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Potent hFPRL1 (ALXR) agonists as potential anti
Hederacoside C 14216
CRBN ligand
Novel DAG
Discovery and Optimization of a Non
1
Benzoheterocyclic analogues of dotinurad as orally efficacious human urate transporter 1 inhibitors Design, synthesis, structure
Safety, tolerability, and preliminary efficacy of SYN120, a dual 5
The 5
MSDC 0160 146062
Red nucleus mGluR4 and mGluR8 inhibit nociception and the development of neuropathic pain by restraining the expressions of TNF
[D
MB
Pou2f2
Design of MC1R Selective γ
Ilf3
Reduced FRG1 expression promotes angiogenesis via activation of the FGF2
Studies on mitochondrial Ca2+
HBX 28258 1426544
Anxiolytic effect of NKP608, a NK1
Prdm9
Lessons Learned from Past Cyclin
Quantitative analysis of cellular senescence phenotypes using an imaging cytometer PMID 22406489
Benufutamab 2109730
Gfra2
Mnt
A novel pyrrole derivative, NS
(Des
rel
Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury PMID 11268417
Phenotypic screening in influenza
Ac
The cyclooxygenase
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality PMID 24226769
A novel dual amylin and calcitonin receptor agonist, KBP
A Novel Plant Sesquiterpene Lactone Derivative, DETD
核糖体蛋白 S6 激酶 B1（RPS6KB1）基因
Microbial and Nonvolatile Chemical Diversities of Chinese Dark Teas Are Differed by Latitude and Pile Fermentation PMID 35502792
CRBN ligand
Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti
Integrative analysis identifies IL
Trpc2
Mazisotine 1638588
p38 mitogen
A new mechanism of respiratory syncytial virus entry inhibition by small
朗格汉斯细胞组织细胞增生症
Angioaccess for hemodialysis which, when, why PMID 1095268
半乳糖变旋酶（GALM）基因
The transport of cimetidine across the rat small intestine in vitro [proceedings] PMID 526766
Advances in oligonucleotide drug delivery PMID 32782413
Natural Product 2
Macamide
WYE
Wtap Mouse Pre
'Click' D(1) receptor agonists with a 5
The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high
MART
Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish PMID 22891320
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors PMID 31784185
Effect of 4
Cell cycle effects of fatty acid derivatives of cytarabine, CP
Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction PMID 36108628
Chemical profiling of triacylglycerols and diacylglycerols in cow milk fat by ultra
Smarcd3
CRBN ligand
Miptenalimab 2249882
Ube2o
Electrophysiologic effects of AHR 10718 on isolated cardiac tissues PMID 3838726
MCE
A technique for the study of muscle relaxants by stimulating the spinal motor nerve outflow in the pithed rat PMID 4511872
MCE
A distinct sodium channel voltage
Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells PMID 10103034
SELE
Heme Oxygenase (HO)
核糖体蛋白 S6 激酶，多肽 2（Rps6kb2）基因
Anti
The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia the DALI study a double
异质核核糖核蛋白 R（HNRNPR）基因
Emb
Fmoc
Novel co
Pancreatic Polypeptide, bovine 179986
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13 isolation, structure elucidation, and SAR studies PMID 11473410
Resveratrol Interferes with IL1
Arformoterol maleate 1254575
Antifungal ether diglycosides from Matayba guianensis Aublet PMID 24485783
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox) PMID 11433301
Corynoxine B ameliorates HMGB1
Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin
Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC) PMID 30274779
Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages PMID 36542700
Melanogenesis inhibitory activity of a 7
Noxa B BH3 505070
Activity of the new OSBP inhibitor Y18501 against Pseudoperonospora cubensis and its application for the control of cucumber downy mildew PMID 37532305
Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat PMID 3954800
In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells PMID 27539371
4
EGFR
MCE
Modulation of haematopoietic progenitor development by FLT
From Tryptophan to Toxin Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin PMID 35142504
Phosphorylcholine chloride 107
Osmr
Btg2
D
Rotenolone 509
Egg oil from Portunus trituberculatus alleviated obesity and regulated gut microbiota in mice PMID 32439940
CDK2
Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin PMID 6262771
Discovery of AM
Cultivation at high osmotic pressure confers ubiquinone 8
Antiviral COVID
Discovery of PFI
Ubd
Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies PMID 30513472
Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain PMID 27779399
Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up
