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Cannabinoid receptor 2 activation alleviates septic lung injury by promoting autophagy via inhibition of inflammatory mediator release PMID 32027949
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID
Characterization of an A
Cox6c Mouse Pre
6
PRL
Benzophenone
NSC87877
Sanggenol F exerts anti
The PARP inhibitor, olaparib, depletes the ovarian reserve in mice implications for fertility preservation PMID 32604417
Hypaconitine inhibits TGF
Triazolopyridinone (3
DL
KLH
Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes PMID 7480201
destabilizing
Inhibition of IgE
Fumarate hydratase
Therapeutic potential of targeting the oncogenic SHP2 phosphatase PMID 25003231
Descarbon Sildenafil
Deficiency in the function of inhibitory interneurons contributes to glutamate
Absolute stereostructures of cell adhesion inhibitors, macrosphelides H and L, from Periconia byssoides OUPS
Plantagoside 78708
Meclizine N
Dihydroobovatin
Improved method for elimination of bovine viral diarrhea virus from contaminated cell lines using virus inhibitor DB772 PMID 40754431
tsFT210
DBCO
MSK
Hepatocyte
noncompetitive
Inhibition of purine nucleoside phosphorylase activity and of T
PB
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation PMID 34954108
PTPN5
Abeta(31
millet
AGN 191976 a novel thromboxane A2
Design, synthesis and evaluation of carbamate
HIP1R
Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE
HC
Synthesis of isoquinolinone
LM 41
Identification of a Small
Machine Learning Models Identify Inhibitors of New Delhi Metallo
L
JY2
NCGC00378430 920650
Multiple Mechanisms of Anti
CFM1
Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple
An Unmanned Aerial Vehicle
(–)
Ghrelin mitigates MPP+
Total flavonoids of litchi seed inhibit breast cancer metastasis by regulating the PI3K/AKT/mTOR and MAPKs signaling pathways PMID 40231974
Lith
AIMP2 Human Pre
Unveiling the Hidden Impact Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage PMID 38748378
Interleukin
EPHX1 Human Pre
Production of viable chicken by allogeneic transplantation of primordial germ cells induced from somatic cells PMID 34017000
The AMPK
Proof
Mirtazapine N
hsa
N
CFM
HDAC6
NSC
The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the classical cytokinin ribosides PMID 28153445
Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998
PRL 2915
OSI
Application of deep generative model for design of Pyrrolo[2,3
H8
Xcl1 Mouse Pre
FPL
Myrothecine A 910292
Influence of mycophenolic acid on inosine 5'
Suppression of Tumorigenicity 5 Ameliorates Tumor Characteristics of Invasive Breast Cancer Cells via ERK/JNK Pathway PMID 34395234
Desmosterol ester
MOS Human Pre
PTP1B
Combining Multiplexed CRISPR/Cas9
Chitosan oligosaccharide (MW 2000) (COS (MW 2000))
hCA I
Angiogenic activity of syndecan
DNAJB4 Human Pre
Terpenoids from the aerial parts of Parasenecio deltophylla PMID 20968296
THOC7 Human Pre
KL 201
Identification of Bithionol, Dichlorophen, and Miconazole as Antibacterial Agents against Acinetobacter calcoaceticus PMID 32984715
GSK8612
Karanjin
Acetyl coenzyme A trilithium 75520
JY
AG 73
Snip1 Mouse Pre
Pyrimethamine Triggers the Apoptotic Pathway in Mucoepidermoid Carcinoma in Cell
GSK8612 2361659
Tecovirimat monohydrate 1162664
OOEP Human Pre
Azgp1
Evaluation of mutagenic effect of the fungicide fenaminosulf in Drosophila melanogaster PMID 6402695
Azido
Afmid Rat Pre
lipid levels
VVD
PRT3789 epimer
Regulation of c
Non
CMX990 2882934
Thalidomide
1,3,5,6
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities PMID 32222339
FF2049
Metal binding pharmacophore click
Lysyl oxidase
Mycophenolate Mofetil 128794
MM.1S
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion PMID 9930751
Jatrorrhizine 3621
NB
Cactus alkaloids. XXXIV. Hordenine HCL from Coryphantha vivipara var. arizonica PMID 866495
Small Molecule Lysyl Oxidase
RXP03
