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Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL
Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3 PMID 38055393
JCS
TTC
Rivaroxaban impurity 6 64491
JCS1
Epimer.
Nordoxepin hydrochloride 2887
Lewis a
Ccnh Rat Pre
Idalopirdine, a selective 5
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii PMID 10978218
Human iPSC and CRISPR targeted gene knock
Aflatoxins B(1), B(2) and G(1) modulate cytokine secretion and cell surface marker expression in J774A.1 murine macrophages PMID 22445859
Growth differentiation factor 11 alleviates oxidative stress
Astaxanthin has a beneficial influence on pain
1
Dithianon 3347
Baicalin promotes random
Synthesis of 2
SCR
MC1742
WNT 信号通路的 APC 调节因子（APC）基因
Ivaltinostat 936221
Kynapcin
Glucosylsphingosine (lyso
TRAF3
Atropine hydrobromide 6415
Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity PMID 34284105
Overview of Recent Strategic Advances in Medicinal Chemistry PMID 31050421
Macrocalin B 93781
The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ PMID 26700222
Biological evaluation of tubulysin A a potential anticancer and antiangiogenic natural product PMID 16489930
9,10
Synthesis and anticancer activity of novel spiro
highly bioavailable
TAC model
Tectol 24449
Designing and developing S100P inhibitor 5
Sex
Exercise
In vitro and in vivo characterisation of ASP9521 a novel, selective, orally bioavailable inhibitor of 17β
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF
CEP7055
PT109
Characterization of Novel Antimalarial Compound ACT
COTC
Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti
The Circadian Rhythm Gene Network Could Distinguish Molecular Profile and Prognosis for Glioblastoma PMID 40565338
The sirtuin 1/2 inhibitor tenovin
Swertiaside 96087
An Integrated Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation Study to Investigate the Potential Mechanism of Isoliquiritigenin in the Treatment of Ischemic Stroke PMID 40864781
Autophagy
Molecular profiling identifies distinct subtypes across TP53 mutant tumors PMID 36256461
TAK070
Discovery of 1
Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF
Deoxyfunicone
Identification and Characterization of Novel CFTR Potentiators PMID 30416447
Selective screening for fatty acid oxidation disorders by tandem mass spectrometry difficulties in practical discrimination PMID 12828998
Urolithin A protects against domoic acid
The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma PMID 28938586
Aflatoxin M1
Danger signals Chemotherapy enhancers? PMID 29027217
Cadisegliatin 859525
Photothermal
Iberin
PB 200
Two dose
The dual epigenetic role of PRMT5 in acute myeloid leukemia gene activation and repression via histone arginine methylation PMID 26536822
COP9 信号体亚基 2（COPS2）基因
Progesterone review of safety for clinical studies PMID 17924777
Apoptosis inducer 25 2763063
Pterulinic acid 190143
RHOQ Human Pre
Novel erbium complex with anticancer activity against radiation resistant lung adenocarcinoma cells PMID 40132280
Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1 PMID 37267298
Pemetrexed disodium heptahydrate 357166
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti
Design, Synthesis, and Activity Evaluation of C
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons PMID 37651231
Damascenone inhibits osteoclastogenesis by epigenetically modulating Nrf2
Adherent cells undergo rate softening mediated by actomyosin kinetics PMID 40714842
4
Structure
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression PMID 37770567
PROTAC BRD9 Degrader
MCE
Inhibition of Polo
Hybrid molecules The privileged scaffolds for various pharmaceuticals PMID 27598238
MCE
A negative allosteric modulator modulates GABAB
Dioscin 19057
DNMT/HDAC
The inhibitory effects of class I histone deacetylases on hippocampal neuroinflammatory regulation in aging mice with postoperative cognitive dysfunction PMID 33090427
An ultrafast insulin formulation enabled by high
白细胞介素 4（IL4）基因
Blood
Synthesis of novel peptide inhibitors of thrombin
Differential Effects of CORM
Synthesis and evaluation of 1,2,3
Hydroxy Varenicline (2
GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette
Eeyarestatin I (ESI)
MCE
Jionoside D 120406
1, 2
Thrombospondin
Inhibition of cyclic GMP
A co
β
MCE
Miniaturized skeletal muscle tissue fabrication for measuring contractile activity PMID 33358352
Antibacterial and anti
PROTAC