SAR of Novel 3
Pralnacasan, an inhibitor of interleukin
MCE
Interspecies comparison in the COMT
In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin
2'
Structure and lipid interactions of an anti
A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066
Iron
Cbl
MEDI0639 a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo PMID 22679110
Dkk4
WNT3A
Ibutamoren 159634
Deacetylcephaloglycin 3890
Decreased susceptibility to cefepime/zidebactam among carbapenemase
Total synthesis and evaluation of 22
Toluidine blue A review of its chemistry and clinical utility PMID 22923899
Thiazolinobutazone 54749
Liver X receptors inhibit human monocyte
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma PMID 36068788
N
Blockade of human neutrophil activation by 2
Physiology and Pharmacology of DPP
Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors Synthesis, biological evaluation and radiosensitizing activity PMID 32485534
Design and optimization of piperlongumine analogs as potent senolytics PMID 38104906
Oxyberberine ameliorates TNBS
Calcitonin gene
19
Targeted Delivery of AGO
Seco
Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells PMID 24444929
A novel ligand of the formyl peptide receptor annexin I regulates neutrophil extravasation by interacting with the FPR PMID 10882119
Targeted 8
The function neutralizing anti
Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis PMID 1196754
Rapid gas chromatographic method for the determination of famoxadone, trifloxystrobin and fenhexamid residues in tomato, grape and wine samples PMID 16950327
AM
Imidazole alkaloids from Lepidium meyenii PMID 12932133
Dacarbazine
N
Crocetin monomethyl ester 25368
FK
Effects of Nutritional Disturbances on the Structure and Function of Mitochondria, Oxidative Stress Level, and Fat Deposition in Chicken Liver Cells PMID 41227481
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists PMID 24597733
HDAC6
Scorodonin 74660
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2
N
CRBN ligand
Metabolic footprint analysis uncovers strain specific overflow metabolism and D
1,2
Niraparib 1038915
Structure
Discovery of potent Keap1
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non
ELP1
Antioxidative and prooxidative action of stilbene derivatives PMID 10862501
Glrb
SATPdb a database of structurally annotated therapeutic peptides PMID 26527728
Mafa
Bromomaleimide
Identification of imidazo[1,2
Anitrazafen (LY 122512，阿尼扎芬)
P
BMS
磷脂酶 A2 组 IID（PLA2G2D）基因
BYK 49187 163120
Mitophagy
Opposing effects of HNP1 (α
Norfloxacin
MT
Inhibitors of human immunodeficiency virus type 1 (HIV
Nogo presence is inversely associated with shifts in cortical microglial morphology following experimental diffuse brain injury PMID 28736137
An efficient and diastereoselective synthesis of PSI
Untargeted metabolomics for uncovering plasma biological markers of wet age
(
Proanthocyanidin and mitoglitazone suppress lipogenesis by targeting ferroptosis in metabolic dysfunction
UvCYP503 is required for stress response and pathogenicity in Ustilaginoidea virens PMID 40033930
SST0116CL1 free base 1202920
Bmf
PRCP 蛋白, Human (HEK293, His)
Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia PMID 23186065
The generation and characterization of antagonist RNA aptamers to human oncostatin M PMID 10882721
Cyanazine
PEG300 Protects Mitochondrial Function By Upregulating PGC
CRBN ligand
Protective effect of 2
Site
Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model PMID 33538148
蛋白激酶 cAMP 激活的催化亚基 β（PRKACB）基因
Sensitization of B
CRBN ligand
Macrophage
TIGIT as an emerging immune checkpoint PMID 31828774
Src
Usp9x
Different molecular events account for butyrate
(+)
Linker length modulates DNA cross
Mdga2 Mouse Pre
A small proportion of X
Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations
Regulating astrocyte phenotype by Lcn2 inhibition toward ischemic stroke therapy PMID 39836995
PDD00017238
Benadrostin
2′
Trpv6
FK 633 (FR
Discovery of Thieno[3,2
Design, Synthesis, and Antifungal Activities of Novel Pyrazole
Usp9x
Novel Allosteric Inhibitor
Orally bioavailable 6
Molecular basis of pimarane compounds as novel activators of large
Z
单胺氧化酶 B（Maob）基因
Liver X receptor unlinks intestinal regeneration and tumorigenesis PMID 39567700
Srgn
Hmbs
CRBN ligand
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit PMID 12670652
Exploring Structural Determinants of Bias among D4 Subtype
(R)
Ekatetrone 12794
Highly sensitive nuclease assays based on chemically modified DNA or RNA PMID 25019631
