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Tizanidine 51322
BrBzGCp2 166038
Glycybenzofuran
3
GPR40 agonists for the treatment of type 2 diabetes mellitus The biological characteristics and the chemical space PMID 27825762
3
Phytochemical
New Vanillyl
Azido
Nicotinic acid N
FOY [ethyl P
Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes PMID 37697219
Glidobactin C 108351
Asperphenamate 63631
KD014
MGD4
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62
Mulberrofuran G and isomulberrofuran G from Morus alba L. anti
Hypoxia
Terbinafine
Sinigrin Attenuates the Dextran Sulfate Sodium
The 5
Cux1
Murayaquinone (PKF118
Differential effects of macrophage subtypes on SARS
PTP1B
Sedative and analgesic effects of detomidine and romifidine in horses PMID 7604508
CLEC4C
A common mechanism of action for three mood
Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor PMID 20236823
Difelikefalin 1024828
Modification of osimertinib to discover new potent EGFRC797S
Identification of a beta
Srrm1 Mouse Pre
Pomaglumetad methionil hydrochloride (Standard)
SARS
MKI
Azgp1 Mouse Pre
SH3RF2 Human Pre
Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram
Exosomes derived from endoplasmic reticulum
HPK1
XRN2 Human Pre
TRAIP Human Pre
BAY
CPA
hsa
Strong cytotoxic effect of the bradykinin antagonist BKM
Mdp1 Rat Pre
Cytip Rat Pre
RBMS1 Human Pre
Effect of anti
LY
Cortisone
Prevention of bleomycin
Azido
PGRMC2 Human Pre
Tubulin polymerization
BMS
Ginsenoside F
TERT transcription and translocation into mitochondria regulate benzo[a]pyrene/BPDE
Anti
RP 4753
Effects of the peroxisome proliferator
SIX5 Human Pre
MCE
Synthesis and Evaluation of 1,3
Enpp
Fenretinide
Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress
Butetamate
SIKE1 Human Pre
Azido
VU0155056
CUL4A Human Pre
CD44 蛋白, Mouse (HEK293, His)
TERT ligand
UAB 116
PRR4
GNF
MCE
Val
BIBP3226 159013
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity PMID 23333938
2
Lith
L
SF1 Human Pre
Phillyrin A potential therapeutic agent for osteoarthritis via modulation of NF
Monaspin B
Protocol for inducing branching morphogenesis in human cholangiocyte and cholangiocarcinoma organoids PMID 37432852
mmu
15 0 Lyso PG
SORCS3 Human Pre
8
Design, synthesis, and biological evaluation of Pseudolaric acid B derivatives as Ferroptosis inducers in Colon Cancer cells PMID 40795665
SGTB Human Pre
MCE
Cy3.5 carboxylic acid 1144107
A pH
Azido
Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas PMID 32464274
4
Discovery of 2,3
3’
MCE
(3R,5R)
N
Z19024498
Identification of novel subtype selective RAR agonists PMID 16303118
eIF4A3
VCAM
PARP1
3
5
Ube2z
Human branching cholangiocyte organoids recapitulate functional bile duct formation PMID 35523140
Role of miR
Discovery of pyrazolo[1,5
Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury PMID 38937512
4
7
The biology and role of CD44 in cancer progression therapeutic implications PMID 29747682
Discovery and Characterization of the Potent and Highly Selective (Piperidin
Phthalic acid
GSK984 827591
Cyclic GMP
Design, synthesis and evaluation of novel pyrrole
MCE
Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor PMID 33492938
Identification of the GPR55 agonist binding site using a novel set of high
MCE
MCE
Melatonin reverses tumor necrosis factor
Maternal carbohydrate
Microbial signals, MyD88, and lymphotoxin drive TNF
Anzurstobart 2543693
Beaucage reagent 66304
Rosavin protects the blood
The structure and substrate specificity of human Cdk12/Cyclin K PMID 24662513
Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF
Prucalopride N
Macrocyclic hexaoxazoles Influence of aminoalkyl substituents on RNA and DNA G
Cadm4 Mouse Pre
5
Two
VU6010608, a Novel mGlu7 NAM from a Series of N
Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration PMID 27081915
(Des
PRX933 hydrochloride 639029
Lacticaseibacillus paracasei Glu
Effects of flavonoids isolated from Scutellariae radix on cytochrome P
Degradation and mineralization of organic UV absorber compound 2
A nanoprobe for fluorescent monitoring of microRNA and targeted delivery of drugs PMID 35423397
VRT
Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC) PMID 26885448
EBOV
Ddourine