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14) sensitization by heat and MDL 72527 PMID 16962187
Bufadienolides from the Bufo viridis toad venom exert cytotoxic effects on cancer cells by inducing cell apoptosis and cell cycle arrest PMID 36738868
TANK
HS
BO264
Heterocyclic 1,7
albicans
7
Resveratrol promotes HSV
TEM
(I
LI2124
Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats PMID 11278058
Hydrazine
HDAC
Alkyne
Glucosylsphingosine Causes Hematological and Visceral Changes in Mice
9
RMC0331
Molecular glue degrader function of SPOP enhances STING
TRITC
TRITC
Precision targeting of ALK
The ketone body metabolite β
Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation PMID 39232498
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β
1
IP3(1,3,4) ammonium
In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives PMID 1665961
Discovery and Pharmacological Evaluation of Potent and Highly Selective PARP1 Inhibitors PMID 40530818
NAMPT activator
Protein disulfide isomerase a multifunctional protein with multiple physiological roles PMID 25207270
Azido
The effect of acute ethanol (EtOH) exposure on protein kinase C (PKC) activity in anterior pituitary PMID 9160797
Lometrexol disodium 120408
MCE
HH105
DPPA4 Human Pre
Psicofuranine 1874
Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats PMID 16444582
Solubilization and Stability of Mitomycin C Solutions Prepared for Intravesical Administration PMID 28470465
GSK2881078, a SARM, Produces Dose
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP
Nab2 Mouse Pre
MI
Levofloxacin
Onjixanthone II
NELL2
Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression PMID 39294262
CL 286558
Surfactin C2 86711
AIstain Enhancing microglial phagocytosis analysis through deep learning PMID 41109218
Altissimacoumarin K
KL
Recombination of a dual
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase PMID 23453069
Dysregulation of CRY1 impairs brain thyroid hormone pathway and promotes anxiety
NHERF1 and NHERF2 regulation of SR
mitotic index
Discovery of novel functionalized 1,2,4
Synthesis of novel dual target inhibitors of PARP and EGFR and their antitumor activities in triple negative breast cancers PMID 35393219
Cholesteryl oleate
Perazine
Design, synthesis and evaluation of 3
Gallium maltolate 108560
Rho guanine nucleotide exchange factor 39 increases the viability, migration and invasion of clear cell renal cell carcinoma cells via the activation of the AKT/ERK signaling pathway PMID 33231603
Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton's Tyrosine Kinase PMID 29991334
Hydroxysafflor yellow A promotes the proliferation and differentiation of endogenous neural stem cells with neural regenerative effects in ischemic stroke PMID 40494015
Efficacy of gallium maltolate against Lawsonia intracellularis infection in a rabbit model PMID 24730377
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo PMID 25877780
6
Razaxaban hydrochloride 405940
Comparative aquatic toxicity of the pyrethroid insecticide lambda
hsa
JTP74057
Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats PMID 33283643
(5R)
Etheroleic acid
Alpha
Osteoarthritic Milieu Affects Adipose
LMO1 Human Pre
Hic
Fobrepodacin 1384984
Ampreloxetine 1227056
1
IMP
8
Itaconimide
MDALDL
Biological evaluations
Furanosesquiterpenoids of Commiphora myrrha PMID 11720534
AM 001
A20 protects cells from TNF
isorhamnetin
CFTR
RAS
The death
Photoaffinity labeling of the D2
Cryptophycin 52 186256
Design, synthesis, and biological evaluation of some novel 4
Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti
Suppression of melanin synthesis by the phenolic constituents of sappanwood (Caesalpinia sappan) PMID 23154842
6
PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP
Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum PMID 39378318
Development and Evaluation of Benzofuran Oxoacetic Acid Compounds as EPAC1 Activators PMID 41826280
Ovol2 Mouse Pre
