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ABCB1 confers resistance to carboplatin by accumulating stem
Sodium
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation PMID 30226904
Homing of neural stem cells from the venous compartment into a brain infarct does not involve conventional interactions with vascular endothelium PMID 24396034
High anticancer potency on tumor cells of dehydroabietylamine Schiff
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin
Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death PMID 31995763
N
TGF
Effects of beta
Oridonin acts as a novel senolytic by targeting glutathione S
Acid
1,4
Tenovin
2,4,6
Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models PMID 39834305
IL
3,4,5
The Wnt non
A flow
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors PMID 23509154
Appl1 Rat Pre
5
Lycopene acts through inhibition of IκB kinase to suppress NF
An overview of treatment strategies for Hutchinson
Antidepressant
Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity PMID 16050990
Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA
DNA intercalator 2 864281
Single dose anti
Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase
NDRG2 overexpression suppresses hepatoma cells survival during metabolic stress through disturbing the activation of fatty acid oxidation PMID 28069379
Concomitant Inhibition of PI3Kβ and BRAF or MEK in PTEN
Val
Effects of erythromycin and its derivatives on interleukin
Antibiotics and immunomodulation effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin PMID 3969058
Upregulation of CYP2E1 expression causes oxidative damage induced by 2
β
A novel protein FNDC3B
Design, synthesis, and anticancer evaluation of arylurea derivatives as potent and selective type II irreversible covalent FGFR4 inhibitors PMID 37196426
4,4'
1
PRAME peptide (425
TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase PMID 24014597
JF526–Pepstatin A TFA 2410614
Pig bile powder maintains blood glucose homeostasis by promoting glucagon
Rps27a
ATF4 抗体 (YA3845)(ATF4 Antibody (YA3845))
Functionalised molybdenum disulfide nanosheets for co
N
mmu
Cn
HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke
Neutrophil
Gut microbiota
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam PMID 1975272
Cytotoxic and nitric oxide production
5
Glaucocalyxin A and B
EMP3 Human Pre
SJ11646 2933135
[2,2'
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300 PMID 33400925
poly (A) 结合蛋白胞质 1(PABPC1)基因
Dipyrido[3,2
The roles of interleukin
Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus PMID 20336498
ALC
2
The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy PMID 37126209
Mca
miR‑204 inhibits the osteogenic differentiation of mesenchymal stem cells by targeting bone morphogenetic protein 2 PMID 31746352
Selective novel inverse agonists for human GPR43 augment GLP
Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol PMID 31423204
Aldgamycin E
N
Incorporation of macrophage immune stresses into an intracellular assay of drug tolerance in Mycobacterium tuberculosis PMID 40934365
lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression PMID 33576445
Evolving an Ultra
Toxic and adjuvant effects of silica nanoparticles on ovalbumin
Microarray expression profiles analysis revealed lncRNA OXCT1
Structural analysis of human dual
1
circ0101675 promotes malignant process via sponging miR
Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters An Important Role in Transplacental Pharmacokinetics PMID 31266750
Chronic 5
Lipopolysaccharide
HCN4
Effects of icariin on cGMP
Eupalinolide B attenuates lipopolysaccharide
Identification of apoptotic cells by formamide
Design, synthesis, anti
LC
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα
Chronotherapy involving rosiglitazone regulates the phenotypic switch of vascular smooth muscle cells by shifting the phase of TNF
One molecule two goals A selective P
Effects of the oxoaporphine alkaloid hernandonine on dengue virus. Evidence for its mechanisms of action PMID 39232285
Ursodeoxycholic acid protects against sepsis
Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma PMID 30400968
MBD1 抗体 (YA2441)(MBD1 Antibody (YA2441))
Selective Modulators of PPAR
PDHK1
PERP 抗体 (YA1674)(PERP Antibody (YA1674))
Trim14 Rat Pre
Niacin Ester Derivative of Brefeldin A as a Potential Dual
Down
GABRD Human Pre
m
Age
A novel dual mode
Neurotensin counteracts hair growth inhibition induced by chronic restraint stress PMID 38071436
