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Epitranscriptomic m6A modifications during reactivation of HIV
Creating Chemiluminescence Signature Arrays Coupled with Machine Learning for Alzheimer's Disease Serum Diagnosis PMID 40357359
Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways PMID 35352213
(E/Z)
An isoflavone derivative potently inhibits the angiogenesis and progression of triple
Single
Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice PMID 19357274
Bufadienolides from Chansu Injection Synergistically Enhances the Antitumor Effect of Erlotinib by Inhibiting the KRAS Pathway in Pancreatic Cancer PMID 39770538
PEDA
Semzuvolimab 2409099
Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression PMID 37981439
Antimalarial agent 24 2299199
molecular formula
Chlorpheniramine
The structural basis for receptor recognition of human interleukin
Targeting STING with covalent small
云甘定
跨膜 4 域 A1（MS4A1）基因
N
2’,3’
6,6',6',6''
UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin
YS110 1656248
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT PMID 37559472
Exploring the therapeutic potential of deuterated PPARγ agonists for NASH PMID 41319815
4
Tyrphostin AG 494 blocks Cdk2 activation PMID 9237626
thrombi
Design strategy for serine hydroxymethyltransferase probes based on retro
Recycling of autophagosomal components from autolysosomes by the recycler complex PMID 35332264
FAP
CRBN ligand
SC 13
Anabsinthin 6903
AMPA receptor modulator
T 盒转录因子 3（TBX3）基因
Ppp1r13l
Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF
Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice PMID 28714852
PSMA6 Human Pre
pH Receptor Probe 312961
YY1
Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1) PMID 12608861
D
Upregulation of the key biomarker kinesin family member 20A (KIF20A) is associated with pulmonary artery hypertension PMID 37703933
L
N
Characterising the expression and function of CCL28 and its corresponding receptor, CCR10, in RA pathogenesis PMID 24833787
RES
MCE
(±)
SYK 抗体 (YA4025)（SYK Antibody (YA4025)）
Prolactin R 蛋白, Human (HEK293, His)
Ponatinib
3
protein quantitation
6
Syntheses and binding affinities of 6
Evidence that TNF
A role of IL
Simultaneous determination of 13 representative saponins from the total saponins of Gynostemma pentaphyllum in rat plasma using LC
Hyaluronic acid shell and disulfide
Synthesis and structure
赖甲环素
MCE
Analysis of sesquiterpene lactones, lignans, and flavonoids in wormwood (Artemisia absinthium L.) using high
IL
SHP2WT
Tetrathiafulvalene 31366
Msr1
The syntheses of isotopically labelled CB
2
Picumeterol 130641
EET homologs potently dilate coronary microvessels and activate BK(Ca) channels PMID 11356595
The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc
Shh controls epithelial proliferation via independent pathways that converge on N
Flupirtine
Chitosan nanoparticles functionalized with β
1
FEM1B Human Pre
[1,1' 3',1''
Neuropeptide Y 3
LC kinetic stabilizer
GLP
Pyrrole
Therapeutic effects of histone deacetylase inhibitors in a murine asthma model PMID 27565183
Tetraethyl [4,4'
Glucocorticoid receptor agonist
Arsenic trioxide potentiates Gilteritinib
Structural basis for inhibition of the RNA
Exploration and biological evaluation of 7
Cnnm1 Mouse Pre
R406 free base 841290
2,2'
Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo PMID 30054429
4,6
Lens Culinaris Agglutinin (Fluorescein) (LCA (Fluorescein))
Ricinus Communis Agglutinin I (Fluorescein) (RCA I (Fluorescein))
4
Specific inhibitors for prolyl endopeptidase and their anti
PCN
IRMOF
Inhibition of the Ubiquitin
Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization PMID 38376465
UTSA
A metabolic synthetic lethality of phosphoinositide 3
Herpes simplex virus as an in situ cancer vaccine for the induction of specific anti
OFD1 Human Pre
Effect of pirazolac on prostanoid synthesis by human gastric mucosa in vitro PMID 2115830
Caspase
XTT sodium 111072
Novel selective COX
Identification of Regulators for Ciliary Disassembly by a Chemical Screen PMID 34761911
PSNCBAM1
Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. III. Structural determination of mycoplanecin A PMID 6630067
Identification of TMEM53 as a novel SADS
Fmoc
BMS
AU
Efficient chemoenzymatic synthesis of UDP
iPAF1C 950403
RM
Unveiling the immunoregulatory role of interferon
Brogidirsen 2409088
Scyptolin A and B, cyclic depsipeptides from axenic cultures of Scytonema hofmanni PCC 7110 PMID 11730873
6'''
DLK
Eda2r Rat Pre
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER
The rational design of a novel potent analogue of the 5'
Discovery of 1,3,4
Capsaicin Mitigates Reverb α
GDF
Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration PMID 35785701
Histidine re
Chloroprocaine hydrochloride 3858
Hippocampal Nogo66
Generation of fluorescent and bioluminescent induced pluripotent stem cells with their application in tracking organoid development PMID 40789431
Design of Potent pan
Activation of the SH2
Anticancer agent 186
Human cytomegalovirus protein pUL36 A dual cell death pathway inhibitor PMID 32690704
MCE
Sirt6 opposes glycochenodeoxycholate
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC
2
Transferrin receptor 1 plays an important role in muscle development and denervation
Ketopioglitazone
NPBA 524033
Prevention of arterial structural alterations with verapamil and trandolapril and consequences for mechanical properties in spontaneously hypertensive rats PMID 9851541
F 13714 208109
The HSP90 inhibitor 17
Plug
Helper T
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6 PMID 18642892
Gasdermin D Protects Mouse Podocytes Against High
Clinical pharmacology and pharmacogenetics of thiopurines PMID 18506437
Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth PMID 27439478
2
GANT
MCE
2,2'
Extracellular vesicles of carcinoma
Characterization of the interaction of N
In Vivo Tracking of Human Adipose
P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling PMID 35266012
BIIB021, an orally available, fully synthetic small
Gas therapy potentiates aggregation
Integrin alpha V beta 3 蛋白, Human (Biotinylated, HEK293, His
Design, synthesis and activity evaluation of a novel PPARα agonist based on virtual screening PMID 41692311
Transfluthrin 118712
Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases PMID 22352892
Reduction of ubiquinone
Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange PMID 9527154
Mal
TISSUE REPRESSOR CONCENTRATION AND TARGET ENZYME LEVEL PMID 14170316
IL
Norzine dimalate 52239
Toxicologic evaluation of cefamandole nafate in laboratory animals PMID 650004
The role of TBC1D15 in sepsis
Vasoactive intestinal polypeptide VPAC1 and VPAC2 receptor chimeras identify domains responsible for the specificity of ligand binding and activation PMID 10491203
Biomaterial
An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension PMID 39946184
Gluten exorphin C. A novel opioid peptide derived from wheat gluten PMID 8422933
SU 5402 (Standard)
In vitro and in vivo anti
Synthesis of N(1)
Equine β
The role of JPT1 in hepatocellular carcinoma tumor progression, microtubule dynamics regulation, and potential mechanisms within the immune microenvironment PMID 40610765
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase
Human CD1 dimeric proteins as indispensable tools for research on CD1
RNA Polymerase II Subunit B3 抗体 (YA2447)（RNA Polymerase II Subunit B3 Antibody (YA2447)）
Reprogramming of Protein
IL
Cephalexin hydrochloride 59695
LRCH1 Human Pre
Inhibition of MMP
LPCAT1 reduces inflammatory response, apoptosis and barrier damage of nasal mucosal epithelial cells caused by allergic rhinitis through endoplasmic reticulum stress PMID 39837174
Murine models of VACTERL syndrome Role of sonic hedgehog signaling pathway PMID 11172440
Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms PMID 33723058
Alpha
Soluble Expression and Purification of the Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor 2 in Escherichia coli PMID 25907066
HIV
Inhibition of USP10 induces degradation of oncogenic FLT3 PMID 28967922
Ginsenoside Rg3 Alleviates ox
Carboxylesterase inhibitors PMID 21609191
eIF4A3
Acetone Extract of Cornus officinalis Leaves Exerts Anti
CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR
Involvement of the vacuolar H(+)
Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one
Release of cholesterol
2
Gypenoside XCI 2793436
Col6a3 Mouse Pre
Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition PMID 32890136
Mitochondrial GRIM
A general method to improve fluorophores for live
Acyl
Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF
Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD
Metal
PLLA10000
Kif18a
Focal adhesion kinase and osmotic responses in ionocytes of Fundulus heteroclitus, a euryhaline teleost fish PMID 31863842
Rheumatoid arthritis pathogenesis and therapeutic advances PMID 38469546
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium
Argininosuccinate synthetase is a functional target for a snake venom anti
FmocNH
Flupirtine in pain management pharmacological properties and clinical use PMID 20839897
FITC
An Unusual Binding Model of the Methyl 9