Design, synthesis, and biological evaluation of biotin
DTX3
ANKS6 Human Pre
UTP(αB) 199116
Fluorinated betulinic acid derivatives and evaluation of their anti
M122 2127411
Mbd5
Azido
DM
7
GPS2 Human Pre
PON2 Human Pre
rat forebrain tissue sections
Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re
Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms PMID 15475571
Mediation of beta
Procyanidin C1 37064
Pyr1
The discovery of a new uncompetitive inhibitor of nucleoside hydrolase from Leishmania donovani PMID 39908737
DSM502
SF
HDAC5
Association of idealized amphiphiles and protease inhibitors Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug
IFN
IMB
2′
GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway PMID 35973673
Single
Targeting metabolism by B
Identification of small molecule activators of cryptochrome PMID 22798407
CLEC10A/CD301 蛋白, Mouse (HEK293, Fc)
Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR
BX471 217645
Inhibition of Hyperpolarization
Dexrazoxane hydrochloride 149003
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF
L
Single
damaged
Fe
TC
Fesoterodine for the treatment of urinary incontinence and overactive bladder PMID 19956551
Dihydrodaidzin
p38 MAP Kinase
Transport of amino acids in gamma
Cositecan
CER8
MS 48107
ML241 1346528
Design and synthesis of 2
Pharmacokinetic profiling of ZCL
Mos Rat Pre
Kallikrein 5
Dnajb4 Rat Pre
Anti
7
PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice PMID 19819333
Benzophenone Compounds, from a Marine
Lauric acid
Eslicarbazepine Acetate
Anti
9
SCO
CXCL12 Signaling in the Tumor Microenvironment PMID 34286441
AY 31906 124788
Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats PMID 16395300
chromosomal aberrations
6
14 1 cholesteryl ester
Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation PMID 34144035
SRCAP Human Pre
mmu
MG53 binding to CAV3 facilitates activation of eNOS/NO signaling pathway to enhance the therapeutic benefits of bone marrow
MCE
Rafoxanide
EMD638683 R
Dual inhibitors of thromboxane A2 synthase and 5
xanthosine
Dmrt3 Rat Pre
Induced effect of zinc oxide nanoparticles on human acute myeloid leukemia cell apoptosis by regulating mitochondrial division PMID 35383422
Captopril alleviates glucocorticoid
CIB3 Human Pre
Desmethyl cariprazine
Fcrl6 Rat Pre
Azido
Pharmacological and x
TKL
KIRREL3 Human Pre
Inhibitory effect of a novel bisphosphonate, TRK
KHDRBS3 Human Pre
PXYC13 1031940
Treatment with a novel hemigramicidin
Alkyne maleimide 2785323
DNAJC11 Human Pre
KX2
BRD9185 2057420
MJ 210
3,4
Follistatin
F
Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes PMID 33824424
YCH3971
PfDHODH
Sanggenol F 202526
PF
AChE/BuChE
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI
2′,3,5,6′,7
An Open Drug Discovery Competition Experimental Validation of Predictive Models in a Series of Novel Antimalarials PMID 34748707
Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine PMID 21793214
Metabolism of vesatolimod in rat, dog, and human liver microsomes Metabolic stability assessment, metabolite identification, and interspecies comparison PMID 30129284
TGF
Brevicompanine B 215121
Brefeldin A reduces anchorage
NSC
Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of colorectal cancer PMID 36228523
fungi
c
DMA135
Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells molecular docking and in vitro studies PMID 37705281
Ifenprodil discriminates subtypes of the N
First
FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking PMID 32678845
GKA50
JNJ
New homocamptothecins synthesis, antitumor activity, and molecular modeling PMID 18207748
The anticonvulsant effect of the non
MPEP Hydrochloride 219911
LM
Aripiprazole metabolite
Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA
Tinostamustine
Effects of Tempol on Epileptic Activity in Picrotoxin
MicroRNA let
Macropinocytosis controls metabolic stress
Kynapcin
Injectable celastrol
(S)
JTT 551 776309
Env
Albendazole
