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Enhancing the antiviral potency of ER α
Network pharmacology and biological verification of morusin's therapeutic mechanisms in inhibiting nasopharyngeal carcinoma growth PMID 39132159
Discovery of a first
Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve PMID 22403485
3
J
Targeting Microtubule
Relfovetmab 2171034
Synthesis and evaluation of anti
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7
Cyclopentenyl cytosine primes SK
Surfactant protein
Discovery of (E)
Acteoside Presents Protective Effects on Cerebral Ischemia/reperfusion Injury Through Targeting CCL2, CXCL10, and ICAM1 PMID 33439460
Novel peptide inhibitor (SPAI) of Na+, K+
FATTY ACID DESATURASE4 enhances plant RNA virus replication and undergoes host vacuolar ATPase
Nucleic acid aptamer controls mycoplasma infection for inhibiting the malignancy of esophageal squamous cell carcinoma PMID 35189346
匕首龙舌兰提取物 (Agave lechuguilla Torr.)
Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice PMID 33863883
Med24
Direct and indirect immune effects of CMP
Diet induced mitochondrial DNA replication instability in Rad51c mutant mice drives sex
Upregulation of long non
Magnoflorine Enhances LPS
Phenotypic pharmacology of novel Complex I inhibitors eliciting tissue repair concurrent to control of inflammation PMID 40782522
Blocking virus infection with BacMam virus delivery bovine interferon
(R)
Design, Synthesis, and Evaluation of Novel ROCK Inhibitors for Glaucoma Treatment Insights into In Vitro and In Vivo Efficacy and Safety PMID 40340390
Tenidap 120210
Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats PMID 16415533
SGK1.1 limits brain damage after status epilepticus through M current
Development of the hidden multi
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation PMID 23155046
11
Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats PMID 34748768
Dexmedetomidine alleviates sevoflurane
YM114 153608
Cross
Sp
Calcium 2
Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide
Highly
[1
Structure
WR19039 disodium
RAF inhibitors that evade paradoxical MAPK pathway activation PMID 26466569
ODM
Meningitic Escherichia coli
The role of insulin receptor InR in photoperiod
Cav 3.2 inhibitor 2 2878598
Quantitative determination of individual non
Inhibition of microRNA
Finerenone attenuates downregulation of the kidney GLP
Pam16
Pentan
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression PMID 29487338
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2
Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2 PMID 28391780
CG alpha 蛋白, Human (HEK293, mFc)
Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11 PMID 38610018
Azithromycin hydrate 117772
Polystyrene nanoplastics enhance poxvirus preference for migrasome
Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1 selective inhibitors of lysosomal sialidase (NEU1) PMID 18068975
Anticancer agent 170
c
Aryl hydrocarbon receptor (AhR) alleviates the LPS
Protective effect of T
Discovery of JAB
Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin PMID 6411052
Xalnesiran sodium 2538784
Multiple RONS
A natural ErbB4 isoform that does not activate phosphoinositide 3
Mki67 Mouse Pre
METTL3
MCUB Human Pre
Discovery of (5S,6S,9R)
Cd19 Rat Pre
Substrate recognition by RNA 5
Copper
Cldn3
HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes PMID 31311649
Tariquidar
Identification of the key ferroptosis
Overexpression of ELF3 in the PTEN
Rcan2
HARS1
ML
Artificial intelligence accelerates the identification of nature
Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma PMID 28476794
Immunomodulatory activity of 4
Picfeltarraenin IB 97230
A fully human anti
PPDA
The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia PMID 40474580
The ERBB4/HER4 intracellular domain 4ICD is a BH3
Design, synthesis and evaluation of γ
CXCL12
IL
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3
Semustine 13909
Prdx2
PPA24 3035032
The identification of ciclacidine an antibiotic from Streptomyces capoamus sp. nov PMID 5636926
3’
Cdh3
Polg2
Additive enhancement of implant fixation following combined treatment with rhTGF
2,6
Itga4
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats PMID 30530165
Tumor infiltrating mast cells determine oncogenic HIF
Dihydromaniwamycin E, a Heat
Aspirochlorine class compounds from Aspergillus flavus inhibit azole
Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost PMID 21331688
Design and synthesis of trans
HPLC
Acp6
hsa
A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia PMID 34103967
