最近收录_第800页_生物活性分子
生物活性分子最近更新
FBPase
rabbit eye
FLI1 regulates inflammation
Phototherapeutic agent
dry coffee samples
Carmichasine B 2245700
Chlormequat chloride induces hepatic steatosis by promoting mTOR/SREBP1 mediated lipogenesis via AMPK inhibition PMID 38849044
Synthesis and Biological Evaluation of Peripheral 5HT2B Antagonists for Liver Fibrosis PMID 40048549
Edonerpic
7
Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis PMID 32326215
T
Gas chromatography
Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI
5
ent
Diethylglycine 1606
Amifostine ameliorates induction of experimental autoimmune encephalomyelitis Effect on reactive oxygen species/NLRP3 pathway PMID 33182064
AgrC
N,O
A BPTF Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Murine Triple
Determination of fetal hemoglobin by time
Functional analysis of antibodies against dengue virus type 4 reveals strain
Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication PMID 23735301
FTI
CRAMP
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming PMID 37611093
Diesel exhaust promoted diethylnitrosamine
Yohimbine
AM404 and VDM 11 non
Lipase Assisted (S)
Rifaximin pharmacology and clinical implications PMID 19442033
Targeting the HNRNPA2B1/HDGF/PTN Axis to Overcome Radioresistance in Non
Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors PMID 37704905
Design, synthesis, and studies of small molecule STAT3 inhibitors PMID 18006313
Targeting EPAS
Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94 PMID 12177176
Homoharringtonine inhibits melanoma cells proliferation in vitro and vivo by inducing DNA damage, apoptosis, and G2/M cell cycle arrest PMID 33548212
Isokotanin B 154160
PROTAC BTK Degrader
Novel furostanol glycosides from Allium macrostemon PMID 7700993
Cy5.5 bis
Inhibitory effects of flavonoids from Abelmoschus manihot flowers on triglyceride accumulation in 3T3
Azomethine
Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching PMID 35931675
Ellagic Acid Reduces Cadmium Exposure
Convulsant action of D,L
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro PMID 2457906
Human interleukin
L
C2
Na /H exchange system
MC
6
Development of a protease
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity PMID 33135724
Cell Reprogramming
HA1/Hemagglutinin 蛋白, H1N1 (ACR38870, HEK293, His)
Asymmetric total synthesis and antifibrotic agents evaluation of fornicin A and its derivatives PMID 41066959
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease a systematic review PMID 38587758
(6
Sbf1 Rat Pre
Methyl tetracosanoate 2442
Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG
Regioisomerism
Cellular crosstalk mediated by Meteorin
Glucocorticoids receptor agonist 3 305821
Diguanosine 5′
Glucocerebrosidase (GCase) activity modulation by 2
LOC102553417 silencing facilitates the apoptosis of hepatic stellate cells via the miR‑30e/MTDH axis PMID 36177898
Alkaloids and Iridoids From Phlogacanthus curviflorus PMID 39727202
Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9
[P
The amnesic substance 2
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor PMID 25271963
New hopane triterpene from Dicranostigma leptopodum (Maxim) Fedde PMID 20390749
ZnMP
Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion PMID 3537810
HMG
AEBP1 drives fibroblast
Daphnicyclidin F 385384
JMJD3 Promotes Myeloid Fibroblast Activation and Macrophage Polarization in Kidney Fibrosis PMID 37076137
(+)
Menin and its interacting proteins elucidation of menin function PMID 16997566
Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3
CLEC7A Human Pre
conference
Hypoxia
BRL 42810
Synthesis, Labeling, and Biological Evaluation of P2Y12 Receptor Radioligands for Positron Emission Tomography Imaging of Neuroinflammation PMID 40553386
Morinda citrifolia extract
EGFR
Dixylyl disulphide 13616
The Cerebellar Thalamus PMID 30827014
Verbenalin Reduces Amyloid
Characteristics of a cytosolic arylacylamidase metabolizing thiacetazone PMID 1382131
Prunetin inhibits lipopolysaccharide
Fosl2 Mouse Pre
3D nanofiber scaffolds from 2D electrospun membranes boost cell penetration and positive host response for regenerative medicine PMID 38849858
A pathogenic variant of AMOT leads to isolated X
Tubastatin A TFA 1239262
Momelotinib sulfate 1056636
Erythrodiol 3
Essential role for CD103 in the T cell
Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors PMID 32717477
E3 ligase Ligand 59 2913165
FadD32 Inhibitor
PI3K/mTOR Inhibitor
Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S
thiourea
(±)
WST
Samixogrel (DTTX30)
APG808 (PR001)
Erbicin
AurkA
Thiazole Orange (solution)
Chenodeoxycholyl
S
L
INA Human Pre
NARI
The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema
Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition PMID 32919131
Sinafloxacin free base
Antibacterial and Anticancer Properties of Endophenazines from Streptomyces prasinus ZO16, an Endophyte in Zingiber officinale Rosc PMID 39415555
Specific cell
Glycidyl Stearate
tRNA 甲基转移酶 10C，线粒体 RNase P 亚基（TRMT10C）基因
[Protective effect of ligustrazine hydrochloride on homocysteine
Short
Caesalpine B 1616757
The pharmacokinetics of oral carbamazepine in rats dosed using an automated drug delivery system PMID 31329272
RPR
Gliclazide produces high
Thiabendazole
Methyl dodovisate A 1246937
PROTAC FSP1 degrader 1 3096510
Coffea robusta extract
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties PMID 18789703
6
rel
Xanthine oxidase
Atopaxar 751475
Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor PMID 21461793
Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up
Studies toward the total synthesis of angelmicin B (hibarimicin B) synthesis of a model CD
Murepavadin induces envelope stress response and enhances the killing efficacies of β
TCF25 Human Pre
Biotin
Design, synthesis and evaluation of novel UDCA
Oncostatin M promotes the ox
Acid
Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin
S 0636
ALP/Carbonic anhydrase
CHI3L1
An efficient metal
Activation of Sirt1 by acetate alleviates silicofibrosis Contribution of the gut microbiota PMID 40020386
Improving ACE inhibitory activity of hazelnut peptide modified by plastein Physicochemical properties and action mechanism PMID 36303388
IL1R1
Avibactam sodium salt
Identification of oxazolidinediones and thiazolidinediones as potent 17β
Dibutyl malate (DL
Lasalocid 25999
Monoterpene
17
Imidazoquines as antimalarial and antipneumocystis agents PMID 19799426
KAT6A/KAT7
Effect of bisacodyl on the structure and function of rodent and human intestine PMID 849815
JNJ
10(S)
Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA putative implications in colonic cancer PMID 10219835
Enhancement of NK cell
Five
Comparative pharmacology of chemically distinct NADPH oxidase inhibitors PMID 20860666
Shinjulactone M 103630
Solution structures and integrin binding activities of an RGD peptide with two isomers PMID 11327857
Carvone and its pharmacological activities A systematic review PMID 34999510
Reduction of canine myocardial infarct size by CI
The effects of traxanox sodium of cyclic AMP phosphodiesterase and the concentration of cyclic AMP in the plasma of rats PMID 6309423
Biological activity of netilmicin, a broad
Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR
URI1 suppresses irradiation
Comprehensive evaluation of a novel nuclear factor
Response and acquired resistance to MET inhibitors in de novo MET fusion
Discovery of a Selective and Potent Inhibitor of Mitogen
谷氨酸
Structure optimization and discovery of novel compound for the treatment of insertion mutations within exon 20 of EGFR and HER2 PMID 36804726
酪蛋白激酶 1 epsilon（CSNK1E）基因
The chain
Hypolipidemic activity of antiepileptic 5
Discovery of Hepatitis B Virus Surface Antigen Suppressor GS
Novel endoperoxide
Role of proline and pyrroline
Boc
Novel 5
Diltiazem Promotes Regenerative Axon Growth PMID 30232777
ICG
[Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators] PMID 2453423
3D
8
The effects and mechanism of peiminine
Metal
Opto
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor PMID 28761099
Antigen
MCE
NSC 357754 2938216
Preclinical activity of hepsulfam and busulfan in solid human tumor xenografts and human bone marrow PMID 1450448
Exogenous acetate attenuates inflammatory responses through HIF
MCE
Inhibition of IKKβ via a DNA
Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts PMID 8135856
DBPR108 1186426
Identification of a macrocyclic compound targeting the lassa virus polymerase PMID 38844175
MCE
Analgesic effects of ASP3662, a novel 11β
Lysophosphatidic acid induces anxiety
A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation PMID 25003319