blocke
WJM
The specific inhibition of HepG2 cells proliferation by apoptosis induced by gabexate mesilate PMID 20830242
Cytotoxic activity of 3
N, N', N″
Luteolin ameliorates rat myocardial ischaemia
The mitochondria
In silico design, synthesis and biological evaluation of 2
3
Effects of fucoxanthin on lipopolysaccharide
XC219
Phosphonic analogues of glutamic acid as irreversible inhibitors of Staphylococcus aureus endoproteinase GluC an efficient synthesis and inhibition of the human IgG degradation PMID 23357627
Traf1 Mouse Pre
Identification of potential extracellular signal
KCC
Ibuprofen L
Changes in the mobile phase composition on a stepwise counter
Comparative analysis of response to treatments and molecular features of tumor
1,4
Delivery of replication
Laniquidar
PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction PMID 36091033
Mahuang Xixin Fuzi decoction ameliorates apoptosis via the mitochondrial
SRT501
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors PMID 34095840
Evaluation of 18F
Comparing SARS
Reprogramming of ovarian aging epigenome by resveratrol PMID 36743471
ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments PMID 29138439
Dicloxacillin 3116
Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica PMID 6100431
Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itch PMID 27422716
glutaminase activity
MCCC1 Human Pre
Oxytocin action in the ventral tegmental area affects sucrose intake PMID 23548602
PSB
BMS
LEF
Engineering bi
Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway PMID 36825581
20(R)
ACu1 1314527
1
Anti
CAII
GSK
MK
Loxl3 Mouse Pre
Coa6 Rat Pre
BAHD1 Human Pre
Multimechanism biological profiling of tetrahydro
Fluazaindolizine 1254304
Protein tyrosine phosphatase enzymatic assays PMID 15588980
Cyflufenamid
Ephrin
Highly potent cyclic disulfide antagonists of somatostatin PMID 10354394
TCMDC
Rnf43 Rat Pre
NPD
Mid1 Rat Pre
OSBPL8 Human Pre
HOXC8 Human Pre
Lapaquistat acetate development of a squalene synthase inhibitor for the treatment of hypercholesterolemia PMID 21518985
Emrusolmin
A novel BCMA/CD3 bispecific T
STn/sialyl
Tanezumab 880266
SETBP1 Human Pre
HACD3 Human Pre
Comparative proteome and serum analysis identified FSCN1 as a marker of abiraterone resistance in castration
p97
CDC20
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK
Fibroblastic reticular cells regulate intestinal inflammation via IL
DNase1L3 蛋白, Mouse (His)
TREM2
CNX
STA
Repeated exposure to aerosolized brevetoxin
(Rac)
MDM2
4
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis PMID 34239273
MurA
Triterpenoid saponins from the roots of Pulsatilla koreana PMID 15730260
ZN148 2190527
Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells PMID 17273780
AAA
Butyrolactone Ia 942986
Arginase inhibition alleviates hypertension associated with diabetes effect on endothelial dependent relaxation and NO production PMID 22281732
Downregulation of PDZK1 by TGF
Trk
CD19/CD20 dual
Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5
Nigericin
Bioassay
Erythroleukemia cells acquire an alternative mitophagy capability PMID 27091640
Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT
IID432
Aflatoxin B
Chloroquine inhibited Helicobacter pylori
Atagabalin 223445
Mechanical force promotes the proliferation and extracellular matrix synthesis of human gingival fibroblasts cultured on 3D PLGA scaffolds via TGF‑β expression PMID 30664222
Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice PMID 3394590
ortho
Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp PMID 19652417
GDC
MRNIP Human Pre
Isomorellic acid 5262
SNIPER(ABL)
AES
Tocotrienol monomers and dimers from the roots of Litchi chinensis with tyrosinase inhibition activity PMID 37952709
In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells PMID 25910917
Cornoside 40661
AN
2
SF 733
LASSBio1985
Rasd1 Mouse Pre
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