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生物活性分子最近更新
METTL3
Protein tyrosine phosphatase receptor type C (PTPRC or CD45) PMID 34039664
Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth PMID 40825832
Probing Nanoscale Diffusional Heterogeneities in Cellular Membranes through Multidimensional Single
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress PMID 38163553
In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum PMID 21357292
PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/β
Gastrodin inhibits hexokinase
MK
Laboratory exploration of the use of ripasudil in descemetorhexis with a human ex vivo model PMID 38901724
Design, synthesis and structure
Selective Butyrate Esterase Probe for the Rapid Colorimetric and Fluorogenic Identification of Moraxella catarrhalis PMID 33211958
JAK1 抗体 (YA722)(PBS only)（JAK1 Antibody (YA722)(PBS only)）
Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II Molecular docking and apoptosis inducing activity PMID 33171405
Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies PMID 36175412
Naratriptan
ML359 1069858
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection PMID 36896968
LY456066 338738
WDR5 facilitates EMT and metastasis of CCA by increasing HIF
miR
Discovery and Optimization of wt
IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer PMID 36358799
Age
Hafnium hydride Nanosheets with reactive oxygen and nitrogen species and cell
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system PMID 27356951
Cucurbitacin E reduces IL
(S)
EXOC4 Human Pre
Combining PIM
MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1
NDM
Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways PMID 31877536
JWA binding to NCOA4 alleviates degeneration in dopaminergic neurons through suppression of ferritinophagy in Parkinson's disease PMID 38744191
PCAF
Class A capsid assembly modulator RG7907 clears HBV
6
Human protein C receptor is present primarily on endothelium of large blood vessels implications for the control of the protein C pathway PMID 9396465
Piceatannol
5
AZT triphosphate 92586
CAY10731 2119597
The enhanced green fluorescent protein (eGFP) is minimally immunogenic in C57BL/6 mice PMID 11803402
MCE
Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica PMID 23054715
Natural compound cudraflavone B shows promising anti
Targeting KRAS Mutant Cancers with a Covalent G12C
N
中华青荚叶提取物 (Helwingia chinensis Batalin)
The M1 muscarinic receptor allosteric agonists AC
Des(1
Chromosome congression is promoted by CENP
Wogonin attenuates inflammation by activating PPAR
Activins and Inhibins Roles in Development, Physiology, and Disease PMID 27328872
Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils PMID 26139511
Oximino Oxamyl
Microbiota derived D
Discovery and pharmacologic characterization of CP
The Translation from In Vitro Bioactive Ion Concentration Screening to In Vivo Application for Preventing Peri
Nanoparticle
Lachnone A 903892
GS
Isoxazolo(aza)naphthoquinones a new class of cytotoxic Hsp90 inhibitors PMID 22538015
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy
CRBN ligand
Design, synthesis and anticancer evaluation of selective 2,4
P
MCE
Bacillibactin 95536
Bactobolamine 78013
Carbodine 71184
Epigallocatechin gallate up
A novel procedure for the assessment of the antioxidant capacity of food components PMID 27184074
The dual role of p62 in ferroptosis of glioblastoma according to p53 status PMID 35216629
Characterization of ubiquitin and ubiquitin
Neutrophil
Discovery of 3
Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta
Smarca5
Indole
Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice
RABIF Human Pre
Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p
The CXCL8/IL
MCE
Variety of antiprion compounds discovered through an in silico screen based on cellular
Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+
UCCB01
MCE
5
Ivermectin Combined With Recombinant Methioninase (rMETase) Synergistically Eradicates MiaPaCa
Fasinumab (REGN475), an antinerve growth factor monoclonal antibody, for the treatment of acute sciatic pain results of a proof
MCE
FTY720 ameliorates experimental MPO
Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney PMID 34627808
The antinociceptive and anxiolytic
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2+ axis PMID 38695251
2
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor PMID 25068800
HIF
CRBN ligand
A novel kinase inhibitor, INCB28060, blocks c
