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Interaction between CA repeat microsatellites and HIF1α regulated the transcriptional activity of porcine IGF1 promoter PMID 31673965
Telmisartan
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 PMID 36117290
Modular PROTAC Design for the Degradation of Oncogenic BCR
Lemnalol 82570
The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation PMID 25484239
MCE
CD4 aptamer sodium
Bonaphthone
MCE
NCD
Cholinergic crisis caused by ingesting topical carpronium chloride solution A case report PMID 34030906
Structure
Identification of Four Enhancer
Rebaudioside A two
CXC 基序趋化因子配体 3（CXCL3）基因
Coumarins and anti
An Autism
D
INCB050465 (Parsaclisib), a Novel Next
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR
Evaluation of ocular tolerability and bioavailability of tonabersat transfersomes ex vivo PMID 40358832
4SC
Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas PMID 30720075
Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A PMID 29285146
Rifamdin
XAT
Ppm1e
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors PMID 20576576
GuaB
Ppm1e Mouse Pre
U
Molecular Imaging of Labile Heme in Living Cells Using a Small Molecule Fluorescent Probe PMID 35133144
Antiproliferative effects of Norartocarpetin isoflavone in human lung carcinoma cells are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S
Sulcardine hydrochloride 343935
Cyclolignans as inhibitors of the insulin
Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity PMID 25372046
Ppm1d
Hydroxy
MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha
Candidate Drugs Screening for Behcet's Disease Based on Bioinformatics Analysis and Mouse Experiments PMID 35799784
MCH
BI
Optimization of a potent class of arylamide colony
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric
Entpd2 Mouse Pre
MCE
SKF 106760 126053
Pharmacological suppression of HHLA2 glycosylation restores anti
3
Ribosomal S6 kinase (RSK) modulators a patent review PMID 27410995
Stachyflin and acetylstachyflin, novel anti
12
Cxcl3 Mouse Pre
Z
Dehydroepiandrosterone attenuated the immune escape of oral squamous cell carcinoma through NF
XMD8
A novel anti
Anti
Benzo[b]thiophene
Livagen 433257
Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism PMID 8491706
Design, synthesis and structure
Polyinosinic
Boc
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias PMID 9572893
DHQZ 36 1542098
Effects of recombinant human GM
Efficient fungal and bacterial facilitated remediation of thiencarbazone methyl in the environment PMID 32592941
2
H
DL
Discovery of Triazine
humanized PDX models
Metabolism of desciclovir, a prodrug of acyclovir, in humans after multiple oral dosing PMID 3680558
ANAT inhibitor
2,5
24(28)
TLSC
5
H
Mono N
MLS
Maximizing ER
H
Establishment of Novel Biosynthetic Pathways for the Production of Salicyl Alcohol and Gentisyl Alcohol in Engineered Escherichia coli PMID 29570271
In vivo protection provided by a synthetic new alpha
Therapeutic potential of targeting IRES
BMS986331
Development of novel lab
Characterisation of alkaloids from some Australian Stephania (Menispermaceae) species PMID 12842145
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers PMID 31402173
cryo
Fmoc
Regiafuran C 2059921
Di
The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors PMID 28229135
TMPRSS11A Human Pre
Bicuculline methiodide potentiates NMDA
Dermatology
Small Molecule Modulation of MHC
OMTX
Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage PMID 38252510
Canagliflozin differentially modulates carfilzomib
Thalidomide
Prenylated 2
Dapoxetine a new option in the medical management of premature ejaculation PMID 23024705
3
Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine
Bis
Phytotoxic furanocoumarins from the shoots of Semenovia transiliensis PMID 23157001
Z
H
PC
Design, synthesis, and biological evaluation of a hydrophilic 20
MCE
quinone methide
1,2
Boc
Aritinercept
Lipophilic Group
The isolation and structure elucidation of macrocyclic lactone antibiotic, A26771B PMID 142754
Anti
Synthesis of N
Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen
Thiencarbazone
Synthesis and biological evaluation of isoxazoline derivatives as potent M₁ muscarinic acetylcholine receptor agonists PMID 25765911
Therapeutic Effect of a Latent Form of Cortistatin in Experimental Inflammatory and Fibrotic Disorders PMID 36559278
Multicomponent and Multiphase Lipid Nanotubes Formed by Gliding Microtubule
