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Epha8 Rat Pre
SYT3 Human Pre
MCE
Flumazenil induces benzodiazepine partial agonist
RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis PMID 35019797
Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure
Structural analysis of N
A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non
Lithium chloride protects PC12 pheochromocytoma cell line from morphine
Receptor specificity of the fibroblast growth factor family PMID 8663044
Hit Recycling Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing PMID 26121309
WRX606 899937
Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells PMID 35286922
轧棉厂复杂亚基 1（GINS1）基因
Exploring the purine core of 3'
BIO5192, a small molecule inhibitor of VLA
Novel AMPK/ORP8
Cytotoxic oleanane triterpene saponins from Albizia chinensis PMID 19256478
Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro PMID 38515757
CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF
MCE
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267 PMID 7142192
MLi
GSK503 1346572
SLC51A
Targeting of the FOXM1 Oncoprotein by E3 Ligase
NME/NM23 核苷二磷酸激酶 3（NME3）基因
Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus PMID 11213287
RAD18 E3 泛素蛋白连接酶（RAD18）基因
CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation PMID 38154213
Aloeresin J 1431370
核糖体蛋白 L18（RPL18）基因
Exposure to extremely low
Auxinole 86445
荷马支架蛋白 3（HOMER3）基因
白细胞免疫球蛋白样受体 A6（LILRA6）基因
HUS1 Human Pre
MCE
Exploring the mechanism of Schisandra rubriflora in the treatment of polycystic ovary syndrome based on network pharmacology and molecular docking PMID 39875917
Low Doses Naltrexone The Potential Benefit Effects for its Use in Patients with Cancer PMID 33504322
CXC
Two TRPV1 receptor antagonists are effective in two different experimental models of migraine PMID 26109436
Identification of human CCR8 as a CCL18 receptor PMID 23999500
CXC 基序趋化因子配体 6（CXCL6）基因
SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells PMID 23733203
Activation of CB1 receptors by 2
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model PMID 27563401
肾上腺素 A1（EFNA1）基因
Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation PMID 363127
DAMPA methyl ester
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons PMID 34230223
Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia PMID 24951854
Non
Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome
Cyclosieversioside B
肌聚糖α（SGCA）基因
富亮氨酸重复神经元 1（LRRN1）基因
外泌体组分 2（EXOSC2）基因
EC1169 1610413
β
makorin 无名指蛋白 2（MKRN2）基因
MRPS11 Human Pre
Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease PMID 22160715
胞嘧啶
Metabolism of coumarin and 7
Notch2
MCE
MCE
N
Structure
N
The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low
Novel selective quinazoline inhibitors of endothelin converting enzyme
Developing new anticancer agents Design, synthesis, biological evaluation and in silico study of several functionalized pyrimidine
Endoplasmic reticulum stress
Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3
Probing Ligand Structure
Multi
Estrogen receptor antagonist 6 2136600
CpG ODN 10101 1234402
N
Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp PMID 24690913
Effects of hexahydrocurcumin in combination with 5
Synthetic analogues of the microtubule
P
Rapid luminescence
IIIM1
Class I mGlu receptor antagonist 1
Cell
LSD1/EGFR
Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton PMID 20406461
ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial
Salipurpin 28757
New positive Ca2+
SLC40A1 Antibody
1
GDC
Dexmedetomidine ameliorates LPS induced acute lung injury via GSK
DDC
Pyridostigmine in the treatment of orthostatic intolerance PMID 17284509
Dual
Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway PMID 31967324
mmu
ATF4
Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1 PMID 21762700
DRAM 抗体 (YA9238)（DRAM Antibody (YA9238)）
A subcortical maternal complex essential for preimplantation mouse embryogenesis PMID 18804437
Trace amine
NCR3LG1
Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo PMID 16970390
Vadalentamig 3030203
Supramolecular Nanosubstrate
MCE
The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle PMID 26305889
CS 682
Propionamide 79