A small molecule accelerates neuronal differentiation in the adult rat PMID 20823227
AM
SC
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics PMID 36727438
Pgrmc2 Rat Pre
Synthesis, structure
(S,R,S)
Absence of PD
Fcrla Mouse Pre
Discovery of the first potent and selective small molecule opioid receptor
Medicinal Chemistry Strategies for the Development of Bruton's Tyrosine Kinase Inhibitors against Resistance PMID 35594541
Mesenchymal Niche
MCE
MM 42842 free acid 113784
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5
Design and synthesis of cis
The in vitro activity of terconazole against yeasts its topical long
Thrombospondin
3
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain PMID 3686012
Cannabisin F 163136
Stearyl oleate 17673
NSC 17821
MDH1
USP1
A focused compound library of novel N
Compounds containing 2
SNC80
283629
Experimental versus theoretical log D7.4 , pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances PMID 29582576
Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG
NCX 466 1262956
LANCL1 Human Pre
Fcrl1 Rat Pre
Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics PMID 36170112
Basal cell of origin resolves neuroendocrine
AGX51 330834
ADAMs contribute to triple negative breast cancer via mTORC1 pathway targeting ADAM
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) PMID 40474483
MCE
5
Notch3 enhances the synergistic effect of all
Antifungal and Antiviral Cyclic Peptides from the Deep
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway PMID 10027409
In vitro and in vivo efficacy of an anti
Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re
4
Targeting Monoallelic CREBBP / EP300 Mutations in Germinal Center
Pik3ap1
AZD
Efaproxiral
The role of the natural compound naringenin in AMPK
Pyridoxine 3,4
mt
CRBN ligand
SPD304 869998
AZ14170133 2495742
Neonootkatol 196399
Study of the hydrolysis of 4
Cremophor EL the drawbacks and advantages of vehicle selection for drug formulation PMID 11527683
ROR
MCE
H
Kinetic and inhibition studies of cinnamoyl
S07
MCE
Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application PMID 34672064
Development of an Fc
Engineering a Mechanoactive Fibrous Substrate with Enhanced Efficiency in Regulating Stem Cell Tenodifferentiation PMID 35544769
Ack1 tyrosine kinase activation correlates with pancreatic cancer progression PMID 22322295
DS2 374084
2,4
Design and discovery of novel pyrazole
Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134) PMID 17115070
CPN
Pharmacological and Toxicological Properties of the Potent Oral γ
Oxidation
The crucial role of prolactin
2OH
Glycoproteomics Analysis to Identify Potential Biomarkers and Investigate CD14+ Monocyte Activation Mechanisms via Exosomal Proteins in Cerebral Infarction Using a Novel Glycogen
t
Microsphere
Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis PMID 37792308
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs PMID 32313245
Boc
MK
Fast Green FCF 2353
Molecular docking predictions of fragrance binding to human leukocyte antigen molecules PMID 30957232
Azintuxizumab 1826819
Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)
The effect and apoptosis mechanism of 6
Design, synthesis, and evaluation of unsymmetrical trifluoromethyl
Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N
6
Synthesis and biological evaluation of a tumor
Delineating Structural Functionalities of Lenacapavir Amenable to Modifications for Targeting Emerging Drug
hsa
CCG
Potent and selective pyrazole
A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist PMID 16406722
HOPan 18679
MurA
Boc
Bone
Itgb1 Rat Pre
5
LASP1
MCE
H
Design and Synthesis of Dual
LY393558, a 5
Design, synthesis, structure
DTHIB
Antifibrotic TSG
OSI
The safety and anti
KLF13 overexpression protects sepsis
BPDA2
ITGB1 Human Pre
JB062
Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC) PMID 39946350
Design, synthesis, biological evaluation and docking analysis of pyrrolidine
Gedivumab 1807954
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors PMID 22024272
SSBP1 Human Pre
Molecular mechanism and functional role of brefeldin A
Beaucage reagent (Standard)
Rps14 Mouse Pre
Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase PMID 34857958
Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative
The periplasmic cyclodextrin binding protein CymE from Klebsiella oxytoca and its role in maltodextrin and cyclodextrin transport PMID 9573146
Ddx11 Rat Pre
EPHA8 Human Pre
Clinical pharmacology review of escitalopram for the treatment of depression PMID 24289655
Rho GDP 解离抑制因子 α（ARHGDIA）基因
Tetrahydrocarbazole amides with potent activity against human papillomaviruses PMID 19556128
Pathological phosphorylation of tau and TDP
BPN
Sulfonamide
seedling
Radiologically enlarged cardiophrenic lymph nodes and CA
BAF complex vulnerabilities in cancer demonstrated via structure
Galantamine increases hippocampal insulin
YAE1 Human Pre
Trimetazidine impurity 10 879646
Construction of developmentally inspired periosteum
MC(C5)
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis PMID 35717783
MRN
Binding of Hoechst 33258 to the minor groove of B
3
Systemic transport of trans
Bruton's tyrosine kinase inhibitor BMS
Protection of the receptor binding domain (RBD) dimer against SARS
L
(1H
(6Z,16Z)
Ethylbenzene
Posttranslational splicing modifications as a key mechanism in cytarabine resistance in acute myeloid leukemia PMID 37422594
H
Selective Brain
Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad
Modulators of hepatic lipoprotein metabolism identified in a search for small
Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists PMID 26185418
LM41
Discovery of N
着丝粒蛋白 C（CENPC）基因
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine
PZR suppresses innate immune response to RNA viral infection by inhibiting MAVS activation in interferon signaling mediated by RIG
VKOR
New chemical tools for investigating human mitotic kinesin Eg5 PMID 17587586
interference with replication
Elastase inhibitory activity of quinoline Analogues Synthesis, kinetic mechanism, cytotoxicity, chemoinformatics and molecular docking studies PMID 35421709
Neuritic regeneration and synaptic reconstruction induced by withanolide A PMID 15711595
CPPQ
A new triterpene saponin from the roots of Ilex pubescens PMID 23092447
Cytotoxic prenylated xanthones from Calophyllum inophyllum PMID 19003621
Filanesib 885060
Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity PMID 28003376
Zfp36l2
Nme3
几多糖酶（CTBS）基因
Promotion Effect of Catalpol on Angiogenesis and Potential Mechanisms A Research Based on Network Pharmacology PMID 39134897
Hacking macrophage
08 0 PI(4,5)P2 ammonium 852043
The important role of the Wnt/β
A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity PMID 19539585
A new class of symmetric bisbenzimidazole
6
Two Phase 1, Randomized, Double
R1530 882531
Derivation of Mouse Haploid Trophoblast Stem Cells PMID 30625323
TMEFF2/Tomoregulin
Multi
Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC
Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)
Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol PMID 8026274
Lotusine hydroxide 3721
Inhibition of polo
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U
tert
Fmoc
The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries PMID 15971273
3
LY3009120, a panRAF inhibitor, has significant anti
The sympathetic nervous system regulates the three glycerol
Discovery and evaluation of new compounds targeting ribosomal protein S1 in antibiotic
N
Bullatine A suppresses glioma cell growth by targeting SIRT6 PMID 39845013
Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP
A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts Med25 Protein
Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co
Small molecule NS5B RdRp non
MCE
Hydrogenated DGDG 960204
The Discovery of VX
Chemoproteomic development of SLC15A4 inhibitors with anti
Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo PMID 28936484
Reduction of aryl acids by white
Allosteric modulation of sigma
PROTAC A promising technology for cancer treatment PMID 32698111
The Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons PMID 39880095
R59949, a diacylglycerol kinase inhibitor, inhibits inducible nitric oxide production through decreasing transplasmalemmal L
γ
Trimethoprim
TC LPA5 4 1393814
A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system PMID 2780225
IL4R
