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Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β
Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer's Disease Therapy PMID 39995296
Alprenolol hydrochloride 13707
LacZ β
2
Madecassoside ameliorates bleomycin
Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism PMID 26625251
Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7 PMID 28017662
Comparative antibacterial activities of temafloxacin hydrochloride (A
C
Fumarate suppresses B
Synergistic Effects of Kartogenin and Transforming Growth Factor
Evaluation of selective gamma
Epac
Rragd Rat Pre
DMT
Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine
Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII
AF9/ENL
Triadimefon and triadimenol effects on monoamine uptake and release PMID 8806838
Velusetrag (Standard)
CYD
Fluorescent labeling of signal
TCB2 (Standard)
Muramyl dipeptide
Glycerol phenylbutyrate (HPN
锌指 DHHC 型棕榈酰转移酶 5（ZDHHC5）基因
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation PMID 20832749
Endothelin
Discovery of a C
Vasorin 蛋白, Human (552a.a, HEK293, His)
A novel immunofluorescence detection method for renal cell
Antioxidative and Angiogenesis
Effect of pinaverium bromide on stress
Protective effect of ibuprofen in a rat model of chronic oxaliplatin
Activity of Fenticonazole, Tioconazole and Nystatin on New World Leishmania Species PMID 30569856
HIV
A randomized, placebo
A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification PMID 40747425
Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non
Glutamine transporter inhibitor enhances the sensitivity of NSCLC to trametinib through GSDME
2
Study of the anti
4
Elesclomol induces cancer cell apoptosis through oxidative stress PMID 18723479
Vindoline mitigates cisplatin
7
Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers PMID 31398598
Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation cannabinoid and non
SB204144
Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2
TGF
Chemoproteomics of Marine Natural Product Naamidine J Unveils CSE1L as a Therapeutic Target in Acute Lung Injury PMID 39324953
Targeting CSF1R in myeloid
Etazolate, an α
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3 PMID 35594990
1,2
(S)
IL1R1 Human Pre
4
BP Light 650 carboxylic acid 1638197
CPI
Rezivertinib analogue 1 2227103
Highly efficient antitumor agents of heterocycles containing sulfur atom linear and angular thiazonaphthalimides against human lung cancer cell in vitro PMID 17707644
N
Oxaloacetate decarboxylase (草酰乙酸脱羧酶)
Amyloid precursor protein trafficking, processing, and function PMID 18650430
NKP608 177707
salvage pathway
1,4
m
NF
PRKD3 Human Pre
DB0614
IGSF9 promotes tumor invasion and metastasis through GSK
Imeglimin suppresses glucagon secretion and induces a loss of α cell identity PMID 40713970
Actithiazic acid 539
GLX
()
Identification of the binding sites and selectivity of sarpogrelate, a novel 5
Tolterodine does not affect memory assessed by passive
Mitemcinal 154738
Zidovudine and Lamivudine as Potential Agents to Combat HIV
HIV
Choline salicylate an effective, well
Retinoic acid
Discovery of a clinical candidate from the structurally unique dioxa
Euxanthone 529
Effects of phoxim exposure on gut microbial composition in the silkworm, Bombyx mori PMID 31796255
Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen
PAR1
Semaxinib 204005
Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury PMID 9651211
Shikonin inhibits epithelial
MRE11 p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC PMID 37759323
Leptin 抗体（Leptin Antibody）
Thrombin receptors
Role of lipid peroxidation derived 4
Difethialone
Identification and SAR exploration of a novel series of Legumain inhibitors PMID 31005445
T
Carnitine functions as an enhancer of NRF2 to inhibit osteoclastogenesis via regulating macrophage polarization in osteoporosis PMID 38246515
Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence PMID 40631164
Neuronal paxillin and drebrin mediate BDNF
Phthalic acid induces oxidative stress and alters the activity of some antioxidant enzymes in roots of Malus prunifolia PMID 19352774
(±)11(12)
DecRVKRcmk
GZMA Human Pre
Cstf2
Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells PMID 36484282
SCH 14342
The orally available spleen tyrosine kinase inhibitor 2
Defb1 Rat Pre
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo PMID 32788207