Collagens I and V differently regulate the proliferation and adhesion of rat islet INS
5(6)
Study on the detoxification mechanisms to 5,10,15,20
Antiparasitic agent
The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT PMID 30257990
In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity PMID 34352214
GW 275175X
Exploiting Metabolic Vulnerabilities in Cancer with a Dual
Pterocarpan scaffold A natural lead molecule with diverse pharmacological properties PMID 28189086
Fmoc
Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS
MTIC
Rational design of dual PB2/JAK2 inhibitors achieving balanced antiviral and host
Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor
A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain PMID 24120516
H
Discovery of a novel niacin
(Rac)
Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea PMID 14627391
2,3
WITHDRAWN SNX10 deficiency restricts foam cell formation and protects against atherosclerosis by suppressing CD36
Discovery of potent and selective urea
Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery PMID 27149904
Toward the development of biomimetic polymers by protein immobilization PEGylation of insulin as a model reaction PMID 15165461
Pyranine 6358
The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine
Structure
NAD (P) HX 差向异构酶（NAXE）基因
SCH79797 245520
MCE
Selective stalling of human translation through small
Scaffold Hopping Strategy toward New 4‑Aminoquinazolines Active Against Extracellular and Intracellular PMID 40666484
MCE
Tamarixin 27542
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV
Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations PMID 39869768
MCE
Fomepizole
MCE
Targeted Capture of Chinese Hamster Ovary Host Cell Proteins Peptide Ligand Discovery PMID 30965558
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1 PMID 33484341
G
Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3
Ghrh
Reversal by RARα agonist Am580 of c
蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1M（PPM1M）基因
Visfatin is regulated by interleukin‑6 and affected by the PPAR‑γ pathway in BeWo cells PMID 30483779
IMB
ENTPD2 Human Pre
Novel antagonists of alcohol inhibition of l1
3,3'
MH
Comprehensive evaluation of fluroxypyr herbicide on physiological parameters of spring hybrid millet PMID 31579632
Lonidamine alleviates inflammation and tissue remodeling in a mouse model of eosinophilic chronic sinusitis A single
Binding of estrogen and progesterone
Sub
Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2
Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas PMID 25099181
Letter Fenticlor, actinic reticuloid, and antihistamines PMID 4152080
Pharmacological properties of 2
GyrB
Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives
H
MCE
Towards selective peptide deformylase inhibitors A mass spectrometry
Antitumor effects of BI
Cimicifugic acid L (升麻酸L)
Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti
BMI1 Human Pre
Effect of some new thioglycosides on endotoxin
1
Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine
Oxidative Stress
alpha5beta1 integrin antagonists reduce chemotherapy
Murepavadin a new antibiotic class in the pipeline PMID 29451043
Synthesis of retinoid X receptor
Cholesteryl docosahexaenoate 70110
Bmi1 Rat Pre
Pyrrolopyrimidines A promising scaffold for the development of novel cathepsin K inhibitors PMID 41192281
Endotoxin inhibitor blocks heat exposure
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes PMID 27472162
Azaindoles as potent CRTH2 receptor antagonists PMID 21185722
MRT68921 dihydrochloride 2080306
H
Antivascular therapy for multidrug
Z
Widespread PRC barrel proteins play critical roles in archaeal cell division PMID 37090588
Sulforhodamine 101 DHPE 187099
Fmoc
Esonarimod (KE
The cooperative effect of Lewis pairs in the Friedel
Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung PMID 8876156
Fmoc
Fmoc
Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade PMID 39423817
Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities PMID 9360617
Icariin ameliorates cisplatin
Structure
Z 7149
A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity PMID 24871339
PEP
Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold PMID 29317150
Brain distribution and bioavailability of elacridar after different routes of administration in the mouse PMID 22611067
Involvement of substance P in the anti