MIL
J5 peptide 444305
Semi
Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors PMID 21334890
Dichapetalin
Sorafenib N
(
AK177
Atxn1
FSC(PEG4
Anemarnoside B
Discovery and Characterization of Nonpeptidyl Agonists of the Tissue
MCE
Mechanistic study of modulating mitochondrial fission and fusion to ameliorate neuropathic pain in mice PMID 40320455
Neural cell isolation from adult macaques for high
Cdc7
Direct factor IXa inhibition with the RNA
Hippocalcin 抗体 (YA2752)（Hippocalcin Antibody (YA2752)）
MCE
Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation PMID 23132859
Original antileishmanial hits Variations around amidoximes PMID 29459275
DMAC
Evaluation of ABD
腺苷 A2B受体（Adora2b）基因
SAP2
2
Neuronal HIPK2
Octopamine hydrochloride 770
Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH PMID 37626430
ACSL4
Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs PMID 2565757
Impact of tocilizumab on anti
α
(1R,3S)
Development of ligands for the peripheral benzodiazepine receptor PMID 16842193
MiR
RIPK1
N
Targeting isoprenoid
JBIR
1,3
Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders PMID 39570797
Glucagon Regulation of Energy Expenditure PMID 31671603
Rxfp4
癌症/睾丸抗原 2（CTAG2）基因
A new ex vivo skin model for mechanistic understanding of putative anti
Structure of gliocladic acid PMID 7096211
ADP
mTOR inhibitor
Cyp1a1
Msc
AA38
Rxfp4
Hydroxy
Dolichol (13~21)
Single
磷脂酰肌醇 4
血管心外膜物质（BVES）基因
1,2,3
Antimicrobial agent
The influence of food intake on the bioavailability of timegadine, a novel non
Cish
(±)EP
In Vitro and In Vivo Evaluation of Pellotine A Hypnotic Lophophora Alkaloid PMID 37854625
Rationally designed less toxic SPD
SLIGRL
(R)
Tspan1
hsa
Synthesis and in vitro evaluation of 2,4
Meltf
Oxygen Enhancement of bactericidal activity of rifamycin SV on Escherichia coli and aerobic oxidation of rifamycin SV to rifamycin S catalyzed by manganous ions the role of superoxide PMID 6279585
Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation PMID 39424784
Differences in the recognition by CTL of peptides presented by the HLA
Binding and agonist/antagonist actions of M35, galanin(1
Acetoacetyl
磷脂酰肌醇 4
Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats PMID 27992940
Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection PMID 30805776
New azolyl
7
CTSE 抗体（CTSE Antibody）
Kallikrein
MCE
CSH2 Human Pre
Tpbg
Neuropeptide VGF
MCE
Recilisib (Standard)
Macrophage
Pharmacological profile of neuroleptics at human monoamine transporters PMID 10193665
Neurogenin3 activates the islet differentiation program while repressing its own expression PMID 14576336
A nonautophagic role of ATG5 in regulating cell growth by targeting c
1,2,3,4,6
Peptidases structure, function and modulation of peptide
Metabolic stability of 3
Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf
2
Win 47338 80047
Regulation of the Hippo
The antibacterial efficacy of econazole nitrate in interdigital toe web infections PMID 2319018
Ebi3
Sirtuin
The IL
4
The GLP
Maximin 1 479664
Selective degradation of cellular BRD3 and BRD4
MCE
Studies on pyrazinoylguanidine a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus PMID 10781866
Tom1
GNA002 1385035
Isolation of apigeninidin from leaf sheaths ofSorghum caudatum PMID 24242734
(Z)
General model of phospholipid bilayers in fluid phase within the single chain mean field theory PMID 24811664
Synthesis and anti
Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity PMID 36543766
4
4
Rational Design of Oxazolonylflavone Derivatives as Novel CDK4/9 Inhibitors with Potent Antitumor Efficacy and Oral Bioavailability PMID 41410431
ZL
fractional distillation
Phenylphosphoric acid 701
Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. I. Taxonomy, fermentation, isolation and antimicrobial activities PMID 9592560
Structure
Hepatitis C viral IRES inhibition by phenazine and phenazine
Mdga2
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS
Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice PMID 24696677
Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells PMID 11169965
The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules PMID 39002128
Leonuriside B
Effects of a long
Low
Anabasine 494
2
Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid PMID 35311622
Pyrimidinylimidazole inhibitors of p38 cyclic N
Scarf1 Rat Pre
Targeting the Inactive Conformation of the Epidermal Growth Factor Receptor Identifies EG31 A Novel Small Molecule Inhibitor Effective Against Normal and 5
Evodiamine 518
gamma Adaptin 抗体 (YA2993)（gamma Adaptin Antibody (YA2993)）
