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Synthesis and biological evaluation of N
HCV
Fmoc
Design, Synthesis, and Biological Evaluation of Heterocycle
Spinal microglia
Dye Reagents 抑制剂
Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer PMID 39003742
Lck
MF
Mechanisms of tolvaptan
Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase PMID 11360997
Ala
Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis PMID 39828712
1,10
Tspan1 Rat Pre
Cyclooxygenase
Sacubitrilat impurity 32 (Standard)
The tumour suppressor Pdcd4 recent advances in the elucidation of function and regulation PMID 19356152
Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time PMID 33995036
Wittifuran X
Chronic Anatabine Administration Attenuates Cardiovascular Activity by Targeting NF
Heyl Rat Pre
ATF4 protects against sorafenib
Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines PMID 28121440
Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence PMID 34587364
Therapeutic potential of the probiotic Lactiplantibacillus plantarum BX 62 and its postbiotics in alleviating rheumatoid arthritis in mice PMID 39582573
Lysosome dysfunction enhances oxidative stress
RAD1901 S enantiomer
Mal
Receptor
红细胞生成
TNFR
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin
(S)
Fezakinumab 1007106
Yy1 Rat Pre
Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages PMID 39047035
Fmoc
FNC
TRIB3 Interacts with STAT3 to Promote Cancer Angiogenesis PMID 36245025
Synthesis and characterization of novel 1,2,4
Poly(Lysine)
Taxachitriene A 167906
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen
Nonin B
Carbiphene hydrochloride
MCE
MCE
Novel Camptothecin Derivative 9c with Enhanced Antitumor Activity via NSA2
DM51
Selection of single
ML175 610263
Paeoniflorin mitigates iron overload
MicroRNA
KRT5 Human Pre
N
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic
Phenylglycine methyl ester
Dose and species dependent pharmacokinetics of a novel sigma receptor antagonist, DuP 734 PMID 7620836
GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR
PET
ADS
Indole
DC41
Trisubstituted ureas as potent and selective mPGES
Property
PfATP4
Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart PMID 7922863
Minodronic acid impurity 2
Design, synthesis and biological evaluation of novel SIRT3 inhibitors targeting both NAD+ and substrate binding sites for the treatment of acute myeloid leukemia PMID 39053191
ML
2',6'
Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury PMID 29587798
CTLA
(
Crebinostat a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin
Ceritinib
Scrambled 10Panx 1315378
Gastrin stimulates MMP
CD8 T cells and natural killer (NK) cells
Discovery of pyrrolo[2,3
16
L2H2
autophosphorylation
CD36
Discovery of a novel CDK4/6 and HDAC dual
Upregulation of LRRC8A in the anterior cingulate cortex mediates chronic visceral pain in adult male mice with neonatal maternal deprivation PMID 39962353
Efficacy of Dexrazoxane in Cardiac Protection in Pediatric Patients Treated With Anthracyclines PMID 37182052
MCE
马兜铃酸 C (Standard)
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis PMID 39633048
MP
The R3 receptor
Procarbazine 671
Anti
MSCs
CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth PMID 28817386
Induction of calf thymus topoisomerase II
Cloticasone propionate 80486
Janus kinase
Sex hormone
Essential role of zyxin in platelet biogenesis and glycoprotein Ib
Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening PMID 29656085
Fipexide improvement of cognitive functions in rat behavioural and neurochemical studies PMID 2158654
dTAG13
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell
Topographical Mapping of Isoform
SARS
SIRT1 prevents cigarette smoking
Cell
Lysosomal dysfunction disturbs porcine oocyte maturation and developmental capacity by disorganizing chromosome/cytoskeleton and activating autophagy/apoptosis PMID 31437668
Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors PMID 37730974
Violacein 548
79862
Development of an improved in vitro activity assay for medium chain length PHA polymerases based on CoenzymeA release measurements PMID 10856771
TSPAN1 蛋白, Human (HEK293, His)
SFTSV Infection Induces BAK/BAX
Hit
溶质载体家族 7 成员 5（SLC7A5）基因
NAMPT 蛋白, Human (sf9, His, GST)
Azide
Bst1 Mouse Pre
Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb PMID 7172337
Unraveling the structure and mechanism of acetyl
RIPK1
Phenolics with PPAR
Lauric acid
Mild
Comparison of the antileukaemic activity of 5 aza
Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia
Warangalone 4449
Pyrazine
ZC0101 2541604
BRD4 Inhibitor
The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy PMID 25205113
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium
MOCAc
Analysis of the mechanism of fibrauretine alleviating Alzheimer's disease based on transcriptomics and proteomics PMID 38926843
The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions
15(S)
PTH1R
Kif7
Store
Inhibition of hepatitis C virus RNA replication by 2'
Morinda citrifolia mitigates rotenone
i
(±)
MCE
Synthesis and antileishmanial activity of novel 2,4,6
Spisulosine (ES
MCE
MCE
Boc
MCE
Cardiotoxicity of tris(2
ALKBH5 prevents hepatocellular carcinoma progression by post
A Single
含 FERM 域的 kindlin 2（FERMT2）基因
Overexpression of β
ZINC00881524
Hsa_circ_0001583 fuels bladder cancer metastasis by promoting staphylococcal nuclease and tudor domain containing 1
Aspirin
Emb
JNJ
LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa
光亲和标记
2
TAAR1 agonist 2 1804128
Ror1 Rat Pre
Biguanides Species with versatile therapeutic applications PMID 33857729
Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism
Domiphen bromide 538
ADD
KOR/DOR agonist 1
GP130 receptor agonist
B/B Homodimerizer
2
The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice PMID 25738896
Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage PMID 36848438
IS20
A novel anti
Polyphyllin VI A promising treatment for prostate cancer bone metastasis PMID 39602960
Proximity labeling reveals OTUD3 as a DNA
Phosphonodiamidate prodrugs of N
S
MCE
Bis
MCE
Venetoclax 1257044
MCE
Val
Diethyl disulfide 110
Evidence for the involvement of metalloendoproteases in the acrosome reaction in sea urchin sperm PMID 3553177
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model PMID 17655859
Dimaprit
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low
(S)
Tetrabromophenol blue, IND 4430
N6
Azido
A Data
Ror1 Mouse Pre
NH2
Annonacin promotes selective cancer cell death via NKA
RWJ
Tubulin inhibitor 44 3025180
Wls Mouse Pre
Mef2d
跨膜蛋白 97（TMEM97）基因
hsa
HSP90 co
Bcl
Vitamin D Binding Protein A Potential Factor in Geriatric COVID
Cdkl4
Pgap1
有丝分裂出口网络拮抗因子 1 同系物（AMN1）基因
IL7R
MCE
(3R,6E)
Regulation of epithelial shunt conductance by the peptide leucokinin PMID 8459448
Activating SIRT
RELT
Methyltetrazine
BRAF V600E
AUP1 Human Pre
MCE
MCE
Structure and function of factor XI PMID 20110423
Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells PMID 19935879
MCE
Orenasitecan
Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.) PMID 23790901
OSI
Hydrosorbaldehyde 4440
3D
KY
Fenoprofen Calcium hydrate 71720
SID 7969543 868224
Nucleus
N
Cartilage progenitor cells derived extracellular vesicles
Galactamine 488
ClpP activator
2
A Novel Nrf2 Activator Suppresses Osteoclastogenesis and Ovariectomy
Atherosperminine 5531
Activation of PI3K
Identification of New Small
Prefoldin 6 promotes glioma progression via the AKT signalling pathway PMID 36300673
pAF
Amythiamicin C 156620
TC
Fraxetin pretreatment alleviates cisplatin
Sofosbuvir impurity 6 1496551
miR
Methyllycaconitine alleviates amyloid
SPDMB
SPDMV
dioxin response element
Discovery of novel antibody
MSC Human Pre
Development and validation of an LC
VHL Ligand 35
[Role of macrophage migration inhibitory factor in septic shock
Msc Rat Pre
Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast
Bisabolene (mixture of isomers) 495
MCE
Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2
DYRK
Pharmacological studies on the new quinoline derivative 1
Methylnissolin
PC58538 434910
Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells PMID 35686705
Triptohairic acid
Acetylthiocholine chloride
MCE
A Platinum(IV) Prodrug
Berberine Reverses Nitroglycerin Tolerance through Suppressing Protein Kinase C Alpha Activity in Vascular Smooth Muscle Cells PMID 34319490
Strategic Incorporation of Polarity in Heme
细胞分裂周期相关 4（CDCA4）基因
核仁蛋白与 MKI67 的 FHA 结构域相互作用（NIFK）基因
3
Tolerability, safety, and pharmacokinetics of a single intravenous administration of a novel recombinant humanized anti
Evaluating variations in bilirubin glucuronidation activity by protease inhibitors in canine and human primary hepatocytes cultured in a 3D culture system PMID 37660998
Activin RIB/ALK
Structural hybridization as a tool for developing novel biologically active analogues of protulactone A PMID 41435775
BCMA/TNFRSF17 蛋白, Rabbit (HEK293, His)
DOTAP mesylate (DOTAP（甲磺酸）)
Overt
Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs
Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids PMID 28279860
GP4G
STING
MNPCE
Calcium pyrophosphate 7790
Antifungal agent 74
OVA
Biphenyloxy
β
Overexpression of miR‑424‑5p reduces cisplatin resistance by downregulating SMURF1 in gastric cancer PMID 39850720
Tranexamic acid
Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF
CD19
KAT8
Combined treatment with a β3
HW091077 2766757
AMP
Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive
4,5
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck PMID 34667025
Effect of heparin and fractionated heparin on trophoblast invasion PMID 17611187
Design, Synthesis, and Antimicrobial Activity Evaluation of Novel Isocryptolepine Derivatives against Phytopathogenic Fungi and Bacteria PMID 39284582
Palladium nanocrystals regulates scleral extracellular matrix remodeling in myopic progression by modulating the hypoxia signaling pathway Nrf
STF
RETRACTED ARTICLE Physcion 8
P3
The effect of esculentoside A on lupus nephritis
Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid
Bepridil differentially inhibits two delayed rectifier K(+) currents, I(Kr) and I(Ks), in guinea
Transport of cysteate by synaptosomes isolated from rat brain evidence that it utilizes the same transporter as aspartate, glutamate, and cysteine sulfinate PMID 2875128
Shank3 deficiency induces NMDA receptor hypofunction via an actin
Crocin attenuates NF
Discovery and optimization of Menin
StSAT
Inhibition of Erythrocyte Cell Membrane Scrambling Following Energy Depletion and Hyperosmotic Shock by Alectinib PMID 30522123
Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells PMID 22081495
Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase
Formic acid ammonium 540
2
Regulation of lipid dysmetabolism and neuroinflammation linked with Alzheimer's disease through modulation of Dgat2 PMID 40027815
N6
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 PMID 25452335
compound
Nonylbenzene
Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis PMID 31257490
Proton Pump
Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF
STING Agonist Delivered by Neutrophil Membrane
Simvastatin
Visualizing collagen proteolysis by peptide hybridization From 3D cell culture to in vivo imaging PMID 30149231
NAZ2329 2809469
DuoBody
Short
TMEM175 modulator 3
RX 801077 hydrochloride 89196
Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency PMID 6980397
Nucleoside Diphosphate Prodrugs Nonsymmetric DiPPro
Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells PMID 28359723
Calhex
Antibacterial activity of sphingoid bases and fatty acids against Gram
Colony
Introduction to confocal microscopy PMID 23187113
S1PR4
ST2146
Novel 2,4
S1PR1/S1PR5 agonist
Polg2 Mouse Pre
蚊母树提取物 (Distylium racemosum Siebold & Zucc.)