Complete solubilization of mammalian cells in lysates PMID 39105088
Photobiomodulation therapy for thrombocytopenia by upregulating thrombopoietin expression via the ROS
Design and Synthesis of 1,2
Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT
Lipopolysaccharide
Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP01532 for the control of potato soft rot caused by Erwinia carotovora subsp. atroseptica PMID 26856451
TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling PMID 34902478
Global lactylome reveals lactylation
Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection PMID 40815641
[1,1' 4',1'' 4'',1''' 4''',1''''
UDP
Human placental mesenchymal stem cells regulate the antioxidant capacity of CD8+PD
Discovery a series of quinazolin derivatives as potent AXL inhibitors PMID 35483321
Effects of S
Neuroprotective effects of (
Inhibition of TBK1 by amlexanox attenuates paraquat
Sulfur Amino Acid Restriction Mitigates High
1
1
Antitubercular and Antiparasitic 2
Antitumor Effects of β
In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis PMID 6840932
Glycerophosphoinositol 4
Combination of Ginsenoside Compound K and Anti
A combination of Trastuzumab and 17
含 FERM 和 PDZ 结构域 1（FRMPD1）基因
1,1'
Synergistic and mechanistic effects of neogambogic acid in enhancing almonertinib sensitivity in non
CircFAM53B promotes the proliferation and metastasis of glioma through activating the c
TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B PMID 31875525
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells PMID 21412271
Proteasome alpha 6 抗体 (YA1749)（Proteasome alpha 6 Antibody (YA1749)）
2,6
Secondary resistance to anti
Nitric oxide prevents a pathogen
Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence PMID 34663475
C11
Fenitrothion oxon
PD 140248 hydrochloride 147208
The synthesis of ethacrynic acid thiazole derivatives as glutathione S
Ezrin Inhibition Up
[1,1′ 2′,1′′
Tumor Microenvironment
Bone marrow stem cells secretome accelerates simulated birth trauma
miR
Locked Dimerized CXCL12 Exerts Radiosensitizing Effects in Head and Neck Cancer PMID 39722591
DCP
Novel n
Theranostic Rhenium(I)
Creatine
Pharmacological inhibition of acyl
FAK
Inhibition of demethylases by GSK
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles PMID 36368621
Tyrosine kinase inhibitors. 1. Structure
HY
MCE
(±)
Discovery and synthesis of methyl 2,5
Lysophosphatidic acid induces YAP
PRMT5 抗体 (YA1853)（PRMT5 Antibody (YA1853)）
Chromium picolinate attenuates hyperglycemia
TLR7/8 agonist 12
Small molecules with big roles in microRNA chemical biology and microRNA
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG
ATR
12/15
Cannabidiol
Polyketides and Anthranilic Acid Possessing 6
Perspectives on the development of antibody
2
Molecular basis for keratoconus lack of TrkA expression and its transcriptional repression by Sp3 PMID 16275928
Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis PMID 37820423
Effects of electroacupuncture combined with interleukin‑10 on chronic sinusitis in mice PMID 31257460
XR 5118 hydrochloride 174766
Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates PMID 29459431
Melatonin attenuates Helicobacter pylori
Betulinic acid exerts anti
5
Procaine is a DNA
Programming of the preimplantation embryo by the embryokine colony stimulating factor 2 PMID 24954585
PTC124 targets genetic disorders caused by nonsense mutations PMID 17450125
Ceftolozane sulfate 936111
4
CHA
Modulation of Neural Networks by Interleukin
Critical role of Casein kinase 2 in hepatitis C NS5A
O
Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan
Piezo1 Mediates Ultrasound
Ultra
Hepatic stellate cell stearoyl co
PIERCE1 Human Pre
PROTAC ERα Degrader
The mTORC1 Signaling Support Cellular Metabolism to Dictate Decidual NK Cells Function in Early Pregnancy PMID 35359988
Preclinical evaluation of an anti
Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA
Scutellarein stimulates human sperm function by increasing the levels of intracellular calcium and tyrosine phosphorylation PMID 36257765
Paliperidone Inhibits Ferroptosis Mediated by Autophagy in Renal Tubular Epithelial Cells by Targeting CHAC1 PMID 40259582
New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis PMID 40138999
Metabolism of the endocannabinoids, 2
The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer PMID 19671764
Isatuximab 1461640
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer PMID 38834297
Tetrabromobisphenol S (TBBPS) exposure induced the testicular aging through NLRP3
Single
