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CDK8 ligand 1 2924557
Glutathione conjugates of 4
Discovery of a potent and selective human AC2 inhibitor based on 7
C53 A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti
Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways PMID 40075566
The TRPV4
Development of Ligands and Degraders Targeting MAGE
N
Pharmacological properties of thiazolinobutazone (LAS 11 871). III. General pharmacology, ulcerogenic effects and acute toxicity PMID 1036923
抗苗勒管激素 2 型受体（Amhr2）基因
PARP1
MCE
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats PMID 2854247
The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene PMID 22649303
Mvd
Superinfection with intact HIV
Free fatty acids derived from lipophagy enhanced resistance to anoikis by activating Src in high
Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use PMID 3512234
BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway PMID 22906008
Unveiling hepatic Krüppel
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection PMID 40010342
Structure
Fbxl5
ZT
Srsf3
UHRF1
Genome
Discovery of novel 1,2,4
Inhibition of excitatory neuronal cell death by cell
STAT5A is epigenetically silenced by the tyrosine kinase NPM1
Small
Inhibition of cyclin
DMT
Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2 PMID 10561509
Anatomical distribution of prolactin
Cacna1a
Obesity subtypes, related biomarkers & heterogeneity PMID 32134010
Ribosome
SP140 核体蛋白样（SP140L）基因
MCE
Pivampicillin 33817
Ro 24
Angiotensin
Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications PMID 9608431
HER2/CD340 蛋白, Human (Biotinylated, HEK293, Fc)
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria PMID 24900364
Kelch 样 ECH 相关蛋白 1（Keap1）基因
INTS6 Human Pre
Osbpl7
SPECT imaging with the D(4) receptor antagonist L
Impact of prenatal Di(2
MCE
In vitro and in vivo comparison of two non
Dual
Muc6
筐条菝葜提取物 (Smilax corbulariaKunth)
真核翻译起始因子 4 伽玛 3（EIF4G3）基因
Ultrasound assisted one
Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium PMID 28648491
GNF
2,2
Metallodrug ranitidine bismuth citrate suppresses SARS
2
Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence PMID 39178863
Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains PMID 25870060
MCE
Biomedical Applications of Biosynthesized Nickel Oxide Nanoparticles PMID 37534055
Antineoplastic and antiviral activities of some cyclolignans PMID 8391145
In vitro catabolism of histidine by mixed rumen bacteria and protozoa PMID 11116390
mmu
Rauvotetraphylline D
CRBN ligand
Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction PMID 10036138
Grepafloxacin hydrochloride 161967
Discovery of the novel Benzo[b]thiophene 1,1
EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection PMID 41354653
IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD
Inhibition of acyl
SB
m6A
Activation of Peroxisome Proliferator
Cortistatin exerts antiproliferation and antimigration effects in vascular smooth muscle cells stimulated by Ang II through suppressing ERK1/2, p38 MAPK, JNK and ERK5 signaling pathways PMID 31807542
核糖体蛋白 S6 激酶多肽 6（Rps6ka6）基因
Discovery of Efficient Hypoxia
In vitro cultivation of human islets from expanded ductal tissue PMID 10884429
Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment
CRBN ligand
Imaging of effector memory T cells during a delayed
Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse PMID 15890550
Benzene
核受体亚家族 1 ，H 组，成员 4（Nr1h4）基因
Multifunctional Abl kinases in health and disease PMID 26729027
Peptidomimetic inhibitors of APC
Carcinogenic action of elaiomycin in rats PMID 5766647
CRBN ligand
Eif4a3
IP6C
Plumericin
Premetastatic Niche Mimicking Bone
Pth
A Bifunctional Noncanonical Amino Acid Synthesis, Expression, and Residue
CGP 52608
B5 Medium (B5培养基)
STK32C promotes colon tumor progression through activating c
Anticancer agent 294
CRBN ligand
Dual effects of spinally delivered 8
cerberus 1，DAN 家族 BMP 拮抗因子（CER1）基因
7
PRX
Gylongiposide I 206876
Anticancer agent 301
Microtubule/Tubulin
Allele
Salvianolic acid B exerts anti
BMS
Vopimetostat 2760483
HypoxyStat, a small
In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993
GPR40 agonist 9
Design of photoactivatable methylene blue
Jinflexin A
Tumor
Mef2d
UK 14819 (5
无名指蛋白 183（RNF183）基因