HA/Hemagglutinin 蛋白, H1N1 (AGL04329, HEK293, His)
Methocinnamox Produces Long
Antitumor efficacy of a novel class of non
A protein
CRGDS 726187
persistent light reaction
MLS000536924 511306
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas PMID 37465309
2
Apoc3
The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high
DAP12 抗体 (YA1651)（DAP12 Antibody (YA1651)）
Physical characterization of meso
PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas PMID 30194764
BI
MCE
MS33 2407449
OMTX 005
IRE1
InhA
Identification and optimization of novel 6
Mycoplanecin B
Mycoplanecin D
LASSBio
Eteplirsen 1173755
SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK
Discovery of Sophoridine α
Dihydrocaffeic Acid Prevents UVB
Polybrominated Diphenyl Ether Quinone Exposure Induces Atherosclerosis Progression via CD36
Pivotal role of voltage
Chemical Composition and the Effect of Walnut Hydrosol on Glycemic Control of Patients With Type 1 Diabetes PMID 27335580
VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX
Fluorescence study of steroid hormone binding activity of Helix pomatia agglutinin PMID 18501393
4
UNC5293, a potent, orally available and highly MERTK
Fmoc
N3
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD
Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti
Z
Penetration Enhancement Strategies for Intradermal Delivery of Cromolyn Sodium PMID 35739411
Linoleic acid metabolite drives severe asthma by causing airway epithelial injury PMID 23443229
m
Suppression of ZEB1 by Ethyl caffeate attenuates renal fibrosis via switching glycolytic reprogramming PMID 39270946
Polo
Snap23
PI3K/AKT/mTOR signaling regulates BCP ceramic
Potency, selectivity and prolonged binding of saxagliptin to DPP4 maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly
Demissidine 474
Ganoderterpene A, a New Triterpenoid from Ganoderma lucidum, Attenuates LPS
Mizoribine prodrug
SKF
Insulin eflivet
4
Galanin (1
JMV 179 119386
HA1/Hemagglutinin 蛋白, H1N1 (ACP41105, HEK293, His)
Opuntiol (仙人掌醇)
Etaconazol (Etaconazole，乙环唑)
6‑Hydroxy‑FAD
BMS
NS
Armanezumab
HJ03
Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA
Behavioral pharmacology of methocinnamox A potential new treatment for opioid overdose and opioid use disorder PMID 36759567
CDD
Fatty acid esters of hydroxy fatty acids A potential treatment for obesity
The effect of RG 12525 on leukotriene D4
MG53/CAV1 regulates transforming growth factor
Effect of decoyinine on the regulation of alpha
Detecting normal and cancer skin cells via glycosylation and adhesion signatures A path to enhanced microfluidic phenotyping PMID 38703495
The lonidamine derivative H2
Acrinathrin 101007
Polyamine and EIF5A hypusination downstream of c
Natural Product
High
Alpinia oxyphylla Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells PMID 31001353
Cadherin
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B
MCE
Honyucitrin 114542
Engagement of cellular cholesterol in the life cycle of classical swine fever virus its potential as an antiviral target PMID 30484759
good permeability
Sodium ionophore III 81686
F
Slpi
F10126
Anti
iNOS inhibitor
BCL2 inhibitor ABT
G6PD
The EZH2
MCE
PI3K/mTOR Inhibitor
Identification of a druggable protein
Phospho
Sufentanil inhibits Pin1 to attenuate renal tubular epithelial cell ischemia
KT D606 1429063
Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non
CRS400393 2253175
Effects of nanocarbon solution treatment on the nutrients and glucosinolate metabolism in broccoli PMID 36211778
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo PMID 14695831
L 0042
Recent advances in the diagnosis of dermatophytosis PMID 32003043
Anti
Populus tremula
A plant virus hijacks phosphatidylinositol
Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3 PMID 31612426
Enhanced 3,5
Lysicamine 15444
MCE
Boc
A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors PMID 32512835
GEN
Treatment of paragonimiasis with bithionol and bithionol sulfoxide PMID 6038780
Effects of the Aurora kinase inhibitor VX
Metabolism and excretion of tolcapone, a novel inhibitor of catechol
Nucleotide
Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia
LY219057 150351
Establishing an experimental rat model of photodynamically
Discovery of ABBV
MAO
MRL
MCE
Preclinical efficacy of carfilzomib in BRAF
A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation PMID 21593768
18 1 Dimethyl PE 96687
Generation of survivin
Pik3ap1 Mouse Pre
