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PROTAC BRD4 Degrader
TAAR1/5
Senaparib 1401682
pre
CRBN ligand
HEC72702 1793063
Dibenzo[b,d]furan
Angiotensin
Antimicrobial agent
1,4
PI3K
Methoxycarbonyl
2,2'
MCE
CRBN ligand
(2E,9Z)
Apostatin
Comparative analysis of taxol
FK 3311 116686
Ganetespib, a unique triazolone
Smo antagonist M25 1186293
醛脱氢酶 3 家族成员 A1（ALDH3A1）基因
Measuring nitric oxide in single neurons by capillary electrophoresis with laser
Insulinotropic action of glutamate is dependent on the inhibition of ATP
para
Withanoside V 256520
AVE0991, a nonpeptide analogue of Ang
FITC
Draflazine 120770
PD
BChE/HDAC6
JBJ
Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells PMID 39410845
MCE
Kinase scaffold repurposing for neglected disease drug discovery discovery of an efficacious, lapatinib
Androgen receptor ligand 2 3056514
(1S,2R)
CD47 ligation induces a rapid caspase
CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences PMID 9443558
Isoverticine 23496
PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds PMID 33689792
7
Di(5
Targeting of mTORC1/2 by dihydroevocarpine induces cytotoxicity in acute myeloid leukemia PMID 30548613
Pharmacokinetics of nikkomycin Z after single rising oral doses PMID 19349517
Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications PMID 34994556
4,4',4''
KW
DOTA
Potent and selective xanthine
7
Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL PMID 29259259
Silychristin Skeletal Alterations and Biological Activities PMID 28006905
HY
Three new terpenes with potential antibacterial and anti
MCE
The SMAC Mimetic APG
Tofogliflozin 903565
8MDP 29491
MOF
18 1 Biotinyl Cap PE 384835
Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis PMID 23944963
OZO
Atropine resistant excitation of the urinary bladder the possibility of transmission via nerves releasing a purine nucleotide PMID 4339250
Case
Dihydrodiol
Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17
Azido
1
Unveiling the anti
Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl
PARP1
Pyrazole N
4
15
N
8
Quecitinib 2416858
Florasulam
Discovery and Preclinical Evaluation of BMS
CRBN ligand
TWEAK/TNFSF12 蛋白, Mouse (HEK293, Fc)
Ginsenoside Ra1 83459
Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms PMID 31385615
Microcystin
In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4
Zuclomiphene
(+)
(S)
Super
A randomized trial of budiodarone in paroxysmal atrial fibrillation PMID 22205496
Dovitinib
Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID
AVE 0991 304462
4
4,4'
Antibiotic adjuvant 3 2972593
Slow Dissociation from the PARP1
Involvement of Polo
TQS 353483
Perindopril impurity 1 129970
4,4′,4′′,4′′′
A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors PMID 41476656
Dazcapistat 2221010
CCDC6 and USP7 expression levels suggest novel treatment options in high
Biological and computer
Dutogliptin 852329
Thalidomide
TAN
3
IL
para
2,4'
Mu opioid receptor antagonist 1 2767446
2
4,4',4''
Adenine nucleotide translocase family four isoforms for apoptosis modulation in cancer PMID 21076465
Photo
RWJ52353 hydrochloride 245744
Mammea A/BA 5224
Escin alleviates cerebral ischemia
High
0990CL (Standard)
Cleroindicin D 189264
N
Aminopicoline 695
Identification of a novel class of retinoic acid receptor beta
4'
(±)
PQ401 196868
Proteome and Glycoproteome Analyses Reveal Regulation of Protein Glycosylation Site
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune
二肽基肽酶 4（DPP4）基因
2
Gem
Different charged biopolymers induce α
Pimonidazole a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma PMID 9826471
CD1530 107430
1H,1'H
Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress PMID 18579108
UBIAD1 effectively alleviated myocardial ischemia reperfusion injury by activating SIRT1/PGC1α PMID 35491985
NOD2 negatively regulated titanium particle
3'
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus
JNJ
Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5
GsMTx
OSIP
TFAP2A upregulates FAM83A to suppress ferroptosis and diminish cisplatin sensitivity in non
Oxopurpureine 32845
Unoprostone reduces oxidative stress
Azaperone
NHS
SNAI1 is upregulated during muscle regeneration and represses FGF21 and ATF3 expression by directly binding their promoters PMID 35726676