Targeting Tropomyosin Receptor Kinase in Cutaneous CYLD Defective Tumors With Pegcantratinib The TRAC Randomized Clinical Trial PMID 29955768
Adenosine A2A receptor is a tumor suppressor of NASH
Batf
Scaffold hopping for designing of potent and selective CYP1B1 inhibitors to overcome docetaxel resistance synthesis and evaluation PMID 38356135
Aipl1
肌动蛋白 α 心肌 1（ACTC1）基因
Morin inhibits the growth of human leukemia HL
Identification of a potent and orally active non
NU 1085
Atp13a2
Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1) PMID 11405660
MCE
Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin
Cbs Mouse Pre
S32212, a novel serotonin type 2C receptor inverse agonist/α2
Tcea3
cms1 核糖体小亚基同系物（CMSS1）基因
KX2
miR
Epopromycins, novel cell wall synthesis inhibitors of plant protoplast produced by Streptomyces sp. NK04000 PMID 9439699
In vitro and in vivo activities of clinafloxacin, CI
Albizia lebbeck and Albizia zygia volatile oils exhibit anti
Inhibition of angiotensin
丙氨酸
Spp2
Modified Simiaowan prevents articular cartilage injury in experimental gouty arthritis by negative regulation of STAT3 pathway PMID 33460754
Amarouciaxanthin A
N
ω
Ggt1
6
YAP/TAZ drives cell proliferation and tumour growth via a polyamine
Discovery, Synthesis, and Biological Evaluation of Novel Quinoline
Dermatomyositis treated with triamcinolone diacetate PMID 13619285
Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride
MCE
Discovery of glycine sulfonamides as dual inhibitors of sn
ONO
Colistin B
ML095
Oxidized Juncuenin B Analogues with Increased Antiproliferative Activity on Human Adherent Cell Lines Semisynthesis and Biological Evaluation PMID 33064469
(R)
Cfl1 Mouse Pre
Gender
NLRP3
动力蛋白细胞质 1 中间链 2（DYNC1I2）基因
Mivazerol 125472
E
Preclinical pharmacokinetics, metabolism, and toxicity of azurin
Daily consumption of wild olive (acebuche) oil reduces blood pressure and ameliorates endothelial dysfunction and vascular remodelling in rats with NG
Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin
Sel1l
细胞受体 β 常数 1（TRBC1）基因
Rap1 GTPase
Adenosine (A2) antagonist inhibits induction of long
Advancements in the Development of non
Tnfrsf12a
Toxic properties of Beauveria pigments on erythrocyte membranes PMID 9278984
白介素 17 受体 E 样（IL17REL）基因
2
Discovery of potent and selective small
Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide
Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions PMID 40592185
Erythromycin derivatives inhibit HIV
GSK2324 1020567
Cyclo(Pro
Hydrocotarnine 550
mmu
Arc is a flexible modular protein capable of reversible self
hsa
Rnf114
Identification of a novel small
Physcion
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3
EFNA5
1
Nanoparticle
DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects A potential role of adenosine PMID 27260206
N
Hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii as a new type of anti
Acp2
Synergistic growth
Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects PMID 2633923
Angelol B 83156
含乳脂肪球 EGF 和因子 V/VIII 结构域（MFGE8）基因
检查点激酶 1（Chek1）基因
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation PMID 22571355
白介素 20 受体亚基 β（IL20RB）基因
ATR
Others 抑制剂
A New Approach in Cancer Treatment Discovery of Chlorido[ N, N'
Arf3
UDP 葡萄糖醛酸转移酶家族 1 成员 A3（UGT1A3）基因
Early
Acbp is essential for decidualization during early pregnancy in mice PMID 35275842
Pim
Role of IL
MAPK 相互作用的丝氨酸/苏氨酸激酶 1（MKNK1）基因
Effects of the beta
Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2 PMID 34248979
Inhibition of ion transport in Ehrlich cells by muzolimine PMID 2429195
Some in vitro and in vivo actions of the new histamine H2
Frmd5
EAFGVNMQIVR
AP21998
Ethinylestradiol sulfate
Benzylpiperidine
Special Issue C
SCOTfluor
Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages PMID 8010057
Laptm4b
Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo PMID 26751436
Pivmecillinam
Discovery of novel pyridone
有丝分裂原活化蛋白激酶激酶 2（Map2k2）基因
Ackr2 Rat Pre
Monocytes Acquire the Ability to Prime Tissue
ML18
Ano1
Diarylurea derivatives comprising 2,4
Nonclinical Development of SRK
The pro
Proteinase K 39450
The pharmacology of rocuronium bromide (ORG 9426) PMID 8122487
Desthiobiotin
Oxytocin attenuates hypothalamic injury
Effects of new calcium channel blocker of niludipine on the coronary hemodynamics, diastolic properties, and metabolic responses to tachycardia stress in patients with coronary disease PMID 7127462
BC
trans
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode PMID 19256503
CRBN ligand
Emerging Therapies in Neovascular Age
绒毛膜促生长激素 2（CSH2）基因
Rising TRPV4 expression in the central nucleus of amygdala is involved in tooth movement pain PMID 41203189
Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa PMID 34905092
K
In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor), tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae PMID 9429250
Tat
Antibacterial Polyketides Isolated from the Marine
CASK promotes prostate cancer progression via kinase
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism PMID 33637724
Complement C5a receptor antagonist in the treatment of experimental periodontitis in mice PMID 41299858
FR
Isostrictiniin Alleviates LPS
hsa
Novel synthesized SLC
CENP
Reticulol, an inhibitor of cyclic adenosine 3', 5'
Knockdown of PAR2 alleviates cancer
水龙提取物 (Ludwigia adscendens (L.) Hara)
Characterization of Ro 04
A novel molecule (frakefamide) with peripheral opioid properties the effects on resting ventilation compared with morphine and placebo PMID 15728057
Tofacitinib impurity 59 (Standard)
ERα, but not ERβ and GPER, Mediates Estradiol
IACS
MCE
含 NLR 家族 pyrin 结构域 4（NLRP4）基因
Diketone
Expression and activity of cocaine
Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation PMID 40999987
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis
NPPA
双特异性磷酸酶 8（DUSP8）基因
MCE
A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS
IRL 1038 144602
Diglycolic acid 110
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities PMID 34455231
Rps12
mmu
Protection against convulsion
Werner syndrome protein interacts functionally with translesion DNA polymerases PMID 17563354
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5
4
Tenatumomab
Biotransformation of betulinic and betulonic acids by fungi PMID 17258248
Discovery of novel 1
Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety PMID 39136957
Antibacterial agent 70
Monamycin F 31594
The non
Cspg4
Differential anticholinergic activity, metabolism and excretion of the optical isomers of 14C
Kdm4a
Kat8
20 4
Gsdma
含血影蛋白重复序列的核膜家族成员 3（SYNE3）基因
Identification of an orally active small
Pharmacokinetics of intra
MCE
3
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays PMID 37858335
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria PMID 12959277
Octyl gallate targeting the 3C
ROOT HAIR DEFECTIVE 2 vesicular delivery to the apical plasma membrane domain during Arabidopsis root hair development PMID 34986267
Inducing aortic aneurysm/dissection in zebrafish evaluating the efficacy of β
18 1 Propargyl PC 1830366
2FA
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C PMID 31883964
Elp3
Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models PMID 27136102
PAF1C
Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC
learning and memory.
GAS6
Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand PMID 12593648
Dpt Rat Pre
Alterations of serotonin neurotransmission and inhibition of mouse
Effects of Z
rot
MON4660
MCE
Flumezapine and zotepine 5
Repurposing Drug Metabolites into Dual β
DNA damage induced by a new 2
Polyinosinic acid is a ligand for toll
Simultaneous Study of Anti
ALX1
Progesterone regulates granulosa cell viability through a protein kinase G
Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria PMID 6654760
Lrg1
NADPH 氧化酶 4（NOX4）基因
Dicaffeoylquininic acid 251320
Calcium imaging of cortical neurons using Fura
Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma PMID 39350123
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury PMID 37027003
介体复合体亚基 11（MED11）基因
Dihydrojasmonic acid 3572
Serine Hydrolase inhibitor
Neuromuscular blocking agents. Replacement of quaternary ammonium groups in bis
A Fluorescent Probe to Detect Quick Disulfide Reductase Activity in Bacteria PMID 35204259
Design, synthesis, and structure
Human hepatic in vitro models reveal distinct anti
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions PMID 30739444
Extracellular BCL2 proteins are danger
Determination of sunitinib and its active metabolite, N
Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats PMID 26354994
Trappc4
抗紫外线辐射相关（UVRAG）基因
CRBN ligand
Rational design of urea
Fcrl5
Inhibition of histamine release from human lung in vitro by antihistamines and related drugs PMID 6159940
Chavicol 501
2
Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex PMID 10864959
Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2 PMID 23589174
四跨膜蛋白 1（TSPAN1）基因
黄香附提取物 (Cyperus esculentus L.)
Design, synthesis and biological evaluation of novel thiosemicarbazone
A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata) PMID 1425705
Rspo3
Suberylglycine
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