最近收录_第825页_生物活性分子
生物活性分子最近更新
WASP 肌动蛋白成核促进因子（WAS）基因
Gli2 is required for the induction and migration of Xenopus laevis neural crest PMID 30086335
Characterization and preclinical development of LY2603618 a selective and potent Chk1 inhibitor PMID 24114124
CHIP protects against MPP+/MPTP
Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3
Opposite effects of endothelin
Discovery of quinazolin
CRBN ligand
MCE
Sissotrin 5928
Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells PMID 11356826
Anticancer agent 89 2977251
MeO
5
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation PMID 39218923
Icariin maintaining TMEM119
AF555
Development of a high
CP94253 hydrochloride 845861
Motor protein
TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations PMID 29748209
Persistent expression of canine factor IX in hemophilia B canines PMID 10516718
Piericidin A aggravates Tau pathology in P301S transgenic mice PMID 25437199
First
Senolytic elimination of senescent cells improved periodontal ligament stem cell
PF
DUSP2 recruits CSNK2A1 to suppress AKT1
The thyrotropin receptor and the regulation of thyrocyte function and growth PMID 1425489
A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS PMID 14066143
Inhibition of USP7 suppresses advanced glycation end
3
2
Formamide as the main building block in the origin of nucleic acids PMID 17767725
On
Murine Colitis modeling using Dextran Sulfate Sodium (DSS) PMID 20087313
PI3K
Synthesis of para
Mechanism and molecular targets of Euphorbia fischeriana Steud root extract in hepatocellular carcinoma PMID 40147679
Tiratricol inhibits yellow fever virus replication through targeting viral RNA
RFB
HDAC inhibitor, MS
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV
Cortisol
HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability PMID 39676171
Difluoro atorvastatin 693794
Hedgehog signaling regulates differentiation from double
The inhibition of polynucleotide phosphorylase by certain substrate analogues PMID 5339439
Effectiveness and safety of the SREBP1/2 inhibitor, fatostatin, in a preclinical model of metabolic dysfunction
USP8
Magnolin Promotes PINK1
Improved synthesis and antitumor activity of 1
MCE
PRX
CN
A multiplex single
TY
MOFs
Opioid
Neocrocin B 2001062
ALK
97USSN54
Carboxy
Fesoterodine fumarate 286930
Larixnaphthaone
IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1 PMID 38760723
EIF5 Human Pre
ALK binding pocket
Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival PMID 38429848
Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple
MCE
Inhibition of c
Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c
N
Speract 76901
GHRF causes biphasic stimulation of SRIF secretion from rat hypothalamic cells PMID 2904766
H
ALK
LIN28B inhibition sensitizes cells to p53
TRPV4 agonist
KIF1A Human Pre
DT
MID1IP1 Human Pre
Ellipticine derivatives as Toll
Three
GPR141 Human Pre
Novel non
APL
Prenalterol hydrochloride 61260
EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs PMID 29329202
ZY
Sanfetrinem sodium 141611
Epha5
Upregulation of cIAP1 induced by AZD8330 alleviates osteoarthritis progression by inhibiting the RIP1
DL
Targeting Mitogen
Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4
Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β
2
Exploring fluorine
Demospongic acids
HSF target protein
HSC mobilizer 1
acetolactate synthase
Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1 PMID 23562244
Sauristolactam 128533
New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment farnesylthiosalicylamide inhibits tumor growth in nude mice models PMID 19072665
Dcc
MDA
Discovery and characterization of small molecule inhibitors of the BET family bromodomains PMID 21568322
TPBG/5T4 蛋白, Human (HEK293, Avi
HDAC6
TAP1 promotes immune escape by activating JNK/STAT1/PD
NS5A inhibitors unmask differences in functional replicase complex half
Core
(±)
ST91 [2
Recognition and maturation of IL
NMDA receptor modulator 5 2758256
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation PMID 34707087
Mechanism of rat liver microsomal stearyl
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains PMID 40132582
Pharmacokinetics and metabolism of 3'
A genome
Interactions of Indoleamine 2,3
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis PMID 40236556
Diphenhydramine active uptake at the blood
Design and development of potent roflumilast analogues targeting PDE
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency PMID 38064686
Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta PMID 16579983
In silico identification of novel stilbenes analogs for potential multi
Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes PMID 34425835
Methyltetrazine
Efonidipine 111011
A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro PMID 28708884
MAO
Disodium 1,2
GnRH antagonist 3 292141
Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA
E09241
Epha5
ALK
Antitrypanosomal agent 30 3113099
NSC
Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin
Desogestrel 54024
Allatostatin C (AstC)
MAO
CRT0093964
MCE
Omzotirome (Standard)
Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts PMID 25139351
A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche PMID 40719185
Structure
GLP
Partitioning of penoxsulam, a new sulfonamide herbicide PMID 16131127
The membrane
METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A
GIPR antagonist 1
PIK3CG
GOAT
Carmegliptin (hydrochloride) (RO
Regiafuran A 2060544
neural cell adhesion molecule
3’
AMP
c
Amsacrine
Cyclo(Pro
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10
Transferrin
11S(12R)
Oat Rat Pre
Selenodiglutathione (GSSeSG)
CD7
5
MCE
Toxicological Evaluation of Camellia euphlebia Leaves Aqueous Extract Using Acute and Subacute Toxicity Studies in Mice and Genotoxicity Studies PMID 35211181
Tumor
Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors PMID 32297665
Design, synthesis, and biological evaluation of N
Udifitimod 1883345
NPD001
N
Basiliximab 179045
HCN2
Ginkgolide M (银杏内酯M)
CSF1R 蛋白, Cynomolgus (498a.a, HEK293, Fc)
LINC01433 targets miR
3tBu
2,3
Ganoderma lucidum stimulates autophagy
Purification of functional reprogramming factors in mammalian cell using FLAG
PBS
FGFR
Oat
Highly selective extraction of uranium from wastewater using amine
Effect of luteolin on oxidative stress and inflammation in the human osteoblast cell line hFOB1.19 in an inflammatory microenvironment PMID 38997762
Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC
SC
N
Ercc2 Rat Pre
Different concentrations of lipopolysaccharide regulate barrier function through the PI3K/Akt signalling pathway in human pulmonary microvascular endothelial cells PMID 29967433
Paullinic acid 17735
Ewsr1 Rat Pre
Tetradecyl
6a
Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways PMID 40014988
Activity of selected salicylamides against intestinal sulfate
Drospirenone
The induction of bladder stones by terephthalic acid, dimethyl terephthalate, and melamine (2,4,6
coreceptor CCR5
Lefelsiran 2765645
LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway PMID 36055602
Usage tests of oak moss absolutes containing high and low levels of atranol and chloroatranol PMID 24287679
Pharmacology of RG W
N
Strategically Engineered Ru(II) Complexes with Enhanced ROS Activity Enabling Potent Sonodynamic Effect against Multidrug
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation PMID 39235066
Il5ra
TCHP Human Pre
southern Italian red onion
Granulocyte
2
Structure activity relationships of aristolochic acid analogues toxicity in cultured renal epithelial cells PMID 15840026
JRN73958 (Reduced scytonemin)
Octopamine
Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol
Combination Foretinib and Anti
PD
Three new derivatives of anti
High
Omentin
Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice PMID 31182089
Sp
MCE
ZHX2 inhibits SREBP1c
MK
5’
MCE
hsa
Deubiquitinase ubiquitin
Mettl3
[Evaluation of a new cardiotonic agent on human isolated atrium] PMID 8494322
CPI
F820
pFGFR1
2
Carnitine palmitoyltransferase (CPT) modulators a medicinal chemistry perspective on 35 years of research PMID 21504156
SARAF Human Pre
Pinolenic acid ethyl ester 493015
Enhancement of Potency and Selectivity of 2
Inhibition of glioblastoma cell proliferation and invasion by the choline
OS cell lines
Biotin
Efficacy of gefitinib‑celecoxib combination therapy in docetaxel‑resistant prostate cancer PMID 30066906
Dexbrompheniramine maleate 2391
NCF4 Human Pre
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway PMID 38555991
Phospho
Biotin
Immunostimulatory action of L
Fluoxastrobin
Megestrol acetate improves cardiac function in a model of cancer cachexia
17 0 Cyclo acid 5618
Clstn1 Mouse Pre
Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties PMID 1399838
Oxidative stress
Indaziflam a new cellulose
Resolvin D5, a Lipid Mediator, Inhibits Production of Interleukin
DAF
1,6
JAS239
8"
brain parenchyma
The BACH1 inhibitor ASP8731 inhibits inflammation and vaso
Immunosuppressive effect of ER
Fructose induced deactivation of antioxidant enzymes preventive effect of pyruvate PMID 10826918
HIRMab
Leniquinsin 10351
DT
Cirtuvivint 2143917
In vitro evaluation of Ro 09
Agonists of proteinase
Lasofoxifene 180916
Spsb3 Rat Pre
7
Heneicosanoic acid
Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer A Plausible Alliance to Enhance Cell Death PMID 39594688
Discovery of CHD1 Antagonists for PTEN
(+)
Programmable Porous Silicon Microparticles for Temporally Staged Drug Delivery in Combination Cancer Immunotherapy PMID 39847761
Orai1
Contrary influence of clinically applied sorafenib concentrations among hepatocellular carcinoma patients PMID 27936391
Lipid 8 2226547
Pyrimidine
JNK2/MKK7 PPI
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti
The injury effect of osteopontin in sepsis
MANF protects pancreatic acinar cells against alcohol
CSTF2T Human Pre
Fine particulate matter inhibits phagocytosis of macrophages by disturbing autophagy PMID 33124742
Kadsuralignans H
High
7,8
CCDC134 蛋白, Human (HEK293, His)
Effects of K
Galanin (2
Discovery of potent and selective PKMYT1 inhibitors for the treatment of CCNE1
Identification and validation of the pivotal role of MANF gene in pancreatic β
Inhibition of calcium
Biarylpropylsulfonamides as novel, potent potentiators of 2
Canthin
UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer PMID 29207160
Pharmacokinetics and concentration
Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide
HDAC6 inhibition through WT161 synergizes with temozolomide, induces apoptosis, reduces cell motility, and decreases β
Hypoxia induces miR
Ligustilide covalently binds to Cys254 of the creatine kinase, M
Poly I C Alleviated Duck Intestinal Injury Infected with Duck Viral Enteritis by Inhibiting Apoptosis PMID 39105989
IL
Discovery, Optimization, and Biological Evaluation of Novel Pyrazol
The Akt inhibitor, triciribine, ameliorates chronic hypoxia
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement effects on E
Molecular Hybridization
NFE2L1 Human Pre
Telmapitant
The role of ATM in sodium butyrate
IGF2BP2 stabilized by USP7 promotes cancer
Development of JNK2
Preventive effects of etodolac, a selective cyclooxygenase
Augmentation of the antitumor effects of PARP inhibitors in triple
CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor
MCE
Unleashing new MTDL AChE and BuChE inhibitors as potential anti
Potential role of Bcl2 in lipid metabolism and synaptic dysfunction of age
ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway PMID 36327089
Two new sesquiterpene glycosides isolated from the fresh needles of Pinus massoniana Lamb PMID 27825248
PDZ proteins interacting with C
S 26948 a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects PMID 17704298
Bortezomib
Design, synthesis and in vitro and in vivo antitumour activity of 3
Peptidylarginine Deiminases Inhibitors Decrease Endothelial Cells Angiogenic Potential by Affecting Akt Signaling and the Expression and Secretion of Angiogenic Factors PMID 38374715
ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c
SA09
H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells PMID 40250488
Gli2
Stabilization of microtubular cytoskeleton protects neurons from toxicity of N
Ly86
Sulforaphene suppresses growth of colon cancer
Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation PMID 36990137
Analgesic Effects of Acupressure on Jing
TMUB1 is an endoplasmic reticulum
Regulated Induced Proximity Targeting Chimeras (RIPTACs) a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively PMID 36711980
Myoseverin B 361431
CD30 targeting with brentuximab vedotin a novel therapeutic approach to primary effusion lymphoma PMID 23838350
Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling PMID 27327035
Rapid and direct control of target protein levels with VHL
Identification of human saliva by antisera to alpha
Microplastics impair wound healing via NAT10
The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation PMID 29740072
Fmoc
Discovery of diamine
Antifungal agent 47 2719867
The cancer
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy PMID 38149821
Biotin
IL
MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC
Caging giants Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae PMID 40476443
FXR agonist 15 2991276
recombinant
TFAP2A Activates S100A2 to Mediate Glutamine Metabolism and Promote Lung Adenocarcinoma Metastasis PMID 39187936
Single
Folipastatin 139959
Acetylclonidine 54707
CD4 helper T lymphocytes
rat nNOS
Heneicosanoic acid
Phosphorylation
SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling PMID 35794581
Solanesol derived therapeutic carriers for anticancer drug delivery PMID 31715346
3
Evaluating the Potential of Cyclodextrins in Reducing Aggregation of Antibody
Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion PMID 25422374
Effects and mechanism of Qingke Pingchuan granules against influenza virus infection PMID 38807015
