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Anaplastic lymphoma kinase (ALK) structure, oncogenic activation, and pharmacological inhibition PMID 23201355
Cereport (RMP
ROCK inhibitors upregulate the neuroprotective Parkin
A Multiligand Architectural Photosensitizer That Targets Hemagglutinin on Envelope of Influenza Virus for Photodynamic Inactivation PMID 32329578
Molecular and cellular biology of interleukin
Triplex
ARM domain
α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding PMID 41396300
CD11a
HSPB7
S
JNK3
Characteristics of n
Colistin
UGM
Fmoc
DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer PMID 21311763
Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles for Efficient Tumor
(S)
UVI 3003 847239
Characterization of human A(2B) adenosine receptors radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC
Emtricitabine S
Comparative analysis of antiviral efficacy of FDA
LIGHT/TNFSF14 蛋白, Mouse (HEK293, His)
UQCRB and LBH are correlated with Gleason score progression in prostate cancer Spatial transcriptomics and experimental validation PMID 39310280
Ch25h
(
In vitro microbiological characterization of novel cyclic homopentapeptides, CP
Chromium acetate stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate
Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP
Bromuconazole impairs implantation process through cellular stress response in human trophoblast and endometrial cells PMID 40915813
Marine natural product
Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin PMID 3924086
MH6419c5
Esculentoside T 1346652
specific phobia
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators PMID 23916258
Simultaneous determination of pyrametostrobin and its two metabolites in cucumber and soil using a quick, easy, cheap, effective, rugged, and safe method with HPLC
Unlike Its Paralog LEDGF/p75, HRP
Demeclocycline Reduces the Growth of Human Brain Tumor
Benzothiazole Amphiphiles Ameliorate Amyloid β
ANK101
Hapten application to the skin induces an inflammatory program directing hapten
Dalbergin 482
Boc
Pyrametostrobin 915410
Sutantatug 3049680
NSC37410
Hydroxypheophytin a 20240
Omphalocarpin 120693
FaDu cell
Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase identification of the two cysteine disulfide bonds and crystal structure of a non
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells PMID 27261575
Electroacupuncture improves gastrointestinal motility through a central
Croverin 76475
IRBM
Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase PMID 34132537
Baicalein exhibits anti
MC2050
OP
Omega
Aluminium increases xanthine oxidase activity and disturbs antioxidant status in the rat PMID 11787993
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1 PMID 19132534
ATP Synthase
Ibramvibart 3031270
NCS1 抗体 (YA6673)（NCS1 Antibody (YA6673)）
Pepstatin, a new pepsin inhibitor produced by Actinomycetes PMID 4912600
Development of Novel Gastrin
Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M PMID 40758225
Discovery and structure
CDH8 Human Pre
Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors PMID 12091352
Chamaejasmine 69618
PPIC
FM 8007
Bromuconazole exposure induces cardiotoxicity and lipid transport disorder in larval zebrafish PMID 36064135
Pancreatic
CRBN ligand
ABT
Design and evaluation of substituted cinnamoyl piperidinyl acetate derivatives as potent cholinesterase inhibitors PMID 40456843
The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β
Design, Synthesis, and Bioassay for the Thiadiazole
Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO
FNDC5 Human Pre
Systematic characterization of cancer transcriptome at transcript resolution PMID 36357395
Discovery and Evaluation of N
Quaternium
Subcellular localization of xanthine oxidase in rat hepatocytes high
Fragment
HSPB7 Human Pre
MET793
NVP
LJ
MAPKAPK5
MCE
Synthesis and antitumor activity of a new class of pyrazolo[4,3
SARM1
ATP Synthase
ZW
Oral administration of PIISVYWK and FSVVPSPK peptides attenuates obesity, oxidative stress, and inflammation in high fat diet
Rational design of drug
5
3,3′,5
h
6
STUB1/CHIP
Response to the methylation inhibitor dihydro
Osmanthuside D 97549
SPF mice
XAT13
Bromuconazole caused genotoxicity and hepatic and renal damage via oxidative stress process in Wistar rats PMID 34601692