MRS 5980
EP2 receptor agonist 2
Validation of the epigenetic reader bromodomain
FIIN
Novel antileukemic compound with sub
TLX agonist 3
RhlR agonist
HR1
EZH1
横纹肌富集蛋白激酶（SPEG）基因
Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity PMID 39787362
MCE
A Novel Scalarized Scaffold Hopping Algorithm with Graph
UCM 549
PSB
LC
Comprehensive high
Chebulinic acid and Boeravinone B act as anti
Methyltransferase
Chalepensin 13164
Cd72
FXR agonist 16
DMT
FGF8 induces therapy resistance in neoadjuvantly radiated rectal cancer PMID 30276721
刺猬酰基转移酶（HHAT）基因
Cpd
NOD2 agonist 1
Long
DNA 聚合酶 γ 2，辅助亚基（POLG2）基因
Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions PMID 2260127
Discovery of N
Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives PMID 27406794
Comparative studies of AJG049, a novel Ca2+ channel antagonist, on voltage
Wnt 家族成员 4（WNT4）基因
PROTAC EZH2 Degrader
CHF6001 Inhibits NF
Evidence for involvement of neuropeptide Y receptors in the regulation of food intake studies with Y1
d
RO2959 hydrochloride 1219927
Effects of behaviorally active ACTH (4
溶质载体家族 2 成员 1（Slc2a1）基因
MCE
Human Growth Hormone Fragment 176
HY
Ebola virus Glycoprotein/GP
Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo PMID 26648540
Antitumor activity of julimycin B
Rolafagrel (FCE 22178)
MCE
Peptide B, bovine 87713
Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys PMID 16571967
Srebf2
FXR agonist 15
Y4R agonist
Resveratrol, 4' Acetoxy Resveratrol, R
Parbendazole
TRAF2 mediates Wnt
LS
84292
Rational Design of Bioorthogonally Activatable PROTAC for Tumor
Synthesis of new non
8
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion PMID 33729773
Structural Characterization of Diazabicyclooctane β
CRBN ligand
Structure
Mincle agonist 1
CRBN ligand
5
Discovery and Characterization of a Eukaryotic Initiation Factor 4A
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2
3,4
(S)
Development of a selective small
Modulating the selectivity of matriptase
Smc4
Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission PMID 19962870
Metap2
FXR agonist 14
Mebarase alfa 2408855
Minecoside 51005
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus PMID 29891595
Fgf9
Optimization of First
Discovery of peptide inhibitors targeting human programmed death 1 (PD
Ano1
YM116, 2
Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity PMID 2106503
Pml
Antitrypanosomal activities of tryptanthrins PMID 11850279
Kentsin tetrapeptide from hamster embryos produces naloxone
Efficacy and Safety of Encaleret in Autosomal Dominant Hypocalcemia Type 1 PMID 37754292
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse PMID 12409010
Inhibition of PRMT5 attenuates cerebral ischemia/reperfusion
CBX7 promotes choroidal neovascularization by activating the HIF
Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL
Human full
HY
Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling PMID 39802513
Finafloxacin first global approval PMID 25808831
Map3k6
Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery PREVENT IV a randomized controlled trial PMID 16287955
Z
Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine
GPR17 agonist 1
Lycium barbarum glycopeptide reduces inflammation and fibrosis in corneal injury by modulating the NF
hAChE
Laquinimod attenuates oxidative stress
New phenylpropenoids, bis(1
Nkrf
New series of antiprion compounds pyrazolone derivatives have the potent activity of inhibiting protease
RPS6
Silicon dioxide particles induce DNA oxidative damage activating the AIM2
Ceritinib inhibits growth and ACTH production of PitNETs Insights from patient
CRBN ligand
Trimegestone expanding therapeutic choices for the treatment of the menopause PMID 11772282
AC
Bis
Thymidine phosphorylase 9030
Maltose
Redaporfin 1224104
Rassf5
含三方基序 13（TRIM13）基因
核转运蛋白亚基 alpha 4（KPNA4）基因
Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5
IL
Early administration of the glucose
Inhibition of GPR40 protects MIN6 β cells from palmitate
Identification of a Potent CDK8 Inhibitor Using Structure
Broxaterol (Z 1170)
ONO
Xanthine oxidase inhibitors from the heartwood of Vietnamese Caesalpinia sappan PMID 16079532
Mast cell death induced by 24(S),25
Cynanoside J 1800029
CRBN ligand
Discovery of a Small
ATP 合酶外周茎膜亚基 b（ATP5PB）基因
