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Gba2
Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses PMID 23420883
PIK90
Two new antibiotics, A
Structure
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei
Collision
Pharmacological characterization of SC
Rutaecarpine Increases Anticancer Drug Sensitivity in Drug
Discovery of a macrocyclic FAK inhibitor GZD
Reverse Microemulsion
The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor
Pyrocincholic acid methyl ester 107160
MEHHTP
Alpiropride 81982
Synthesis and Structural Characterization of Novel Trihalo
Dopamine
CRBN ligand
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non
Initiation of apoptosis and autophagy by the Bcl
Mechanisms and clinical translation of ICOS/ICOSL signaling pathway blockade in delaying vascular complications of type 2 diabetes PMID 40804414
Phosphodiesterase 10 Inhibitors
Identification of BMS
BAM8
Fgf16
Reverse transcriptase pauses at N2
磺基转移酶家族 1E 成员 1（SULT1E1）基因
An All
Ryr2
PROTAC BCL6/GSPT1 Degrader
TYMJ
NOD2 agonist 3 2289702
小核核糖核蛋白 U5 亚基 40（SNRNP40）基因
T cell gelatinases mediate basement membrane transmigration in vitro PMID 7722295
Structure
Complete inhibition of ABCB1 and ABCG2 at the blood
A monoclonal antibody against CD86 and its protection in a murine lupus nephritis model of chronic graft
9
Tyrosinase inhibitory components from the seeds of Cassia tora PMID 29721815
Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication
Methapyrilene 91
Studies on the chemistry, antitumor activity, and pharmacology of ethyl di
Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma PMID 34049151
Grifolic acid induces mitochondrial membrane potential loss and cell death of RAW264.7 macrophages PMID 29257254
Lactobacillus reuteri DSM 17,938 ameliorates LPS
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI PMID 38029807
S
Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P
The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein PMID 32022559
Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse a potential translational biomarker PMID 21742809
Ibrutinib
AHR activator 1 352346
Ctps1
Central administration of the muscarinic receptor subtype
Low expression of miR
Pharmacokinetics and tolerability of NSC23925b, a novel P
Chemical profiling of Ziziphi spinosae semen using on
SMAD2 S
Dietary 5,6,7
TNIK
Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure
V2rf2
What Do We Know About Remdesivir Drug Interactions? PMID 32402130
Hexanoyl
Bioorganometallic chemistry with IspG and IspH structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis PMID 24481599
DS42450411 2247168
A Combined Experimental and Computational Study of Halogen and Hydrogen Bonding in Molecular Salts of 5
A facile method for the preparation of 7,8
BMS
Fmnl1
Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease PMID 24299463
Anti
4
Effective inhibition of acid and neutral ceramidases by novel B
Gnaq
Cell
Synthesis and mechanistic investigation of N
Targeting cyclin
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel PMID 37142682
Flutroline 70801
The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events PMID 26420422
Bioactive recombinant human oncostatin M for NMR
Betanin exhibits significant potential as an antihyperglycemic and attenuating the glycoprotein components in streptozotocin
胚胎外胚层发育（EED）基因
FZ
德罗沙核糖核酸酶 III（DROSHA）基因
MYH9
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention PMID 31632965
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity PMID 20598882
Aminoguanidine hemisulfate 996
Esd
17
Computational identification of potential inhibitors targeting cdk1 in colorectal cancer PMID 38099190
Ethylenethiourea teratogenicity study in rats and rabbits PMID 4807127
4
Glycerophosphorylethanolamine sodium (GroPEtn sodium)
Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms PMID 33326493
Intranasal vaccination promotes detrimental Th17
Mat1a
Labdane
The ESCRT
BMP3 Alone and Together with TGF
Epipodophyllotoxin acetate 1180
DMT
Antihypertensive and hypotensive actions of atiprosin (AY
Utreloxastat 1213269
Exploration of nuclear body
Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog PMID 2534798
Erlec1
FITC
Tmprss2
Structure
Scp2
Synthesis of new spirooxindole
Crh
Effects of a highly selective plasma kallikrein inhibitor on collagen
A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl
11(Z)
Evidence that somatostatin sst2 receptors mediate striatal dopamine release PMID 10578151
