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CCL8 secreted by tumor
1,3,5
Development of dihydropyridone indazole amides as selective Rho
Comprehensive Analysis of NADH Ubiquinone Oxidoreductase Subunit B3 in Gynecological Tumors and Identification of Its Natural Inhibitor Wedelolactone PMID 39469770
Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells PMID 31026735
Examining Myc
Radixin knockdown improves the accumulation and efficiency of methotrexate in tumor cells PMID 31115547
Discovery of a novel and potent series of thieno[3,2
Targeting antioxidants to mitochondria by conjugation to lipophilic cations PMID 17014364
Zinc meso
4
Tris(4
An Effective Reaction
Astragaloside IV promotes cerebral tissue restoration through activating AMPK
Combination of Geniposide and Eleutheroside B Exerts Antidepressant
The RNA
Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment PMID 34439352
Kinesin KIF16B Participates in G2/M Transition and Microtubule Dynamics via Aurora A
2,3
5,5'
Renin inhibitor peptide,rat
Disodium 3,3'
Neuronal CCL21 up
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and
MIL
Endocytotic Albumin Uptake Pathways in Human Adipose Stem Cells and Connection to Intracellular Calcium Oscillations and the Neonatal Fc receptor PMID 40239638
Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca2+ permeable AMPA receptor
1,1,2,2
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells PMID 21706056
SIRP alpha V8/CD172a 蛋白, Human (Biotinylated, S44L, S50T, I52T, H54R, V57A, HEK293, His
The anticancer effect of EGFR
4,4'
1,6
Pioglitazone decreased renal calcium oxalate crystal formation by suppressing M1 macrophage polarization via the PPAR
Discovery of Aryloxyphenyl
The mechanism of acentrosomal spindle assembly in human oocytes PMID 36395215
O
Inhibition of p53
(Z)
Dipyridin
[1,1′ 4′,1′′ 4′′,1′′′
MCE
5,5'
Activation of GCN2/ATF4 signals in amygdalar PKC
2,4,6
Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage PMID 32260136
Levistolide A Inhibits PEDV Replication via Inducing ROS Generation PMID 35215851
Combinatorial Nonribosomal Peptide Synthetase Libraries Using the SEAM
1,2
Erythropoietin signaling in peripheral macrophages is required for systemic β
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity PMID 29407988
1,4
VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ
Discovery of a Novel and Potent Cyclin
2,7
PCSK9
2
(E)
Fosquidone
The unfolded protein response controlling cell fate decisions under ER stress and beyond PMID 22251901
4,4' 2',2'' 4'',4'''
2
Structural analysis of human KDM5B guides histone demethylase inhibitor development PMID 27214403
LINC01410 accelerates the invasion of trophoblast cells by modulating METTL3/Fas PMID 39115693
Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils PMID 34702814
Macrophage
Influence of formulation on the in vitro transdermal penetration of flutrimazole PMID 9368709
5
[2,2'
1,4
4
2,2'
Engineering Corynebacterium glutamicum with Effective Heme Supply for the Synthesis of High
Diverse Sesquiterpenoids and Polyacetylenes from Atractylodes lancea and Their Anti
Structure
Fexinidazole and Corallopyronin A target Wolbachia
In vitro approach to elucidate the relevance of carboxylesterase 2 and N
5,5'
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma PMID 29232556
Regulatory Phenomena in the Glutathione Peroxidase Superfamily PMID 31822117
1,3,5
[2,2' 6',2''
N
2,4,6
SLC51B 蛋白, Human (sf9, His, MBP, FLAG)
Enniatin B1 19914
5,5',5'',5'''
锌指蛋白 503（ZNF503）基因
3,3'
4
Discovery of selective small molecule type III phosphatidylinositol 4
Palmitoyllactic acid 7795
Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes
1H
Intermedine N
Enhanced bypass of PD
IRX5010 856683
8(S),9(R)
2
1,3,5
MCE
RuDiOBn 13459
2
Synchronous intracellular delivery of EGFR
1,2,3,8,9
β
5'
A drug screening toolkit based on the
Tubulin inhibitor 29 2905
WASHC1 interacts with MCM2
MCE
MCE
SB
Synthesis of d
Efficacy of Tie2 receptor antagonism in angiosarcoma PMID 22431921