Combination of two novel blocking antibodies, anti
INHIBITION OF TYROSINE HYDROXYLASE BY 3
The farnesyltransferase inhibitor FTI
Tuning caged calcium photolabile analogues of EGTA with improved optical and chelation properties PMID 16303177
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment PMID 31259550
Josd2
Butaverine
rel
Asenapine a novel psychopharmacologic agent with a unique human receptor signature PMID 18308814
CRBN ligand
Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis PMID 36577213
A novel PI3K inhibitor PIK
Jdp2
DRGN
MCE
Accumulation of molybdenum in major organs following repeated oral administration of bis
Nlrc4
Murine Cytomegalovirus Disrupts Splenic Dendritic Cell Subsets via Type I Interferon
Abemaciclib impurity 1
核糖核酸酶 A 家族成员 3（RNASE3）基因
Discovery of 3
In vitro resistance development for RO
STAT3
Excessive hydrogen sulfide causes lung and brain tissue damage by promoting PARP1/Bax and C9 and inhibiting LAMB1 PMID 35119561
Raspberry Extract
PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer PMID 37813837
Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons PMID 8666034
Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation PMID 7575433
[(3)H]PNU
Synthesis and biological evaluations of 3
Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity
PROTAC EZH2 Degrader
Mvp
LL
Caffeoyltartaric acid
Thbs3
Molecular tumor targeting of gelonin by fusion with F3 peptide PMID 28414205
Mal
Targeting interferons in systemic lupus erythematosus current and future prospects PMID 25940912
Molecular mechanisms for large conductance Ca2+
MCE
Lipe
TIAM Rac1 相关 GEF 1（TIAM1）基因
Cell
Intra
Nrf2 (69
Colistin B sulfate (Polymyxin E2 sulfate)
Bixalomer, a novel phosphate binder with a small swelling index, improves hyperphosphatemia in chronic kidney disease rat PMID 26452517
EYA 转录共激活因子和磷酸酶 2（EYA2）基因
Epsiprantel (BRL
Secondary metabolites from the roots of Neolitsea daibuensis and their anti
Dose
Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age
Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6) PMID 29752182
Preclinical characterization of INCB053914, a novel pan
Fomecin A
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK
Discovery of Small
4
胱硫醚β
AI
CV
Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models PMID 17510422
Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animal models PMID 15328250
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism modulation at the N
Acyclovir
PD
Discovery of 2
Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos PMID 811164
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity
Dimecrotic acid
PAT1inh
3'
Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva
decrease mitochondrial membrane potential
The Werner syndrome protein is a DNA helicase PMID 9288107
NRMA
Fortunellin 20633
Eif5a2
MCE
Daidzein
Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy PMID 32813878
Grpr
Highly Potent, Selective, and Orally Bioavailable 4
Base Addition Sequencing Scheme
MCE
CRBN ligand
2
Amh
Engineering Hierarchically Grooved Structures for Enhancing Interfacial Solar Thermal Water Purification PMID 39999438
2
An MDM2 degrader shows potent cytotoxicity to MDM2
轴蛋白相互作用，背化相关（AIDA）基因
3
Loss of the proapoptotic BH3
The selective depigmenting action of 8
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non
First
Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin
CRBN ligand
Pep63 1781242
Regulation of the innate and adaptive immune responses by Stat
淋巴细胞胞质蛋白 1（LCP1）基因
Melatonin
Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation
Interaction of new, very potent non
New prostaglandin derivative for glaucoma treatment PMID 19233645
Efficacy of oral E1210, a new broad
Rivaroxaban impurity 7 (Standard)
酰基辅酶 A 脱氢酶短链（ACADS）基因
Tst
Discovery of benzo[d]oxazol
activator
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia genome
CFP10 (71–85) 646997
FTIR spectroscopy study of PTHrP(1
A 5‑lipoxygenase
A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth PMID 23322205
P
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract PMID 20307554
Novel analogs of D
AYK004
Evaluation of an in vitro parathyroid hormone antagonist in vivo in dogs PMID 2982567
Differences in left
腺苷酸激酶 9（AK9）基因
MCE
MCE
Foxo4
CRBN ligand
