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Rifamycin S 13553
APL
(S,S)
MCE
Eukaryotic ADCY7 catalyzes the production of c
hsa
Identification of the antimetabolite of L
Actions of U
Methyl
Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta
Golgi Apparatus Polarity Indicates Depression
KRAS G12C inhibitor 34 2749948
CRBN ligand
Flunarizine blocks voltage
Novel coumarin
Discovery of 2
ADP 核糖基化因子样 GTPase 2 结合蛋白（ARL2BP）基因
Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis PMID 40035499
Salvianic acid A inhibits lipopolysaccharide
Human sialidase inhibitors design, synthesis, and biological evaluation of 4
Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors An effective strategy towards development of potent anti
N
Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster PMID 15998112
MCE
S0456 1252007
Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1
NOTCH1 蛋白, Human (HEK293, His)
Foxc1
Hyperexcitation of ovBNST CRF neurons during stress contributes to female
Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells PMID 18349845
The ZmWAKL
Inhibition of Skp2 enhances doxorubicin
BHLHE40
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice PMID 26712379
On the genotoxicity of the pesticides Endodan and Kilacar in 6 different test systems PMID 3892282
4
Inhibition of the thyroid hormone pathway in Xenopus laevis by 2
Alclometasone dipropionate 66734
Src
PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF
Discovery of DS42450411 as a potent orally active hepcidin production inhibitor Design and optimization of novel 4
The PI3Kδ inhibitor idelalisib suppresses liver and lung cellular respiration PMID 26823960
MCE
Rozibafusp alfa 2143449
MCE
hsa
2
Huwe1
Myocardin
Hsf4
A multivalent approach to the discovery of long
The effects of an H3 receptor antagonist (PF
Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin
MCE
Bone marrow
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway PMID 30390593
MCE
Bacillus pfraonensis sp. nov., a new strain isolated from a probiotic feed additive with low cytotoxicity and antimicrobial activity PMID 37356781
DiOC7(3) 53213
p53
CRBN ligand
Glucose
Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2
Concentration
The Thyrotropin
Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism PMID 40884045
DDO
CHMIS
Viomellein 55625
Acetylcholinesterase inhibitors from Corydalis yanhusuo PMID 20234973
Expanding the Repertoire for Large Small Molecules Prodrug ABBV
Haloperidol decanoate 74050
BMS
MTIC 3413
LILRA5/CD85f 蛋白, Human (HEK293, His)
Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site
SB
DNA intercalator BMH
BPR1J
Enantioselective quantitation of (R)
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin PMID 19266534
Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin PMID 23771043
Design and synthesis of N
(S)
The Antitumor Drug LB
(5)6
RON ( MST1R) and HGFL ( MST1) Co
Fgf23
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone PMID 15534001
Arylazolyl(azinyl)thioacetanilides. Part 10 design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV
MCE
MCL
Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4
Evidence of a novel mevalonate pathway in archaea PMID 24914732
N',2
Cenpf
Pharmacology of (2S,4Z)
MCE
MiR
Ocular hypertension general characteristics and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011 PMID 24988292
Neuregulin
S100A9
A Staphylococcus pro
CRBN ligand
Second generation of 5
A novel GalR2
MCE
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP
The 5
Relaxin influences ileal muscular activity through a dual signaling pathway in mice PMID 29491682
Glutathione S
A novel small
N6
Irf7
(2S)
An Erythrocyte Membrane
Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima PMID 28614730
Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases PMID 40112040
Homocysteine activates endothelial TP receptor to promote von Willebrand factor secretion and thrombosis PMID 41183610
Glipizide 29094
Synthesis and biological evaluation of novel 2
Interleukin
Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death PMID 31756542
BACH1 is stabilized by vitamin E and attenuates the formation of hypertrophic scar through the Wnt/β
Tyr
Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO
Tpm2
In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes PMID 29517824
Nedd8
Thiazole
The Analgesic Effect of the Mitochondria
Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress
SAMe
[Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450] PMID 25850285