(S,S)
His210
Boc
Lupane
β
Cucurbitacin IIb mitigates concanavalin A
Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo PMID 32824616
Fmoc
Dcc Mouse Pre
CHNQD
Acetaminosalol (醋氨沙洛)
(S)
Simultaneous enantiomeric separation of linagliptin and clopidogrel by capillary electrophoresis for the individual, combined, and enantiomeric ecotoxicity evaluation on Pseudokirchneriella subcapitata PMID 40132408
防御素β1（DEFB1）基因
Relacatib (Standard)
Klc1
Pharmacokinetics and safety of FV
BIX
Affinity purification and characterization of serine hydroxymethyltransferases from rat liver PMID 3110140
KCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease PMID 33727847
Eflornithine hydrochloride 68278
MY11 exerts antitumor effects through activation of the NF
Lophophine hydrochloride 77158
GM1a Ganglioside oligosaccharide
hsa
β
Mal
N
Multi
Hydroxypinacolone retinoate 893412
Valeramide 626
Mipletamig 2839556
Embryonic 6 2 Fluorotelomer Alcohol Exposure Disrupts the Blood‒Brain Barrier by Causing Endothelial‒to‒Mesenchymal Transition in the Male Mice PMID 39417922
2,2′,4,5,5′
A small molecule promotes mitochondrial fusion in mammalian cells PMID 22907892
MCE
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives PMID 25958248
Anti
Fmoc
PfPKG
YM
LY
Uchl1
Melineurine
脂蛋白 2（PLIN2）基因
AG2034 a novel inhibitor of glycinamide ribonucleotide formyltransferase PMID 8958185
Enpp1
(S)
Synthesis and biological evaluation of novel cabazitaxel analogues PMID 34058663
DNA 甲基转移酶 1（DNMT1）基因
SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c
Oxygen sensors mediated HIF
Naxe
Myricananin A 1079941
PXN
Cdh8 Mouse Pre
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR
CIDD 0067106
Synthesis of new ent
Development of progressive kidney damage and myeloma kidney in interleukin
Updates on the Management of Ocular Vasculopathies with VEGF Inhibitor Conbercept PMID 32631094
Dichloro
Porcine IFI44L inhibits transmissible gastroenteritis virus (TGEV) replication by activating IFN
Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway PMID 37967710
Discovery of diverse small molecule chemotypes with cell
基质金属肽酶 9（Mmp9）基因
Discovery of novel andrographolide derivatives as cytotoxic agents PMID 23768904
Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood
The oxacillinase variant, OXA
Baquiloprim 102280
具有 1 型血小板反应蛋白基序的 ADAM 金属肽酶 10（ADAMTS10）基因
Antimicrobial Activity of β
In vitro synergistic activity of the sulbactam/avibactam combination against extensively drug
TREM2 Impairs Glycolysis to Interrupt Microglial M1 Polarization and Inflammation via JAK2/STAT3 Axis PMID 39240442
Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer PMID 38015476
HYAL2 Human Pre
Atuliflapon 2041075
Rfamide
ASH2L Human Pre
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC PMID 27929535
Fenbufen based 3
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas PMID 11271786
MCE
p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis PMID 32377739
mmu
SPC4061 1018108
Discovery of dihydropyridinone derivative as a covalent EZH2 degrader PMID 37826933
Hsp90 beta 抗体 (YA4897)（Hsp90 beta Antibody (YA4897)）
Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia PMID 28249141
Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells PMID 20929261
Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal PMID 39257755
BAG3 抗体 (YA2240)（BAG3 Antibody (YA2240)）
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) PMID 24134204
ERK inhibitor A candidate enhancing therapeutic effects of conventional chemo
Modelling the binding mode of macrocycles Docking and conformational sampling PMID 31771798
Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non
Immunoproteasome function maintains oncogenic gene expression in KMT2A
Structure
Kidney tissue hypoxia dictates T cell
GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo PMID 26940138
Cltc
Mbd4 Rat Pre
The Integrin Inhibitor Cilengitide and Bleomycin
Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH
Beta
N
Spinal effects of the fesoterodine metabolite 5
Antiproliferative effects of Turkish pomegranate (Punica granatum L.) extracts on MCF
Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses (99m)Tc
CD30 and its ligand possible role in regulation of teratoma stem cells PMID 9524575
Zglp
