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PF
Investigations on the 4
10m/ZS44 3008988
TRAP1
Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo
DG5128
phytaspase
Tilmicosin 108050
Discovery of a New Four
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis
ABX 1431
Epimedoside A 39012
Gd
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130 PMID 12417753
Avermectin A1a 65195
KCA 098 129794
WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia
Ambra1 Deficiency Inhibits the Proliferation of Breast Cancer Cells Through the Akt
In vitro and in vivo characterization of SARS
Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenin
An efficient asymmetric synthesis of the potent beta
Caloxin a novel plasma membrane Ca2+ pump inhibitor PMID 11245619
RQ
Danazol 17230
Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in
Galectin
Japanese Leigh syndrome case treated with EPI
AHR 10240 91713
Tramiprosate 3687
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac
Anti
Bioactive spirobisnaphthalenes from the endophytic fungus Berkleasmium sp PMID 25237727
Aftin
Protein
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry PMID 19961183
Vacquinol
DNA Gyrase
Five new withanolides from Tacca plantaginea PMID 16819218
Ifetroban sodium (Standard)
Cromakalim 94470
L
Structure
IGFBP
Raddeanin A Enhances Mitochondrial DNA
rabbit lung ACE
Tolonidine
SNAP 505
Development and pre
SNAP
Plenolin 34257
Entpd2 Rat Pre
L
Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry PMID 25450204
Site and mechanism of uncoupling of nitric
PPM1G Human Pre
CEACAM4 Human Pre
GS9350
Tandutinib 387867
Isoplumbagin 14777
AMPA receptor antagonist
GS
D
FcγRIV
Fcγ receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid PMID 25043618
Sphingosine
3
Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciens PMID 32637665
MCE
Anticoronavirus activity of rhizome of Dryopteris crassirhizoma via multistage targeting of virus entry and viral proteases, Mpro and PLpro PMID 38925321
Synthesis, Characterization, and Bioactivity of the Lichen Pigments Pulvinamide, Rhizocarpic Acid, and Epanorin and Congeners PMID 36897305
N
Thalidomide
14
L
(S)
ACY
Thalidomide
Secondary metabolites isolated from Castilleja rubra exert anti
NMS
ATG7
NAT8L
Reboxetine, a unique selective NRI, prevents relapse and recurrence in long
L 44
COX
Osteosarcoma Cell
MCE
Neuroprotective effects of beta
MicroRNA 181a
Nanoparticles generated from a tryptophan derivative physical characterization and anti
Prolylendopeptidase, myxococcus xanthus (PEP
Methyl 3
Transport of enniatin B and enniatin B1 across the blood
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling PMID 27129165
Novel combretastatin A
[Asu1,6]
P2X7 Receptor in microglia contributes to propofol
ac4CTP
Small
Involvement of P2X7 Receptor in Proliferation and Migration of Human Glioma Cells PMID 29546069
Fmoc
SiO2 NP promotes allergic gastritis induced by degranulation of mouse MC9 cell through AQP4
Development and validation of LC
Computer
Synthesis and antiproliferative activity of indolizinophthalazine
RGH
Antimycobacterial agent
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A
MCE
Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl
Identification of novel azaindazole CCR1 antagonist clinical candidates PMID 30595446
complement C5 factor inhibitor
Is OM
Design, synthesis, and evaluation of cystargolide
Novel chemotype NLRP3 inhibitors that target the CRID3
PTPRC/CD45R0 蛋白, Human (HEK293, Fc)
FR
Tan
MCE
MtTMPK
Impact of an herbicide combination of bromoxynil and prosulfuron on soil microorganisms PMID 16855810
Tri(Amino
Isomannide
DG70
Transforming growth factor alpha and mouse models of human breast cancer PMID 10713694
Elfritatug
HD202A
VX
Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD
MHY
Indolcarboxamide is a preclinical candidate for treating multidrug
Tan
Bicalutamide sulfide 90356
Tan931
Nonsteroidal antiandrogens. Synthesis and structure
dehydrogenase activity
DG70 930470
Streptococcal autolysin promotes dysfunction of swine tracheal epithelium by interacting with vimentin PMID 35921364
BODIPY
BI1124
Structure
KJM429
