最近收录_第814页_生物活性分子
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Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease PMID 39031498
MicroRNA
Desmethyl Levofloxacin
Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair PMID 36168631
CMX
Galbonolides A
GARP 复合体的 VPS52 亚基（VPS52）基因
AF3485 1195786
SOF
Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain facts and challenges PMID 23270993
3
Th17 cell
KN
Salidroside overcomes cisplatin resistance in ovarian cancer via the inhibition of CRNDE
Asiaticoside hampers epithelial
MCE
Acetyl zingerone inhibits chondrocyte pyroptosis and alleviates osteoarthritis progression by promoting mitophagy through the PINK1/parkin signaling pathway PMID 40494201
Eflapegrastim 1384099
MGAT2
JAK2(JH1/JH2) Recombinant Human Active Protein Kinase
Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II
SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells PMID 39160617
4
Decrease in GPSM2 mediated by the natural product luteolin contributes to colon adenocarcinoma treatment and increases the sensitivity to fluorouracil PMID 38823277
Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells PMID 38581243
Development of N
RPR 102341
KJ 103
Regulation of cyclooxygenase activity by metamizol PMID 10493111
Tau
L 36358
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin
BMS
MOLM13 cell
KS370G
ODN
CCT251236
Small
Novel anti
Apba1
µ
CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug
Lipid
Anticodon Edited Transfer RNAs (ACE
Ivabradine 155974
TGFβ1 is essential for MSCs
Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti
EPHA10
Pdk3
白细胞介素 16（IL16）基因
Itgb7 Mouse Pre
IO21
VEGFR
Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis PMID 37856847
LJ
H
Targeting melanoma resistance Novel oxindole and non
SKLB102 242473
Tau deficiency contributes to impaired bone formation via activating PPARγ signaling PMID 40373841
Quaternium 15
The Identification and Pharmacological Characterization of 6
Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts PMID 17509413
Murine oncogenicity and pharmacokinetics studies of 9
Indole
Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001
Ethylene glycol diacrylate 2274
2
Topotecan 123948
BNIP3 upregulation by ERK and JNK mediates cadmium
MI30
Solidagolactone III 41943
AY 25674 65425
Synthesis of unsymmetrical pyrazines based on α
Sceptrin dihydrochloride 79703
The chemical constituents of the fungus Stereum sp PMID 17193259
Rational design of 2
Diplomorphanins A and B new C
LMPTP
Peptidase, Porcine
Salfredin C1
黄嘌呤脱氢酶（Xdh）基因
Modelling the reaction mechanism of ribulose
TPST2 Human Pre
Ribulose bisphosphate carboxylase 9027
BTA
Two new compounds from Dendrobium candidum PMID 18827395
NUFIP1
DF1111301
Nitrofurantoin revisited a systematic review and meta
COQ8B Human Pre
Discovery of 2
L2
NAD salvage pathway
OP
Bioactive constituents from the leaves of Clinacanthus nutans Lindau PMID 19223186
Oridonin promotes endoplasmic reticulum stress via TP53
Lefelsiran sodium 2728713
AG024104
LJ2698
NecroX
PTPN22 Human Pre
Anti
CDK4
MPT cells
GK
GypenosideZ
Umesolerbart 2456307
chlorophyll derivative
Fmoc
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats PMID 38532543
MC 2050
MTOA
Quercetin
Cannabidiolic acid methyl ester 55658
2
GypenosideZ
Dowicil200
GR
Sanggenon N
C12
Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer PMID 20222671
脱氢酶/还原酶 11（DHRS11）基因
DCC netrin 1 受体（DCC）基因
辅酶 Q10A（COQ10A）基因
DKFZ
ELTLGEFLKL 303068
Effect of N
Design, Synthesis, In Vitro Evaluation, Multitargeted Molecular Docking, and In Silico Analysis of Some Azo
ZM323881, a novel inhibitor of vascular endothelial growth factor
1,2
BDM31343 1001468
Boc
Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET PMID 26755770