Defactinib hydrochloride 1073160
Glutamate rescues heat stress
Down
ACC1/2
Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH PMID 27264949
Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy PMID 3905333
Design, synthesis and bioevaluation of novel hydrazide derivatives as enhancers of immunotherapy and DNA
The pharmacology of McN
PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma PMID 29440296
Hedgehog IN
Primary myelofibrosis 2014 update on diagnosis, risk
Engineered nano
[1,1′ 4′,1′′
Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase PMID 24080726
Benzbromarone aggravates hepatic steatosis in obese individuals PMID 29526820
P4Q
Autophagy supports PDGFRA
The Protective Effect of (
Early
4
GCN5 acetylates and regulates the stability of the oncoprotein E2A
ACS03 2227022
Y4R agonist
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances PMID 1336040
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes PMID 41026524
PROTAC SOS1 degrader
Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo
A novel dual ATM/DNA
BIOLOGIC EFFECTS OF MELENGESTROL ACETATE PMID 14192473
The CD160, BTLA, LIGHT/HVEM pathway a bidirectional switch regulating T
4,7
ZD 2486 185836
WDR62 mediates TNFα
Cancer
Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms An Effective Treatment with Fludrocortisone PMID 26240768
Lifitegrast impurity 4 hydrochloride 2049127
Comparative analysis of novel decynium
Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer PMID 33313947
CRBN ligand
Kidins220
Lufepirsen 287122
MCE
MCE
5,7,3'
Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats PMID 28054477
[Cu2(bdc)2(bpe)]n 1421612
D
2,4
Norswertianolin 54954
SUMO Protease 1607459
Schisantherin S 2230512
IL
BAP1 promotes the repair of UV
m
Irisin
7
MCE
FBXL8 inhibits post
The discovery of 4
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO
MCE
Seletracetam 357336
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis PMID 37536034
Dimeric Pyranonaphthoquinone Glycosides with Anti
The potency of fluvoxamine to reduce ethanol self
Absence of neutrophils impairs the host defense in murine footpad model of chromoblastomycosis PMID 40267064
CD73 expression and fyn
Integration of vitro models with machine learning and epidemiological data reveals PCB
Patient
Adam15 Rat Pre
Copper
4,4'
ErbB2
Cy5.5 210892
Leucodin 17946
CD27/TNFRSF7 蛋白, Rhesus macaque (HEK293, His)
Molecularly Stimuli
Interactive Analysis of TX
Low
Antinephritic effects of PGE1 and thiaprostaglandin E1, TEI
Tnfsf12 Mouse Pre
Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway PMID 19642865
The lipid
Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3
One
Tnfrsf13b Mouse Pre
Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells PMID 34363252
δ ENaC a novel divergent amiloride
Zeranol 26538
Colorimetric Detection of Uranyl Using a Litmus Test PMID 30140672
Proadrenomedullin (1
Safe drugs with high potential to block malaria transmission revealed by a spleen
The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes PMID 12196477
REV
Natural product
CRBN ligand
Ultrasound
Cholesterol 25
Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities PMID 32876846
(Rac)
AVE 0991, a nonpeptide mimic of the effects of angiotensin
Plasmodium PK9 Inhibitors Promote Growth of Liver
Retinoid X receptor
KSG
CA
The impact of enriching heat
AMADH inhibitor optimization and its effects on GABA accumulation in soybean sprouts under NaCl
Lentztrehalose B 1808096
1,2,3,4,8,9,10,11
CGP 53153 a new potent inhibitor of 5alpha
Norneostigmine 16088
2,3,5,6
Exploring thienothiadiazine dioxides as isosteric analogues of benzo
S
7
Dual potent ALK and ROS1 inhibitors combating drug
An O
The cytotoxic natural compound erianin binds to colchicine site of β
Discovery and development of spleen tyrosine kinase (SYK) inhibitors PMID 22257213
Hyaluronic Acid The Influence of Molecular Weight on Structural, Physical, Physico
BI
Tabersonine Induces the Apoptosis of Human Hepatocellular Carcinoma In vitro and In vivo PMID 38465429
8
4,4′
Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats PMID 22865388
UR
Gastric cancer
Abituzumab Targeting of αV