Effects of a leukotriene D4 receptor antagonist, L
T808 1320211
BAM
Huwe1
Characterization of the binding of [(125)I]
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites PMID 25547934
Rpa3
Green/red dual fluorescence detection of total protein and alkaline phosphate
DBCO
A selective metabotropic glutamate receptor 7 agonist activation of receptor signaling via an allosteric site modulates stress parameters in vivo PMID 16339898
Potent inhibition of checkpoint kinase activity by a hymenialdisine
The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells PMID 10933686
Design, synthesis and biological evaluation of novel zanamivir derivatives as potent neuraminidase inhibitors PMID 30389293
N
Synthesis and identification of a novel selective USP7 degrader that inhibits the migration of upper gastrointestinal cancer cells without affecting proliferation PMID 41418743
9
成纤维细胞生长因子 22 (FGF
Discovery of APS03118, a Potent and Selective Next
Endoplasmic reticulum
Participation of epoxygenase activation in saikogenin D
AZ
Neutrophil NADPH
Asenapine, a novel psychopharmacologic agent preclinical evidence for clinical effects in schizophrenia PMID 17940749
Essential fatty acids are antagonists of the leukotriene B4 receptor PMID 7630916
Ramp1
PEG4
MrgprX2
Cytoprotection of pyruvic acid and reduced beta
The Definition of Open Reading Frame Revisited PMID 29366605
BAY 12
Discovery of new pyridine
Remifentanil
线粒体编码的细胞色素 c 氧化酶 II（MT
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells PMID 25210320
G 蛋白偶联受体 83（GPR83）基因
MCE
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans PMID 27721479
Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease PMID 37652099
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling PMID 19759537
Molecular dynamics simulations of pro
Use of fluorescein
The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine
Decursin a cytotoxic agent and protein kinase C activator from the root of Angelica gigas PMID 8720379
CRBN ligand
Mimicry of a Non
Neoechinulin A suppresses amyloid
2'
The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention from phytochemistry to pharmacology PMID 28634392
CV
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia PMID 26602277
In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates PMID 3486628
Phase I trial of Perrimustine, a new cysteamine (2
CRBN ligand
Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS
Cd72 Mouse Pre
f
Pharmacokinetic of sulfaclozine in broiler chickens PMID 19887098
Cnidioside B methyl ester
Nuciferine suppresses adipogenesis and mitochondrial function in brown adipocytes PMID 41319924
Protective Role of mPGES
The subcortical maternal complex safeguards mouse oocyte
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast
Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve PMID 203356
MCE
Anti
Identification of a broad
Pharmacological profile of TP
Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti
Identification of benzothiazinones containing 2
VHL Ligand 39 2876809
ACLP promotes activation of cancer
Mepe
Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy PMID 28427561
Pharmacological evidence of the stimulation of central alpha
Symmetrical bis(heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis PMID 10966751
Anti
Soat2
Pltp
IDO1 Human Pre
Scyliorhinin I 103425
Cellular metabolism of 3'
Crem
PC SPDP
Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses PMID 7325642
Discovery of novel imidazo[1,2
Discovery of MDM2
BMS
Non
B
Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P the naked mole
The HIV
Conformationally constrained farnesoid X receptor (FXR) agonists alternative replacements of the stilbene PMID 21890356
Ets1
CRBN ligand
beta
Genameside A 872515
Fertirelin 38234
Two field strains of Haemonchus contortus resistant to rafoxanide PMID 3306550
ICI 185282
Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'
A neural circuit for sex
Hesperetin
Dehydrodiconiferyl alcohol promotes BMP
Dehydrojuncuenins A
抗苗勒管激素受体 2 型（AMHR2）基因
Carumonam 87638
Discovery of Thiadiazoleamide Derivatives as Potent, Selective, and Orally Available Antagonists Disrupting Androgen Receptor Homodimer PMID 39340456
Neuropeptide Y family
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