Synthesis and activity of N
Naprt
Red nucleus mGluR1 and mGluR5 facilitate the development of neuropathic pain through stimulating the expressions of TNF
BO
Solution structure of the interacting domains of the Mad
CER1 (d18 1/26 0/18 1)
Isolation and characterization of two new chroman
Mitochondrial Targeted Antioxidant SKQ1 Ameliorates Acute Kidney Injury by Inhibiting Ferroptosis PMID 36193064
MCE
A practical synthesis of nitrocefin PMID 15624952
The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity PMID 36458202
Drug
YOK24
DMTr
2′
(
A second
Pentaethylene glycol 4792
Msc Mouse Pre
PK14105
转铁蛋白受体 2（TFR2）基因
CRBN ligand
MCE
MCE
含 Tudor 域 7（TDRD7）基因
MCE
Structure
Mutanocyclin 875455
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus implications for the development of broad spectrum anti
Bupropion, methylphenidate, and 3,4
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 PMID 31209349
Ciproxifan hydrochloride 1049741
LLGL scribble 细胞极性复数组分 1（LLGL1）基因
Design and Synthesis of Mandelic Acid Derivatives for Suppression of Virulence via T3SS against Citrus Canker PMID 38646906
Sustained activation of NF
18 1 PEG2000 PE ammonium 474922
Transmission electron microscopy in molecular structural biology A historical survey PMID 25475529
TWEAK
immunosuppressive
Endothelin PMID 26956245
Synthesis and anticancer evaluation of 6
Anti
MCE
Machine learning driven web
Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia
Gemcabene, a First
2
Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling PMID 26459563
A randomized study of BI 671800, a CRTH2 antagonist, as add
Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway PMID 27893719
IKBKB 蛋白, Human (HEK293, His, Strep)
Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin PMID 34332978
Transformation of bile acids into iso
Inhibition of P53/miR
Synthesis, kinase inhibition and anti
Inotersen new promise for the treatment of hereditary transthyretin amyloidosis PMID 31118583
5
2
[Fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh Inula viscosa (Asteraceae) flowers from the Puglia region] PMID 11921538
Amylase 9000
SP140
Bdh2
Lrp8
Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin
In silico design of natural
Physical dependence of a dermorphin tetrapeptide analog, [D
含缺陷 cullin neddylation 1 结构域 1（DCUN1D1）基因
Pyrido[2,3
Protecting Against Postsurgery Oral Cancer Recurrence with an Implantable Hydrogel Vaccine for In Situ Photoimmunotherapy PMID 39467056
Cep
Alkyl esters of gallic acid as anticancer agents a review PMID 23291333
Conditional Inducible Triple
Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration PMID 22209712
MAPTAM 147504
TAM
Phosphatidylinositol(4,5)bisphosphate diverse functions at the plasma membrane PMID 32844214
LAIR2 蛋白, Human (HEK293)
TNF
Synthetic methodology
Monoamine oxidase (MAO) inhibitory activity 3
Leucokinin activates Ca(2+)
PI3K
Discovery of a potent tubulin polymerization inhibitor synthesis and evaluation of water
Signal transduction via platelet
Effects of undecylenic acid released from denture liner on Candida biofilms PMID 22904206
DMEA
PIK3C2A
Antithrombotic effects of KP
SMPT
A first
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor PMID 19171797
Desmethylflutiazepam 41191
Functional investigation of β
PL
Efficacy, safety and genomic analysis of SCT200, an anti
MAO
CRISPR
Adenosine
Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication PMID 33654169
Branched
PHA 408 503555
Synthesis of a Complex and Highly Potent PCSK9 Inhibitor PMID 37382389
Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling PMID 28927791
Targeting NADPH Oxidase with APX
Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma PMID 39818011
Growth inhibition by fusidic acid in cervical, thyroid, and breast carcinoma cell lines PMID 36575560
Structure
Tff2
Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor PMID 30706071
Elacestrant demonstrates strong anti
PTUPB ameliorates high
ROR1 Human Pre
Fumarranol
Dansylcadaverine (solution) (Monodansyl cadaverine (solution))
Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis PMID 36048501
(±)
Atalaphyllidine
Potent SARS
Elisrasib 2914919
GATA1 Human Pre
Potent repression of C
Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10 PMID 17695534
氧化磷酸化 (Oxidative Phosphorylation)
The novel ROCK2 selective inhibitor NRL
Effects of Y
The ECF
MCE
MCE
Ceftolozane/tazobactam disrupts Pseudomonas aeruginosa biofilms under static and dynamic conditions PMID 39657684
AFG206 630122
卷心莴苣提取物 (Lactuca sativa var. capitata DC.)
