin E1 analog (RX
Anti
Design and Discovery of N
Combinatorial chemistry identifies additional compounds that selectively inhibit DLK
Neurotoxic effects of local anesthetics on the mouse neuroblastoma NB2a cell line PMID 25539050
Fragment
Discovery of CP
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress
(E)
GABAA receptor agent 4 2035203
The design and synthesis of novel orally active inhibitors of AP
Reinvestigating Old Pharmacophores Are 4
DXR
CD6 蛋白, Human (HEK293, His)
hCAIX
Development of an immunoassay for urinary galactosylhydroxylysine PMID 9839938
Pyrotinib and chrysin synergistically potentiate autophagy in HER2
Lophophorine 17627
4,4',4'',4'''
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia PMID 12738069
2
Moxifloxacin (BAY12
Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells PMID 18218611
An in situ dual
The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2
Bach1 Rat Pre
Local translation in nuclear condensate amyloid bodies PMID 33568529
MicroRNA
Neuroprotective effect of melatonin on soluble Aβ1
5
Amplification of Plasma MicroRNAs for Non
5,5'
UPF
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF
Small molecule inhibition of cyclic GMP
56122
SKF89976A hydrochloride (Standard)
Eprenetapopt (APR
h15
3
Serotonin
3,3''
4,4'
Glisoprenin E 205594
The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer PMID 36325338
1,2
Schizonepeta tenuifolia Briq
Polyinosinic
2,2'
Nd
Dipyrido[3,2
Tris(4
Polychlorinated Biphenyl Quinone Induces Caspase 1
KAUST
2
Dihydrofuran
3
ATG10 蛋白, Human (GST)
6
4
GPR120/FFAR4 protects retinal vascular endothelial cells against high glucose injury via suppressing ROS
PFI
4
4
4,5
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators PMID 17470817
Variable antiviral activity of islatravir against M184I/V mutant HIV
Bis(N,N'
1,1,2,2
MIL
1,4
2,3
Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2
2,2'
Sulfaethoxypyridazine
4,4'
5,5'
1,5
4
Granulocyte
Probucol
Anti
Interferon
Identification of thyroxine
1,2
Effects of compound 21, a non‑peptide angiotensin II type 2 receptor agonist, on general anesthesia‑induced cerebral injury in neonatal rats PMID 30365086
Curcumin attenuates potassium oxonate
Phospho
Atrial and brain natriuretic peptides inhibit the endothelin
The development of a selective cyclin
4,4'
5,10,15,20
Antimicrobial activity of new antibiotics against bacterial isolates from a community hospital PMID 8370322
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect PMID 34448460
METTL3 facilitates tumor progression via an m6A
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds PMID 34569655
[1,1'
Down
Regulated production of the chemokine CCL28 in human colon epithelium PMID 15246961
Lymphocyte activation and cytokine production by Pisum sativum agglutinin (PSA) in vivo and in vitro PMID 10102796
Erichrome blue black B
2
Inhibition of HDAC6 with CAY10603 alleviates acute and chronic kidney injury by suppressing the ATF6 branch of UPR PMID 38642631
Dapagliflozin, a Sodium
Sevoflurane
Protocol for a semi
How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin
Novel Rho kinase inhibitors with anti
Repurposing Axl Kinase Inhibitors for the Treatment of Respiratory Syncytial Virus Infection PMID 36853000
Erythrabyssin ll is identified as a late
MCE
Codelivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models PMID 37142191
CRACR2A Human Pre
Angiogenic and Fibrogenic Dual
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma PMID 32128917
C1q/tumour necrosis factor
PIBF1 Human Pre
PPARγ regulates fabp4 expression to increase DHA content in golden pompano ( Trachinotus ovatus) hepatocytes PMID 33663633
The Gut Microbiota
Levistolide A Induces Apoptosis via ROS
Lysine crotonylation regulates leucine
Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia PMID 38488453
Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects PMID 24900524
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor PMID 9751783
Novel 15
The Role and Mechanism of Ambra1
Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL
(2E,2'E)
Anticancer effect of tectochrysin in colon cancer cell via suppression of NF
The impact of acyl
Study on the Effect and Mechanism of Weichang'an Pill and Its Extract on Slow Transit Constipation PMID 40273379
Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune
MicroRNA
Rac1 plays a crucial role in MCP
The high
Exploration of piperidine
Isoform
Human UDP
SP1
Characterization of a Na(+)
Protective effects of 10,11
Dppa3 Improves the Germline Competence of Pluripotent Stem Cells PMID 37171679
Pharmacokinetics and antineoplastic activity of galectin
Anxiolytic
1,4
Chemical characterisation of polysaccharides from Lilium davidii PMID 20221942
Novel oxadiazole analogues derived from ethacrynic acid design, synthesis, and structure
HNRNPF Human Pre
A first
2
A new flavone C
Propargyl
Clenbuterol Hydrochloride PMID 28431781
S
Drotaverine interacts with the L
HOE961 152819
MCE
Liver X receptor
4
RU 56187 143782
α
Mechanism for neutralizing activity by the anti
Wheat Germ Agglutinin (Rhodamine) (WGA (Rhodamine))
Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases PMID 28106377
Lortalamine (LM 1404，氯他拉明)
(Benzene
Tris(pyrazol
Sodium 4,4',4'',4'''
3,8
TGF
Tris(2
3H,3'H
Antiviral Bafilomycins from a Feces
pre
CAU
Piperazine
Al
N2,N7
Scpep1 Rat Pre
1,3
1,1'
(1,2
2,3,5,6
Discovery of novel antitumor nitric oxide
Effususol A
H
Naphthalene
4,4',4''
2,5
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling PMID 34135321
2,4,6
Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD
2
Tetrafluoroisophthalic Acid (2,4,5,6
Benzo[b]quinolizinium,bromide
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR
1,4
Importin
SnRK
CD98 蛋白, Human (HEK293, His)
BRD4 Inhibitor
A Cell Membrane
ACH
N
MCE
High PARP
Recombinant human heavy
The Protective Role of the IRE1α/XBP1 Signaling Cascade in Autophagy During Ischemic Stress and Acute Kidney Injury PMID 39983812
Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche PMID 39910049
Rolipram attenuates bleomycin A5
6
Anxiolytic
Tumor necrosis factor α induces a model of preeclampsia in pregnant baboons (Papio hamadryas) PMID 21737300
BRD4 Inhibitor
Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis PMID 26651537
Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN
5
Potent growth
N
CRBN ligand
2',3',5',6'
Long non
Flazo Orange 3566
5',5''
(E)
Werner syndrome RecQ helicase
Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non
4
PKM2 modulator 2 1356760
The GLP
tris(N
Broad activation of latent HIV
Lung tumorigenicity of NNK given orally to A/J mice its application to chemopreventive efficacy studies PMID 2050045
The signal peptide as a new target for drug design PMID 32209293
Identification of bacterial N
Effects of icariin on reproductive functions in male rats PMID 24995929
Exatecan
WDR62 Human Pre
The KN
Click to a focused library of benzyl 6
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands PMID 18243711
The beta 1
A Brief Overview of the Antitumoral Actions of Leelamine PMID 31330969
N
Covalent binding of the organophosphorus agent FP
Anti
The LTB4
PPARβ/δ activation protects against hepatic ischaemia
IL
BMAA and Neurodegenerative Illness PMID 28540663
Sulfated Polysaccharide Regulates the Homing of HSPCs in a BMP
The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models PMID 25637314
1,3,5
Pentosan polysulfate a novel therapy for the mucopolysaccharidoses PMID 23365668
2,2'
ARN25068, a versatile starting point towards triple GSK
Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1
Tumor cells impair immunological synapse formation via central nervous system
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell PMID 30797555
2,2',2'',2''',2'''',2'''''
Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/β
Reshaping Intratumoral Mononuclear Phagocytes with Antibody
Activin B is produced early in antral follicular development and suppresses thecal androgen production PMID 22450673
Influence of cellular ERalpha/ERbeta ratio on the ERalpha