Effects and mechanisms of trifolin on attenuating hypertension
Targeting the apoptotic Mcl
CCR5 antagonist 2 1800570
Scalable Synthesis of TRPV1 Antagonist Bipyridinyl Benzimidazole Derivative via the Suzuki
Management and treatment of deep vein thrombosis in special populations PMID 30016119
Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells Involvement of oxidative stress and antioxidant protective system PMID 26282491
Transcriptional activation of peroxisome proliferator
Repositioning of Omarigliptin as a once
MCE
Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products PMID 12694884
Peptide
TEQUILA
Involvement of hydrogen peroxide production in erbstatin
N
Design, synthesis and biological evaluation of novel non
LOC14 (Standard)
In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA PMID 26730986
Effects of ketamine
Synthesis of 2',3'
MCE
The pharmacokinetics of pentazocine and tripelennamine PMID 3709032
Fluorescent cancer
VR23 1624602
Molecular Glues for Targeted Protein Degradation From Serendipity to Rational Discovery PMID 34319094
AGG
Use of beta
The lysosome as a cellular centre for signalling, metabolism and quality control PMID 30602725
Synthesis and selective class III antiarrhythmic activity of novel N
Rapid labeling of intracellular His
Chronic administration of the metastin/kisspeptin analog KISS1
MCE
In vitro, in vivo and ex vivo characterization of ibrutinib a potent inhibitor of the efflux function of the transporter MRP1 PMID 25164592
Design, synthesis and optimization of pyrazolo[3,4
L
AZD8848 866269
The effect of dimorpholamine on crayfish neuromuscular junction PMID 4403079
泛素结合酶 E2 S（UBE2S）基因
Discovery of PD
Cross
Targeting ABL
BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant PMID 32298200
Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung PMID 27720610
Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training PMID 21820454
Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG
An orally available PD
Design, synthesis and biological evaluation of novel pyrazoline derivatives as dual EGFR/VEGFR
MCE
Matrix metalloproteinases
MCE
Cephaeline promotes ferroptosis by targeting NRF2 to exert anti
PF
Preclinical pharmacokinetics of MK
CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development PMID 40593606
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators PMID 33933516
SU4312 5812
2
无生殖细胞 2，精子发生相关（GMCL2）基因
NEROFE
Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation PMID 35036869
Diallyl disulfide attenuates pyroptosis via NLRP3/Caspase
proprotein convertase subtilisin/kexin 9
Benidipine, a dihydropyridine
ADCC增强型抗体 (ADCC Enhanced Antibodies)
Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo PMID 22595511
Gestational intermittent hypoxia induces endothelial dysfunction and hypertension in pregnant rats role of endothelin type B receptor† PMID 37823770
Discovery of Pyridazinone and Pyrazolo[1,5
MCE
Eeyarestatin 24 impairs SecYEG
ATZ
MCE
IL
New fluorescent probes for the measurement of cell membrane viscosity PMID 11251287
Antifreeze Polypeptide 6 (winter flounder) 122604
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress PMID 35228749
Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition PMID 38562022
MCE
Ricinus Communis Agglutinin I (Biotinylated) (RCA I (Biotinylated))
ZLWT
Sulfo
MK
4,4'
Serpin B9
Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors PMID 32184015
Lemairamin (Wgx
HOS cells
Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti
Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities PMID 14700200
HA1/Hemagglutinin 蛋白, H5N1 (ABF93441, HEK293, His)
Fmoc
protein tag
CaMKIIα
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors PMID 36109631
Cys
Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle PMID 38608014
t
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis PMID 19846295
Moxifloxacin ethyl ester
Dysregulation of brain
Myristoyl tetrapeptide Ala
2,4
Phase 1a/b study of monoclonal antibody CAEL
Danoprevir for the Treatment of Hepatitis C Virus Infection Design, Development, and Place in Therapy PMID 32764876
Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain PMID 20437566
4
Therapeutic RNA interference A novel approach to the treatment of primary hyperoxaluria PMID 34022071
Lerimazoline
Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin
L
Isoscopoletin 776
Notch1/Hes1‑PTEN/AKT/IL‑17A feedback loop regulates Th17 cell differentiation in mouse psoriasis‑like skin inflammation PMID 35582997
A Novel HDL
GSK 1842799 TFA 1005407
WQ3810
WCK
组蛋白脱乙酰酶 2（HDAC2）基因
Beneficial effect of 1,3
Phenylephrine
OX40 Ligand/TNFSF4 蛋白, Human (HEK293, Fc)
Evidence to support cultivated fruiting body of Ophiocordyceps sinensis (Ascomycota)'s role in relaxing airway smooth muscle PMID 39182700
BAY
T
Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha PMID 8999827
ERK5
(R,R)
CF
mitotic disrupter
BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery PMID 23146905
MCE
肿瘤坏死因子α诱导蛋白 3（TNFAIP3）基因
KDU731
Hfe
Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients PMID 1458769
Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea PMID 10084498
Nogo
Discovery, Optimization, and Evaluation of Novel N
Cholesterol glucuronide 17435
Falipamil
β
Boehmenan, a lignan from Hibiscus ficulneus, showed Wnt signal inhibitory activity PMID 26026364
Kansl1 haploinsufficiency impairs autophagosome
Pyripyropenes, novel inhibitors of acyl
Nifekalant hydrochloride 130656
Kadsulignan C 137637
Manidipine reduces pro
MK
Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti
KIF26B promotes bladder cancer progression via activating Wnt/β
VP
ICA
Prussian blue insoluble (Standard)
Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity PMID 8457713
3
Palifosfamide tromethamine 1070409
Stauprimide 154589
Methoxylation of resveratrol effects on induction of NAD(P)H quinone
MVT 5873
Liposomal co
Apoptosis inhibitors and mini
PG911
Mitochondria modulator2
2
CVN636 2226732
VIR165
MTPAP Human Pre
GR1803
Indolebutylamines as selective 5
Lomitapide
Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer PMID 38490978
VU6000918 2101737
TGF8027
BLU285
Synthesis and Structure
Transdermal Peptide Disulfide 888486
EPR effect
溶质载体家族 2 成员 12（SLC2A12）基因
1
Human Recombinant Lung βII Tryptase
1,7
mmu
MCE
CCL2/CCR2 axis promotes perineural invasion of salivary adenoid cystic carcinoma via ITGβ5
Mcl
Sulfo
Phenylglyoxylic acid
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug
hsa
BMS
BRL
c
Fructigenine A 144606
Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms PMID 26426004
Zevontabart
Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells PMID 34729926
GMB 805
PAK5
Gα12
Gα13
1
BRL34778
Aftin
WF
Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications PMID 39919587
CRBN ligand
Rev1
Fmoc
MCE
Development of MK
SIMC1 Human Pre
Novel 1,4
Molecular mechanisms of acquired proteasome inhibitor resistance PMID 22978849
Fmoc
Discovery of potential Leonurine
trematocide
Hydroxyhexamide (Standard)
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts PMID 17468933
whole beans
AM8191 hydrochloride 1417548
Pulmonary artery smooth muscle cell pyroptosis promotes the proliferation of PASMCs by paracrine IL‑1β and IL‑18 in monocrotaline‑induced pulmonary arterial hypertensive rats PMID 39171148
1,2
BAR
Shield
Bonannione A 97126
Ricefidase
Creoside III
Identification of novel compounds, oleanane
AMPK/mTOR
MCE
Macrocarpal H 179388
WF 3161
HRH3
Synthesis and antimycobacterial activity of 1
GDC
P 113
p53 Activator 12
A fast response and red emission probe for mammalian thioredoxin reductase PMID 27709154
ppTG
Arg
Fosigotifator THAM sodium 2945073
C5a Receptor agonist, W5Cha 144555
EB42486
6
PXYC2 865101
2,6
Darexaban 365462
SR33805 121345
G551D
MS4322 2375432
INF056
On the ionophoric selectivity of nonactin and related macrotetrolide derivatives PMID 27966685
VMY
Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process PMID 33918226
AMPA receptor modulator
ADAT3 Human Pre
AMG 176
Insecticidal agent28
trans
Ptprg Rat Pre
CXC 基序趋化因子配体 8（CXCL8）基因
Lipid nanoparticle
CgPPOX and CgFECH Mediate Protoporphyrin IX Accumulation Predominantly in the Outer Mantle Fold of Pacific Oyster Crassostrea gigas PMID 39937285
Anti
SDZ
Efadirelaxin alfa 3061442
APOL1
Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis PMID 31129606
5
Z164597606 1050587
Human Relaxin
SNAP
NTPDase/NPP1
NPP1
A Small
PD
ZG
Hexyl methanesulfonate 16156
Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti
共964页
首页
上一页
805
804
803
802
801
800
799
798
797
796
795
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新