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Preclinical Characterization of AZD5305, A Next
A Structure
In vitro and in vivo pharmacokinetic
Discovery and Structural Optimization of 1,2,3,4
basic cosmetics
Bioactive constituents and the molecular mechanism of Curcumae Rhizoma in the treatment of primary dysmenorrhea based on network pharmacology and molecular docking PMID 33866197
Design, Synthesis, and Activity of an α
WNT5B drives osteosarcoma stemness, chemoresistance and metastasis PMID 38689429
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase PMID 19939518
LGK974 suppresses lipopolysaccharide
MCE
MCE
Structure activity relationship of novel antiviral nucleosides against Enterovirus A71 PMID 33031923
FEN1
Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors PMID 18207394
MCE
核仁蛋白 9（NOL9）基因
5'
Efficacy of rocuronium and sugammadex in a patient with dermatomyositis PMID 22419633
CDK2 degrader 8 3099145
Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii PMID 12567284
Anditixafortide 1821136
1
Effect of the coadministration of daclatasvir on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate PMID 24343001
Azobenzene
SPI1
(D
Gasdermin D (GSDMD) as a new target for the treatment of infection PMID 31191857
Txndc12
Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate
Targeting Ongoing DNA Damage in Multiple Myeloma Effects of DNA Damage Response Inhibitors on Plasma Cell Survival PMID 28580318
Liposomal
Dimethyl fumarate improves sepsis
MCE
IL13Rα2 D1 2319573
Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO
1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25
Anticancer agent 57 2408017
Pioneer neutrophils release chromatin within in vivo swarms PMID 34292151
D
Bioorthogonally Functionalized NAD(+) Analogues for In
23
Zeranol is formed from Fusarium spp. toxins in cattle in vivo PMID 9764208
Gardneramine 34274
Construction of chimeric catechol 2,3
The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide
Lead optimization to improve the antiviral potency of 2
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance PMID 41117802
Farnesyl diphosphate synthase inhibitors with unique ligand
NCOA5 suppresses tumor progression and cisplatin resistance in non
Discovery of the Clinical Candidate IDOR
Discovery of 4
7,3',4'
Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats PMID 7938114
Catharanthine tartrate ameliorates osteoclastogenesis by destabilizing HIF
NNC 05
Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress
CyclosporinA derivative as therapeutic candidate for Alport syndrome by inducing mutant type IV collagen secretion PMID 37143203
Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester PMID 4894399
Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart PMID 35349488
Brutieridin 1162664
The emergence of new antidepressants for clinical use Agomelatine paradox versus other novel agents PMID 31211282
Alcam
Triphenylene
Catalytic in vivo protein knockdown by small
MCE
Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF
Exploring TH17
Garlic ameliorates atherosclerosis by regulating ferroptosis pathway an integrated strategy of network pharmacology, bioinformatic and experimental verification PMID 39108744
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures PMID 23801192
Design and synthesis of 1,2,3
Alpha
Substrate specificity of a mannose
UBMOF
The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus PMID 7769678
Trinor
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke
Allicin Attenuates Mitochondrial Calcium (Ca2+) Overload Induced by Acrylamide in Hepatocytes via the NAD+/SIRT3
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK
Targeting nuclear RNA for in vivo correction of myotonic dystrophy PMID 22859208
Aldehyde Trapping by ADX
Effects of tartrazine on proliferation and genetic damage in human lymphocytes PMID 28264634
A new ligand for the peroxisome proliferator
Desmethyl Levofloxacin hydrochloride 2254176
Fibrillin
Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice PMID 31847895
Biotin sulfone tagged oligomannosides as immunogens for eliciting antibodies against specific mannan epitopes PMID 22326546
Microtubule
Ibuzatrelvir 2755812
IIIM
Construction of PROTAC
A slow
Kryptofix 221 31364
Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates PMID 38354417
Methylophiopogonanone A 74805
Hydrogen sulfide ameliorates peritoneal fibrosis inhibition of high mobility group box
SNAP
AChE
MCE
Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors PMID 41061899
Kansuinine B 57685
Angiotensin II human 4474
Gramine
BG
CEP
Ailanthoidol suppresses lipopolysaccharide
Inhibitory effect of ailanthoidol on 12
Cadmium exposure reprograms energy metabolism of hematopoietic stem cells to promote myelopoiesis at the expense of lymphopoiesis in mice PMID 35051759
RRx
CHNQD