Sanguinarine Attenuates Collagen
Preclinical characterization of SHR6390, a novel CDK 4/6 inhibitor, in vitro and in human tumor xenograft models PMID 30724426
HCV
Anti
MS1129
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch PMID 35263588
Carminomycin, 14
Targeting SETD7 Rescues Diabetes
Total tanshinones ameliorates cGAS
Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic
Granulocyte chemotactic protein 2 acts via both IL
Differential effects of complement activation products c3a and c5a on cardiovascular function in hypertensive pregnant rats PMID 25150279
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism PMID 39779666
Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents PMID 25884112
Mannuronate Oligosaccharides Ameliorate Experimental Colitis and Secondary Neurological Dysfunction by Manipulating the Gut
Structure
Dimethylamine
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFRdel19/T790M/C797S and EGFRL858R/T790M/C797S) PMID 35413415
CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials PMID 31721342
RBMX involves in telomere stability maintenance by regulating TERRA expression PMID 37756323
CEACAM5 蛋白, Human (187a.a, HEK293, His)
AK3L1 蛋白, Human (sf9, His
Structural stabilization of transthyretin by a new compound, 6
7
Nonyl 10
GCN2 inhibition sensitizes arginine
HSP90 inhibitor 17
p52
TAK
Neuroligin 1 Regulates Autistic
Circ_0001946 Promotes the Development of Acute Myeloid Leukemia by Upregulating PDL1 PMID 37431262
Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod
Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID
SG3199 1595275
SOX4
Pivampicillin hydrochloride 26309
Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro PMID 2445284
Piezoelectric Injectable Anti
The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti
BSJ
CCPG1 involved in corneal Aspergillus fumigatus infection PMID 35450172
COX
Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G
Patient
Inhibition of hepatitis B virus through PPAR
Conserved structure and function of chemokine CXCL8 between Chinese tree shrews and humans PMID 30012425
Aurora Kinase
Can oxybenzone cause Hirschsprung's disease? PMID 30831214
Discovery of novel 2
Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell
Human menstrual blood
Connexin
Down
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins PMID 35721509
Benchmark Calculations for Bond Dissociation Enthalpies of Unsaturated Methyl Esters and the Bond Dissociation Enthalpies of Methyl Linolenate PMID 27191950
Atezolizumab 1380723
METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability PMID 37195267
Apelin
Niacin restriction with NAMPT
Glycogenesis and glyconeogenesis from glutamine, lactate and glycerol support human macrophage functions PMID 39424955
同源框 B6（HOXB6）基因
An iron
Bupivacaine reduces GlyT1 expression by potentiating the p
TMT
Radix Rehmanniae Praeparata extracts ameliorate hepatic ischemia
Epstein
Preclinical development of G1T38 A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors PMID 28418845
Comparison of Three Species of Rhubarb in Inhibiting Vascular Endothelial Injury via Regulation of PI3K/AKT/NF
Targeting the METTL3/YTHDF3/m6A/PGK1 axis to combat Choriocarcinoma progression PMID 40681032
次黄嘌呤鸟嘌呤磷酸核糖基转移酶
Alternative Splicing Factor HNRNPU as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor
Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL
Arachidic acid
Simple and rapid determination of myristicin in human serum PMID 23440626
ISIS 449884 Injection Add
Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome
Structure
A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX
Fas
Discovery of 6'
Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro PMID 31931104
Effects of the allosteric modulator SCH
circSLTM knockdown attenuates chondrocyte inflammation, apoptosis and ECM degradation in osteoarthritis by regulating the miR
UDP
CENPA
Antileukemic effects of the novel, mutant FLT3 inhibitor NVP
Activation of aryl hydrocarbon receptor ameliorates degranulation of LL
SAT1 Human Pre
Combination therapy with B7H3
Phaseolus vulgaris Erythroagglutinin (PHA
6
SMAD5 Human Pre
The effect of a 5HT2 receptor antagonist sarpogrelate (MCI
Diabetic
Oncogene PRR14 promotes breast cancer through activation of PI3K signal pathway and inhibition of CHEK2 pathway PMID 32541902
IGFBP2 Modulates Trophoblast Function and Epithelial
Potent toxic effects of Taroxaz
The mevalonate pathway couples lipid metabolism to amino acid synthesis via ubiquinone