Molecular structures of human ACAT2 disclose mechanism for selective inhibition PMID 34520735
Kinetics and inhibition of recombinant human cystathionine gamma
Cefuroxime, a new cephalosporin antibiotic activity in vitro PMID 1259407
Sodium tanshinone IIA sulfonate A review of pharmacological activity and pharmacokinetics PMID 31545252
Poliumoside alleviates microglia
Thalidomide
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression PMID 32393761
Sulforaphane Activates a lysosome
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells PMID 36564854
磺基转移酶家族 1B 成员 1(SULT1B1)基因
Fmoc
DCP2
A novel chromone
Effect of chronic treatment with ladostigil (TV
The NMDA receptor antagonist D
Fmoc
Janus efficacy of CX
Bistable Photoswitch Allows in Vivo Control of Hematopoiesis PMID 35106373
Effect of amodiaquine, a histamine N
Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350 PMID 10692484
Prognostic Role of Cuproptosis
IL
Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use PMID 1280568
Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba PMID 1593281
Chalcone derivative 1m mitigates hepatic fibrosis and inflammation, enhances cholesterol efflux and reduces atherosclerosis PMID 40644861
Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors PMID 40709844
JZP
TDCPP promotes apoptosis and inhibits the calcium signaling pathway in human neural stem cells PMID 39798459
5,5',5''
JNK
Tris(2,3,5,6
HIV
Effects of octyl beta
Functional characterisation of the human cloned 5
NKG2A
Investigation of a novel series of 2
A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers PMID 33972573
Calcium
Panobinostat inhibits breast cancer progression via Vps34
Activin B promotes initiation and development of hair follicles in mice PMID 24356544
Trimebutine suppresses Toll
Solanesol induces the expression of heme oxygenase
Advent of Imidazo[1,2
Cy5 maleimide labelling for sensitive detection of free thiols in native protein extracts identification of seed proteins targeted by barley thioredoxin h isoforms PMID 14636158
6
Bioisosteric replacement of an acylureido moiety attached to an indolin
Streptococcus suis synthesizes deoxyadenosine and adenosine by 5'
Ligand recognition by antigen
Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5
25KDa branched polyethylenimine increases interferon
Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non
Synthesis, biological evaluation, and binding mode of novel 1
Quadruple gene
Diiodoacetic acid
Cdk1/p53/p21 feedback loop mechanisms in the pathogenesis of interstitial cystitis/bladder pain syndrome PMID 38880159
Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E PMID 1606174
Novel role of IL
神经调节素 3 (Neuregulin
(+)
Activation of the PERK
Intravenous immunoglobulin skews macrophages to an anti
SRCAP Human Pre
Dissecting the antitumor effects of Scutellaria barbata Initial insights into the metabolism of scutellarin and luteolin by gut microbiota PMID 38959755
HY
PLEKHA1 Human Pre
The mitotic ATR
Enhancement of EGFR tyrosine kinase inhibition by C
Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition PMID 33577603
Targeting DDR2 for Treating Pancreatic Cancer PMID 40568905
TTC4 Human Pre
Pharmacophore based receptor modeling the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models PMID 16821770
NUMB 抗体 (YA258)(NUMB Antibody (YA258))
Design, Synthesis, and Biological Activity of Amine
A role for beta
MISP
25
Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin PMID 15225719
Integrative single
Indazole
TREM2
Meclocycline sulfosalicylate. Topical antibiotic agent for the treatment of acne vulgaris PMID 6452987
Paromomycin
Antimicrobial activity of flavonoids PMID 16323269
Opc
4,3' 5',4''
Repibresib 2523199
TLR3
Targeted intervention in obesity
Targeting SOX10
Inhibition of KSP by ARRY
Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits PMID 17786386
Trop
Resveratrol
norepinephrine reuptake inhibitor
Synthesis and molecular docking of 1,2,3
The antioxidant activities of natural sweeteners, mogrosides, from fruits of Siraitia grosvenori PMID 17852496
1
Siamycin III 152835
MCE
Cox6b1 Rat Pre
hTAS2R46
Tris(2
Chemical composition of the fatty oils of the seeds of Cleome viscosa accessions PMID 23157011
Post column amino acid analysis PMID 12489427
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2 PMID 32184918
HSP90
Identification of GSK
MXene
臭常山提取物 (Orixa japonica Thunb.)