Synthesis and Biological Evaluation of Natural
Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation PMID 21274742
The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH
(+)
Rhodamine 110
Binding of prothrombin and its fragment 1 to phospholipid membranes studied by the solvent relaxation technique PMID 9804936
Myosin Heavy Chain 抗体 (YA5348)（Myosin Heavy Chain Antibody (YA5348)）
organophosphate compound
OICR
Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin
Lgals3 Rat Pre
2
Anti
Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)
Restoration of Extrasynaptic/Synaptic GABAAR
7'
Inactivation of a tachykinin
四肽重复结构域 4（TTC4）基因
NRX
Sarmenoside III 947409
Anti
Development of new chiral 1,2,4
MCE
[Pathways of corticosteroid biosynthesis in human adrenals (Itsenko
DCM
In search of flavivirus inhibitors evaluation of different tritylated nucleoside analogues PMID 23721953
IBR2 (Standard)
Identification of the optimal reference genes for atrial fibrillation model established by iPSC
IC
L
Synthesis and pharmacological profiling of cis
Pazufloxacin mesylate 163680
Bocidelpar 2095128
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads PMID 27882198
Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)
Effects of sodium copper chlorophyllin on mesenchymal stem cell function in aplastic anemia mice PMID 23001462
5
SACLAC 2248703
SU14813 maleate 849643
Methyl trans
Fibrotic collagen
(Rac)
TATA
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist PMID 18550844
HA1/Hemagglutinin 蛋白, H3N2 (AGB08328, HEK293, His)
TLR9 pathway is involved in adjuvant effects of plasmid DNA
The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac
Insulin potentiates inhibitory synaptic currents between fast
Novel N
Lactobacillus plantarum 1
IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease PMID 38796567
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors PMID 27994735
Detection of the designer benzodiazepine metizolam in urine and preliminary data on its metabolism PMID 27671107
(S)
N
Blood
MCE
MCE
GSK3 alpha 抗体 (YA2971)（GSK3 alpha Antibody (YA2971)）
Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice PMID 24904269
m
MCE
Cpn1
SAR Exploration of Tight
Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer PMID 30251407
MCE
ARC 239 67339
Biotin
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development PMID 29799838
PC6
Acetylcholinesterase inhibitive activity
Chemerin/RARRES2 蛋白, Mouse (HEK293, His)
5’
BTBD1 抗体 (YA9027)（BTBD1 Antibody (YA9027)）
Ptprg
MCE
Lithium citrate 919
TMED2 binding restricts SMO to the ER and Golgi compartments PMID 35353806
HJC0152 (Standard)
Ser
EGFR mutant
Chlorotris(triphenylphosphine)copper 15709
A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia PMID 29364906
Zegocractin (Standard)
Cisplatin liposome (Liposomal cisplatin，顺铂脂质体)
Benzofuran
Switching It up with New KRAS Inhibitors PMID 40261144
Interaction of a ferrocenoyl
Anti
Tongmai Yangxin pills anti
Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis PMID 33905250
MCE
Clenbuterol
Brombuterol hydrochloride (Bromobuterol hydrochloride)
ZK
Brombuterol
Ecastolol
3
Protokylol hydrochloride (Caytine hydrochloride)
Bufetolol
Tropodifene (Tropaphen)
Protokylol (Caytine)
The Wnt/β
MCE
Discovery of 1
Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP PMID 17032903
Fosfructose (Questcor) PMID 15931572
Brombuterol
The therapeutic effect of a novel GAPDH inhibitor in mouse model of breast cancer and efficacy monitoring by molecular imaging PMID 38811918
Thiamphenicol glycinate 2393
Neurotoxicity assessment of QoI strobilurin fungicides azoxystrobin and trifloxystrobin in human SH
New therapies for systemic lupus erythematosus
EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway PMID 36932397
MCE
Protease
sEH inhibitor
DPC
NHBoc
NSC756093 1629908
LC
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog PMID 10027293
Il18bp
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide
Comparative Volatile Profiling of Ludwigia stolonifera Aerial Parts and Roots Using VSE
Cardiac effects of 3,5
The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3
Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats PMID 32628132
Genomic characterization of Gli
Smad3 抗体 (YA075)（Smad3 Antibody (YA075)）
GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells PMID 33009637
Povetacicept 2490217
Repair
CRBN ligand
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