Magnetic Resonance Imaging Basics PMID 36306094
TGM3 promotes epithelial
Ruthenium red as an effective blocker of calcium and sodium currents in guinea
SIRT2 ablation inhibits glucose
A novel radioligand [125I]BQ
DOCK7 protects against replication stress by promoting RPA stability on chromatin PMID 33704464
Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive PMID 30023336
Lyve1 Rat Pre
Antitumor activity of HM781
Genetic manipulation of Fonsecaea pedrosoi using particles bombardment and Agrobacterium mediated transformation PMID 29458863
The Interaction of Calcium
Studies on the non
Production of functional sperm from in vitro
Mgp High
Discovery of AG
Potential oral VEGFR2 inhibitors Treatment of wet age
Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3
IL
Zaluzanin C Inhibits Differentiation of 3T3
Mesenchymal Stem Cell
bFGF
A Ligand First Approach toward Selective, Covalent JNK2/3 Inhibitors PMID 40404564
Has_circRNA_0122683 (circ
Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration PMID 37355632
Inhibition of formate production blocks CD8 + T
Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity PMID 36162056
4
Actinomycin D effects on Ridgway osteogenic sarcoma in mice PMID 5224225
Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal PMID 30197195
Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF
Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression PMID 35901491
BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment PMID 24462187
MCE
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis PMID 37501148
NSUN2
AE0047
HA1/Hemagglutinin 蛋白, H1N1 (AAP34324, HEK293, His)
Antibody
Triapine (Standard)
PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF
Gant61 ameliorates CCl4
T
AG
CRBN ligand
Disubstituted pyrimidine
Honokiol reduces fungal burden and ameliorate inflammation lesions of Aspergillus fumigatus keratitis via Dectin
Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation PMID 27573543
Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma PMID 33015852
CLDN6 inhibits breast cancer growth and metastasis through SREBP1
Review of the molecular mechanisms of Ganoderma lucidum triterpenoids Ganoderic acids A, C2, D, F, DM, X and Y PMID 31035236
Dibenzocyclooctadiene lignans and norlignans from fruits of Schisandra wilsoniana PMID 23327759
Ocular hypotensive safety and systemic absorption of AR
Substrate stiffness modulates osteogenic differentiation of BMMSCs via the hedgehog signaling pathway PMID 40712834
Transient hydroxycholesterol treatment restrains TCR signaling to promote long
Cell Type
GLIPR2 regulates EndoMT and cardiac fibrosis after AMI via PDGFRL/AKT/mTOR signaling pathway PMID 40543810
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib
Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress PMID 35883870
Silencing NEDD4L Effectively Inhibits the Malignant Behaviors of Hepatocellular Carcinoma PMID 40661237
Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA
Bioinformatics and experiments reveal the hub genes of age
Different changes of plasma membrane beta
Discovery of Potent and Selective CDK4/6 Inhibitors for the Treatment of Chemotherapy
Critical role of mitogen
蛋白酶体 20S 亚基 alpha 6（PSMA6）基因
Acriflavine, an Acridine Derivative for Biomedical Application Current State of the Art PMID 36018000
Novel 1,6
ABT
Structural characterization of proline
Electroacupuncture promotes resolution of inflammation by modulating SPMs via vagus nerve activation in LPS
Mangiferin prevents glucolipotoxicity
A phase I pharmacokinetic and pharmacodynamic study of s
Distinct pharmacology of rat and human histamine H(3) receptors role of two amino acids in the third transmembrane domain PMID 11090094
GY1
A nanotherapeutic strategy to overcome chemoresistance to irinotecan/7
Rimegepant hemisulfate 1642783
Phospho
PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)
The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma PMID 37853162
4’
Determination of veliparib metabolic stability in the human liver microsomes using a hydrophilic interaction UPLC
The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway PMID 38847482
XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor PMID 34384466
Cytotoxic and antineoplastic activity of timosaponin A
RNA N6
Discovery of Novel Triple A1/A2A/A2B Adenosine Receptor Antagonists for Cancer Immunotherapy PMID 41124668
Recombinant ferritin nanoparticles can induce dendritic cell maturation through TLR4/NF