AZD2171 a highly potent, orally bioavailable, vascular endothelial growth factor receptor
HH105
Mpg Mouse Pre
BMS
Eplivanserin hemifumarate 130580
角蛋白 6C（KRT6C）基因
Heptadecanoyl ethanolamide
synthase
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity PMID 9310473
Crystal structures of full length DENV4 NS2B
14(15)
氟骨三醇
GS493
DL
Shift from biliary to urinary elimination of acetaminophen
A New Fluorescent Chemosensor for Cobalt(II) Ions in Living Cells Based on 1,8
Efna1
Design and total synthesis of (
Rho
Tauro
7,8
Olpadronate a new amino
CCNB1 Expedites the Progression of Cervical Squamous Cell Carcinoma via the Regulation by FOXM1 PMID 33299327
Synthesis of a novel series of 2
MicroRNA
Non
m
Lactivicin, a naturally occurring non
PIN1 inhibitor API
Structure
PFM03 1558598
ART4/CD297 蛋白, Rat (HEK293, His)
Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR
Steroid sulphatase, arylsulphatase and beta
Chemotherapy
New neo
Pharmacokinetics analysis based on target
Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities PMID 10232064
C1q/TNF
A tissue
Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors PMID 33639343
Rat interleukin
A newly synthesized selective casein kinase I inhibitor, N
Dual CDK6 and CDK9 inhibitors as anti
Stim1
Interleukin
Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands PMID 24331758
Tadalafil Alleviates LPS
Radioprotective Effect of Beta D
Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli PMID 3019234
ZEB1
CD63 蛋白, Pig (HEK293, Fc)
A piggyBac
Discovery of 4
Action of tioxamast on various models of anaphylactic shock, hyperreactivity and bronchial inflammation in guinea
Unveiling a new strategy for PDIA1 inhibition Integration of activity
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome PMID 36828203
MCE
CI
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer PMID 37553345
MRPS16 Human Pre
Microneedle Assisted Melittin
Small
Enhancement of antiproliferative activity by molecular simplification of catalpol PMID 20231098
Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia PMID 40543993
Fmoc
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction
Two disparate ligand
Dnmt1 抗体 (YA6058)（Dnmt1 Antibody (YA6058)）
Senna leaf extract
Adrenocorticotropic Hormone (ACTH) (18
Mitochondrial DNA release mediated by TFAM deficiency promotes copper
The EP4 antagonist, L
p15 INK 抗体 (YA5542)（p15 INK Antibody (YA5542)）
ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia
ML213 489402
PD
Identification of antischistosomal leads by evaluating bridged 1,2,4,5
Effects of AHR
Stapokibart (CM310) targets IL
Mechanism of inhibition of translocation by kanamycin and viomycin a comparative study with fusidic acid PMID 6243944
D4476, a cell
Synthesis and antiproliferative activity of 4
PROTAC PDIA1 degrader 1 3024292
dCTPαS (2'
Anti
The fatty acid amide hydrolase (FAAH) inhibitor PF
The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease PMID 36516757
Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL
Discovery of a functionally selective serotonin receptor (5
Inhibition of peptidoglycan biosynthesis in gram
Promoting Multivalent Antibody
m
Nfe2
3
A combination of a TLR7/8 agonist and an epigenetic inhibitor suppresses triple
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats PMID 31702810
Trial of the cysteine cathepsin inhibitor JPM
Dendritic Cell
Potent and selective thiophene urea
Effects of the non
Structure
Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I PMID 20801663
TREM
(
Decursinol angelate a cytotoxic and protein kinase C activating agent from the root of Angelica gigas PMID 9270380
Topobexin targets the Topoisomerase II ATPase domain for beta isoform
Metabolism and transporter
The selectivity of DG
Rho
Inter
Identification and validation of transcriptome
Selective role of neurokinin B in IL
Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small
Intrinsic pressor activity of midaglizole, an alpha
Modulation of Prostaglandin
Preclinical and first
RPS14 Human Pre
Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth PMID 26254477
Nonclinical safety of tildrakizumab, a humanized anti
ASN
(R)
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery PMID 30270039
Novel 4