Bone Gla Protein (45
Tetrabenazine impurity 3
The anti
2
MCE
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos PMID 33094525
Lurasidone metabolite 14326
NOXA2 抗体 (YA1649)（NOXA2 Antibody (YA1649)）
4,4'
CYP3A7 Human Pre
Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors treprostinil is a potent DP1 and EP2 agonist PMID 22480736
DDT 蛋白, Human (His)
Sucrose 6′
Benzaldehyde Semicarbazone
One new bufadienolide from Chinese drug Chan'Su PMID 18335338
4,4'
2'
Livagen
Notch 1 2408730
(Rac)
Chiglitazar sodium 2390374
1,2,4
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist PMID 15555631
GW0791 503620
GLP
Alcohol dehydrogenase 1 is a tubular mitophagy
2'
Dner Mouse Pre
Z
Violet leaf aldehyde
4
UiO66
Unimolecular, Bimolecular, and Intramolecular Hydrolysis Mechanisms of 4
Bromopride stimulates 5
NS 181
Pks13
Garcinia xanthones as orally active antitumor agents PMID 23167526
1,4
A novel P2X4 receptor
Plantamajoside suppresses the activation of NF
1
Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives PMID 24873648
Propacetamol hydrochloride 66532
Surface avidity of anionic polypeptide coatings target nanoparticles to cancer
Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol, and restricted food intake PMID 9262512
Ly86
[The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)] PMID 22562275
11
Discerning the antioxidant mechanism of rapanone A naturally occurring benzoquinone with iron complexing and radical scavenging activities PMID 28237732
MiR
Guanosine
Single
9
Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL
Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1
2’
XY25028
Evaluation of the inactivation effect of Triton X
The Discovery and Characterization of K
Five
Cinacalcet metabolite M4 104774
Structure and conformational dynamics of trichothecene mycotoxins PMID 18327910
PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western
Sec18 D2 domain
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP
Upregulation of A20 and TAX1BP1 contributes to the anti
Boc
Tifa Mouse Pre
Sensory nerves drive migration of dental pulp stem cells via the CGRP
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis PMID 40346800
Enhancement of an outwardly rectifying chloride channel in hippocampal pyramidal neurons after cerebral ischemia PMID 27181516
Replication stress induces POLQ
Ca2+ influx through L
Psmb9 Rat Pre
Fetuin A 抗体 (YA2824)（Fetuin A Antibody (YA2824)）
Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK
LY
Synthesis and serotonin transporter activity of sulphur
HMGN3 蛋白, Human (His)
Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro
2
β cells
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia PMID 34027661
Small Molecule Activation of NAPE
Stimulating the autophagic
FMR1 mutant marmosets show fragile X syndrome phenotypes PMID 40912249
ETM
Toward self
Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains PMID 36271678
Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS
FLI1 抗体 (YA5647)（FLI1 Antibody (YA5647)）
Tumor
Anti
Effects of guaifenesin, N
Identification and structure
Anti
Inhibition of IgE
mitochondrial protein
NLCQ 1
Red ginseng extracts ameliorate high
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia PMID 36306790
Metformin reduces liver glucose production by inhibition of fructose
Naxe Mouse Pre
BI 3802
Alkaline phosphatase an overview PMID 24966474
Il21r
Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC
GLPG2737
Neuroinflammation is induced by tongue
Flazin as a Lipid Droplet Regulator against Lipid Disorders PMID 35406114
3,3'
Epigenetic modulation of odontoblast differentiation implications for regenerative endodontics PMID 40669605
Saikosaponin D ameliorates sepsis
Paxillin mediates lung epithelial injury by activating NLRP3 inflammasomes in an acute respiratory distress syndrome mouse model PMID 41265698
Maternal exposure to PM2.5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS
Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo PMID 39307045
feral rye
2
Contrasting effects of SM
Hspb2
L
hsa
Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival PMID 39523354
CD38 reduces mitochondrial fitness and cytotoxic T cell response against viral infection in lupus patients by suppressing mitophagy PMID 35704572
hsa
Discovery of selective NaV1.8 inhibitors based on 5
The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down