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP
LY 292728 153034
O6
组织胺 (标准品)
H
串珠丝结构蛋白 1（BFSP1）基因
URAT1 inhibitor 5 2102670
Xanthine oxidoreductase One enzyme for multiple physiological tasks PMID 33578127
3
Sclerotiorin 549
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase substrate structural determinants of asymmetric catalysis PMID 7840649
Therapeutic promise of proteinase
Hnrnpa2b1
Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high
S100a14 Rat Pre
Molecular mechanisms and clinicopathological characteristics of inhibin βA in thyroid cancer metastasis PMID 39301627
TNFRSF9
Generation of semicarbazide from natural azine development in foods, followed by reaction with urea compounds PMID 26140456
Characterization, quantification, and bioactivities of anthocyanins in Cornus species PMID 11958615
Disitamab Vedotin First Approval PMID 34661865
Small
A look around the West Indies The spices of life are secondary metabolites PMID 33038665
Novel pyrazoline derivatives as bi
DDO
Design, synthesis and structure
5
CRBN ligand
The cancer antigen CA125 represents a novel counter receptor for galectin
Hypoxia
Lifastuzumab 1615697
ANGPT2
De novo design, synthesis and biological evaluation of 1,4
Mechanistic prediction of first
Caspase
AZA197 1249398
Cdc2 kinase substrate 956004
1
A novel small molecule aurora kinase inhibitor attenuates breast tumor
Eps8l1
Lercanidipine 100427
Maresin 1, a proresolving lipid mediator derived from omega
New macrolactone of the desertomycin family from Streptomyces spectabilis PMID 9090721
Synthesis of thiazole linked indolyl
SLC25A21 downregulation promotes KRAS
Antifungal Activity and Potential Mechanism of Caspofungin in Combination with Ribavirin Against Candida albicans PMID 36640848
Discovery of a potent, orally available, and isoform
Discovery of LY3104607 A Potent and Selective G Protein
DOPAL initiates αSynuclein
KCC2 Modulator
角蛋白（CRNN）基因
FAT1 Enhances the Sensitivity of Non
Multi
TFPI
Biocytin wide
L
Rapid synthesis and synaptic insertion of GluR2 for mGluR
Design, synthesis, and anti
Ursolic acid derivative UA312 ameliorates ionizing radiation
DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3
Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake PMID 39553975
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice PMID 30871577
(R)
New insecticidal cyclodepsipeptides from the fungus Isaria felina. I. Production, isolation and insecticidal properties of isariins B, C and D PMID 7198111
TAK
VH285
Gibberellin Localization and Transport in Plants PMID 29530380
JNJ
层粘连蛋白亚基β2（LAMB2）基因
(S)
Evaluation of the effects of low nanomolar bisphenol A
The Bruton tyrosine kinase inhibitor PCI
PROTAC CRABP
2
Plekhn1
Identification of Polo
N
GAGGVGKSA 1223335
11
G9a deficiency activates TMEM27 to promote ferroptosis and enhances radiosensitivity in head and neck squamous cell carcinoma PMID 41213903
Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis PMID 40379634
Evaluation of the estrogenic activities of some pesticides and their combinations using MtT/Se cell proliferation assay PMID 16781191
Recent advances in the treatment of erectile dysfunction PMID 28751439
N
WAY
Synthesis of core
Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF
Taraxerol (Standard)
Pyruvate Carboxylase
Cylindrospermopsin 143545
Phosphoethanolamine calcium 10389
Hexahydrocurcumin enhances inhibitory effect of 5
MYCi361 2289690
Accurate determination of CRISPR
Novel 5
8
[Leu13]
Renardin (Standard)
GSK2656157, a PERK inhibitor, reduced LPS
Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow
Melatonin and its metabolite N1
A microPLC
Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds PMID 24969013
MCE
Discovery of 5
Dot1L
Molecular Biomarkers for the Early Detection of Ovarian Cancer PMID 36233339
CBR
Picrinine (Standard)
MMP
N
Exploring the importance of piperazine N
3,5
124044
Synthetic CCK8 analogs with antagonist activity on pancreatic receptors in vivo study in the rat, compared to non
Brushed block copolymer micelles with pH
Synthetic peptide substrates for a tyrosine protein kinase PMID 6279650
2
HNRNPA2B1 regulates the epithelial
KNI
Effect of mizoribine on collagen
Design and synthesis of pyrano[2,3
PF
Improvement of glucose tolerance in Zucker diabetic fatty rats by long
EGFR
UNC3866 TFA 1872382
Spectrofluorometric and molecular docking studies on the binding of curcumenol and curcumenone to human serum albumin PMID 25756376
Mono