Indirubins inhibit glycogen synthase kinase
β
FD
Simultaneous radioimmunoassay for plasma arginine
The Designer Antimicrobial Peptide A
Activating the iNOS regulatory pathway by arginine deprivation targets energy metabolism to induce autophagy
Forphenicine 57784
Coniferyl ferulate
Ponatinib promotes a G1 cell
Experiences with propyliodone bronchography PMID 13540854
SuFEx
A comparison of the sedative effects of three alpha 2
Azgp1
A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr
核糖体蛋白 S26（RPS26）基因
hsa
Srrm1
BnO
PINK1
Bifunctional degraders of cyclin dependent kinase 9 (CDK9) Probing the relationship between linker length, properties, and selective protein degradation PMID 37071962
Isobutyric Acid Promotes Immune Evasion in Colorectal Cancer via Increased PD
The formation of the 'footprint of death' as a mechanism for generating large substrate
Glaesserella parasuis infection triggers endoplasmic reticulum stress
Brain
Reduced miR
AIF
Dihydrochelirubine 28342
HDAC
Olumacostat glasaretil 1261491
Polfurmetinib 2845151
Nano
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury PMID 36675183
Cytotoxic sesquiterpenes from Nardostachys chinensis PMID 8370115
纤毛和鞭毛相关蛋白 54（CFAP54）基因
PF
Lack of gastric toxicity of nitric oxide
Azelaic acid
Design, synthesis, and biological evaluation of novel 4,4'
Sodium 4
GW501516 facilitated tumor immune escape by inhibiting phagocytosis PMID 39993702
MRPS34 Human Pre
Glycolithocholic acid sodium 24404
Epidermal growth factor receptor/heme oxygenase
Cytip
Increased caspase
The cryptochrome inhibitor KS15 enhances E
Knockdown of HOTAIR Alleviates High Glucose
Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4
KTX
Role of microRNA
AZD2836 944278
Neflamapimod inhibits endothelial cell activation, adhesion molecule expression, leukocyte attachment and vascular inflammation by inhibiting p38 MAPKα and NF
Lysophospholipid receptors in drug discovery PMID 25499971
Induction of c
Asperilin 7044
Liensinine attenuates inflammatory response and oxidative stress by activation of Nrf2/HO
Discovery of a Potent, Orally Active, and Long
Cycloastragenol prevents age
Interferon
POP
Pharmacologic Characterization of JNJ
The interaction between soluble dietary fiber and bound phenolic from litchi pomace, and its effect on gut microbiota and inflammation PMID 40577909
DJ
LmCPB
VVD
CCG
The FOsmetpantotenate Replacement Therapy (FORT) randomized, double
Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL
ZL
New aryldithiolethione derivatives as potent histone deacetylase inhibitors PMID 20576572
The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity PMID 10697674
Synthesis and Biological Activity of Mono
Interleukin
Hyaluronan fragments/CD44 mediate oxidative stress
Neuroprotective role of Indirubin
MCE
Pgrmc2
Expression of orexin receptors in the pituitary PMID 22640608
hsa
Improved Cell Adhesion and Osteogenesis of op
Discovery of a potent boronic acid derived inhibitor of the HCV RNA
FLI1 promotes IFN
Improving metabolic stability and removing aldehyde oxidase liability in a 5
The Protective Effect of Rosavin from Rhodiola rosea on Radiation
UFMylation A supervisor of the HIF1α pathway and a potential therapeutic target for anti
Phase I/II study of the LAG
(S)
Precemtabart tocentecan, an anti
GDNF promotes neurite outgrowth and upregulates galectin
E1A
Skin reactions to hexylene glycol PMID 2529099
Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia from bench to bedside PMID 28219003
Erythromycin F 82230
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM
Assessing the differential action on cancer cells of LDH
Duvakitug
MCE
Rational Design and Pharmacomodulation of Protein
PB131 2924425
Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway PMID 33683556
N
Discovery of (S)
(S)
Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens PMID 11230993
C1A 1021463
Filapixant 1948232
Microbial transformation of rifamycin B a new synthetic approach to rifamycin derivatives PMID 6685721
A quinoxaline
Photoactivatable crosslinking sugars for capturing glycoprotein interactions PMID 18293988
RO
BeKm 1
Valproic Acid Significantly Improves CRISPR/Cas9
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