Exploring the behavior of fluorinated sulfonylureas herbicides, trifloxysulfuron and prosulfuron, under oxidative water treatment processes Chlorination, ozonation, UV photolysis and hydroxyl radical reactions PMID 41161181
BUA
Prosulfuron 94125
3,5
Serpina3c deficiency induced necroptosis promotes non
Natural products as aromatase inhibitors PMID 18690828
HA/Hemagglutinin 蛋白, H1N1 (AAP34324, HEK293, His)
Amesotatug 3051777
Lys
Design, Synthesis, and Biological Evaluation of Novel Heteroaryl, Squaramide, and Indolcarboxamide Derivatives as Formyl Peptide Receptor 2 Agonists to Target Neuroinflammation PMID 40847912
Inhibition of prolyl 4
MCE
The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells PMID 35589797
NADH：泛醌氧化还原酶 B8 亚基（NDUFB8）基因
KJM
MCE
MCE
BI
rVR1
CHO
Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS
Structural basis of insulin receptor antagonism by bivalent site 1
Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells PMID 23560764
Characterization of the anticonvulsant and neuroprotectant BIIR 561 CL in vitro effects on native and recombinant alpha
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis PMID 35923149
UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol
Serum thymic factor acetate 125117
Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus PMID 11314963
Tolinapant 1799328
Novel insights into the dynamics behavior of glucagon
Structural requirements for the substrates of the H+/peptide cotransporter PEPT2 determined by three
3
Aloperine Inhibits ASFV via Regulating PRLR/JAK2 Signaling Pathway In Vitro PMID 39201769
Cochlioquinone B
CRS400393
Ppm1a
Effects of a potent and selective PPAR
Prostaglandin E2 promotes neural proliferation and differentiation and regulates Wnt target gene expression PMID 27265882
Finerenone
Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF
MCE
1
Bamaquimast (F 10126)
Screening of novel drugs for inhibiting hepatitis E virus replication PMID 31004661
Design, synthesis and biological evaluation of sphingosine
Ovarian Cancer Drives TLR5
Conversion of L
Rxfp3
SBP
MtbHU
MDRTB
Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat
Phosphoinositide 3
2013 Philip S. Portoghese Medicinal Chemistry Lectureship drug discovery targeting allosteric sites PMID 25180768
洛非帕明 (Standard)
Microbial cleavage of various organophosphorus insecticides PMID 225990
BGP
InhA
Mastoparan M tetraacetate 79396
JNJ
Anti
Azide
Unraveling the Molecular Landscape of Neutrophil Extracellular Traps in Severe Asthma Identification of Biomarkers and Molecular Clusters PMID 38801616
POSH
MCT1
Discovery of Potent and Wild
Drug Isomer
Laccase Properties, Physiological Functions, and Evolution PMID 32024019
Antagonism of oxytocin in rats and pregnant rhesus monkeys by the novel cyclic hexapeptides, L
beclin 1 ，自噬相关（Becn1）基因
Synthesis, selective cytotoxicities and probable mechanism of action of 7
(S,R,S)
Design and Synthesis of Novel N
12
Affinity
ZNL0325, a Pyrazolopyrimidine
preferentially
Discovery of novel arylpyrazole series as potent and selective opioid receptor
PTK2
Beacon (47
DL
Anti
2
Focal adhesion kinase
SMO
Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted PMID 22563237
Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators PMID 41129410
白细胞介素 13（IL13）基因
A p38 MAPK
丝氨酸/苏氨酸/酪氨酸激酶 1（STYK1）基因
drug delivery system
Lung delivery of aerosolized dextran PMID 10619803
zebrafish
NEI
3,4
Propargyl
antiemetic
calcium
Asymmetric dimethylarginine 30315
fibroblast
hypercholesterolemia
Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase PMID 18590331
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis PMID 30201291
The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation PMID 25122067
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli PMID 15870344
Structure
protein kinase C
Nocloprost 79360
MCE
RUNX
Development of selective class I protein arginine methyltransferase inhibitors through fragment
Role of epidermal growth factor receptor inhibitor
cattle
MDL 101146 149859
Hexyl methanesulfonate (Standard) (Methanesulfonic acid hexyl ester (Standard))
Carbonic anhydrase
Enantiomer
Magnesium dodecyl sulfate (Magnesium lauryl sulfate，十二烷基硫酸镁)
Dehydroglyasperin C isolated from licorice caused Nrf2
Clostridium difficile