SLC26A4
N
植物激素库
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea PMID 39214086
LC
Specific Turn
Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling PMID 39823248
(2E)
MU1787 2624098
MD2
MCE
Naphthalene
Anagliptin
4,4
Wheat Germ Agglutinin (Fluorescein) (WGA (Fluorescein))
IRMOF
4,7
非洲黄金木提取物 (Chlorophora regia A.Chev)
(Benzene
Tris(4
1,1,2,2
Methyl 3
SIFSIX
MCE
MCT1 lactate transporter blockade re
DTD1 Human Pre
Aminoiminomethanesulphinic acid (Standard) (Thiourea dioxide (Standard))
2,4,5
2,5
Discovery of the First
2,2
2
5
5,10,15,20
Methyl 4'
Protective effect of thymoquinone against doxorubicin
2,6
5
4
7988
4
Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells PMID 38071213
((Benzylazanediyl)bis(methylene))bis(phosphonic acid) ([Benzyl(phosphonomethyl)amino]methylphosphonic acid)
Tri(pyridin
Fibroblast
4
MIL
SPRED1 Human Pre
L
(Rac)
4,4'
DS
Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine mode of action PMID 15148258
Carphenazine 2622
CPI
5
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity
Structures of ternary complexes of rat DNA polymerase beta, a DNA template
5
Modulating the tumor immune microenvironment with sunitinib malate supports the rationale for combined treatment with immunotherapy PMID 32078941
Discovery of (2 R)
5
Reciprocal stimulating effects of bFGF and FSH on chicken primordial follicle activation through AKT and ERK pathway PMID 30986612
2,5
Icariin enhances cell survival in lipopolysaccharide
A hydroxyethylated cholesterol
4
5
5'
Chenodeoxycholyl
Thiol
5
Benzocaine
TAB2 controls a TAK1
3,5
Platelet
CRBN ligand
Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3
Homozygous DBF4 mutation as a cause for severe congenital neutropenia PMID 36841265
Multifunctional Pluronic F
Anisodamine 55869
4
4,4′
5
Glucose isomerase insights into protein engineering for increased thermostability PMID 11150612
Cell apoptosis regulated by interaction between viral gene alpha 3 and host heterogeneous nuclear ribonucleoprotein K facilitates bovine ephemeral fever virus replication PMID 31902512
Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism PMID 21417339
Arundic acid, an astrocyte
Monocyte
Cystemustine INSERM PMID 18465517
Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin PMID 18832915
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma PMID 27221381
5,5',5''
1,3,5
Synthesis and structure
4'
BHQ
MCE
Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency PMID 40091212
Distribution of angiotensin II receptors in the brain of nonhuman primates PMID 2113279
1,3
HORMAD1 Polymorphisms Influence Susceptibility to Esophageal Squamous Cell Carcinoma Through Gene
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR
CRBN ligand
MCE
A SMYD3 Small
AZ3976 1418747
P110α inhibitor alpelisib exhibits a synergistic effect with pyrotinib and reverses pyrotinib resistant in HER2+ breast cancer PMID 37348428
Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra
Ndrg1
(2
Alterations in the BDNF
MCE
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high
Triphala 857906
Discovery of GLPG4471, a potent and selective IRAK4 inhibitor for the treatment of inflammatory and autoimmune diseases PMID 40854432
PKMYT1 is associated with prostate cancer malignancy and may serve as a therapeutic target PMID 32234541
1
NAD+ loss, a new player in AhR biology prevention of thymus atrophy and hepatosteatosis by NAD+ repletion PMID 28536482
Dipeptide diaminobutyroyl benzylamide diacetate 823202
Sodium 3,3'
Polystyrene nanoplastics exposure triggers spermatogenic cell senescence via the Sirt1/ROS axis PMID 38763051
Pyrido[1,2
Piperacillin hydrate 66258
N3
4,6
PCN
MCE
Ubiquitin Isopeptidase Inhibitor I, G5 108477
EZH2
2
Lotus Tetragonolobus Lectin (Fluorescein) (LTL (Fluorescein))
4
Dimethyl 2
2
Clausenalansine B 2365501
(1R,2S,4R)
Sweroside alleviates hepatic steatosis in part by activating AMPK/mTOR
2,8
Breast Milk Excretion of Dinalbuphine Sebacate Injection Administered After Cesarean Section PMID 38425290