Periplocymarin alleviates pathological cardiac hypertrophy via inhibiting the JAK2/STAT3 signalling pathway PMID 35365949
Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy Modulation of Pyroptosis Pathways PMID 39786506
Development of a TBXT
HIV
HNF4A
A selective inhibitor of the UFM1
Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles PMID 26424024
Asatone Prevents Acute Lung Injury by Reducing Expressions of NF
Characterization of synthetic peptide substrates for p34cdc2 protein kinase PMID 2045431
TLR7/8 agonist 4 hydroxy
Generation and characterization of human iPSC lines from two patients with therapy
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes PMID 38198277
MCE
In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride PMID 28885978
Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors PMID 24900658
2'
Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1
Antibacterial agent 152 197909
Hyaluronan
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well
Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products PMID 29488328
Pinning down the polo
Endothelial Yes
Pharmacokinetics and antihypertensive effect of oral pelanserin in renal hypertensive dogs PMID 1445477
Novel lead structures for p38 MAP kinase via FieldScreen virtual screening PMID 19489590
JNJ
Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity PMID 22913627
tLyp
dGTPαS (2'
Daphnetin ameliorates diabetic cardiomyopathy by regulating inflammation and endoplasmic reticulum stress
Determination of a novel Aurora
Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic PMID 17387155
Antibody
AKI603 1432515
Gut
Multi
Total synthesis and biological evaluation of potent analogues of dictyostatin modification of the C2
Hippocampal MEF2C phosphorylation mediates synaptic plasticity in lead
Involvement of a glycerol
Y134 849662
Synthesis, biological evaluation, and docking studies of new pyrazole
5
Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF
Disruption of the c
Inhibition of beta
Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats PMID 33117428
Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate PMID 11847126
Synthesis and biological evaluation of novel analogues of dictyostatin PMID 17336522
Potent antagonists of the CCR2b receptor. Part 3 SAR of the (R)
5
DNALI1 Human Pre
MRPS15 Human Pre
黑皮质素 2 受体（Mc2r）基因
A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain PMID 8702974
5(6)
Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity PMID 24279335
Sennoside D 37271
Do PAKs make good drug targets? PMID 21173843
Discovery of glycine hydrazide pore
Mdp1
Bifunctionality and Antitumor Efficacy of ZG
Arterial pressure lability is improved by sodium
Topoisomerase I inhibitor 17 2413582
The CA 125 tumour
Efpixileukin alfa 2996895
Albofungin 37895
N6
SEN
Cux1
A bi
5
Combinatorial library of chalcogen
p38 MAP Kinase Inhibitor Ⅵ 421578
Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals PMID 6817143
HDAC6
Interleukin 17 regulates SHP
Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide modification of the side chain PMID 15837302
Discovery and structural
Potent activity of the HIV
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70
10074
Discovery of 2
Crystal structure of recombinant human interleukin
p53 Activator 3 2636839
Derivatives of 1,3
Dihydro FF
Decreased Level of Exosomal miR
4
DC4SMe
Photoregulin 3
Sanggenol F (桑根醇F)
CHRNA7
Palmd Mouse Pre
Downregulation of IL
Indicine N
Selective leukemic
NAMALWA
Evidence for eIF2α phosphorylation
Karenitecin
6
Discovery of GSK2656157 An Optimized PERK Inhibitor Selected for Preclinical Development PMID 24900593
Designer Benzodiazepines A Review of Toxicology and Public Health Risks PMID 34208284
MCE
Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide
Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma PMID 26536663
Biotin
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK PMID 22998574
OOEP
A Novel Multi
Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling PMID 17134677
Carteolol
The properties of n
HY
AKR1C3 promotes progression and mediates therapeutic resistance by inducing epithelial
Novel derivatives of 1
Analysis of the phosphoproteome of CK2 α(
γ
The Role of Rosavin in the Pathophysiology of Bone Metabolism PMID 38396794
Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats PMID 15265608
Super
Jiao
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation PMID 34090907
Inhibition activity of a traditional Chinese herbal formula Huang
Design, Synthesis, and Evaluation of Cephamycin
The hiPSC
白介素 17 受体 C（IL17RC）基因
Cadmium exposure activates mitophagy through downregulating thyroid hormone receptor/PGC1α signal in preeclampsia PMID 38581905
An Isoform
Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome
Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4
Evidence for intracellular endothelin
HIPK2 a versatile switchboard regulating the transcription machinery and cell death PMID 17245128
ODE
Bioinformatics analysis of coronary microvascular dysfunction in rats based on single
Selectivity analysis of diaminopyrimidine
m
Hereditary chronic neutrophilic leukemia in a four
Synthesis of hydantocidin and C
Ragaglitazar a novel PPAR alpha PPAR gamma agonist with potent lipid
Direct interaction of a small
钙/钙调蛋白依赖性蛋白激酶 I（CAMK1）基因
SK
diarylether
RO5263397 1357266
The endothelin A receptor antagonists PD 156707 (CI
Allograft inflammatory factor 1 is a regulator of transcytosis in M cells PMID 28224999
PROTAC EZH2 Degrader
AI
ER stress sensor PERK drives ferroptosis by disrupting MAMs
Selective blockade of IL
Anti
Ezetimibe Engineered L14
FASLG Human Pre
Effect of N
An in vivo tumour organoid model based on the chick embryonic chorioallantoic membrane mimics key characteristics of the patient tissue a proof
Oleclumab 1803176
NSC132319
Sorafenib induces ferroptosis by promoting TRIM54
hsa
KRT71 Human Pre
Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators PMID 34930837
STA1474
mmu
CFM 1
MFHAS1 Human Pre
PRIM1 Human Pre
NINJ2 Human Pre
Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di
Enhanced Safety and Antitumor Efficacy of Switchable Dual Chimeric Antigen Receptor
5& 039;UTR
15 0 Cholesteryl ester
托烷类化合物 (Tropane Alkaloids)
ALCAM
MMV666810 1450666
6
Pseudomonas quinolone signal
anticolitis
Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt
Genomic mutation features identify distinct BRCA
DDATHF disodium
Nme3 Mouse Pre
Sadopine
Azido
MK4482
GDC 0980
Development of Inhibitors of the Programmed Cell Death
SMARCC2 Human Pre
Isoliquiritin apioside relieves intestinal ischemia/reperfusion
5
NP 396
Pirimecidan
Lung Purinoceptor Activation Triggers Ventilator
A review of the genotoxicity of triallate PMID 12851156
Targeted delivery of doxorubicin using stealth liposomes modified with transferrin PMID 19429296
RNF8 Human Pre
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways PMID 21224350
TM3 cells
Dinitramine
TPE
Inhibition of protein kinase C increases Prdm14 level to promote self
An Overview of Peripheral Blood Mononuclear Cells as a Model for Immunological Research of Toxoplasma gondii and Other Apicomplexan Parasites PMID 30800644
NNZ
Hexa
hsa
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti
LY
Anantin
Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine
Zfp36l2 Mouse Pre
Curcumin A Potent Modulator of Multiple Enzymes in Multiple Cancers PMID 27102703
Endothelial Cells Promote Pseudo
Structural and enzymatic characterization of a glycoside hydrolase family 31 α
Rosavin Alleviates LPS
MAGEC1 Human Pre
(S)
α
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome PMID 39854311
Ethyl 10(E)
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models PMID 31842999
Hybrid
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine A Review PMID 28337245
CD44 in human glioma correlates with histopathological grade and cell migration PMID 22726066
KRT78 Human Pre
MCE
MOS
(3R,5S)
Changes in the biochemical, hematological and histopathological parameters in STZ
PSB
Cald1
KRT6C Human Pre
FARP1 Human Pre
SNRPC Human Pre
Phase I study of XL281 (BMS
COA6
VU6002703 1934241
Hoxb7 Mouse Pre
HLI98C 317326
Flumetasone
ASB9 Human Pre
Syk
Hnrnpr Mouse Pre
Analogues of σ receptor ligand 1
PSMB1 Human Pre
CD73
Gelatin methacryloyl hydrogel encapsulating molybdenum
Tead4 is required for specification of trophectoderm in pre
H
S
RNF20 Human Pre
PEG10
D,L
H
WAY
CFAP54 Human Pre
IMPDH
Trametiglue
Nano
CP
Nitroxynil
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