New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth PMID 14604232
The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency PMID 8447317
MK
A simeprevir
HDAC1 Promotes Myocardial Fibrosis in Diabetic Cardiomyopathy by Inhibiting BMP
MCE
Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage PMID 31085238
Characterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator PMID 40210660
SAR150640, a selective beta3
antimycobacterial
Tuberculosis inhibitor 1
Baicalin attenuates aflatoxin B1
Gomisin M2 Inhibits Mast Cell
The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell
Stevioside
Zingibroside R1 80930
Protein Z 抗体 (YA5029)（Protein Z Antibody (YA5029)）
Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium
Glutamate signalling via a MEKK1 kinase
BT2 34576
Synthesis and evaluation of the substrate activity of C
Design, synthesis, and biological evaluation of novel 4H
Edatrexate, an antifolate with antitumor activity a review PMID 8422595
HaloTag technology for specific and covalent labeling of fusion proteins PMID 25560071
Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer PMID 33069797
Aspergillolide, a new 12
Sulfated bile acid is a host
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell
Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy PMID 40069295
An integrated in vitro approach to identifying chemically induced oxidative stress and toxicity in mitochondria PMID 38070616
nerve growth factor
ASN
Repirinast inhibits antigen
BT2
Targeting the MARCH5
Myeloma mesenchymal stem cells' bioenergetics afford a novel selective therapeutic target PMID 40216736
Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension
Anti
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia PMID 33217342
Design and synthesis of thiourea
An investigation of the adsorption of hydroxypropylmethyl cellulose 2910 5 mPa s and polyvinylpyrrolidone K90 around Naproxen nanocrystals PMID 22829442
Orphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells PMID 39422036
T20
Granulocyte colony
Microfluidic
Vitamin K2 sensitizes the efficacy of venetoclax in acute myeloid leukemia by targeting the NOXA
Trafficking of Acetyl
Development and validation of bioanalytical assays for the quantification of 9MW2821, a nectin
Etifoxine hydrochloride 56776
Smurf
Effects of MY
A spheroid model that recapitulates the protective role of the lymph node microenvironment and serves as a platform for drug testing in chronic lymphocytic leukemia PMID 40625531
1,2
Dihydro
Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization PMID 30857476
ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2
L
PRMT5 Inhibition Drives Therapeutic Vulnerability to Combination Treatment with BCL
Discovery of a Novel MNK Inhibitor (NSP
Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth PMID 35344040
Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c
ZM
The Therapeutic Synergy of Selinexor and Venetoclax in Mantle Cell Lymphoma Through Induction of DNA Damage and Perturbation of the DNA Damage Response PMID 37880950
Combination of the new minor groove alkylator tallimustine and melphalan PMID 9135501
Muscarinic acetylcholine receptor
BAI1 335165
Sensory neurons promote immune homeostasis in the lung PMID 38134932
ATF4 抗体 (YA6268)（ATF4 Antibody (YA6268)）
HIF
Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C
Firefly luciferase can use L
安徽金粟兰提取物 (Chloranthus anhuiensis K. F. Wu)
The C terminus of DJ
dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function PMID 29285362
Caspase
Anti
Synthesis of new simplified hemiasterlin derivatives with α,β
Nitroimidazole
Dopropidil hydrochloride 117241
PAGE 家族成员 1（PAGE1）基因
2’3’
Discovery of APD334 Design of a Clinical Stage Functional Antagonist of the Sphingosine
Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl
AT
Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)
HIV
Disassociation of bone resorption and formation by GLP
Heterocycle
The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs PMID 21300059
FAK
Discovery of small
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models PMID 17486044
Poly(methyl methacrylate) 9011
MCE
New flavan trimer from Daemonorops draco as osteoclastogenesis inhibitor PMID 38008129