Systemic delivery of factor IX messenger RNA for protein replacement therapy PMID 28202722
(R)
TNFRSF13B Human Pre
The central administration of vitisin a, extracted from Vitis vinifera, improves cognitive function and related signaling pathways in a scopolamine
Cinacalcet impurity 50 1622173
MCE
Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH A Phase 2 Randomized Controlled Trial PMID 32115759
4,4'
O
CRBN ligand
ODN 1585 386832
A Small Molecule Inhibitor of the MITF Molecular Pathway PMID 24027801
Dietary fructose improves intestinal cell survival and nutrient absorption PMID 34408323
Functional Coupling of K+
Discovery of a Copper
(
Compared efficacy of diazepam or avizafone to prevent soman
Basacv 95676
Synthesis and in vitro antiviral activities of 3'
Targeting Wnt
MCE
Synthesis and anti
(S)
Lobeglitazone 607723
PLC and PAD2 Regulate Extracellular Calcium
HEC95468, a novel soluble guanylate cyclase stimulator, shows protection in the Dahl model of cardiorenal disorder PMID 40998191
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells PMID 27057812
On
Novokinin TFA 1262750
Nifuratel in chronic urinary infections PMID 4550718
N
1,5
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta
Prostate
Small molecule inhibitors for cancer immunotherapy and associated biomarkers
Characterization of degradation products and process
Improved Antibacterial Activity of 1,3,4
Characterization of odor
In vitro profiling of the metabolism and drug
Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC
TAB29 2361144
Melagatran, an oral active
Cardiovascular effects of linalyl acetate in acute nicotine exposure PMID 29165169
CRIP1 involves the pathogenesis of multiple myeloma via dual
Dienestrol
CBLC100 1197996
Bortezomib alleviates myocardial ischemia reperfusion injury via enhancing of Nrf2/HO
Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression PMID 37315133
2
Lamivudine triphosphate TEA 2736455
Structure
The effects of nodakenin on airway inflammation, hyper
Effects of valeryl salicylate, a COX
MK
Elucidation of the composition of bovine milk fat triacylglycerols using high
Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT
Ac
Bupivacaine, levobupivacaine and ropivacaine are they clinically different? PMID 15966496
CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist PMID 7824038
Discovery of novel thiourea derivatives as potent and selective beta3
Comparison of the biochemical responses to human parathyroid hormone
Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa PMID 14740869
Synthesis of NVS
Thalidomide
VU6080195
Discovery of N
(2S,3R)
Ethyl phenylglyoxylate
Sorbitan trioleate 26266
A small
CYT387 Inhibits the Hyperproliferative Potential of Fibroblast
Discovery of 1
A Natural TMEM16A Inhibitor with Conformational Lock Mechanism Thymol Reverses Secretory Diarrhea via Chloride Flux Regulation and Antiinflammatory PMID 40905427
Sulfonated Perylene as Three
Confirmation of diosmetin 3
Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide
1,3,5
CRBN ligand
Delayed DNase
1,1,2,2
Design, synthesis and biological evaluation of dual
Discovery of an Allosteric, Inactive Conformation
A novel EPAC
Pyrazine
Structure
HA1/Hemagglutinin 蛋白, H3N2 (AFM71754, HEK293, His)
SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma PMID 35917568
UTSA
Potent and biostable inhibitors of the main protease of SARS
Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway PMID 34745413
视黄醇结合蛋白 4（RBP4）基因
2
alpha
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear PMID 17395647
PAQ 943902
Di(1H
MCE
Isatin
mmu
Synthesis of benzodithiol
Hepatocyte
Analysis of triacylglycerols in fat body of bumblebees by chromatographic methods PMID 16246355
Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM
Angiotensin 1
Factors ameliorate pro
Multistep virtual screening for rapid and efficient identification of non
Genome
Ursonic acid 6246
KLS
Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors potential agents for treatment of erectile dysfunction PMID 12570368
QuEChERS
SOS1
HY
AG337, a novel lipophilic thymidylate synthase inhibitor in vitro and in vivo preclinical studies PMID 8612303
De
Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis PMID 25001622
B 型内皮素受体（Ednrb）基因
7733
Hexb
Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors PMID 31488357
Activating transcription factor 4 regulates stearate
The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro PMID 23331343
Recent Progress in Histone Demethylase Inhibitors PMID 26710088
Cross
Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells PMID 29232926
Evolving Treatment Landscape of HER2
JTH
Hainanenin
[Rocuronium used in rapid sequence intubation and reversal with sugammadex in a patient with myasthenia gravis] PMID 22263415
Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2 PMID 28858248
Luteolin
Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity PMID 40147548