WD40
Chemical constituents of Patrinia heterophylla Bunge and selective cytotoxicity against six human tumor cells PMID 30853646
The discovery of GSK221149A a potent and selective oxytocin antagonist PMID 18032036
P160 peptide 362043
Masitinib mesylate 1048007
Labuxtinib 1426449
Fexapotide triflutate results of long
Identification of Toll
PRMT5
New lytic peptides based on the D,L
The discovery of a new potent FXR agonist based on natural product screening PMID 37995646
ERK5
Luteolin 7
Agkistrodon Haemocoagulase (尖嘴蝮蛇凝血酶蛋白)
METTL3
DIM
Norbiotinamine hydrochloride 160385
Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97
Removal of 8
The sprout inhibitors chlorpropham and 1,4
BC8
Targeting protein arginine methyltransferase 5 in cancers Roles, inhibitors and mechanisms PMID 34619493
Induction of cytolytic cells by pure recombinant human interleukin 2 PMID 6437845
Adgrb1
(
The crystal structure of licarin
Acetyltrialanine 19245
Pallidol
Intracellular processing of DNA
Discovery of Potent, Selective, and Orally Bioavailable Small
Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A
Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells PMID 22216935
Chrdl1
Structure
CMTM6 inhibits tumor growth and reverses chemoresistance by preventing ubiquitination of p21 in hepatocellular carcinoma PMID 35304440
Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin
TRX
Targeting Decidual Macrophage Polarization through JNK Signaling Pathway Inhibition Alleviates Adverse Pregnancy Outcomes in Early Spontaneous Abortion PMID 40550988
Effects of 2
Cdnf
Bamirastine (TAK
Behavioral effects of phenylpiperidine narcotic antagonists PMID 7291232
易位蛋白（TSPO）基因
Tyrosine Hydroxylase 蛋白, Human (sf9, His)
Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre
(S)
Structure, tissue distribution, and pharmacological characterization of Xenopus orexins PMID 10573288
Synthesis, physico
Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of fosfluconazole and micafungin PMID 24042529
Serum Free or Not Two Distinct Recycling Mechanisms Mediated by Alpha v Beta 3 Integrin PMID 28982325
Gsdmc
Short
Side
Levobetaxolol (Betaxon) and other beta
Ramixotidine 84071
Cyclopentenylcytosine (CPE
Effects of KW
Chemerin
The Use of Fluorescently Labeled ARC1779 Aptamer for Assessing the Effect of H2O2 on von Willebrand Factor Exocytosis PMID 33832411
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon
MCE
Oxidative Stress Harms and Benefits for Human Health PMID 28819546
Inhibitors of protein kinase C. 1. 2,3
MCE
7
MCE
Protein Diversity and Immune Specificity of Hemocyanin From Shrimp Litopenaeus vannamei PMID 34950141
Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple
Limaol A Polyketide from the Benthic Marine Dinoflagellate Prorocentrum lima PMID 28383915
Pomalidomide
Baicalin attenuated metabolic dysfunction
Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP
Chemokine (C
Valnemulin 101312
The tachykinin peptide family PMID 12037144
MCE
Lehmannine 58480
Ex vivo stimulation of the trigeminal nucleus caudalis induces peripheral CGRP release in the trigeminal ganglion and reveals a distinct dopamine
HDAC6 inhibition reverses cisplatin
Longdaysin inhibits Wnt/β
A novel ligand
Antibody
A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells PMID 28634059
Function of orthologous fibroblast growth factor 11 protein in angiogenesis and immunomodulatory after spinal cord injury PMID 41052555
Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX
Novel therapeutic nano
Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex PMID 26083124
Saponins of Panax notoginseng chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases PMID 24555869
Corticosteroid
Zingiberis rhizoma a comprehensive review on the ginger effect and efficacy profiles PMID 16194058
Distinct anti
Interleukin
JNJ
Spizofurone (AG
Discovery of an Irreversible and Cell
NDI
Carteolol hydrochloride protects human corneal epithelial cells from UVB
蛋白激酶 C， α（Prkca）基因
死盒解旋酶 3 X 连锁（DDX3X）基因
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo Involvement of dual PI3K/Akt and Nrf2/HO
GLP
Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells PMID 34563224
Disruption of microtubules in living cells by tyrphostin AG
Tiotropium bromide (Ba 679 BR), a novel long
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants PMID 40578364
Cross talk between lysine methyltransferase Smyd2 and TGF
