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Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members PMID 37493498
Tris(4
4,4',4',4''
4,4'
2',5'
Cytotoxic Mannich bases of 6
Hydrazide
Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress PMID 40763038
AVE
5
Fluoroglycofen 77501
2,2
2
MMP activation
1,2
Anabsinthin (安洋艾素)
N,N'
SLC7A6OS Human Pre
Endocytic trafficking of GAS6
Ferulenol 6805
(E)
Hypoxia
4
Sigma receptors are expressed in human non
COX
The anti
Ptges
S
Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling PMID 25636878
An efficient and convenient microwave
CRBN ligand
SLC35A2 蛋白, Human (sf9, His, MBP, FLAG)
Lactobacillus johnsonii
5
SLC16A2 蛋白, Human (sf9, His, MBP, FLAG)
2,2'
Decanedioic acid
MCE
Protein UFMylation regulates early events during ribosomal DNA
Anti
Design of spiro
RO5527239 1354812
Four new triterpenoids from Maytenus ilicifolia PMID 15043435
NocII 188119
N1,N2
Presentation and Delivery of Tumor Necrosis Factor
Sulfo
β
Targeting the tumor cell
Resveratrol prevents Drp1
Preptin, another peptide product of the pancreatic beta
5
Synthesis and characterization of bichromophoric 1
Lansiumamide A 121817
Efficient construction of novel D
NVP
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma PMID 40197257
3,5
Characterization of a novel and specific inhibitor for the pro
SLC16A3 蛋白, Human (Cell
Scutellaria baicalensis Georgi polysaccharide ameliorates DSS
Antitumor agent
Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors PMID 35880853
Suppression of Akt
(E)
Urea
Effects of the new hypolipidemic agent F 2833 on plasma lipoprotein levels in normal and hyperlipidemic hamsters PMID 1287377
Dopamine Transporter 抗体 (YA7711)（Dopamine Transporter Antibody (YA7711)）
[5
1
Risankizumab First Global Approval PMID 31098898
Curcumin
1,3,5
YY1 induced USP13 transcriptional activation drives the malignant progression of hepatocellular carcinoma by deubiquitinating WWP1 PMID 40319251
Alpha
A multimodal RAGE
IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP PMID 40658677
6
2,5
2,5
4,6
Antigen
NPSR1 modulator
1,2,4,5
Effect of Crocin on Cell Cycle Regulators in N
[1,1'
3α
Al
Synthesis of substituted
Vicia Villosa Lectin (VVL)
Bis(1H
Il13ra1 Rat Pre
1
Phaseolus Vulgaris Leucoagglutinin (Fluorescein) (PHA
转录衔接子 2B（TADA2B）基因
Sodium 2,9
5
4
2,6
2,5
N
Selective Irreversible Inhibitors of the Wnt
2,2'
4,4',4'',4'''
1,3
Tris(4
3,6
4
1
meso
4
The Hippo Transducer YAP/TAZ as a Biomarker of Therapeutic Response and Prognosis in Trastuzumab
Erastin 571203
2
Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester PMID 2078540
2,3
1,1′
The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx
Ulex Europaeus Agglutinin I (Rhodamine) (UEA I (Rhodamine))
Graphene oxide leads to mitochondrial
UIO
4,4',4'
2
Fe3+
1,2
4',4''',4''''',4'''''''
Cyclin E 蛋白, Human (sf9)
4
Structure
KLHL3
Discovery of Novel SIK2/3 Inhibitors for the Potential Treatment of MEF2C+ Acute Myeloid Leukemia (AML) PMID 40111261
2,3
Compound Danshen Dripping Pill ameliorates post ischemic myocardial inflammation through synergistically regulating MAPK, PI3K/AKT and PPAR signaling pathways PMID 34390798
Aeide
2,3,5,6
Nimbolinin B 76689
Repeated lidocaine exposure induces synaptic and cognitive impairment in aged mice by activating microglia and neurotoxic A1 astrocytes PMID 40092614
A high proportion of CD38 (high) CD16 (low) NK cells in colorectal cancer can interrupt immune surveillance and favor tumor growth PMID 40650701
4'
2,2'
[4,4'
Activation of the Vascular Smooth Muscle GLP
Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease PMID 34695170
Phytochemical and Antimicrobial Screening of Flavanones and Chalcones from Galenia africana and Dicerothamnus rhinocerotis PMID 26411007
Gastrodin protects endothelial cells against high glucose
A transient wave of Bhlhe41+ resident macrophages enables remodeling of the developing infarcted myocardium PMID 37751357
MCE
Aspulvins A
1,4
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors PMID 12649296
Zilurgisertib 2173389
Ischemic Area
PTP1B
3,3'
[4,4'
(S)
4'
Amantadine sulfate 31377
Mutual communication between radiosensitive and radioresistant esophageal cancer cells modulates their radiosensitivity PMID 38114473
4
Molecular SPECT/CT Profiling of Claudin18.2 Expression In Vivo Implication for Patients with Gastric Cancer PMID 38843446
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade PMID 24903021
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication PMID 39212384
MCE
AP
MCE
SPIRIT BLUE AGAR A MEDIUM FOR THE DETECTION OF LIPOLYTIC MICROORGANISMS PMID 17748334
1,5
Ethyl 6,6''
Fumagillin suppresses HIV
MCE
4,4'
Design, Synthesis, and Biological Evaluation of Selective TBL1X Degraders PMID 39411529
N1,N1
6H05 1469338
Targeting the HDAC6/Hint2/MICU1 axis to ameliorate acute liver failure via inhibiting NETosis PMID 39983829
Laminin 521 enhances self
Quinhydrone (Quinhydrone)
Endothelin
Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells PMID 14629008
MicroRNA
BACE1 蛋白, Human (HEK293, His)
N,N,N
MK
Cepharanthine inhibits the proliferation of glioblastoma cells by blocking the autophagy
A validated rapid stability
Vindoline Inhibits RANKL
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease PMID 27928028
Steviol
5
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor
Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid
DHFR
Estrogen counteracts age
Adenylyl cyclase type 2 agonist
Ablation of Plasma Prekallikrein Decreases Low
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function PMID 39223969
KT2
4
BBR
cis
4
MIL
Isopropyl myristate (十四酸异丙酯)
4,4'
Fancy bioisosteres novel paracyclophane derivatives as super
抗真菌类药库
The Candida albicans Cdk8
Imidazoloquinoline optical isomers as TLR7 selective agonists promote macrophage activation for cancer immunotherapy PMID 41101258
3,3'
Bioactive Enmein
MCE
LPS
Fosifidancitinib 1237168
The human MCP
Palmitate lipotoxicity is closely associated with the fatty acid
[1,1′ 2′,1′′
N
Deubiquitinase OTUD4 Stabilizes SLC5A2 to Promote Pancreatic Cancer Proliferation and Migration Through Enchaining Glycolysis
4,4'
Integration of multi
N,N'
RNA
Sacituzumab Govitecan (IMMU
2
红细胞膜蛋白带 4.1 like 1（EPB41L1）基因
9,10
5,5'
Tetrakis(4
Immunoregulatory effects of RGMb in gut inflammation PMID 36420263
2
4,4'
The flow cytometric PKH
Lupeol, a novel androgen receptor inhibitor implications in prostate cancer therapy PMID 21712449
New insights in the structure
Near infrared photoimmunotherapy with an anti
Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor
Tris(3'
D
多形性胶质母细胞瘤 (Glioblastoma Multiforme)
Identification of bioactive molecules by adipogenesis profiling of organic compounds PMID 12496288
UIO
1
Croconic acid (4,5
In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells PMID 23106460
(4
4,4'
1,1,2,2
ALR2
FAP
Anti
2,2'
Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model PMID 40116635
2,5
Tyrosine kinase inhibitor (Standard)
Lixisenatide Reduced Damage in Hippocampus CA1 Neurons in a Rat Model of Cerebral Ischemia
2',3'
KY
2
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole PMID 27030298
MUF
High‑glucose microenvironment promotes perineural invasion of pancreatic cancer via activation of hypoxia inducible factor 1α PMID 35088883
MOF
2
Discovery of the Aryl
Discovery and Characterization of Potent, Selective, and Orally Bioavailable 7
4,4'
MK
Tanzisertib 899805
Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice PMID 39985830
Human TFF2
2,2',3,3'
5
Investigation of the internalization and transport mechanism of Codonopsis Radix polysaccharide both in mice and Caco
MCE
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor PMID 25262941
Surrogate Wnt agonists that phenocopy canonical Wnt and β
2',5'
5,5'
Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A
PCN
Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway PMID 33279335
Design, synthesis, and biological evaluation of a novel indoleamine 2,3
Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models PMID 19028564
Insight into the mechanism of action of temporin
INSP
Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction PMID 37455625
Identification of substituted 3
MCE
Peimine, a main active ingredient of Fritillaria, exhibits anti
Ampd3
4,4'
Liver X receptor agonists with selectivity for LXRbeta; N
3
Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation PMID 34496251
Cathepsin K inhibitor 4
Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis PMID 15072226
AM
Selective class IIa histone deacetylase inhibition via a nonchelating zinc
Structure
ARRY
Synthesis and antitumor activity of 1,3,4
Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis PMID 37726818
2,2'
3
Correction tRNAGlu Increases the Affinity of Glutamyl
MCE
Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer PMID 40216870
Chimeric antibody targeting unique epitope on onco
5
1,4
β
4′
4
Hypericin
4
Comparison of ketamine, 7,8
HDAC6 inhibitor WT161 performs anti
CSPG4P12 polymorphism served as a susceptibility marker for esophageal cancer in Chinese population PMID 38877481
The activation of PPARγ enhances Treg responses through up
SLC21A3 蛋白, Human (sf9, His, MBP, FLAG)
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity
[4,4'
VRT
Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression PMID 33691697
Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells PMID 6297010
Development of a broad
2
Pinokalant 149759
EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection PMID 39231976
3',5'
DB1055 869767
1,3,5
SR2211 1359164
Seneca Valley virus enters cells through multiple pathways and traffics intracellularly via the endolysosomal pathway PMID 36947577
PGM3 regulates beta
Inhibition effects of benzylideneacetone, benzylacetone, and 4
GIT1 overexpression promotes epithelial
17α
Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production PMID 31642320