Acitretin Promotes the Differentiation of Myeloid
The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF
Discovery of anti
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis PMID 26629594
Discovery of 2(1 H)
Solitomab, an epithelial cell adhesion molecule/CD3 bispecific antibody (BiTE), is highly active against primary chemotherapy
Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein
BCAA insufficiency leads to premature ovarian insufficiency via ceramide
6
IL13
4,2′ 4′,4′′
Human cytomegalovirus UL23 exploits PD
Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri PMID 8991954
2
Revisiting the role of GDF15 in atherosclerosis in mouse and human PMID 40307459
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E
Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones PMID 469554
GSK2245035 1207629
Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer PMID 39511266
The C type lectins DC
Discovery of 3
Mib1 Mouse Pre
Concanamycin A, a vacuolar type H(+)
Gamhepathiopine 1620442
Indolin
H3K36me3 modification by SETD2 is essential for Col11a2 and Sema3e transcription to maintain dentinogenesis in mice PMID 40554768
BMP
RPRM Human Pre
Discovery of V
The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia PMID 27090778
Melicopine 568
Perylene
Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure
Manganese activates autophagy to alleviate endoplasmic reticulum stress
3
Cytotoxic phenylethanoid glycosides from Digitalis davisiana Heywood Evaluation of structure activity relationships and chemotaxonomical significance of isolated compounds PMID 31014930
WY
Activation of the Epac/Rap1 signaling pathway alleviates blood
Hsp90 β is Critical for the Infection of Severe Fever with Thrombocytopenia Syndrome Virus PMID 38008382
Fomentariol 53948
Long lasting control of viral rebound with a new drug ABX464 targeting Rev
RO
The molecular basis of IL
SIFSIX
SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis PMID 40128799
The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica PMID 5743777
Diquinoxalino[2,3
MCE
4,4'
1,4
Cell differentiation
UIO
2
HJ03 3028123
CRBN ligand
Benzene
1H,1'H
1,6
4,4′
9,10
Potassium tetrakis(1
6
Xanthan gum biosynthesis and application a biochemical/genetic perspective PMID 9763683
5
Identification of a novel metabolite of vildagliptin in humans Cysteine targets the nitrile moiety to form a thiazoline ring PMID 30172711
ZIF
6
MCE
meso
4,4'
Tumor
2,2'
Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish A Unique Furan Fatty Acid (F6) and Cholesta
Keap1
5,6
New N
CCR6 antagonist 1 588674
4,4',4'',4'''
1,2
Novel potent substituted 4
Pharmacokinetics of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Mice Potential Enterohepatic Circulation and Target
Blepharotriol 849590
TCO
Potassium hydroxide, 95% 1310
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment PMID 22529382
Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway PMID 35858000
MCE
DSPE
CD33 抗体 (YA1308)（CD33 Antibody (YA1308)）
wheat sharp eyespot
2
Latent TGF beta 3/Latent TGFB3 蛋白, Human (Biotinylated, HEK293, His)
Atorvastatin
AZD1979 1254035
Maximin H5 495395
LIV
EphA3 蛋白, Rat (HEK293, Fc)
STING agonist
Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation PMID 28410751
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential PMID 26503418
CRBN ligand
PARP14 and PARP9/DTX3L regulate interferon
Amino
Identification and characterization of NVP
Clonidine
Protective effects of Aporosa octandra bark extract against D
The Calvin cycle inevitably produces sugar
DT
Degradation of GSPT1 causes TP53
CUL1
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation PMID 11790377
[1,1′ 4′,1′′
Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages PMID 29324976
HA1/Hemagglutinin 蛋白, H1N1 (P03453, HEK293, His)
Tris(pyridin
Galanin Protects Rat Cortical Astrocyte from Oxidative Stress Involvement of GalR2 and pERK1/2 Signal Pathway PMID 31249471
AhR agonist 6 3033281
ATX inhibitor 16 2484811
1,1'
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