2,5
4,4'
HPGDS inhibitor 1 (Standard)
UIO 68
1,5
2,2',2''
Effects of the immunomodulator, VGX
Vimirogant 1802706
Bz
Cesiumiodide (Cesiumiodidewhitextl，碘化铯)
Difluorodi(pyridin
5,5′
5,5'
PI3K inhibition sensitizes EGFR wild
Tbx5 Rat Pre
Cefpodoxime proxetil impurity B 947692
(2E,2'E)
5
4,4',4'',4'''
4,4'
Gageotetrin B 1536405
SC
PCSK9
Discovery of LY3325656 A GPR142 agonist suitable for clinical testing in human PMID 31982234
4,4',4'',4'''
CCL20
MOF
JNK
Small molecule inhibitors and a kinase
Tiglyl carnitine
2,6
4,4′
Discovery of 5
2,5
Pathogenicity and Function Analysis of Two Novel SLC4A11 Variants in Patients With Congenital Hereditary Endothelial Dystrophy PMID 37787991
2,5
[1,1'
3,3'
BAK and ARG Have Moisturizing, Anti
[1,1' 4',1''
1
((1,3,5
Dimer
1H,1'H
Benzyloxy carbonyl
Discovery of 1,8
5
5
ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple
4
GABA negatively regulates adventitious root development in poplar PMID 31740934
Tetrakis(4
Cbl
Inositol
NKG2A 蛋白, Mouse (HEK293, His)
DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive oxygen species or apoptosis PMID 23134995
Protein Disulfide Levels and Lens Elasticity Modulation Applications for Presbyopia PMID 27233034
ALK5 kinase inhibitory activity and synthesis of 2,3,4
Oral strategies to target proprotein convertase subtilisin/kexin type 9 and lipoprotein(a) the new frontier of lipid lowering PMID 37947270
Ptges2
5
5
SZ0232 924851
2
MCE
Treatment of chronic low back pain
The pyroptosis mechanism of ototoxicity caused by unconjugated bilirubin in neonatal hyperbilirubinemia PMID 37467648
5,5',5'',5'''
METTL14
TRAM
Dihydrotanshinone I inhibits gallbladder cancer growth by targeting the Keap1
LRRK1 Human Pre
3(S)
4,4',4''
Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury PMID 40923460
3
Opuntiol 2860
Wheat germ agglutinin and Lens culinaris agglutinin sensitized anisotropic silver nanoparticles in detection of bacteria A simple photometric assay PMID 28693732
Discovery of novel DAPY
Evaluation of ELISA with ABTS, 2
2,2'
L
Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2
A Neuronal Signal Sorting and Amplifying Nanosensor for EEG
Measuring pH in insulin secretory granules by phasor
Doxorubicin biocompatible O/W microemulsion stabilized by mixed surfactant containing soya phosphatidylcholine PMID 16814997
RANTES/CCL5 蛋白, Human (HEK293)
Idrapril 127420
Creatinol hemisulfate
GE11 Peptide Conjugated Liposomes for EGFR
Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure
Nicotinanilide 1752
Identification of spirocyclic piperidine
mRNA
Hydrazine sulfate a current perspective PMID 3104888
[2,2'
Curcumin inhibits neurotensin
The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor PMID 10963748
Design of hybrid molecules as antimycobacterial compounds Synthesis of isoniazid
Therapeutic potential of allosteric HECT E3 ligase inhibition PMID 40179885
Inositol 1,4,5
Pyp25α is required for male gametocyte exflagellation PMID 36316012
MCE
Role of dorsal raphe nucleus GHS
Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis PMID 39613260
Protocol for Efficient Protein Synthesis Detection by Click Chemistry in Colorectal Cancer Patient
Bartonella henselae Persistence within Mesenchymal Stromal Cells Enhances Endothelial Cell Activation and Infectibility That Amplifies the Angiogenic Process PMID 34031126
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy PMID 36588115
In silico and in vitro studies on the anti
NNC 05
M28 family peptidase derived from Peribacillus frigoritolerans initiates trained immunity to prevent MRSA via the complosome
Chemically induced mouse models of intestinal inflammation PMID 17406617
正变构调节剂
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases PMID 18077363
Thalidomide
PD 123319 130663
Possible involvement of nitric oxide in antidepressant
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF
Anti
Optimization of Ligands Using Focused DNA
Mitochondrial dynamics govern whole