Dasatinib, a selective tyrosine kinase inhibitor, prevents joint destruction in rheumatoid arthritis animal model PMID 36808837
Colorimetric estimation of arylsulfatase enzyme kinetics and distribution of the enzyme in seven mammals and in tumors PMID 13283603
2'
Key structural requirements of benzamide derivatives for histone deacetylase inhibition design, synthesis and biological evaluation PMID 38623995
Demeton
hsa
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors The effects of subtype
Tenuazonic acid
CCL23/myeloid progenitor inhibitory factor
GW 9578
AG
hsa
Chemically Diverse Group I p21
Ligustrazine derivatives. Part 3 Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents PMID 19329327
N
Modulation by GABA(B) and delta opioid receptors of neurally induced responses in isolated guinea
CRBN ligand
Downregulation of the NLRP3/Caspse
Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity PMID 35870998
Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor PMID 25100502
Mogroside V 88901
Sparcl1
SLF 195513
CRBN ligand
Drotaverine
4
Mechanisms of GDF
YM
Lomofungin, a new antibiotic produced by Streptomyces lomondensis sp. n PMID 5785961
ENPP3
Creating diverse target
Vps18
Virtual library docking for cannabinoid
Propan
Drug repurposing and rediscovery Design, synthesis and preliminary biological evaluation of 1
Cantrixil 2135511
Laxiflorin B 165337
Biapenem PMID 12381221
A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy PMID 21410686
MCE
Adamantyl N
hsa
(±)
Taste stimuli a behavioral categorization PMID 5664512
In vivo inhibition of dipeptidyl peptidase IV activity by pro
A Mirror Image Fluorogenic Aptamer Sensor for Live
BMPR2 promoter methylation and its expression in valvular heart disease complicated with pulmonary artery hypertension PMID 34793329
Discovery of a potent and selective PROTAC degrader for STAT3 PMID 40756525
In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans PMID 19196846
LCN2
Ceftobiprole medocaril sodium 252188
Evaluation in rat of RS
P
A Small
DBCO
A novel psychedelic 5
磷酸胞苷酰转移酶 1B，胆碱（PCYT1B）基因
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage
Chondramide C synthesis, configurational assignment, and structure
Passage of penicillins from mother to foetus in humans PMID 4648466
D
CU
Hemicholinium
Reversal of acid
TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps
FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway PMID 37752545
MCE
MCE
Dehydrotrametenolic acid selectively inhibits the growth of H
MCE
Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway PMID 38200161
NV03 2448341
胶质纤维酸性蛋白
New antileishmanial quinoline linked isatin derivatives targeting DHFR
Structure
(R)
动力蛋白细胞质 1 重链 1（DYNC1H1）基因
Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer PMID 21464397
TWEAK/TNFSF12 蛋白, Human/Cynomolgus (HEK293, mFc)
2
Effects of helospectin I on insulin and glucagon secretion in the mouse PMID 1855119
Bag4
Inositol 1,3,4,5
Broad
Physiologically
Ancitabine hydrochloride 10212
Use of 3,5
MCE
Discovery of N
TAMRA hydrazide (6
安氯地平
New inhibitors of nitric oxide production from the seeds of Myristica fragrans PMID 23994084
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome PMID 15574503
Mal
Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease PMID 29123083
NTP concentration switches transcriptional activity by changing the large
Actions of Helodermatidae venom peptides and mammalian glucagon
Structure
LVGRQLEEFL (mouse) 608513
Primary Amine Tethered Small Molecules Promote the Degradation of X
2
Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain PMID 21572518
Jak
Synthesis and biological evaluation of dehydroabietic acid derivatives PMID 19892441
Generation of Th1
Acidosis overrides molecular heterogeneity to shape therapeutically targetable metabolic phenotypes in colon cancers PMID 39900217
BMAP
NLR 家族成员 X1（Nlrx1）基因
Creatinine
BRD
Tetrahedral framework nucleic acid loaded with glabridin A transdermal delivery system applicated to anti
Orvinol
Comparative study on Perfluoro(2
Vasoactive intestinal peptide receptor antagonist [4Cl
NSC666715 and Its Analogs Inhibit Strand
Visualizing cancer and response to therapy in vivo using Cy5.5
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK
VPS72 Human Pre
CP
Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt
Nemorubicin 108852
High
Peptide YY (PYY) (3
IL
Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria PMID 30879003
Effectiveness of inhibitor rapamycin, saracatinib, linsitinib and JNJ
黄心树提取物 (Machilus gamblei King ex Hook. f.)