基本转录因子 3（BTF3）基因
Corynoxine B targets at HMGB1/2 to enhance autophagy for α
MCE
CRBN ligand
FRAT1 Human Pre
Substrate
inducer
细胞色素 P450 家族 21 亚家族 A 成员 2（CYP21A2）基因
RLH
CRBN ligand
Advances in Organic Small Molecule
MCE
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures PMID 28726638
Gilteritinib overcomes lorlatinib resistance in ALK
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4
Muscone derivative ZM
Charge
Interactions between amyloid
Synthesis and anti
磷酸二酯酶 7A（Pde7a）基因
Characterization of the locomotor depression produced by an A2
Azido
A modular approach to triazole
Aristolane
Atg16l1
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2
Characterization of G
Design, synthesis and structure
A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells PMID 15705905
ATM
Suppression of non
ATM
3'
Serotonin provides an accessory signal to enhance T
Preparation and Characterization of Novel Microgels Containing Nano
CRBN ligand
Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T
Mcl
Rapid proteasomal degradation of the stress response protein REDD2 is mediated by the E3 ligase HUWE1 PMID 40609208
Quantitative analysis of hemin
MCE
Gaylussacin, a stilbene glycoside, inhibits chronic obstructive pulmonary disease in mice PMID 40614364
上皮性卵巢癌 (Epithelial Ovarian Cancer)
Usp47
Dipentamethylenethiuram Tetrasulfide 120
Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition PMID 25569186
Antiangiogenic agents in the management of non
Targeted Protein Degradation Induced by HEMTACs Based on HSP90 PMID 36574496
CSF1R
Surface chemistry architecture of silica nanoparticles determine the efficiency of in vivo fluorescence lymph node mapping PMID 24070236
4
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging PMID 38065964
MrgprX2 antagonist
Aatk
VMAC
Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells PMID 25627547
Bend5
The treatment of Goji berry (Lycium barbarum) improves the neuroplasticity of the prefrontal cortex and hippocampus in aged rats PMID 32554223
Design, synthesis, and biological activity of novel Magmas inhibitors PMID 21514823
Synthesis and anticancer activity of new benzensulfonamides incorporating s
Cks1b
Monamycin D2 31556
Castor1
Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell PMID 38713163
2
Lemd3
TATA
(±)
Neuropeptide Y in the medial habenula alleviates migraine
Tyrosinase
Usp24
Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts PMID 28135799
Leukotriene B4 creates a favorable microenvironment for murine melanoma growth PMID 19737966
支链氨基酸转氨酶 2（BCAT2）基因
Targeting UGCG overcomes resistance to lysosomal autophagy inhibition PMID 36331284
Telbivudine Reduces Parvovirus B19
MLS6357 932544
Design, synthesis, and biological evaluation of novel double
Lotilaner (洛替拉纳)
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action PMID 30555455
Pigment epithelium
A melanocortin 4
Cytotoxic activity, X
Spns2
Rps6ka5
Diaryl disulfides and thiosulfonates as combretastatin A
Cobra venom factor Structure, function, and humanization for therapeutic complement depletion PMID 20417224
Fluo
The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo PMID 21697455
(2S,3R,E)
Synthesis and SAR investigations for novel melanin
From inflammation to pyroptosis Understanding the consequences of cadmium exposure in chicken liver cells PMID 38290315
Rdm1
Nile Blue
Structural Optimization of Bicyclic Oxo
Pth1r
YAP induces high
嘌呤能受体 P2 Y，G 蛋白偶联 13（P2ry13）基因
Rationally designed dual inhibitors of HIV reverse transcriptase and integrase PMID 17608468
Iron dextran 9004
A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5
Naturally Occurring Cytotoxic [3'→8″]
Cellular effects of olomoucine, an inhibitor of cyclin
Hordenine improves Parkinsonian
Discovery of a novel GLP
Mycn
ADP 核糖基化因子 3（ARF3）基因
跨膜 4 L 六个家族成员 4（TM4SF4）基因
Inhibition of Src homology 2 domain
Aminoalkoxybenzyl pyrrolidines as novel human urotensin
BCL
Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus PMID 29807932
Cytotoxic derivatives of dichloroacetic acid and some metal complexes PMID 35986437
Discovery of MK
CRBN ligand
Antibody
Comparison of mannitol and methacholine to predict exercise
Chaetoglobosin A 50335
Pannexin 1 Channels Contribute to IL
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer PMID 37681484
Picoplatin 181630
5,6
Resilience and vulnerabilities of tumor cells under purine shortage stress PMID 40166329
CD157 蛋白, Human (HEK293, His)
AMHR2/MISRII 蛋白, Human (HEK293, Llama Fc)