Pyrazolopyrimidines as anticancer agents A review on structural and target
Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells PMID 24211639
CSF2
Structure
PTPN22 interacts with EB1 to regulate T
Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues PMID 18587423
CRBN ligand
Downregulation of FASN in granulosa cells and its impact on ovulatory dysfunction in PCOS PMID 40170064
R 1487 449811
(R)
Hexestrol
Diamino lipid DAL4 2939000
Functional characterisation of cellobiohydrolase I (Cbh1) from Trichoderma virens UKM1 expressed in Aspergillus niger PMID 30261309
MCE
Probing the single and combined toxicity of PFOS and Cr(VI) to soil bacteria and the interaction mechanisms PMID 32062202
Microglia sense and suppress epileptic neuronal hyperexcitability PMID 37541638
Metformin and soybean
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β
Repunapanor 1870822
Concentrations of LSD, 2
Teprasiran 1231737
Pycr1 Mouse Pre
1,1'
1,5
Lysoganglioside
NCAPD3
A new strategy to improve the metabolic stability of lactone discovery of (20S,21S)
CD24 Regulates the Formation of Ectosomes in B Lymphocytes PMID 40415253
Effects of PELP1 on proliferation, metastasis and angiogenesis of epithelial ovarian cancer PMID 40715657
Levonadifloxacin arginine 306748
MAT2A
1,4
4
Design, synthesis, and biological evaluation of new bis
CD53
SC13
2'
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes Case study of PI4KIIIβ with Rab11 PMID 26756197
2,5
LP
Sarcosine oxidase, Bacillus 9029
Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis PMID 11310664
HDAC6
The MERTK/FLT3 inhibitor MRX
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer PMID 40768602
MCE
antimicrobials
Discovery of benzo[cd]indol
N
Salbutamol
Inhibitors of the chymotrypsin
fatty liver diseases
4,4',4'',4'''
rno
Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability PMID 39122888
Tet2 Inactivation Enhances the Antitumor Activity of Tumor
PBD
(S)
Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus PMID 37296418
Peroxidase, Lignin 93792
Indazole 1 2252153
Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol PMID 15222401
Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp PMID 20405881
Claudin
NRMA
D
Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10 in vitro comparison with current asthma therapies PMID 23034049
Pyrazinyl
PtdIns
Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I
Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide
Diquinoxalino[2,3
Unveiling ODP4 A breakthrough in PCOS treatment via BAT transplantation PMID 40090595
Antibacterial agent 322 149092
1,4
Classic D1 dopamine receptor antagonist R
JNJ
Creatinol hemisulfate 50648
4,4'
Shikonin 517
ATP
Eaf1
(S)
R406 841290
GX1 1189359
strand fragmentation
BMS194449
t
retention time
NR
[2,2'
Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule
Immunohistochemical localization of afatinib in male rat intestines and skin after its oral administration PMID 31500866
Tiotropium bromide a novel once
Co(III) meso
Gepotidacin hydrochloride 1075235
CPL304110 1627826
Arginine methyltransferase inhibitor
Nefopam
4,4'
J
4,4′
Vesatolimod 1228585
2
Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors PMID 15322260
CB1/CB2
dBRD4
RO1138452 and RO3244794 characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists PMID 16331286
4,4'
Sugammadex 343306
Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin PMID 28659709
Aabomycin A
Ceramide
α
Protokylol
1
ZNF451 favors triple
Effects of (
EP4 receptor antagonist 8 3068255
hu14.18 (K322A) (Gamsitabart)
2
An integrin antagonist (MK
Anti
Ox4
PZP α
N
BODIPY
Tau hyperphosphorylation
MCE
SARS
Naloxone
Beta
Tuning sensitivity to IL
ML395 1638957
(
FGF13 enhances the function of TRPV1 by stabilizing microtubules and regulates acute and chronic itch PMID 38733310
Patecibart 2642374
UDP
Induction of apoptosis, cytotoxicity and radiosensitization by novel 3,4
HLA
Acute myeloid leukemia cell
HY
β
Liraglutide Attenuates Non
Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin
Ammonium
KISS
Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions PMID 23508354
Flame retardant tris(1,3
Amodiaquine clearance and its metabolism to N
HCV
Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal
Sodium 5,8
Acute hemodynamic effects and preload
Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody
Structure
Polygalacturonate lyase production by Bacillus subtilis and Flavobacterium pectinovorum PMID 4207278
[Rh(cod)Cl]2 12092
Benzenesulfonate sodium 515
Cdkn2b Rat Pre
Effects of wild
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