Selenium restored mitophagic flux to alleviate cadmium
Propofol improves ischemia reperfusion
Synthesis of pochoxime prodrugs as potent HSP90 inhibitors PMID 19410458
The progress in the cholinesterase quantification methods PMID 23013366
Rice Bran Extract Protected against LPS
(S)
Circular RNA CircNOLC1, Upregulated by NF
Tuina Alleviates Neuropathic Pain in CCI Rats by Regulating the TRPV4
A Spatially Coordinated Keratinocyte
AQ
EML4
Increased effects of 2,5
Amino acid starvation
PEG4
A non
The essential roles of m6A RNA modification to stimulate ENO1
Nascent Pre
Fmoc
New insights into molecular recognition of 1,1
New oxadiazole and pyrazoline derivatives as anti
Choline kinase alpha regulates autophagy
Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice PMID 38589392
Targeting ARPC1B Overcomes Immune Checkpoint Inhibitor Resistance in Glioblastoma by Reversing Pro
NSUN2 methylates IRF4 to affect the capacity of macrophages attached to titanium implant on osteogenic differentiation of PDLSCs and angiogenesis of HUVECs in vitro PMID 39538267
Microglia
Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells PMID 38946128
Dialkyloxyphenyl hybrids as PDE4B inhibitors Design, synthesis, in vitro/in vivo anti
Novel SERMs based on 3
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction PMID 37966425
GABAergic Neurons in the Dorsal
Piperazine
Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes PMID 38115594
Tenvermectin B, a novel macrocyclic lactone antibiotic, suppresses glioblastoma progression by targeting RhoJ PMID 40939916
PIM1 is responsible for IL
Repositioning Salirasib as a new antimalarial agent PMID 31803400
Synthesis and characterization of a novel Naphthalimide
Protective Role of microRNA
Epinephrine inhibits PI3Kα via the Hippo kinases PMID 38060450
Elevated glutamate impedes anti
(E/Z)
The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPAR γ PMID 34258163
Discovery, design and synthesis of 6H
ER stress induces caspase
Cimicifugic acid N 1215859
Morantel tartrate 26155
Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti
Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation
Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro
CD64 蛋白, Rabbit (HEK293, His)
MCE
SORT1
Yuehgesin C 125072
SDZ
Vitexin attenuates neuropathic pain by regulating astrocyte autophagy flux and polarization via the S1P/ S1PR1
JNJ
Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer PMID 29222162
Autophagy in Cancer Regulation by Small Molecules PMID 30454769
Discovery of EBI
FLT3
Zearalenone at environmental levels promoted ER
Circular RNA 406961 interacts with ILF2 to regulate PM2.5
SPP1 expression after spinal cord compression injury and its effects on glial cell activation PMID 41015119
Blood Serum Stimulates p38
Mechanism of the N6
Astragaloside IV mediates radiation
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model PMID 36108771
Cancer
Tumor endothelial cell up
C
The matrikine N
MATK Human Pre
Pharmacokinetic investigations of the marker active metabolites 4
RP5
A picorna
Post
Effects of Z
In vitro characterization of four N
Therapeutic Strategies to Target the Androgen Receptor PMID 35786895
FGFR
Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens A Perspective from In Vivo and In Vitro Studies PMID 30326566
Reading and writing of mRNA m6A modification orchestrate maternal
Andrographolide exerts anti
METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression PMID 38967523
Design, synthesis, and evaluation of 1,3,4
UBE2M
Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1
Luteolin inhibits GPVI
Heneicosanoic acid (二十一碳酸)
Theaflavin
DMeOB
Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats correlation with penile erection and yawning PMID 9178353
Epigenetic regulation of breast ductal carcinoma in situ by miR
Injectable and Self
(
B2M
14 0 Lyso PC
Refolding and purification of cGMP
Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS
Pioglitazone alleviates maternal sleep deprivation
Monocyte
PADI2
Mitogen
Cytotoxicity of psammaplin A from a two
Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 PMID 29937979
Regulation of inflammatory responses by IL
m6A methyltransferase ZC3H13 improves pulmonary fibrosis in mice through regulating Bax expression PMID 39307407
Detection of peramivir and laninamivir, new anti
Three
Natural small molecule compounds targeting Wnt signaling pathway inhibit HPV infection PMID 39313132
Rabdosia serra alleviates dextran sulfate sodium salt
Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli PMID 3001139
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