Chlorotoxin Structure, activity, and potential uses in cancer therapy PMID 26418522
Antithrombotic effect of topically applied 3
MSX3
Arhgap22
CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway PMID 40937577
Discovery of a Natural
2
3
Novel compounds with dual inhibition activity against SARS
Identification of novel plant cysteine oxidase inhibitors from a yeast chemical genetic screen PMID 37863264
A host
Di(acetyl
2,6
miR
Imipenem (N
23S
An analysis of the synthetic tryptamines AMT and 5
Antioxidant, insecticidal activity and chemical profiling of flower's extract of Parthenium weed (Parthenium hysterophorus L.) PMID 38848347
Alphaherpesvirus US3 protein
Ctsh
Toxicity of the specific antimuscarinic agent methoctramine and other non
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma PMID 16511606
SW480
3
SAR3419 an anti
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy PMID 39871281
Ornithine lipid is a partial TLR4 agonist and NLRP3 activator PMID 39340778
Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder PMID 21985349
DFUs
TAGAP 抗体 (YA5986)（TAGAP Antibody (YA5986)）
Coordinated regulation of iron
AMG 9810 [(E)
8
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor PMID 35167750
4
Catalytic mechanism of human alpha
Anti
SLP
Potential role of gut microbiota
Gsdma
Muscarinic agonist 1
Signal
Cephalexin
(R)
Lavamilast
Cav 3.2 inhibitor 3 2878598
Tfr2
10
KY
N
2,6
Isolation and determination of cholesterol glucuronide in human liver PMID 7132581
Octoclothepine 13448
MCE
The truncated metabolite GLP
ADCYAP1R1 蛋白, Human (HEK293, Fc, solution)
Low
PPBP [4
Heyl Mouse Pre
WEE1
IL
Advance of Seriniquinone Analogues as Melanoma Agents PMID 30783501
Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model PMID 36272632
PPC
Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome
Trap
Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities relevance to glaucoma PMID 15036567
PSMD11 抗体 (YA5585)（PSMD11 Antibody (YA5585)）
YLT205 1316196
RO 4927350
Extracellular HSP90
SCH 2047069 (MK
Functional analysis of desensitization of the beta
procaspases 7
CER1 (d18 1/26 0/18 1)
Discovery, synthesis of novel fusidic acid derivatives possessed amino
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373 PMID 17031385
MK
Interaction between polyamines and bacterial outer membranes as investigated with ion
Antitumor agent
Il24
MAO
Velnacrine
Synthesis and biological activity of novel shikonin analogues PMID 19111464
ATP柠檬酸裂解酶（Acly）基因
Fesoterodine impurity 1
Octanoic acid
Biostructural and pharmacological studies of bicyclic analogues of the 3
Molecular target characterization and antimyeloma activity of the novel, insulin
Rational Drug Design Leading to the Identification of a Potent 5
Inhibition of nitric oxide synthesis by NG
Berkeleyacetal C, a meroterpenoid isolated from the fungus Penicillium purpurogenum MHZ 111, exerts anti
An overview of RAF kinases and their inhibitors (2019
2,4
Designing Dihydrofolate Reductase Inhibitors as X
7
Fe
Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small
Molecular editing of NSC
Re
P4HA2
Studies on chondrocytes from mandibular condylar cartilage, nasal septal cartilage, and spheno
Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO
Luviquat FC 550
IL33 Human Pre
Bisphenol S Exposure and MASLD A Mechanistic Study in Mice PMID 40203079
Myristic acid
Calpeptin
Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti
N,N
MCE
Environment
SNAP/CLIP
(
Small extracellular vesicles from HO
l
PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction PMID 38154546
Cocaine
Ctps2
Clonidine
Fus
Mthfs
Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease PMID 20864505
Pressure
Oleic
Comparison of Tamsulosin and Tadalafil effects in LUTS treatment considering patients' atherosclerosis risk level PMID 35846856
Development of autotaxin inhibitors A series of tetrazole cinnamides PMID 33160025
5'
Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring PMID 8182710
Hexaethylene glycol dimethyl ether 1072
Selective antagonism of 5alpha
Discovery of AZD6642, an inhibitor of 5
Design, Synthesis, and Mechanism Study of Benzenesulfonamide
Inhibitory activity of Juniperus communis on 12(S)
serpin 家族 B 成员 8（SERPINB8）基因
Androsterone glucuronide
Antipain and leupeptin restrict uterine DNA synthesis and function in mice PMID 269427
Phthalylsulfathiazole (sulfathialidine); clinical, chemical and bacteriologic evaluations in infectious diseases of the colon PMID 21004767
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