4,7
Spiroxamine
Reduced thrombosis in Klkb1
Downregulation of circular RNA circDOCK7 identified from diabetic rats after sleeve gastrectomy contributes to hepatocyte apoptosis through regulating miR
The Aldose Reductase Inhibitor Epalrestat Maintains Blood
MCE
CGA
MCE
2',3',5',6'
Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects PMID 14694204
AZ
3
Structural Basis of GABAB Receptor Activation during Evolution PMID 40650551
PHA
LY367385 hydrochloride 2829282
Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl
Caspase
Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents PMID 25462253
Developing potent human uric acid transporter 1 (hURAT1) inhibitors PMID 21449597
Synthesis of cationic N
c
Design and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer PMID 23871909
USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis PMID 31730000
Morin ameliorates rotenone
Dyslipidemia and prevention of atherosclerotic cardiovascular disease in the elderly PMID 33949178
Investigating the effect of tenuigenin on LPS
Discovery of novel Keap1
Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S
CRBN ligand
Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine
Mulberry (Morus alba l.) leaf improves arachidonic acid metabolism disorder in chronic obstructive pulmonary disease PMID 41101074
Nephrotoxic effect of atractyloside in rats PMID 4479740
4'
5
Esculentoside F 95263
Cyclohexane
Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization PMID 7265118
Des(1
(4
Safety and pharmacokinetics of the Fc
2,2'
Hepatoprotective effect of Bacoside
KLS
Irdabisant 1005402
A high content imaging flow cytometry approach to study mitochondria in T cells MitoTracker Green FM dye concentration optimization PMID 29198814
Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy PMID 23449602
meso
Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA
Caenorhabditis elegans recognizes a bacterial quorum
Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models PMID 35128717
TNFSF14, a novel target of miR
PARP inhibition promotes endothelial
TW9 2614417
Imlunestrant a next
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors PMID 31465224
m
Hematopoietic stem and progenitor cell membrane
1,3,6,8
ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy
MCE
Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL
4
Nd
HY
1,3,5,9
Structure
Dapagliflozin stimulates glucagon secretion at high glucose experiments and mathematical simulations of human A
27
CD3E
Biological activity of some coumarins from Sri Lankan Rutaceae PMID 8021652
Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin
Synthesis and biological evaluation of semi
Antibiotic discovery against Piscirickettsia salmonis using a combined in silico and in vitro approach PMID 37094756
Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction PMID 22732700
L
1,3
Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy
Cometabolic degradation of 1,4
Size limits of thiocarbamides accepted as substrates by human flavin
Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2) PMID 25766632
TRIM32
The cytotoxic T
Identification of a Disulfide Bridge in Sodium
The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia
Antiviral effect of octyl gallate against DNA and RNA viruses PMID 16950523
[2,2' 6',2''
2,3,5,6
Temafloxacin an overview PMID 1662889
Phenformin and 5
(S)
Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor PMID 31956418
β
ATF5 Human Pre
Stem cell properties of human periodontal ligament cells PMID 16827724
Genome
Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells PMID 24362821
Sitafloxacin in bacterial infections PMID 21504249
LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells PMID 23168492
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism PMID 33338411
FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics PMID 25277206
Gliotoxin promotes Aspergillus fumigatus internalization into type II human pneumocyte A549 cells by inducing host phospholipase D activation PMID 24637030
Anti
Non
Design, synthesis, and inhibitory activity of potent, photoswitchable mast cell activation inhibitors PMID 23617679
Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM
FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism PMID 31097687
MELK expression correlates with tumor mitotic activity but is not required for cancer growth PMID 29417930
Design, synthesis and biological evaluation of plant
MCE
MEK2 抗体 (YA3980)（MEK2 Antibody (YA3980)）
SESN2 protects against denervated muscle atrophy through unfolded protein response and mitophagy PMID 34429398
2
Membrane
Reparative Effects of Ethanol
(3R,4S)
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea PMID 39905483
High
Tos
Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats PMID 29207045
Discovery of a ZIP7 inhibitor from a Notch pathway screen PMID 30643281
Chronic intranasal oxytocin alleviates cognitive impairment and reverses oxytocin signaling upregulation in MK801
Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1 PMID 39032655
Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ PMID 31346210
1,4
Design, Synthesis, and Mechanism Study of Novel BMX Inhibitors Based on the Core of 1,3,5
Dectin
Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity PMID 30719922
Primary structure of the hypertrehalosaemic factor II from the corpus cardiacum of the Indian stick insect, Carausius morosus, determined by fast atom bombardment mass spectrometry PMID 3828078
ZMAT4 Human Pre
Effects of azathioprine, 6
Hydrophobic penetrating peptide PFVYLI
Human Serine Racemase Key Residues/Active Site Motifs and Their Relation to Enzyme Function PMID 30918891
Exosomes
The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling PMID 39829812
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent PMID 10052965
Vitamin D3 Attenuates Neuropathic Pain via Suppression of Mitochondria
MCE
Inhibition of JNK Signaling Overcomes Cancer
Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia
Cenpa
INH14, a Small
Lucerastat 141206
Galanin Receptor 2 Is Involved in Galanin
Creb3l1
Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies PMID 2745260
Subchronic (13
STAT3 Regulates miR
Targeting USP8 Inhibits O
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling PMID 39215364
Iridoids and sesquiterpenoids from the roots of Valeriana officinalis PMID 19691292
Statins attenuate cholesterol
2
Dihydrocucurbitacin B 13201
Fatty acid beta
BAY
mmu
9
A biallelically active embryonic enhancer dictates GNAS imprinting through allele
MCE
4,4'
Chronic exposure to microcystin
Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism PMID 33662415
Determination of two progestin metabolites (17α
Antifungal constituents of Clytostoma ramentaceum and Mansoa hirsuta PMID 15287070
A novel, sensitive, and fast ultra
Naphtho[1,2
The discovery of (2S,3S)
[1,1'
Tolterodine tartrate 124937
The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice PMID 35788623
Artemisinin
In vivo RNA interference
Glucose Oxidase
NKG2A
Synthesis, bioactivity, docking and molecular dynamics studies of furan
IGF
PTP1B
4
Caroverine 23465
6'
[Orn8]
ZIC 1 抗体（ZIC 1 Antibody）
Design, synthesis and anticancer evaluation of tetrahydro
Orantinib 252916
[Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl)] PMID 535823
Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens PMID 26802604
Ethoxomane (Ethomoxane)
Sequence
Hypoxia
MAO
N3
白头翁素
Adecatumumab an anti
Anti
Ultrasound
A ROS
Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography
Nasp Rat Pre
IL
MCE
USP8抑制剂、基因
CD10 抗体 (YA5352)（CD10 Antibody (YA5352)）
ODC1 loss upon KLF6 upregulation promotes macrophage pyroptosis and acute kidney injury in sepsis PMID 40962975
Effects of Solvents, Emulsions, Cosolvents, and Complexions on Ex Vivo Mouse Myometrial Contractility PMID 33852137
A new immunofluorostaining method using red fluorescence of PerCP on formalin
Anti
ROR
A physiologically based pharmacokinetic model for capreomycin PMID 22143528
Calcilytic compounds potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone PMID 11561095
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy PMID 29180808
DMTMM
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1 PMID 36040348
Borrelidin, a small molecule nitrile
A novel BET bromodomain inhibitor, RVX
CCL2
GOLGA1 抗体 (YA2948)（GOLGA1 Antibody (YA2948)）
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