Acetoxycycloheximide (E
A Proteomic Approach to Study the Effect of Thiotaurine on Human Neutrophil Activation PMID 28849482
Different susceptibilities to 1,25
Astragaloside IV protects renal tubular epithelial cells against oxidative stress
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras PMID 40162713
CRBN ligand
Rare, structurally homologous self
METTL3
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen
Fluasterone 112859
(Rac)
TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM
Orally active MMP
Activation of IRE1, PERK and salt
醛脱氢酶 1 家族，成员A1（ALDH1A1）基因
Proximity labeling
Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer importance of mammary CYP27B1 for treatment and prevention PMID 22939886
MCE
Onvuzosiran
Ctr9
IGF
SAR of biphenyl carboxamide ligands of the human melanin
Reverse of non
MCE
CRBN ligand
Triple reuptake inhibitors Design, synthesis and structure
ICAM1
Tremorgenic indole alkaloids potently inhibit smooth muscle high
Scaffold
SH
A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling PMID 32649856
MCE
Selective alteration of Ca2+
Vimekofusp 2771192
MCE
Discovery of inhibitors of the mitotic kinase TTK based on N
Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics PMID 9614066
Slc9a1
CHK1
Desmethyl Bosentan 253688
Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor
In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma PMID 22386728
Inhibition of crystal
Gata1 Mouse Pre
Human CC chemokine CCL23 enhances expression of matrix metalloproteinase
A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost PMID 28146132
Tributyrin induces differentiation, growth arrest and apoptosis in androgen
MCE
MCE
CCR5 antagonist 4 872879
ROS
Hydroxymethyl dasatinib 910297
Chemical engineering and structural and pharmacological characterization of the α
麦珠子提取物 (Alphitonia incana (Roxburgh) Teijsm. & Binn. ex Kurz)
The pheromone androstenol (5 alpha
Arl2bp
N
HY
Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor
Relationship of inhibition of prostaglandin synthesis in platelets to anti
Structures, Biosynthesis, and Bioactivity of Oligomycins from the Marine
CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR
Stimulatory actions of thymol, a natural product, on Ca(2+)
New bis
F 盒蛋白 2（FBXO2）基因
Sulfation of o
mmu
Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin
Discovery of 2
MCE
Possible involvement of host defense mechanism in the suppression of rat acute reflux esophagitis by the particular histamine H2 receptor antagonist lafutidine PMID 23038658
Autophagy inhibitors 3
A sesquiterpene lactone, tomentosin, as a novel anticancer agent orchestrating apoptosis, autophagy, and ER stress in colorectal cancer PMID 40214725
Kras4B 蛋白, Human (184a.a, G12V, His)
激酶 (Kinases)
Diketone
Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro PMID 35952389
Blockade of the AHR restricts a Treg
Amide conjugates of ketoprofen and indole as inhibitors of Gli1
GLP
SIB
Fluorogenic photoclick labelling of DNA using a Cy3 dye PMID 30307458
KCNJ11 Human Pre
Synthesis, Anthelmintic Activity, and Mechanism of Action of 5
A phase 2a trial of 12
Exposure to polystyrene nanoplastics causes anxiety and depressive
Leveraging Fungal and Human Calcineurin
Clemeprol 71827
1,2
Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine
CRBN ligand
Discovery of Potent, Selective, and Short
KRAS
Slc30a1 Rat Pre
A cell type
Tri
MRS
Approaches to design non
Structure
Mitogen
Selective Inhibition of ADAR1 Using 8
Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells PMID 25564462
Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species
CRBN ligand
Neuronal Nitric Oxide Inhibitor 7
Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease PMID 40359032
An adamantyl
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives PMID 29432947
Aloperine inhibits the progression of non
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice PMID 21340507
A cellular model for Wilson's disease using patient
252Cf plasma desorption mass spectrometry of adenomycin (C19
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway PMID 39488694
SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells PMID 36497110
Structure
SU11606 669764
Gypc
Stearic acid
MCE
Click
Belumosudil 911417
Nrcam
Small Amphiphilic Peptides Activity Against a Broad Range of Drug
Accelerated onset of the vesicovesical reflex in postnatal NGF
Novel vanilloid receptor
FG
Structure and dynamics determine G protein coupling specificity at a class A GPCR PMID 40106559
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