MCE
Methoxyfenoterol
The acrosomal vesicle of mouse sperm is a calcium store PMID 15389568
Mal
IL
Dickkopf
Thiol
Anabsinthin
CHA4583
4,4'
Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1
NGR
ZIF
Thalidomide
P
RM 041
GNF351 1227634
Melithiazole C
Selenodiglutathione 33944
NU1000
TAOK1
(rac)
MNK
Biphenyl urea derivatives as novel GPX4 inhibitors ferroptosis
SP3 pocket
Maniladiol
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model PMID 31801884
Methyl tetradecanoate
(E)
BMS812204
3
(+)
WU
Synthesis and Anticancer Properties of Functionalized 1,6
4,4'
Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp PMID 35746699
1
1,3
SNAP 94847 hydrochloride 1781934
EDA2R
Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome PMID 24752549
Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity PMID 40172224
Galectin
2',6'
MCE
Agistatin E 144096
N
2,3
Bandeiraea (Griffonia) simplicifolia lectin
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I PMID 7853331
[Isolation and identification of ecliptasaponin D from Eclipta alba (L.) Hassk] PMID 11596317
N,N'
Development and validation of an HPLC
HMGB1/HMG
D
Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands PMID 16481428
MCE
Eif3h
Angiotensin I/II (1
4
Bioactive Terpenoids from Salvia plebeia Structures, NO Inhibitory Activities, and Interactions with iNOS PMID 27933899
Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist PMID 10204685
Metamizole hemimagnesium 6150
含 TRAF 型锌指结构域 1(TRAFD1)基因
C
GIGA
Evaluation of PAX1/ ST6GALNAC5 methylation as a triage test for cervical intraepithelial neoplasia and cervical cancer PMID 37020401
Laboratory and Greenhouse Evaluation of a Granular Formulation of Beauveria bassiana for Control of Western Flower Thrips, Frankliniella occidentalis PMID 30791617
4
Omeprazole as a potent activator of human cytosolic aldehyde dehydrogenase ALDH1A1 PMID 31678145
WNT1/ROR2 pathway enhances the Triple
含泛素相关和 SH3 结构域 B(UBASH3B)基因
Ginsenoside Rb1 Alleviates Oxidative Low
Ebola virus disrupts the inner blood
Novel acridine
Pyridin
6
De novo NAD+ synthesis is ineffective for NAD+ supply in axenically cultured Caenorhabditis elegans PMID 40175694
Agonistic analog of growth hormone
(20S,25S)
Felcisetrag 916075
Optimization and biological evaluation of nicotinamide derivatives as Aurora kinase inhibitors PMID 31307762
TIFSIX
SNAP
Magainins, a class of antimicrobial peptides from Xenopus skin isolation, characterization of two active forms, and partial cDNA sequence of a precursor PMID 3299384
Ranolazine 95635
Nivudirsen 3053113
2,2'
DOTATATE 177943
Firocoxib 189954
9,10
2
Acsf2
HDAC
Ebvaciclib 2185857
HC
mmu
4,4'
Pelacarsen 1637637
Interaction With the Extracellular Matrix Triggers Calcium Signaling in Trypanosoma cruzi Prior to Cell Invasion PMID 34671568
HY
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma PMID 37261698
(+)
GRB7 is required for triple
Umbralisib hydrochloride 1532533
DS37571084
N1,N5
Sofosbuvir 1190307
The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice PMID 18356409
Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats PMID 17826174
Predicting response to immunotherapy in gastric cancer via assessing perineural invasion
MCE
New constituents from the leaves of Morinda citrifolia PMID 17268114
3,6
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation PMID 38842922
SPECT probe
Aloe
APOBEC3C Human Pre
HCN2
微管相关蛋白 1 轻链 3 α(MAP1LC3A)基因
25P
Agatolimod 525625
2
Two new flavone glycosides from the seeds of Impatiens balsamina L PMID 21128143
Straightforward synthesis of a novel ring
Inhibition of sphingosine 1
Structure
Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats PMID 23771662
PZP
S
Design, synthesis and biological activity of dimeric pyrazolo[3,4
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PMID 28072869
1,3,5
Intrinsic peroxidase
Immunosuppressive effect of PLGA
5
Bioactive deproteinized bovine bone mineral based on self
Agalloside 221257
MCE
Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway PMID 33508300
Preclinical development of CAT
4,4'
DPP4
An evaluation of sulfasymazine in infections in mice PMID 5338947
Optimization of Physicochemical Properties and ADME for 2,4
4
Subversion of phosphorylated SR proteins by enterovirus A71 in IRES
Atovaquone and proguanil hydrochloride a review of nonclinical studies PMID 23573546
CPBP
Synthesis and biological evaluation of novel naphthoquinone [2,3
4
ZIF90
UIO
Keap1
Mechanisms underlying the anti
AF555 NHS 407627
4
Quindecamine acetate 19146
Distinct changes in endosomal composition promote NLRP3 inflammasome activation PMID 36443515
Inactivation determinant in the I
The total synthesis of an aurone isolated from Uvaria hamiltonii aurones and flavones as anticancer agents PMID 14552774
dl
TNIK
Targeted Demethylation of FOXP3
JAM2 predicts a good prognosis and inhibits invasion and migration by suppressing EMT pathway in breast cancer PMID 34923424
Effects of the novel compound aniracetam (Ro 13
Fibulin 5 抗体 (YA2448)(Fibulin 5 Antibody (YA2448))
β
Studies to investigate the in vivo therapeutic window of the gamma