Knockdown of MTHFD2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through the ERK signaling pathway PMID 35567943
Generation of whole tumor cell vaccine for on
1
Multifunctional human serum albumin
A kinase
Tetrahydropyrimidine
Dysregulation of HO
Cavidine alleviates paclitaxel
Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism PMID 37409454
ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors PMID 38060444
ICy
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN PMID 36043996
MCE
Design, synthesis and evaluation of 2
(S)
Role of diacylglycerol O
Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery PMID 20350765
Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice PMID 40028352
The design and discovery of water soluble 4
4'
Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation PMID 21173118
Adenosine A1 receptor agonist, N6
MCE
N,N,N
The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth PMID 18627423
Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes PMID 18299415
FAAH
CRBN ligand
Interleukin
TGF
Interactions of the prion peptide (PrP 106
AKT1/FOXP3 axis
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma PMID 21081713
Anti
MCE
CJ
FCRL4 Human Pre
3,3'
Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll
Borg5 restricts contractility and motility in epithelial MDCK cells PMID 39503295
3
19
Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G
Collagen
LncRNA OLMALINC promotes osteosarcoma progression through USP1
Par3 promotes breast cancer invasion and migration through pull tension and protein nanoparticle
(3R,4R)
A complement
Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents PMID 24971933
α
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1 S,2 S)
组蛋白脱乙酰酶
Identification and characterization of a second melanin
Novel 4
2,4
Aging
The analgesic and anti
MCE
WRN inhibitor 12 3044040
Peroxisomal lipid metabolism inhibits Pimozide
2,2'
5,5',5''
Theoretical study on the interaction of pyrrolopyrimidine derivatives as LIMK2 inhibitors insight into structure
Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade PMID 30254335
Biological activities of novel pyrazolyl hydroxamic acid derivatives against human lung cancer cell line A549 PMID 24996138
PACAP/PAC1R activation promotes group 2 innate lymphoid cells
5,5'
CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli
Interferon
Loss of BRMS2 induces cell growth inhibition and translation capacity reduction in colorectal cancer cells PMID 33791164
LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway PMID 34837962
Design, Synthesis, and Biological Evaluation of β
Modulation of the Astrocyte
Polo
BCoR 抗体 (YA9595)（BCoR Antibody (YA9595)）
m
L
Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics
Antitumor effect of 3
1,2
OAS cross
Discovery of selective small
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor PMID 16103058
The MRN
YIPF1, YIPF2, and YIPF6 are medial
Increased Cyclic Guanosine Monophosphate and Interleukin
Cevimeline hydrochloride hemihydrate 153504
MIL
PKN1 Human Pre
Nanoscale Mapping of EGFR and c
Utilizing artificial intelligence for precision exploration of N protein targeting phenanthridine sars
Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized
5
Promotion of neurite extension by protrudin requires its interaction with vesicle
Naphthalene
Blastocyst
2,5
A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4 PMID 39002520
Stimulating β
The cardioprotection of dihydrotanshinone I against myocardial ischemia
Tris(4
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance
Wisteria Floribunda Lectin (Biotinylated) (WFL (Biotinylated))
FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early
A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1
Sulfo DBCO
High
5
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4
5′
Network pharmacology and experimental verification
1,10
Trimethylamine N
UiO
5,10,15,20
Sigma
Evaluation of EED Inhibitors as a Class of PRC2
Rhamnose
5
Design and synthesis of novel β
Fluorine
5,5'
TMEM147 Human Pre
4,4'
2'
2,5
Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication PMID 36695658
Cytosolic mtDNA
4′
1,4
Functional characterization of the neuron
1,2
Quinazoline
CDK1 Promotes Epithelial
PCSK9 modulator
4
PRCC
Characterization of WZ4003 and HTH
Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication PMID 27283940
Synthesis and Structure
4,4'
Brevinin
Membrane Fusion Drives Facile Uptake of Cell Membrane
Overexpression of hnRNPK and inhibition of cytoplasmic translocation ameliorate lipid disorder in doxorubicin
Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop PMID 40016338
2
Retinoic acid
Multiplatform molecular analyses reveal two molecular subgroups of NF2
SIFSIX
Cu
YAP antagonizes TEAD
Design of Peptoid
Naphthalene
New morpholine
CD146/MCAM 蛋白, Human (Biotinylated, HEK293, His)
4,4''
CNNM1 Human Pre
SARS
RNF182 Human Pre
G
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