PRMT6 抗体 (YA5152)（PRMT6 Antibody (YA5152)）
rno
IW
hsa
LUF5981 929641
Virtual combinatorial syntheses and computational screening of new potential anti
Isoliquiritigenin alleviates P. gingivalis
mmu
Roflumilast
Lectin
KDM5B promotes self
In Vitro Evaluation of the Effects of Tylosin on the Composition and Metabolism of Canine Fecal Microbiota PMID 31936221
The antimicrobial peptide chensinin
Claudin
Gnao1
CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer PMID 22197219
Pivmecillinam hydrochloride 32887
Tyrosinase inhibitors of Pulsatilla cernua root
hsa
hsa
Retn
AZD 6482 1173900
Tubeimoside I
MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation PMID 24359300
hsa
计算机反向找靶
HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators PMID 34179640
The role of MOTS
Synthesis and antiproliferative activity of podocarpane and totarane derivatives PMID 30248657
Tox3 Mouse Pre
Apoptosis
Effects of zinc gluconate and 2 other divalent cationic compounds on olfactory function in mice PMID 22330252
Mordant Blue 13 1058
Screening for Hepatitis B Serology Markers Interpretation PMID 30136615
HY
The effects of fasudil on the permeability of the rat blood
TrxR inhibitor D9 1527513
Prohormone cleavage prediction uncovers a non
Gender difference in the pharmacokinetics and metabolism of VX
DPEP2 蛋白, Human (HEK293, His)
Chlorfenapyr a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors PMID 21266037
GATA4
Identification of O
SNX
Hypoglycaemic effect of Momordica charantia extracts in normoglycaemic or cyproheptadine
NA/Neuraminidase 蛋白, H4N6 (ABI47998, sf9, His)
The Anti
Calmodulin
Salidroside improves bovine embryo quality by mitigating oxidative stress and regulating mitochondrial lipid metabolism PMID 40652734
Cyproheptadine inhibits in vitro and in vivo lung metastasis and drives metabolic rewiring PMID 39522095
Preschisanartanin O 1457972
Synthesis of Novel 3,5
The activated transforming growth factor
Matrix stiffness modulates ILK
Propiconazole
Toxicological evaluation of two novel bitter modifying flavour compounds 3
Polytonic drug release via multi
Rbbp7
Induction of heat shock protein 27 by bicyclol attenuates d
Establishment and characterization of a new Chinese hepatocellular carcinoma cell line, Hep
Construction of Escherichia coli Whole
Poor penetration of cefcapene into aqueous humor after oral administration of cefcapene pivoxil to patients undergoing cataract surgery PMID 31481306
Carbonic anhydrase inhibitors E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor
Identification of fumarate hydratase inhibitors with nutrient
Hepatitis B Virus X Protein Induces Reactive Oxygen Species Generation via Activation of p53 in Human Hepatoma Cells PMID 39456134
MCE
Behavioral profile of raclopride in agonistic encounters between male mice PMID 7911581
USP8 inhibitor
N
4,4& 039;
Emerging role of lipid droplets in obscure puffer immune response against Vibrio harveyi PMID 40417253
Tenascin
Selective Macrocyclic Inhibitors of DYRK1A/B PMID 35450378
Integrative bioinformatics and proteomics
High
CD200R1L 蛋白, Human (HEK293, His)
Neamine inhibits growth of pancreatic cancer cells in vitro and in vivo PMID 26838745
Tumour cell
Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO
CNB
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects PMID 9671775
5
anti
CD1D 蛋白, Human (His
FEN1 抗体 (YA765)（FEN1 Antibody (YA765)）
ventricular myocytes<br>
Fmoc
Naltrexone/bupropion an investigational combination for weight loss and maintenance PMID 22249001
MCE
Sengosterone 22799
(E)
Palmitoylcholine chloride 2932
PI3kδ inhibitor 1
Aldehyde
Efficacy of topical cobalt chelate CTC
Rubrisandrins A and B, lignans and related anti
B
Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice PMID 36996967
Dendritic Cell Maturation Regulates TSPAN7 Function in HIV
18 0,22 6 PS sodium 474943
Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP
Corylifolin
Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus PMID 32599753
Bivalirudin TFA 1191386
17β
4,4'
(±)13,14
Tyrosine decarboxylase, Microorganism (TDC，酪氨酸脱羧酶，来源于微生物)
Cobicistat, a pharmacoenhancer for HIV treatments PMID 23616950
Roxadustat
Fmoc
Kahweol 6894
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2 PMID 8529658
DU
N
Boc
PP1MG 蛋白, Human (His)
D
5
Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo PMID 31814910
PG490
PDK1
L
Manipulation of Mitophagy by All