MCE
Discovery of Indole
Antibacterial compounds of licorice against upper airway respiratory tract pathogens PMID 11575586
Belnacasan 273404
Discovery of novel selenium derivatives as Pin1 inhibitors by high
pigmentosa
(S)
1
InhA
5,7,3',4'
BRL34915
B16.gp33
Identification of trans,trans
Z118332870 1223377
Lipopolysaccharide
Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes PMID 23946423
DiosMetin 7
Potent and Selective Triazole
NAT8L
一氧化氮合酶
Saquayamycins, new aquayamycin
The cyclic GMP
The evaluation of N
Cobicistat
Tafluposide 179067
Taurocholic acid
Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids PMID 944052
A novel tumor
Tos
Sf3b3
Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non
LAIR
Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas
Ppm1a Rat Pre
Fmoc
Endothelin
MCE
N
MC
Canonical Notch signalling is inactive in urothelial carcinoma PMID 25167871
Murine epidermal growth factor (EGF) fragment (33
Revealing the radiative and non
H
SM19712 free acid 194542
Fmoc
A novel multiple
Claficapavir 2055732
Inhibiting EPAC1 improves brain edema and neurological outcomes by regulating AQP4 polarization after intracerebral hemorrhage PMID 40935163
Thermodynamics of binding of a low
TCO
Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo PMID 31296886
MCE
Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155
The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1 PMID 40365380
VR23 A Quinoline
2'
Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX
Balsalazide sodium hydrate 150399
CAL
Leonurine hydrochloride promotes osteogenic differentiation and increases osteoblastic bone formation in ovariectomized mice by Wnt/β
(S)
H
Thyroxine hydrochloride
N6
L
Kibdelins, novel glycopeptide antibiotics. I. Discovery, production, and biological evaluation PMID 3781909
Epoxide based inhibitors of the hepatitis C virus non
LY 178002 107889
MCE
Degradation evaluation and toxicity profile of bilobol, a promising eco
3,5
Glucagon like peptide
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations PMID 35960817
A high
Hydranthomycin 172923
Escin IIa 158732
L
Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway PMID 39653105
Boc
5
Tofacitinib impurity 59 1616760
Protectin DX attenuates IL
Cholyl
L
EPZ005687
Critical role of astrocytic interleukin
HA/Hemagglutinin 蛋白, H1N1 (528a.a, ABU99109, HEK293, His)
MCE
MELK
Discovery, total synthesis, and biological evaluation of tyrcinnamins as antibacterial agents and tyrosinase activators PMID 40286627
Identification of Selective Lead Compounds for Treatment of High
InhA
Up
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission PMID 24913172
Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets PMID 29413529
Repositioning HIV
Antcamphins A
How filopodia respond to calcium in the absence of a calcium
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent PMID 21316218
Neohetramine and thephorin; two new antihistaminic drugs PMID 18888474
4
MCE
UTPU trisodium
Cys
Emidurdar (Standard)
Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)
EM
MAPKAPK5
Parthenin
2
6"
F81
IFRD1
MU262
1
Cyetpyrafen
Cinnamoylglycine 16534
2
Type II Inhibitors Targeting CDK2 PMID 26158339
Ligand based approach to L
Estrone 3
The umbrella cell keratin network organization as a tile
P7170 A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor
Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability PMID 36253417
R
The effect of vitamin K2 on bone metabolism in aged female rats PMID 15856362
FGF
Amine Analysis Using AlexaFluor 488 Succinimidyl Ester and Capillary Electrophoresis with Laser
MCE
The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus Aspergillus fumigatus PMID 39162512
Boc
Lmtk2
BF389 127245
Limaprost
Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets PMID 8391870
Triptohairic acid 220209
A peptide inhibitor of c
CCL23 A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease PMID 31958084
Velmupressin 1647119
Inhibition of dengue viruses by N
Synthesis, biological evaluation and structure
Farnesiferol A 511
Preclinical Characterization of Relatlimab, a Human LAG
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