Identification of EEF1A2 as a potential therapy target of osteosarcoma using novel compound 8e PMID 41252934
The anti
Tridocosapentaenoin
Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial
Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice PMID 38049080
Bcl
Characterization of Mca
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF
Chalcone Derivative L6H21 Reduces EtOH + LPS
Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1
Revealing Functional Hotspots Temperature
Discovery of novel hybrid tryptamine
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1 PMID 30503941
On the use of L
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor PMID 22859723
Sarsasapogenin reverses depressive
Enfuvirtide acetate 914454
Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes PMID 31787357
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D
EIDD
Anti
CRBN ligand
2,2'
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ
Effects of resistance
高效液相色谱
[2,2'
Structure and Characterization of a Covalent Inhibitor of Src Kinase PMID 32509799
Yin
Phospho
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels PMID 37812700
CEACAM5 蛋白, Human (Biotinylated, 187a.a, HEK293, His
Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPβ in neuronal cells PMID 28947961
4
TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre
BRD4884 1404559
The role and mechanism of the NLRP3
SKF 38393 67287
[1,1'
Ruxolitinib
[1,1' 4',1''
Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction PMID 28084590
CRBN ligand
Endocrine therapy synergizes with SMAC mimetics to potentiate antigen presentation and tumor regression in hormone receptor
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer PMID 36371227
Investigation of tumor cell targeting of a dendrimer nanoparticle using a double
Hydrophilic bile acids protect human blood
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F
SAR131675, a potent and selective VEGFR
1,4
5,6,7,8
2,3
aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β
The effect of dipeptidyl peptidase IV on disease
3,3',5'
Suppression of acute pancreatitis by L
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS
Dynamin
A thiol
2,5
2,2'
[1,1′
(E)
Targeting xCT with sulfasalazine suppresses triple
Transgelin promotes lung cancer progression via activation of cancer
Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II PMID 8124758
2′
CD200
Protective Effect of Gomisin N against Endoplasmic Reticulum Stress
Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen
Long non
A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome PMID 37308559
2,6
Klf5 down
Isolation of a High
3,3',5,5'
Exposure to p,p'
Gomisin N Exerts Anti
Mechanisms of KRAS inhibitor resistance in KRAS
Increased expression of the LGALS3 (galectin 3) gene in human non
Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines PMID 28170128
Ac
The SLC39 family of zinc transporters PMID 23506894
Lactobionamide
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation PMID 23192657
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin
PF
5'
Discovery of a novel small molecule PT109 with multi
4,4',4''
TIFSIX
IL
TIFSIX
4,7
3,5
UBMOF
Astroglial N
Bis(4
Forskolin improves experimental autoimmune encephalomyelitis in mice probably by inhibiting the calcium and the IL
2,1,3
Elucidating the kinetics of sodium fluorescein for fluorescence
467
4,4′
Animal
Novel acylureidoindolin
Pyk2 dysregulation in temporal lobe epilepsy insights from human resected tissues and pharmacological modulation in a rodent model PMID 41051547
FGFR
TFDP1 activates SPC25
Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins PMID 10781000
4,7
9,10
Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy PMID 32209571
Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts PMID 19695259
(4
4,4'
Evaluating β2
Structure
4,4'
Dichlorotris(perfluorophenyl)
Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel
The regulation of the thyroid
Discovery of SA
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