出口 6（XPO6）基因
Inhibition of iodothyronine 5'
LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway PMID 37801199
Furin
Targeting Bcr
SC
A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti
Chrysin protects against cerebral ischemia
Design and validation of the first
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant
6
MCE
Comparative pharmacological studies of melatonin receptors MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 PMID 11331072
TDO2 + cancer
NJH
Effects of tanezumab on satellite glial cells in the cervicothoracic ganglion of cynomolgus monkeys A 26
Renzapride a new drug for the treatment of constipation in the irritable bowel syndrome PMID 18922103
AKT
Structure
Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation PMID 34729889
Dichlorophenyl
Diethyl D
BAL
AB680
Fosmetpantotenate 1858268
Ocular changes in beagle dogs following oral administration of CGS 24565, a potential hypolipidemic agent PMID 10788573
RNA
Antitumour imidazoacridone C
Ro 70‐0004 186386
Loureirin A 119425
The development of MetAP
MCE
Antibacterial Activity of Metergoline Analogues Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery PMID 35178184
Pore
MCE
Heterocycle
Antitumor efficacy of oblimersen Bcl
MES hydrate 1266615
Synthesis and application of MeOSuc
Activation of IGF
An ultrasensitive chemiluminoenzyme immunoassay for the quantification of human tissue kininogens application to synovial membrane and cartilage PMID 8288887
An inhibitor of FtsZ with potent and selective anti
Coptisine
Design, synthesis and bioevaluation of dihydropyrazolo[3,4
Regulation of the Keratocyte Phenotype and Cell Behavior Derived from Human Induced Pluripotent Stem Cells by Substrate Stiffness PMID 36668685
Assessment and Comparison of Early Developmental Toxicity of Six Per
TNF
Personalized Preclinical Trials in BRAF Inhibitor
Targeting Wnt pathway in mantle cell lymphoma
O6BTG
Jag1
Schisandra chinensis Oil Attenuates Aristolochic Acid I
Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors PMID 10486557
Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells PMID 32510663
Tissue
Homogeneous Oligomers of Pro
Overcoming E3 Ligase
FGFR4
(S)
Phase II randomised proof
Rational design of highly sensitive fluorescence probes for protease and glycosidase based on precisely controlled spirocyclization PMID 23205758
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra
Aurantio
CUDA 479413
Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis PMID 35690642
Clec4d
Inhibition of ER stress
hsa
MCE
X
A selective biomarker for confirming nitrofurazone residues in crab and shrimp using ultra
GLTP 蛋白, Human (HEK293, His)
GLP
Rationally designed stapled peptides allosterically inhibit PTBP1
Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway PMID 35912256
The BMI1 inhibitor PTC
Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells PMID 33744762
FAM labled IONIS
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) PMID 27749056
[Chemical Constituents from the Roots of Macleaya cordata] PMID 30204380
Homology
FRET two
A novel lysophosphatidic acid receptor 1 antagonist with high brain penetrability has a curative effect in the empathic pain
Untargeted metabolomic analysis reveals a potential role of saponins in the partial resistance of pea (Pisum sativum) against a root rot pathogen, Aphanomyces euteiches PMID 39186063
GRGDSPK 111119
The Efficacy of Cholesterol
A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin
Gnetin D 84870
Involvement of Integrated Stress Response in Drug
Ro 48
TP
Oxalic acid dihydrate 6153
Phase I trial of indicine
Understanding the effects of per
Structure and dynamics of the active human parathyroid hormone receptor
sn
ROR
Thalidomide
Bid BH3 peptide 300349
Fmoc
Labda
Isolation of chlorogenic acids and their derivatives from Stemona japonica by preparative HPLC and evaluation of their anti
Structural variations in the trans
6
ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma PMID 40581662
p
NBD
Synthesis and antitumoral activity of novel analogues monastrol
Porcine carotid vascular effects of eletriptan (UK
Chemical constituents of plants from the genus Eupatorium PMID 18205126
Imperatoxin A 172451
PTPRR
LEC11
IL18RAP
Potent, orally absorbed glucagon receptor antagonists PMID 10201821
Glucose metabolism through the hexosamine biosynthetic pathway drives hepatic de novo lipogenesis via promoting N
Mechanism of action for NNZ
Ligand