Saruparib 2589531
Biochemistry, Biliverdin PMID 31747188
Development of efficient on
Temporal alterations of the nascent proteome in response to mitochondrial stress PMID 39361503
SKF89976A hydrochloride 85375
Design of Next Generation Polymyxins with Lower Toxicity The Discovery of SPR206 PMID 31525992
Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice PMID 21606596
A pilot study of the UVA
Inhibitory effects of idoxifene on hepatic fibrosis in rats PMID 15842777
Activation of ATM
Stabilized cyclopropane analogs of the splicing inhibitor FD
HPK1
Increased DNA
Napamezole (hydrochloride)
Tuaminoheptane sulfate
Dynamic O
Thromboxane A2
Recombinant human interleukin
PD
3,6
Seliciclib Carboxylic Acid
MCE
Decoding a novel non
DASA
Docosanoic acid
5(S)
Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU
A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum PMID 40099623
Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator
Phenylglycine methyl ester, a useful tool for absolute configuration determination of various chiral carboxylic acids PMID 10813947
Effects of the novel antiarrhythmic compound TR 2985 (ropitoin) on action potentials of different mammalian cardiac tissues PMID 3393234
Txr1 a transcriptional regulator of thrombospondin
FX1 1426138
The Novel Atypical Dopamine Uptake Inhibitor (S)
Dodecyl Stearate 5303
SRSF1 蛋白, Human (His
N3C14SOBRAC
Design, synthesis and biological evaluation of novel hydroxamates and 2
Nifuratel
2
Optimization of 3,5
The deubiquitylase USP9X controls ribosomal stalling PMID 33507233
MCE
The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL
CRBN ligand
Perylene
Molecular targets of cisplatin in HeLa cells explored through competitive activity
Cryo
Kinetic enzymatic method for automated determination of HDL cholesterol in plasma PMID 3681196
PROTAC CDK9 Degrader
PCI
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β
AM580 102121
ΔNp63α promotes Bortezomib resistance via the CYGB
Naphthoquinones, anthraquinones and naphthalene derivatives from the bulbs of Eleutherine americana PMID 19777423
In vitro and in vivo enhancement of ricin
A potent bioreducible ionizable lipid nanoparticle enables siRNA delivery for retinal neovascularization inhibition PMID 38636882
A potent and selective calcitonin gene
CRBN ligand
Crizotinib
Nifuratel reduces Salmonella survival in macrophages by extracellular and intracellular antibacterial activity PMID 37732770
Propiomazine 362
Inhibition of NLRP3 enhances pro
Estrogenic activity of glycitein, a soy isoflavone PMID 10564025
Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV
The GSK
18 3 PE 34813
Targeted Biomolecule Regulation Platform A Split
CD96 Downregulation Promotes the Immune Response of CD4 T Cells and Associates with Ankylosing Spondylitis PMID 35769669
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF
Superoxide is an intrinsic signaling molecule triggering muscle hypertrophy PMID 38877802
337874
N,N'
A medicinal chemistry perspective of drug repositioning Recent advances and challenges in drug discovery PMID 32283298
Fmoc
Anti
CG400549
Chemokine CXCL14; a double
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors PMID 33835811
SUMOylation and the HSF1
Protective effects of tenuigenin on Staphylococcus aureus
MANF regulates neuronal survival and UPR through its ER
Progress in the development of selective inhibitors of aurora kinases PMID 16101420
anti
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis PMID 32805235
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma PMID 40750706
Milnacipran inhibits glutamatergic N
4
Spg21
CAY10621 120005
Structure
Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties PMID 1470228
The inhibition of pancreatic cancer progression by K
The Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Orally Dosed QY201, a Novel JAK1/TYK2 Inhibitor, in Chinese Healthy Subjects PMID 40424417
The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation PMID 26878209
Mac
Azaxanthene based selective glucocorticoid receptor modulators design, synthesis, and pharmacological evaluation of (S)
Three new lanostanoids from Ganoderma lucidum PMID 3783158
Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii PMID 37199655
Effects of SARS
CD59 蛋白, Rat (HEK293, Fc)
1,4
5,15
CRBN ligand
UV filters, ingredients with a recognized anti
Exploiting endogenous and therapy
Pharmacological enhancement of naltrexone treatment for opioid dependence a review PMID 21731898
Carbidopa
2’
Anti
Drug
Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells PMID 9210464
L
SAIRGA 2059978
MK
Exploring the substituent effects on a novel series of C1'
2,2'
1,4
Molecular mechanisms of inverse agonism via κ
Recombinant human annexin A5 a novel drug candidate for treatment of sepsis? PMID 24346537
18 1 Aminoethyl PC 2342573