Uncoupling protein 1 of brown adipocytes, the only uncoupler a historical perspective PMID 22649389
Caplacizumab (His Tag) 915810
Mitochondrial uptake of aristolactam I plays a critical role in its toxicity PMID 38428544
PDCD6/ALG
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment PMID 26529431
DM
The chemokine system in innate immunity PMID 25635046
Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1
Discovery of Brain
Antiallergy activity of substituted 11
Gnl2
Avibactam is a covalent, reversible, non
Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity
4
Angiotensin converting enzyme versus angiotensin converting enzyme
4
TNF 超家族成员 13（TNFSF13）基因
Smad1 抗体 (YA4297)（Smad1 Antibody (YA4297)）
Emergence of drug
Ndufaf3 Rat Pre
NH
Discovery of an in Vivo Tool to Establish Proof
Rapamycin Inhibits Nf
The liver X receptor agonist T0901317 protects mice from high fat diet
A selective agonist affinity label for A3 adenosine receptors PMID 8074705
BTK
CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients PMID 39741181
Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2
Memory restoring and neuroprotective effects of the proline
Adrenomedullin (11
Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism PMID 29403354
Drebrin 抗体 (YA3318)（Drebrin Antibody (YA3318)）
Benzyl
Enhanced autophagic clearance of amyloid
Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non
GNAI2 抗体 (YA2944)（GNAI2 Antibody (YA2944)）
Europium
Phosphatidylinositol (3,5)
HCN channel inhibitor induces ketamine
Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis PMID 40698330
OFD1 中心粒和中心粒卫星蛋白（OFD1）基因
载脂蛋白 C4（APOC4）基因
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2
Defb1 Mouse Pre
IL
23361
Maz Mouse Pre
ATOX1
Rrm1 Rat Pre
ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus
RESA peptide
Neuromedin S(rat)
Odiparcil (Standard)
Voriconazole camphorsulfonate (UK
Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension PMID 27927914
Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia PMID 39412990
β
Engineering a controllable and reversible switch for CAR
Drug repurposing Discovery of troxipide analogs as potent antitumor agents PMID 32619887
Acamprosate 77337
iNOS inhibitory activity of sesquiterpenoids and a monoterpenoid from the rhizomes of Curcuma wenyujin PMID 25275213
Glutamine binds HSC70 to transduce signals inhibiting IFN
NS2B/NS3
Discovery of a Novel CRBN
New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P
Opa interacting protein 5 promotes metastasis of nasopharyngeal carcinoma cells by promoting EMT via modulation of JAK2/STAT3 signal PMID 30720169
S 1432 24932
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen
DORA
Orantinib (Standard)
白细胞介素 6（IL6）基因
BDP 581/591 maleimide 2183473
13
Ro 20
Synthesis and properties of a new fluorescent analog of ATP adenosine
Dhcr7
D
VGF
Mmrn1
Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma PMID 39630579
TrkC 蛋白, Human (HEK293, His)
Olvanil 58493
突触体相关蛋白 25（SNAP25）基因
Pyrametostrobin
Tifa
Ppm1g
rust
10(S)
Inhibition of TNF
MCE
UBIAD1 Human Pre
Lefelsiran sodium scrambled negative control
Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease PMID 36174844
The TREM receptor family and signal integration PMID 17110943
Synthesis and antiparasitic and antifungal evaluation of 2'
Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs PMID 11728193
HO221
Immune checkpoint programmed death
Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway PMID 33173979
Novel β
solid
SORT1
L
SFTPC
Mal
Inhibitor of ovarian cancer cells growth by virtual screening a new thiazole derivative targeting human thymidylate synthase PMID 23075414
A BRD4
TNFSF13
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11 PMID 39146936
Calycosin promotes proliferation of estrogen receptor
Sin3A 相关蛋白 130（SAP130）基因
Antitrypanosomal agent 11
Antitrypanosomal agent 8
Spectroscopy
CDK8
Silencing Smad7 potentiates BMP2
Fmoc
Flavopiridol (Standard) (夫拉平度 (标准品))
S100 钙结合蛋白 A16（S100A16）基因
MIR002 2217671
LIBX
Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma PMID 35797592
钙敏感受体（Casr）基因
CalFluor 580 azide 1798306
OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1 PMID 37977070
Structure
Microenvironment
GD2
Novel adamantyl retinoid
Resolvin D3 916888
Involvement of α7nAChR in the hepatic
22,23
Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation PMID 39729480
[3H]Ro 22
D
Cryo
Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT
TOP2A deficit
Igf2bp3
Antiproliferative agent
Mitigation of sepsis
Smad4
Pre
MCE
The specificity of the trimethylammonium group in acetylcholine PMID 18144913
Croconazole metabolism in rats PMID 2346035
MiR
(R,S,R)
L
Human recombinant hyaluronidase (Cumulase) improves intracytoplasmic sperm injection survival and fertilization rates PMID 19490785
Design, synthesis and evaluation of pyrrolo[2,3
N
The pro
The mTOR chromatin
Umesolerbart
EN523 2094893
Distearin 1323
C12
Structure elucidation of Sch 725674 from Aspergillus sp PMID 16266128
CAY10499 359714
Processing of an antibacterial peptide from hemocyanin of the freshwater crayfish Pacifastacus leniusculus PMID 12493771
Atranol
Asiatic acid inhibits keloid fibroblast migration and collagen deposition via suppression of STAT3 activation PMID 40700781
Scpep1 Mouse Pre
Coumarin and chromen
CER1 (d18 1/26 0/18 1) 2260670
Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well
Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents PMID 32690268
USP11抑制剂、基因
Anti
NSC
5
A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI
Larixnaphthaone 864452
EPO
Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis PMID 39472556
Anti
F44
解整合素和金属肽酶结构域 8（Adam8）基因
Lauryl linolenate (Dodecyl (9Z,12Z,15Z)
Vezf1
Liensinine Inhibits Osteosarcoma Growth by ROS
FAM labled Bamosiran sodium
DKFZ
Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents PMID 11728386
Pyrazole NNRTIs 4 selection of UK
Heat stress enhances the expression of METTL3 to mediate N6
Adamts10
Discovery of Novel Selective Estrogen Receptor β (SERβ) Agonist (S)
Distearin
The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin
Knockdown of periostin attenuates 5/6 nephrectomy
ICAM3 Human Pre
Dual
Enzyme
A Computational Study of Carbazole Alkaloids from Murraya koenigii as Potential SARS
Mechanically tunable fiber
HIV
Cholesterol esterase, Candida Rugosa
Anti
(R)
Development of TGF
ZW 49
Cefotiam
Bromo
Gne
GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines PMID 38319157
Pentamidine a review PMID 3903942
C
Molecular docking and differential rbcl gene expression reveal variation in glyphosate herbicide tolerance of sugarcane varieties PMID 39873836
L
(R)
1
Binding of Galanthus nivalis lectin to Chlamydia trachomatis and inhibition of in vitro infection PMID 8534430
Synergistic effect of a retinoid X receptor
Hexapeptide model
SorCS1 蛋白, Human (HEK293, His)
Ndufv2 Rat Pre
PU
CDK4
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy PMID 32705206
PTGFRN Human Pre
异质核核糖核蛋白 F（HNRNPF）基因
Antinociceptive profile of hodgkinsine PMID 11199142
Minimal
PAB
MCE
富半胱氨酸和丝氨酸的核蛋白 1（CSRNP1）基因
An ATP
β
Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect PMID 35105898
SAG
Bombesin in human neuroendocrine (NE) neoplasms PMID 3008115
GRN Human Pre
siRNA
Click to Self
N
Saliva
The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans PMID 16702340
7
Dimethoxyindoles based thiosemicarbazones as multi
PNA synthesis
Cytochrome P450
Blue light photobiomodulation induced osteosarcoma cell death by facilitating ferroptosis and eliciting an incomplete tumor cell stress response PMID 39121719
Growth inhibitory effect of the somatostatin structural derivative (TT
Molecular cloning, expression and biological activity of rhesus macaque interleukin
rHuPH 20
ANK 101
Discovery of non
Design, Synthesis, and Antiviral activity of 1,2,3,4
Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35
Prospects of siponimod in secondary progressive multiple sclerosis PMID 30038666
Semisynthesis of an Active Enzyme by Quantitative Click Ligation PMID 30883092
NKG2D blockade attenuated cardiac allograft vasculopathy in a mouse model of cardiac transplantation PMID 23638995
1,6
Trelagliptin succinate 1029877
Cdh8
PLIN2 Human Pre
MCL1 inhibition is effective against a subset of small
Melineurine
Naxe
TGGGPLGVARGKGGC
LY402913
PfPKG
YM
2,3
Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives PMID 9734316
Miraculin (1
SHLD1 Human Pre
Fmoc
LY
Development of coumarin
The sweetness
Beyond TGFβ inhibition Chitosan oligosaccharide targets PGC
Melineurine 85802
hydrophobic interactions
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