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis PMID 35092824
Isopropamide
甲基巴豆酰辅酶 A 羧化酶亚基 1（MCCC1）基因
Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species PMID 22985628
wireweed
Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR
Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists PMID 31820985
(Rac)
Growth inhibition and apoptosis
OBFC1 抗体 (YA7820)(PBS only)（OBFC1 Antibody (YA7820)(PBS only)）
4
PMA
Talmapimod
GLUT1
Green CMFDA 136832
Idh3a
Bullatine A 1354
MCE
Fbxo32
Chromosome 1 trisomy confers resistance to aureobasidin A in Candida albicans PMID 37007527
Tnfaip3
Intra
Discovery of 3,5
2
Topical Dihydroartemisinin Improves Wound Healing in Diabetic Mice PMID 37314293
Rnf31
Pfkfb4
MCE
VASP 抗体 (YA6215)（VASP Antibody (YA6215)）
Dimethyl isorosmanol 116064
A Multifunctional Nanoparticle Dual Loading with Chlorin e6 and STING Agonist for Combinatorial Therapy of Melanoma PMID 39289781
5
Thioredoxin
Naringenin 4',7
CSF1R
适配器相关蛋白复合物 3 亚基西格玛 2（AP3S2）基因
Cdc25a
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator
The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis PMID 20967473
内质网到细胞核信号 1（Ern1）基因
Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation PMID 33639566
Effects of bencyclane on normal and cevadine
δ
4
TOK
CD44
Peptide
Pharmacological disruption of mSWI/SNF complex activity restricts SARS
An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics PMID 26630438
LDN
H3 成簇组蛋白 2（H3C2）基因
A MAS
Coptisine inhibits lipid accumulation in high glucose
Anti
Thioredoxin
CM
Discovery and evolution of berberine analogues as anti
F
Comparative Study of pH
Mitoribosome
Rps14 Rat Pre
MCE
AFMK 52450
CWP232228 targets liver cancer stem cells through Wnt/β
Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT
MCE
BRD4770 1374601
N
Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta
(R)
9c11tCLA modulates 11t18 1 and 9t18 1 induced inflammations differently in human umbilical vein endothelial cells PMID 29367652
TH6
Improved neuronal tract tracing with stable biocytin
Morcamilast 2231329
7,8
Diallyldimethylammonium (chloride) (60% in water) 7398
Small
SmBiT Tag 1628913
8
Racemic intrathecal mirtazapine but not its enantiomers acts anti
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation
Pharmacokinetics of cligosiban in dog plasma after oral administration by liquid chromatography electrospray ionization tandem mass spectrometry PMID 31145820
FAM20B Human Pre
AS2077715 a novel antifungal antibiotic produced by Capnodium sp. 339855 PMID 24865863
Determination of enantiomeric impurity of levamlodipine besylate bulk drug by capillary electrophoresis using carboxymethyl
GLPG2737 2093974
MP
ZG
Studies on the metabolism of the novel, selective cyclooxygenase
Selective binding of biotinylated albumin to the lymphoid microvasculature PMID 15856274
The Central Analgesic Mechanism of YM
Strain
NMT
3,5,3'
TDIQ (5,6,7,8
MCE
1,2
Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid
一切同源盒 2（ONECUT2）基因
PRT3789 epimer
Dual modulators of aggregation and dissociation of amyloid beta and tau In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components PMID 36242849
(R)
AG73
Phenotypic susceptibility to bevirimat in isolates from HIV
Anxiolytic
Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression PMID 33367557
TEI
Rapid synthesis of VX
p53 is not directly relevant to the response of Polo
Letter Acetyl transfer reaction in catechol acetate malonate. A model for the biosynthesis of polyketides and fatty acids PMID 1176738
[3H]
Differential effects of triacylglycerol positional isomers containing n
Cytip
A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli PMID 26627837
Tekt1
Buvacitam impurity 27 50840
TIGIT 蛋白, Human (HEK293, mFc)
6,8
Triamcinolone acetonide
PROTAC IRAK3 degrader
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC
Rescue of calcium
Purinostat mesylate 2650188
CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity PMID 10973820
Small molecules direct the generation of ameloblast
Roles of full
Aurora
Ferroptosis is involved in Staphylococcus aureus
Isosteviol 27975
Neohesperidin dihydrochalcone presentation of a small molecule activator of mammalian alpha
MCPA
Deregulation of alternative splicing of fibronectin pre
Uptake of glucose
Novel derivatives of brincidofovir and (S)
LQZ
Methyl (2E,4Z)
Tubulysin G
Ro 42
Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P
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