LGK974 suppresses the formation of deep vein thrombosis in mice with sepsis PMID 38160565
[4,2' 5',4''
EBI2 regulates intracellular signaling and migration in human astrocyte PMID 25297897
4'
CS
Serotonin maleate 18525
MCE
Curcumin analog CUR5
MNK1/2
MCE
Jpt1
Dihydrotanshinone I targets the spike N
MCE
Synthesis and in vitro anti
Discovery of novel melanocortin4 receptor selective MSH analogues PMID 9630346
Senataxin prevents replicative stress induced by the Myc oncogene PMID 40108134
Orally bioavailable BTK PROTAC active against wild
MCE
Neobulgarone F 315209
Repeated pregnant mare serum gonadotropin
CP
Fast and effective mitochondrial delivery of ω
Quantitative Proteomics Implicates Rictor/mTORC2 in Cell Adhesion PMID 30156101
Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1
GSDMD
2,6
Immunomodulation of the NLRP3 Inflammasome through Structure
Angeloylgomisin H 66056
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors PMID 23061660
Discovery of a new eugenol
WCK
Ethane
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy PMID 34414762
2,6
Reproductive toxicity of linuron following gestational exposure in rats and underlying mechanisms PMID 28007637
Copper(II)
Guanosine 5'
Epa
Thrombospondin
R(+)
PROTAC IRAK4 degrader
1
Nectin1
H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair PMID 34099628
HIF
XmAb 5592 1221901
Skimmianine Showed Neuroprotection against Cerebral Ischemia/Reperfusion Injury PMID 39057078
Synthesis and in vitro activity of novel N
Actions of pregnant mare serum gonadotropin in the immature female rat correlative changes in blood steroids, gonadotropins, and cytoplasmic estradiol receptors of the anterior pituitary and hypothalamus PMID 174887
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition PMID 25310383
Optimization of an indazole series of selective estrogen receptor degraders Tumor regression in a tamoxifen
白细胞介素 3（IL3）基因
T
Iridoids from Valeriana jatamansi induce autophagy
High
Thalidomide (methylamino)acetaldehyde
A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells PMID 35592997
Antibacterial and COX
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA
Tetrahydropyranodiquinolin
2
Benzo[b]quinolizinium,bromide 7547
Cerebral amyloid
Synthesis, biological evaluation and 3D
Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel
Transport of N
TIP2
TREM2 Activation by First
Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM
Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6
PARP
TEI
(S)
The kinase p38α functions in dendritic cells to regulate Th2
Fructose
Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages PMID 33139505
A gut
含 SPG21 脱氢酶结构域，maspardin（SPG21）基因
4
Rotigaptide inhibits spontaneous contractions of gastric smooth muscle in diabetic rats via the PKCα
CRBN ligand
染色体比对维持磷蛋白 1（CHAMP1）基因
A Novel Near
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors PMID 21233313
Leucopelargonidin
Glycitein 40957
1,3
Azure C Targets and Modulates Toxic Tau Oligomers PMID 29378132
Incorporation of L
Characterization of alternate encounter assemblies of SARS
Spinal serum
Bacterial vaginosis, Atopobium vaginae and nifuratel PMID 22082330
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth PMID 40742808
Human PTH
APRIL (TNFSF13) regulates collagen
Mass Spectrometry Measurements of Neuropeptides From Identification to Quantitation PMID 35324254
A selective WDR5 degrader inhibits acute myeloid leukemia in patient
Galunisertib monohydrate 924898
A small
In vitro and in vivo characterization of the non
eIF4A3
Prostaglandin E2 receptor antagonist (SC
Effect of thrombin inhibitors on platelet functions comparative analysis of DuP 714 and hirudin PMID 1450317
Efficient synthesis and anti
Pomalidomide 4'
Identification of a new class of WNT1 inhibitor Cancer cells migration, G
MCE
NKG2D
Iron(II) phthalocyanine 132
KC 12291 an atypical sodium channel blocker with myocardial antiischemic properties PMID 14978516
DOTAMTATE 2415661
MCE
Synthesis and Anti
D18 2230218
Nerve Growth Factor and Pathogenesis of Leprosy Review and Update PMID 29867937
CP
Microtiter plate
N
mmu
trans
Synovial fluid from end
Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis PMID 35385208
A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle PMID 9765340
Meroterpenoids with Antitumor Activities from Guava (Psidium guajava) PMID 28578580
Novel Mixed Serotonin Receptor Binder Compounds as 5‑HT2C Agonists for Treating Psychotic Disorders PMID 40832520
(S,R,S)
5'
Sulfo DBCO
Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway PMID 40274709
Single dose oral pharmacokinetic profile rubraxanthone in mice PMID 35342834
Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure
Fc 受体样 2（FCRL2）基因
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti
Validating novel tau positron emission tomography tracer [F
S
Efna4
LGK974 1243244
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