Co
Host glycocalyx captures HIV proximal to the cell surface via oligomannose
CD4+ anti
Discovery of potent, selective chymase inhibitors via fragment linking strategies PMID 23659209
BG
Mechanisms of volatile organic compounds from bat cave environments against Pseudogymnoascus destructans in vitro PMID 41231001
Flavanone hydrazone 1692
Oral prodrug of remdesivir parent GS
Structure
Ethyl N
Identification and characterization of two P450 enzymes from Citrus sinensis involved in TMTT and DMNT biosyntheses and Asian citrus psyllid defense PMID 38617747
Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB
NMDA Receptor
D4 dopamine receptor
Nr2f6
Lead
PARP
CCR2 antagonist 6
CCDC57 Human Pre
Lef1
Machine learning
sulfo
Phosphoethanolamine N
hsa
永恒的昼夜节律调节器（TIMELESS）基因
Microporenic Acids A
Design, synthesis, and structure
FTO
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity PMID 1652464
MCE
Identifying a selective inhibitor of autophagy that targets ATG12
Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters PMID 16434549
MCE
MCE
Studies on the participation of different T cell subsets in rat liver allograft rejection. Comparison of liver with heart graft PMID 14621896
Velinotamig 2848586
Rauvotetraphylline E
CYP1B1 Mediates Cigarette Smoke
POU 2 类同源框 3（POU2F3）基因
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched PMID 10500113
Design and Application of Conjugatable Small Molecule Toll
Adrenotensin (human) TFA (Pro
Preclinical antitumor activity of SST0116CL1 a novel heat shock protein 90 inhibitor PMID 25096516
DE
含 splA/ryanodine 受体结构域和 SOCS 盒 2（SPSB2）基因
Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma PMID 34676038
软骨粘附素（CHAD）基因
维生素 D 受体（Vdr）基因
Mxd1
MCE
NH125 kills methicillin
Pop1
Potential roles of flavin
Synthesis of saframycins. I. Total synthesis (+/
A CD1d
Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep PMID 18297309
Ccnb2
Alamandine Rescues Cognitive Impairment and Ameliorates Alzheimer's Disease
Effect of clindamycin hydrochloride on oral malodor, plaque, calculus, and gingivitis in dogs with periodontitis PMID 19757560
Substituted 2
Syntheses of some polyunsaturated sulfur
(Rac)
Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic PMID 22718832
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO
Imipramine pamoate in depression PMID 1103212
MCE
Hydroxy
Inhibition of Nek2 by small molecules affects proteasome activity PMID 25313354
Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites PMID 18667785
Scopine as a novel brain
Sfxn3
Cryo
MCE
Discovery of a series of 6,7
Neuronal TCF7L2 in Lateral Habenula Is Involved in Stress
apelin受体（Aplnr）基因
Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial
The Anti
The scaffold protein DLG4 facilitates RNF63
Fas/CD95/Apo
In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta
Combining virtual screening with cis
RAGE/AP
N6
ATP 结合盒亚家族 D 成员 1（ABCD1）基因
Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse PMID 23631463
Functionalized nitrogen
Maturation of kisspeptinergic neurons coincides with puberty onset in male rats PMID 19944729
白细胞介素 2 受体亚基γ（IL2RG）基因
Hes6
Structure
5
Histone serotonylation regulates ependymoma tumorigenesis PMID 39085609
(R)
Angiotensin II receptors on human platelets PMID 6288286
Dependence on phosphoinositide 3
Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom PMID 1977212
Activity of Mannich bases of 7
In Vitro and In Vivo Validation of EP2
CRBN ligand
gingerdiol
PROTAC IRAK4 degrader
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function PMID 24766809
Discovery of novel structural imidazolylvinylquinolones exerting excellent broad
Z
The Bone Morphogenetic Protein Signaling Inhibitor LDN
The 5
Capn5
Antioxidant Ability and Stability Studies of 3
REV 5901 101910
3’
Ndufs2
Effect of cyclolinopeptides on the oxidative stability of flaxseed oil PMID 24313572
Influenza Therapeutics in Clinical Practice
GITR Protein, Rat (HEK293, Fc)
USP10 蛋白, Human (sf9)
Identifying PD
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma PMID 37904651
EGFR
In Vitro and In Vivo Activities of DS
直标一抗 (Conjugated Primary Antibodies)
Fbln2
NHPI
HHAT Human Pre
Tazarotene
Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins PMID 22311980
Synergistic antibacterial activity of curcumin and phage against multidrug
Discovery of MK
Bisphenol A
New insights in the development of positive allosteric modulators of α
Flavonolignans and other constituents from Lepidium meyenii with activities in anti