CM
VPM peptide 1428885
Total synthesis and biological activities of (+)
Tcf4
Acetyl tetrapeptide
Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum PMID 6090026
DNA damage checkpoints in mammals PMID 16314342
Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)
(2S,4R)
MDP
Macrocyclic Inhibitors of HGF
Selective cytotoxicity of ginkgetin from Selaginella moellendorffii PMID 9134745
Schwann cell
Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptosis inducers PMID 28463785
2
Control of ventricular fibrillation during induced hypothermia in cats after differential depletion of cardiac catecholamine stores with prenylamine (Segontin) PMID 6028854
LT
Di
PD
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non
Receptor specificity and trigemino
M
VU0152099 612514
Emixustat 1141777
endo
HX
Single
Isolation and identification of an antioxidant flavonoid compound from citrus
5,6
SP1
Azido
[Des
Melamine/BSA
Nme2 Rat Pre
Azeloprazole 955095
λ
TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis PMID 25338756
Hypocrellin B
Wwtr1
CBS
Candidalysin discovery and function in Candida albicans infections PMID 31288097
CYD
CDCP1 Human Pre
溶质载体家族 26 成员 1（SLC26A1）基因
Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan PMID 39327392
Selective export of autotaxin from the endoplasmic reticulum PMID 28298439
4
XC 基序趋化因子配体 1（XCL1）基因
PKA
(R)
Catalytically Active Metal
Antifungal agent 158 27593
Kemptide, 5
Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis PMID 34126456
Antimicrobial agent
IL
Ntf4 Rat Pre
64Cu Radiolabeled PDGFRβ
Pefloxacin impurity 1 (Pefloxacin impurity B)
4'
Nifurpipone 24632
Oxaloacetate decarboxylase 9024
A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple
DB
A novel N
Coroxon 321
KWR095 3057980
Probe Report for NOX1 Inhibitors PMID 21433358
Diplomorphanin A 1559076
Fmoc
Lenalidomide improvement of cisplatin antitumor efficacy on triple
4
Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist
Three new diterpenoid alkaloids from the roots of Aconitum duclouxii PMID 24498916
NLGN1
Cellular protection of morin against the oxidative stress induced by hydrogen peroxide PMID 18793623
7
Extracellular vesicles isolated from curcumin
Dodecyl gallate 1166
Inhibition of the transmembrane transporter ABCB1 overcomes resistance to doxorubicin in patient
A Novel Sulfonated Derivative of β
DNAAF6
4
Sucrose 6′
AQP4
Cedirogant 2055496
Involvement of peroxisome proliferator
Benzaldehyde Semicarbazone
Exenatide improves hypogonadism and attenuates inflammation in diabetic mice by modulating gut microbiota PMID 37210914
Antitumor Activity of Amivantamab (JNJ
Discovery of the first selective, small
Functional defect of variants in the adenosine triphosphate
Sat1 Rat Pre
Intracranial injection of recombinant stromal
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk
4′
L
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors PMID 25609585
Targeting USP11 counteracts SFTPCI73T
DNSAH
Pharmacokinetics and pharmacodynamics of intravenous inotropic agents PMID 14871156
INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti
SAR125844 1116743
REF1 peptide 1198397
(±)
Diterpenoids from the Whole Plants of Ajuga nipponensis and Their Inhibition of RANKL
Bis(pyridin
4,4′
Cinanserin reduces plasma extravasation after burn plasma transfer in rats PMID 23523219
The LXR
Lycorine hydrochloride inhibits metastatic melanoma cell
Phenol, potassium salt (4 1) 5233
ST6GAL1 蛋白, Mouse (HEK293, His)
Preclinical efficacy and safety pharmacology of SUN
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients a double blinded placebo controlled randomized study PMID 34923903
In Situ Formation of Fibronectin
NSC
MiR
STAT2 蛋白, Human (sf9, GST)
TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation PMID 23680150
18 1 Glutaryl PE monosodium 111516
Dual centrifugation as a novel and efficient method for the preparation of lipodisks PMID 38350501
(R)
1,25
Friedelin inhibits the growth and metastasis of human leukemia cells via modulation of MEK/ERK and PI3K/AKT signalling pathways PMID 32862609
Ppm1e Mouse Pre
Loviride 147362
CircP50 functions through the phosphorylation
Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF
Saikosaponin D suppresses esophageal squamous cell carcinoma via the PI3K
Insect repellent M 3535 52304
Satralizumab, Novel Interleukine
K
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