Cyprodinil
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine PMID 21134979
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I the discovery of CCR3 antagonist development candidate BMS
3
Sodium 2
WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation PMID 18245540
4
AZD9567
Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer PMID 39855898
4
Folimycin (concanamycin A) inhibits LPS
Cholinesterase inhibitor rivastigmine enhances nerve growth factor
Antimicrobial agent
7
4'
Molecular glues modulate protein functions by inducing protein aggregation A promising therapeutic strategy of small molecules for disease treatment PMID 36176907
Interplays of Gli2 and Gli3 and their requirement in mediating Shh
iST2
PF
Bis(4
Poly(ADP
Deoxyguanosine triphosphate trisodium solution (100mM) 93919
Characterization of the individual domains of the Bacillus thuringiensis Cry2Aa implicates Domain I as a possible binding site to Helicoverpa armigera PMID 38754546
Histone H3 抗体 (YA4349)(Histone H3 Antibody (YA4349))
1,4
Reactive oxygen species
YE6144 free base 3065657
Cbs Rat Pre
Homozygous synonymous FAM111A variant underlies an autosomal recessive form of Kenny
BAY
Potential Value of AURKA and CDK6 Amplification for the Response of Patients With Gastric Cancer to Neoadjuvant Chemotherapy PMID 40222043
DL
Cytotoxicity and Efflux Pump Inhibition Induced by Molybdenum Disulfide and Boron Nitride Nanomaterials with Sheetlike Structure PMID 28841301
Santamarine 4290
Colorectal cancer
Methyl lucidenate A 105742
Mitochondria as new therapeutic targets for eradicating cancer stem cells Quantitative proteomics and functional validation via MCT1/2 inhibition PMID 25415228
Alpha(1,3)
Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits PMID 12696918
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3
Inhibition of GBP1 alleviates pyroptosis of human pulmonary microvascular endothelial cells through STAT1/NLRP3/GSDMD pathway PMID 38996607
ATR
Lasiodiplodin 32885
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration PMID 31834798
The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells PMID 39639097
The co
Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1 SLC21A6)
A KLF4/PiHL/EZH2/HMGA2 regulatory axis and its function in promoting oxaliplatin
Functional expression of BMP7 receptors in oral epithelial cells. Interleukin
(Asp)2
Quantification of 1,3
Mitochondrial electron transfer chain activation in atrophic Muscle Implications for calcium signaling and chondrocyte apoptosis in osteoarthritis PMID 40403938
MCE
Small molecule antagonist reveals seizure
Lunsekimig's bispecific targeting of IL
PFOS Elicits Cytotoxicity in Neuron Through Astrocyte
Two
ASH2L 抗体 (YA4551)(ASH2L Antibody (YA4551))
IL
Metabolomic analysis of cholestatic liver damage in mice PMID 30009888
Cbl
ZIF
Discovery of Small
Human urine stem cells protect against cyclophosphamide
Electrospun polymer fibers modified with FK506 for the long
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence PMID 38459002
Comparison of the effects of ascorbyl palmitate and L
Antidepressant
Screening of CXC chemokines in the microenvironment of ovarian cancer and the biological function of CXCL10 PMID 34794429
Celastrol protected the MPTP
Simultaneous targeting of Aurora kinases and Bcr
The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in vitro PMID 32377718
Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation PMID 40613196
Glutamine affects T24 bladder cancer cell proliferation by activating STAT3 through ROS and glutaminolysis PMID 31661119
Evaluation of the Effect of Contezolid (MRX
Identification of 4
含 FERM 域 6(FRMD6)基因
Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations PMID 38580646
Mefloquine Inhibits Esophageal Squamous Cell Carcinoma Tumor Growth by Inducing Mitochondrial Autophagy PMID 32850358
Targeting the BMK1 MAP kinase pathway in cancer therapy PMID 21385929
Study on collateral sensitivity of tigecycline to colistin
Traxoprodil mesylate 188591
TSPAN9 inhibits malignant progression of hepatocellular carcinoma PMID 40792132
Calcium
Icariin inhibits RANKL
KAUST
N6
MCE
Inhibition of KIAA1429/HK1 axis enhances the sensitivity of liver cancer cells to sorafenib by regulating the Warburg effect PMID 38996929
Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets PMID 29518093
Inhibition of Acyl
Ginsenoside Rs2 87733
A selective ACAT
Sustained Release of Immunosuppressant by Nanoparticle
GRT
5
Sudemycin K A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry PMID 28103691
Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC
Pomalidomide
Self
Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats PMID 25846481
Dapagliflozin Ameliorates the Formation and Progression of Experimental Abdominal Aortic Aneurysms by Reducing Aortic Inflammation in Mice PMID 35126822
mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism PMID 27518770
Rsu1 Mouse Pre
Protective Effect of β
23
HCN
Norfloxacin
The sulindac derivatives OSI
Molecular mechanisms of posaconazole
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