In vitro and in vivo activity of DQ
1,2
Potent action of RFamide
脱氢酶/还原酶 7B（DHRS7B）基因
Lrp6
CDK6
Synthesis, Characterization, and Biological Activity of Aminated Zymosan PMID 32656418
Rab31
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity PMID 17691783
E/Z
4ME 16 0 Diether DG
Indicaxanthin 2181
Analysis of beta
Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property PMID 35623141
MCE
Harmalan 525
Differences in backbone structure between angiotensin II agonists and type I antagonists PMID 7473593
Stafia
H3B
Cyclizine lactate 5897
Pyridoxamine
Short Link N Stimulates Intervertebral Disc Repair in a Novel Long
CRBN ligand
核受体结合蛋白 1（NRBP1）基因
β
Emodin suppresses adipogenesis of bone marrow derived mesenchymal stem cells from aplastic anemia via increasing TRIB3 expression PMID 38086146
mt
Dynorphin block of N
卵泡抑素样 3（FSTL3）基因
Ahsp
Antibiotic use in early life impairs MAIT cell
Electrosynthetic reduction of 1
Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle PMID 40543756
Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203 PMID 36142240
Scg5
Boc
Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension PMID 33660517
Nerve Growth Factor as an Ocular Therapy Applications, Challenges, and Future Directions PMID 33641595
Discovery and Development of a Small
METTL3 promotes colorectal carcinoma progression by regulating the m6A
Cell permeable Bcl
Nanog
Menin
The ApoA
Discovery and Characterization of a Hydroxypyridone
Hazelnutin F
Iapp
NBR1 自噬货物受体（NBR1）基因
Modulation of regulatory T
Benzoylgomisin P
Massonianoside B 188300
Insight into the reactive form of the anticancer agent iproplatin PMID 17707553
Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1 PMID 34767771
Synthesis and biological activity of open
FGFR2
Nephroprotective Efficacy of Sugammadex in Ischemia
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies PMID 36153841
RJPXD33 1613160
Atrazine
Cip2a
MCE
Antibacterial activity and beta
含 SPRY 结构域 4（SPRYD4）基因
Inhibition of CACNA1H can alleviate endoplasmic reticulum stress and reduce myocardial cell apoptosis caused by myocardial infarction PMID 33378039
FGL1
CDP
Cytidine 5′
An integrated in silico 3D model
SNF2L suppresses nascent DNA gap formation to promote DNA synthesis PMID 39413208
Nr5a1
FK 973
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell
Tumor
A small
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin
CRBN ligand
Evaluation of β
Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors PMID 20045222
Thiothixene hydrochloride 49746
Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During Sleep PMID 39119847
Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys evidence of uncharted dopamine D1 receptor actions PMID 11600103
Effect of synthetic progestogens and estradiol
Integrated analysis of FKBP1A/SLC3A2 axis in everolimus inducing ferroptosis of breast cancer and anti
Zfpm1
Antimalarial compounds from Rhaphidophora decursiva PMID 11421741
N
Olorofim 1928707
(S)
8
ALK1
BpV(phen) trihydrate 171202
Novel 1H
Adenosine receptor agonists inhibit K+
Identification of peptides that antagonize formyl peptide receptor
Molecular evolution of dihydrouridine synthases PMID 22741570
CRBN ligand
Human stresscopin and stresscopin
S100A9 protein activates microglia and stimulates phagocytosis, resulting in synaptic and neuronal loss PMID 39884585
Interleukin
Development of Peptide
Fumigant antifungal activity of Myrtaceae essential oils and constituents from Leptospermum petersonii against three Aspergillus species PMID 22945026
The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα PMID 37026450
Pappa
Hypotensive effect of bopindolol in pithed rats PMID 8097742
Rosuvastatin lactone
Antitumor benzothiazoles. 26.(1) 2
OSI
Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics PMID 32234489
Bile Acid
Manf
Eif4g1
Ultrasensitive and green electrochemical immunosensor for mycotoxin ochratoxin A based on phage displayed mimotope peptide PMID 30609625
A Novel Peptide Antibiotic Targeting Gram
The prevention of latanoprost on osteoclastgenesis in vitro and lipopolysaccharide
Enhancement of the Clastogenic Effects of Topotecan In Vivo by Tyrosyl
CRBN ligand
Two Small RNAs Conserved in Enterobacteriaceae Provide Intrinsic Resistance to Antibiotics Targeting the Cell Wall Biosynthesis Enzyme Glucosamine
Exploratory studies with NX
A potent synthetic peptide inhibitor of the cAMP
Smad9
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