Cimicifugic acid N (升麻酸N)
Synthetic lethality of cyclin
ADAMTS10 Human Pre
MCE
LY294002 hydrochloride 934389
AG
HIVEP 锌指 2（HIVEP2）基因
H1 histone
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage PMID 26095040
AG
具有序列相似性的家族 72 成员 A（FAM72A）基因
L 44
rel
endogenous ceramide
NecroX 2
Adamts10 Rat Pre
YM
Regulatory Fibroblast
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients PMID 38579402
RND Pump
Phomapyrrolidones A
Indirubin shows anti
Dengzhan Shengmai capsules and their active component scutellarin prevent cognitive decline in APP/PS1 mice by accelerating Aβ aggregation and reducing oligomers formation PMID 31810113
生长停滞和 DNA 损伤诱导 alpha（GADD45A）基因
Naxe Mouse Pre
Tnfsf13
(Rac)
Purmorphamine activates the Hedgehog pathway by targeting Smoothened PMID 16408088
Discovery of (R)
MCH
rel
3,5
Boc
Fmoc
Melithiazole C
Rhodanese (硫氰酸酶)
Fmoc
Fmoc
3
2,6
PLX5622 1303420
Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury PMID 31616413
Gnl2 Rat Pre
PACSIN3 Human Pre
NSC 37410
adenine base
TREM2
NCGC00247743 1435192
Tofacitinib
ITRI
Ebola virus Glycoprotein/GP 蛋白 (QDA39862, HEK293, His)
YM
High
somatostatin
Edotreotide
emission
Enzalutamide 915087
Discovery of novel human lactate dehydrogenase inhibitors Structure
Androgenic activity of synthetic progestins and spironolactone in androgen
CUEDC1 inhibits epithelial
RS6212
NPR
Amyloid
Liproxstatin
Updating the Definition of Cancer PMID 37409952
WDFY3 抗体 (YA4364)（WDFY3 Antibody (YA4364)）
T2D
A critical step in antidepressants onset Excitation of glutamatergic pyramidal neurons in rodents' medial prefrontal cortex PMID 38065287
β
CARD9 抗体 (YA566)（CARD9 Antibody (YA566)）
Tropanserin 85181
Embryo
Interferon alpha/beta Receptor 1 抗体 (YA3112)（Interferon alpha/beta Receptor 1 Antibody (YA3112)）
RG 7697
辅酶 Q10B（COQ10B）基因
JPC
M
4
OK
TNFα
BT18 924811
ADCC
Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity PMID 20594848
NLRP3 inflammasome
Excessive proliferating cell nuclear antigen attenuates endometrial adhesive capacity and decidualization in patients with recurrent implantation failure PMID 38783610
Rusfertide
MAR 709
OK101
Medium
mcK6A1
α
MEDI 0382
MH6419c5
APX 007
β
MDL
RS
Progesterone Receptor
PANC
Noraramtide
A Novel NF
acceptable plasma exposure
含山梨醇和 SH3 结构域（SORBS2）基因
RS 6212
GIP/GLP
SCH13521
5
BHV1100
fatty liver diseases
NNC0090
p65
RO6811135
Yadanziolide B
BT18
MC38
SRTCX 1003
BT
anti
Mesothelin 抗体 (YA4237)（Mesothelin Antibody (YA4237)）
MAR709
OK 101
Natriuretic Peptide Receptor
HCT116
Lipid
LIB 003
Adenosine receptors and their ligands PMID 11111832
m
Genotype 5 Hepatitis E Virus Produced by a Reverse Genetics System Has the Potential for Zoonotic Infection PMID 30620002
HO
Recanaclotide 1667762
Discovery of D6808, a Highly Selective and Potent Macrocyclic c
Dodecanoate
FBXO3 抗体 (YA6569)（FBXO3 Antibody (YA6569)）
Dual effects of propyl gallate and its methylglyoxal adduct on carbonyl stress and oxidative stress PMID 29884377
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR
Synthesis of novel spiro[pyrazolo[4,3
Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy PMID 36894566
Diabetes induces hepatocyte pyroptosis by promoting oxidative stress
Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines PMID 28475922
Paulomycin A 81988
HO
NKG2A
Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway PMID 31461977
LIM Kinase 1+2 抗体 (YA5556)（LIM Kinase 1+2 Antibody (YA5556)）
基质金属肽酶 8（MMP8）基因
N
(±)
Cysteine protease inhibitor
DLG3 Human Pre
Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis PMID 36233194
Rala Rat Pre
(S)
MK 319
KAT2B 抗体 (YA4403)（KAT2B Antibody (YA4403)）
DNA
ALK
Pharmacokinetics of esmolol and ASL
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple
Single and combined effects of amino polystyrene and perfluorooctane sulfonate on hydrogen
mmu
Length and saturation of choline plasmalogens alter the aggregation rate of α
Design and synthesis of 3,4
Ataxin 3 抗体 (YA4087)（Ataxin 3 Antibody (YA4087)）
Gas1
hsa
ALKBH5 promotes PD
Ptpn22 Mouse Pre
Di(N
Atractylodin Ameliorates Colitis via PPARα Agonism PMID 36614242
Spag5 Rat Pre
m
AR
GPX3 promotes cisplatin resistance in TNBC by manipulating ROS
First
MAP4K1 抗体 (YA4410)（MAP4K1 Antibody (YA4410)）
ADCY4 Human Pre
3,4',5
VASP 抗体 (YA018)（VASP Antibody (YA018)）
Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri PMID 25576609
CRBN ligand
BODIPY 530/550 NHS ester
HIV
1
NS2B/NS3
Contribution of amylose
Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive
Latozinemab 2376132
Cholesterol Esterase, PEG Modified
JS04
13′
MSPE
In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna PMID 21505084
F44
BDM31827
4
(S)
Canagliflozin improves fatty acid oxidation and ferroptosis of renal tubular epithelial cells via FOXA1
ZLN005 alleviates PBDE
Gala
Tigolaner 1621436
1,4
Forskolin
Macrophage
Inactivation of caspase
TAF1 ligand 1 1926986
热休克蛋白家族 B (小) 成员 2（HSPB2）基因
Generation and Phenotypic Analysis of the IL
DAPK
A novel benzodiazepine inverse agonist, S
Beta cells are essential drivers of pancreatic ductal adenocarcinoma development PMID 39677599
RO9021
MCE
Prospective treatment in carnitine
Effects of MCI
Larixnaphthaone
Specific binding of cinnamycin (Ro 09
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor in vitro and in vivo characterization PMID 15858066
Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb PMID 16325912
Clinical pharmacokinetics and exposure
TTP
Recombinant ACE2 protein protects against acute lung injury induced by SARS
Mitochondrial fission inhibition protects against hypertension induced by angiotensin II PMID 38383894
STK16 promoted colorectal cancer progress in a c
Clec4d
MCE
SV 293 873445
Discovery of novel pyrrolo[2,3
Discovery of PT
Ex Vivo High
1
Glimepiride 93479
Comparative investigation of the in vitro inhibitory potencies of 13
(R)
Development of Alectinib
WRN
TOR kinase activity in Chlamydomonas reinhardtii is modulated by cellular metabolic states PMID 32677084
MCE
USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14 PMID 39814232
COL6A2 in clear cell renal cell carcinoma a multifaceted driver of tumor progression, immune evasion, and drug sensitivity PMID 40770761
Benzyl
Design, synthesis, and biological evaluation of novel artemisinin
Sirtinol 410536
Fmoc
Combi
PLEK2 promotes the proliferation and migration of non
G3
Vascular Effects of H2S
Z
Transcripts 202 and 205 of IL
Inhibition of ID1
FBLN2 inhibits gastric cancer proliferation and metastasis via the TGFβ/TGIF2 pathway PMID 40168772
(Rac)
A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate
Genistein inhibits both estrogen and growth factor
Vacquinol
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice PMID 21264226
AI
MCE
Simultaneous determination of TUG
The synthesis and evaluation of thymoquinone analogues as anti
N
S100A14 Human Pre
PHLDA2 overexpression facilitates senescence and apoptosis via the mitochondrial route in human nucleus pulposus cells by regulating Wnt/β
Molecular mechanism of HDAC6
A new structural class of S
(E/Z)
A review on poly(3
Metabolomic Analyses Reveal Extensive Progenitor Cell Deficiencies in a Mouse Model of Duchenne Muscular Dystrophy PMID 30282911
Interleukin 6 exacerbates the progression of warm autoimmune hemolytic anemia by influencing the activity and function of B cells PMID 37580421
Thellungianate
RRM1 Human Pre
Proteinase, Aspergillus melleus
Hyperwightin C
Protease, Rhizopus sp.