Loss of FBXW7
A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC
Wnt/beta
Development of a Series of Pyrrolopyridone MAT2A Inhibitors PMID 38466661
Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers PMID 38323982
DR4485 hydrochloride 402942
CSF1R
Dysregulation and antimetastatic function of circLRIG1 modulated by miR
miRNA let
LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2 PMID 37652169
Ubiquitin
N
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H
Phospho
Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii
Up
TLR9 in satellite glial cells promotes paclitaxel
Clozapine, a fast
Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury PMID 36299685
Trace amine
RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma PMID 35847905
20
Deciphering the Distinct Roles of Molecular and Supramolecular Chirality in Osteogenic Differentiation of Mesenchymal Stem Cells in 3D Hydrogels PMID 40425514
Discovery of SYD5115, a novel orally active small molecule TSH
HIF
Development of a TNF
Homobivalent ligands of the atypical antipsychotic clozapine design, synthesis, and pharmacological evaluation PMID 22243698
Recent advances in the development of ubiquitin
TSSK3 蛋白, Human (Inactive, sf9, His, GST)
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p
Obacunone Alleviates Thalamic Pain via Promoting LCN2
Bioisosterism
HA/Hemagglutinin 蛋白, H1N1 (ABQ44416, sf9, His)
BIRC5 facilitates cisplatin
RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1 an experimental research PMID 35668458
Apolipoprotein L genes are novel mediators of inflammation in beta cells PMID 37924378
CRBN ligand
Non
Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen a phase I, pharmacokinetic, and biologic correlative study PMID 12525512
Apoptosis induced in rats by 4
MCE
Berberine
Dclk1 Inhibition Cancels 5
Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis PMID 34143514
Coq5
Essential role of docosahexaenoic acid towards development of a smarter brain PMID 26321578
complement 3
miR
Curcumin promotes the survival of ischemic random skin flaps via autophagy PMID 33841660
Spatial Domain
Revealing transport, uptake and damage of polystyrene microplastics using a gut
Brivudin (bromovinyl deoxyuridine) PMID 15341504
Cyproheptadine
The Importance of Thrombin in Cerebral Injury and Disease PMID 26761005
Role of IL
Exploration of naphthoquinone analogs in targeting the TCF
Intracellular Mechanism of Rosuvastatin
APT1
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells PMID 31452785
Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR
ADP 核糖基化因子 GTP 酶激活蛋白 1（ARFGAP1）基因
4’,5’
Highly active anticancer curcumin analogues PMID 17569206
Neurotrophic Factors in Parkinson's Disease Clinical Trials, Open Challenges and Nanoparticle
Cadmium exposure causes trophoblast abnormal syncytization and endocrine dysfunction in preeclampsia PMID 40300673
Erythrina cristagalli lectin
Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest PMID 30235818
SJFδ 2254609
MCE
CP21R7 125314
Carvedilol Ameliorates Intrahepatic Angiogenesis, Sinusoidal Remodeling and Portal Pressure in Cirrhotic Rats PMID 30448852
N
Matricellular proteins Extracellular modulators of bone development, remodeling, and regeneration PMID 16412713
TNFSF13B Human Pre
PPPA 113190
Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia
Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor PMID 18519779
CD59
Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni A Preclinical Study PMID 26574746
Inhibition of USP1 activates ER stress through Ubi
FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival PMID 33791149
AGB
ST91 (Standard)
Requirement for ERK activation in cisplatin
SBI
Polyphyllin I inhibits ovarian cancer growth by inducing G0/G1 phase arrest and inhibiting the c
Acetoacetyl coenzyme A reductase and polyhydroxybutyrate synthesis in rhizobium (Cicer) sp. Strain CC 1192 PMID 9687441
Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis
Palmitic acid
LncRNA
Targeted imaging of uPAR expression in vivo with cyclic AE105 variants PMID 37821532
CD40 蛋白, Canine (HEK293, His)
TDP
CAMKIV/CAMK4 蛋白, Mouse (sf9)
6
Bergamottin, a bioactive component of bergamot, inhibits SARS
Itch
PSB
DBCO
MCE
INCB054329
线粒体相关 ER 膜
Celastrol Targets Cullin
Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation PMID 39333009
Effects of allylglycine on photosensitivity in the lateral geniculate
Phorbol 12,13
Phenolic Compounds in Organic and Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS
Osteogenic
Design, synthesis, and biological evaluation of novel hybrid dicaffeoyltartaric/diketo acid and tetrazole
Long noncoding RNA SENCR facilitates the progression of acute myeloid leukemia through the miR
RPS15A Human Pre
Novel, Reproducible, Consortia Factors Derived from Adipose Stem Cells for Burn Wound Treatment PMID 40495998
Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses PMID 8834832
GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin
RO5256390 1043495
Chlorantholides A
HY
Oral valganciclovir versus ganciclovir as delayed pre
C
Nicotinamide
EGFR
Optimization of an ether series of mGlu5 positive allosteric modulators molecular determinants of MPEP
CRBN ligand
RP
N
LY 78335 39226
Role of nuclear factor
A new perspective on the antimicrobial mechanism of linezolid against Staphylococcus aureus revealed by proteomics and metabolomics analysis PMID 40049374
Tailored quinoline hybrids as promising COX
Schiff's base derivatives bearing nitroimidazole and quinoline nuclei new class of anticancer agents and potential EGFR tyrosine kinase inhibitors PMID 24630412
An allosteric modulator of HIV
Affinity
TIGIT modulates sepsis
Constitutive β
FABP5 regulates ROS
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta
KLF 转录因子 1（KLF1）基因
Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus PMID 12237067
Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats PMID 31199171
risvutatug
Synthesis of methyl 4'
Tetrahydrofolic acid accelerates amyloid fibrillization, decreases cytotoxic oligomers and suppresses their toxicity PMID 39708879
Identification of 2
Nα,Nα
Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF
Regulation of Interferon
BP Fluor 488 Tetrazine 1466419
Rilematovir 1383450
A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals PMID 11032777
Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes PMID 17726152
SLAMF7
Precision Oncology for High
MCE
Ropinirole
CFM
5
Iotroxic acid 51022
Hygromycin
Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR
MCE
Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2
Harzianol O 3033994
Dendronobiloside A
Thalidomide
Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction PMID 17416906
Effect of maraviroc on HIV disease progression
Ac9
Cadmium exacerbates liver injury by remodeling ceramide metabolism Multiomics and laboratory evidence PMID 38432385
Ebola virus Glycoprotein/GP 蛋白 RBD (AAC54887, HEK293)
Vm24
Development of a novel 99m Tc
The impact of targeting TRAF2 and NCK
SOS1 activator 2 2245237
2
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence PMID 18276850
Ethyl linoleate
Pharmacokinetics and metabolism of bepridil PMID 3872057
Blockade of cannabinoid CB1 receptors potentiates the anti
Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis PMID 30016153
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases PMID 12208741
Recent Advances in the Synthesis and Development of Nitroaromatics as Anti
Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies PMID 25716480
Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II
Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis PMID 40586264
Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin
NBD peptide 371915
AldoView precursor
Astragali radix
Curcumin Ameliorates Copper
Pulmonary carcinogenesis in mice with a single intratracheal instillation of 9, 10
Morphothiadin 1092970
CRBN ligand
Discovery and Characterization of SY
Chronic systemic D
Interaction between enantiomers of mianserin and ORG3770 at 5
Synta66 835904
Bivalirudin Attenuates Thrombin
Effects of Trichinella spiralis and its excretory/secretory products on autophagy of host muscle cells in vivo and in vitro PMID 33600403
黄花落叶松提取物 (Larix olgensis A. Henry)
Cleavage of SQSTM1/p62 by the Zika virus protease NS2B3 prevents autophagic degradation of viral NS3 and NS5 proteins PMID 39128850
Regulatory T
Mapping the Biotransformation of Coumarins through Filamentous Fungi PMID 31569547
Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis PMID 35809382
Docking simulation and antibiotic discovery targeting the MlaC protein in Gram
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity PMID 39174522
Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance PMID 29050982
Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP
Robust central reduction of amyloid
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion
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