MCE
Slit2
Hydrocortisone
Cadherin 8 regulates proliferation of cortical interneuron progenitors PMID 30315415
MCE
Remetinostat 946150
Liph Mouse Pre
Symmetric benzidine derivatives as anti
tert
Novel DNA
The Hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells PMID 36210514
Ginsenoside F1 promotes angiogenesis by activating the IGF
Antibiotics in development targeting protein synthesis PMID 22191530
Ginsenoside Rg2 Ameliorating CDAHFD
Pten positively regulates brown adipose function, energy expenditure, and longevity PMID 22405073
KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease PMID 26111032
Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress PMID 30356804
Serum LUCAT1 implicates the pathogenesis of muscle
Antiseizure activity of novel gamma
Novel sorafenib analogues induce apoptosis through SHP
SOTS
Synthesis of and anti
Structure
LEAPS Vaccine Incorporating HER
Cathepsin B and its role(s) in cancer progression PMID 14587299
Scarf1 Mouse Pre
Overexpressed Claudin
FNDC5/Irisin inhibits pathological cardiac hypertrophy PMID 30782608
Bromoacetamide
RN941
DUBA
MCE
Optimization of Allosteric With
Quercetin 4′
[Results of the clinical study of the antineoplastic preparation phenamet] PMID 4612985
Pgap1 Rat Pre
Amn Mouse Pre
AMG 369
Nanozymes as Glucose Scavengers and Oxygenerators for Enhancing Tumor Radiotherapy PMID 39480068
The chemokine CCL1 triggers an AMFR
雌激素受体 1（Esr1）基因
Cryo
LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway PMID 32841643
The Alkaloids from Lophophora diffusa and Other False Peyotes PMID 34264089
Role of the Na(+)/K(+)
Effect of endothelin
Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3
Renal clearance and serum protein binding of acetaminophen and its major conjugates in humans PMID 6491906
Cd19 Mouse Pre
驱动蛋白家族成员 15（KIF15）基因
Palmatine improves cognitive dysfunction in Alzheimer's disease model rats through autophagy pathway and regulation of gut microbiota PMID 38609032
β
SIRT3
Effects of JTV
Immunotherapy for osteosarcoma Fundamental mechanism, rationale, and recent breakthroughs PMID 33359211
AMBN
Pharmacology of CP
Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands PMID 27546834
Mepe
Ovalbumin
Metformin attenuates post
m
Plastoquinone In and Beyond Photosynthesis PMID 32713776
Amino
Optimisation of a 5
Lenalidomide potentially reduced the level of cell
1
Ethyl 6
Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice PMID 25614969
MCE
Assessment of anti
N
Total synthesis of absinthin PMID 15631427
Bradykinin (1
Podocarpic acid 5947
Discovery and optimization of (2
MCE
Human iPSC
二肽基肽酶4（DPP4）基因
TSSC3 promotes autophagy via inactivating the Src
F
Itga6
STING
1,4
N
Pdx1
Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity PMID 6792176
Expression and Role of the Calcium
RWJ
Antimicrobial activities of novel mannosyl lipids isolated from the biocontrol fungus Simplicillium lamellicola BCP against phytopathogenic bacteria PMID 24660753
口咽性吞咽困难
Carbazole
Rev 2’
Somatostatin receptor subtype 4 modulates L
Bis(tri
Chemical phosphorylation amidite
Pelagiomicin A 173485
MCE
DM1
Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production PMID 36822370
An assessment of the reproductive toxicity of GONPs exposure to Bombyx mori PMID 33421719
WTAP contributes to platinum resistance in high
Propargyl
Contact
Inhibitory effect of antineoplaston A
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