Cemadotin 159776
Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells PMID 18380477
S
PSI
Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease PMID 31683484
mmu
Bridging pyrimidine hemicurcumin and Cisplatin Synthesis, coordination chemistry, and in vitro activity assessment of a novel Pt(II) complex PMID 39163714
Adamantan
Hypotensive actions of some analogues of platelet
GSK778 hydrochloride 2863657
Growth Hormone
CDK5 调节亚基相关蛋白 3（CDK5RAP3）基因
Targeting Rab26 to Conquer Cisplatin
Deucravacitinib analog 1 1609529
Preclinical toxicology studies with a new antiarrhythmic agent pirmenol hydrochloride (CI
Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides PMID 18500841
PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity PMID 38948056
3
CRBN ligand
Thioanisole
Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC
锌指蛋白 165（ZNF165）基因
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus PMID 26519380
纤维蛋白 5（FBLN5）基因
Pharmacological Management of Dementia with Lewy Bodies PMID 30680679
Exploiting the co
Methyl p
JAK2 as a surface marker for enrichment of human pluripotent stem cells
Persistent hypertension induces atrial remodeling and atrial fibrillation through DNA damage and ATM/CHK2/p53 signaling pathway PMID 39366645
CRBN ligand
2MD 213250
Neurogenic transdifferentiation of human adipose
EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma PMID 32360600
8(S)
LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage
Epstein
INCB38579 1246207
AJ
Norcepharadione B attenuates H2O2
Azido
Biotinyl
Ulex Europaeus Agglutinin I (Biotinylated) (UEA I (Biotinylated))
D
Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells PMID 30562828
Fmoc
MCF7
Cy3 labled Bamosiran sodium
Targeting the HGF/Met signalling pathway in cancer PMID 20303741
Acrolein 2,4
12β
Smad3 Mouse Pre
Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers PMID 15182391
3'
ZLWH
endothelial monolayers
细茎石斛提取物 (Dendrobium moniliforme (L.) Sw.)
Ins(1)P1
Ginsenoside Rk3 364779
Cy
SARM1_C311
Thermal proteome profiling identifies the membrane
NN 6020
MC2050 1301757
AOC
Lefelsiran
KDM4A
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy PMID 34844982
Co
GDC
p38 mitogen
GOLGA5/Golgin
FSH 蛋白, Human (HEK293, Flag
Dione
BIO
Aristoforin
NKH477 (Standard)
ZW
13
Esculentoside S (商陆皂苷 S)
Ppm1d Mouse Pre
Stx4a
Lilrb2
NSC
突触融合蛋白结合蛋白 1（STXBP1）基因
FabH
Enzyme
MMAE
蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1E（PPM1E）基因
I
Designing Trifluoromethyl Pyrazolones for Selective Molluscicidal Activity Against Monacha cartusiana Toward Sustainable Land Snail Control PMID 40497300
Esculentoside T
JS
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