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Inhibition of integrin receptors reduces extracellular matrix levels, ameliorating benign prostate hyperplasia PMID 37659484
Benzo(h)quinoline derivatives as G
Eurocidin D 130433
HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors PMID 35278779
(+)
Novel expression of CD11b in epithelial ovarian cancer Potential therapeutic target PMID 29329880
UAB
Ligand
Activation of G
Itpkb Mouse Pre
Trimethylammonium chloride
LM
Sceletium strictum提取物 (Sceletium strictum)
GSH Tracker Probe 1888323
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents PMID 26396686
Monaspin B 2897653
5
5α
BMS
Ndufa9 Mouse Pre
A putative role for ALDH inhibitors and chemoprevention of BRCA
Effects of Chitosan on Drug Load and Release for Cisplatin
Bamzireotide navoxetan 2641216
FANK1 Human Pre
Trimethylammonium chloride
Subelliptenone G 162473
Antifungal agent 105 3038220
EV
MASTL
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 PMID 35613620
Antibacterial agent 45 1426572
PROTAC CBP/p300/BRD4 Degrader
Crocin II
Parvifolixanthone B
GSK3368715 dihydrochloride 1628925
Aspergillus nomius
kairomone
WZ4002 1213269
Ac
Mutanolysin
Desertomycin
Merotocin 1190083
NDUFA9 Human Pre
(R,R)
Glidobactin G 119259
GSTO1
Mitochondrial Energy
osteomyelitis
YYSW001
WFS1 Human Pre
NAPA (Standard)
Longanlactone 1438721
ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside PMID 10079051
ACAT2
PTC124 (Standard)
SBP
hsa
Neomangiferin
PTC
βTC6 cells
Rps5 Rat Pre
Bismuth(III) nitrate pentahydrate, ACS, 98% 10035
Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO
KCC009
WT161
8
Cornoside
Protective Effect of Piceatannol Against Acute Lung Injury Through Protecting the Integrity of Air
TEAD ligand 5 2417720
F
Effects of malotilate on alcoholic liver injury in rats PMID 3067613
COR628 550310
CD11b
The effects of pterostilbene on neutrophil activity in experimental model of arthritis PMID 24195064
MitoQ alleviates H2O2
S1024
6
G2/M arrest
Pindolol
FGF8 protects against polymicrobial sepsis by enhancing the host's anti
Twist2 Reduced NLRP3
Analysis of miRNA expression profiles in exosomes of SMB
Effect of resveratrol on skeletal slow
Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent
Huntingtin interacting proteins are genetic modifiers of neurodegeneration PMID 17500595
TNKS
Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer PMID 30053783
Effects and mechanism of perinatal nonylphenol exposure on cardiac function and myocardial mitochondria in neonatal rats PMID 37146387
WT
(S)
Resveratrol regulates Thoc5 to improve maternal immune activation
Galangin Improved Non
HDAC
Neolancerin 117221
Resveratrol Attenuates Meningitic Escherichia coli
Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2
Effect of resveratrol on the biofilm formation and physiological properties of avian pathogenic Escherichia coli PMID 34450330
NKCC
Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice PMID 38813717
Assessment of cytotoxic and genotoxic effects of enniatin
Resveratrol Inhibits Colorectal Cancer Cell Tumor Property by Activating the miR
Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol PMID 38488303
Eif5
Estrogenic tamoxifen derivatives categorization of intrinsic estrogenicity in MCF
Retinyl palmitate
MeDZ lipid
内硫素α（ENSA）基因
Werner syndrome RecQ helicase
Exosomes from human adipose
lncRNA Gm16410 Mediates PM2.5
Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS
Chimeric proteins tagged with specific 3xHA cassettes may present instability and functional problems PMID 28800621
Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3 PMID 26078354
Cancer
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma PMID 30842654
Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic PMID 26832790
Estrogen induces apoptosis in estrogen deprivation
Zeniplatin in advanced malignant melanoma and renal cancer phase II studies with unexpected nephrotoxicity PMID 9272122
human NAMPT
Acute human self
1,3
Nirsevimab 1989556
Design, synthesis and biological evaluation of novel fluoroquinolone
S
plant
Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice PMID 23291365
VIPR2
Cardiac and skeletal muscle delivery of biotherapeutics with a blood vessel epicardial substance
Trimovate
MiR
Inhibition of the p62
N
(Rac)
Liposomal Melatonin
In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling PMID 40634958
Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway PMID 27235707
CDODA
Galangin Rescues Alzheimer's Amyloid
SSVFVADPK
CX1739 1086377
Tralomethrin 66841
Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage PMID 39251572
NMS
MK7622
STA4783
Evans blue
mmu
hsa
ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells PMID 34169392
HSP
Teneligliptin
PRC2 overexpression and PRC2
Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells PMID 39125764
Agarotetrol a source compound for low molecular weight aromatic compounds from agarwood heating PMID 29464509
The Mutual Impact of Smoking and Low Cholesterol on All
D
A practical approach to the management of cerebral amyloid angiopathy PMID 33252026
Protective Effect of Purple Tomato Anthocyanidin on Chromium(VI)
PD
A20 inhibits osteoclastogenesis via TRAF6
C3a receptor agonist 1 944997
Hydrogen
PM2.5 triggers autophagic degradation of Caveolin
Epigenetic potentiation of 5
3
Activation of cannabinoid receptor type 2
CircLDLR acts as a sponge for miR
IP3 R attenuates oxidative stress and inflammation damage in smoking
Ginsenosides Regulate PXR/NF
Ailanthone targets the KMT2A
Chinese Tuina ameliorates muscle damage by regulating endoplasmic reticulum stress and autophagy in a rat model of skeletal muscle contusion PMID 40168839
Autophagy contributes to the feeding, reproduction, and mobility of Bursaphelenchus xylophilus at low temperatures PMID 31314052
6
Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection in regulating apoptosis in osteosarcoma PMID 38297292
Methoxsalen
Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma PMID 31088402
N
NDV
Adipose tissue
Bloodletting Acupuncture at Jing
Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation PMID 38346941
Forkhead box K1 regulates the malignant behavior of gastric cancer by inhibiting autophagy PMID 32175400
Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke PMID 35318305
Activation of Autophagy Through the NLRP3/mTOR Pathway A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin PMID 35111047
tRF
SIRT1/FOXO3
TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET
Myt1
Effects of N
Quisinostat hydrochloride 1083078
MicroRNA
LncRNA small nucleolar RNA host gene 5 inhibits trophoblast autophagy in preeclampsia by targeting microRNA
Y1693
Vipr2 Mouse Pre
TRK530
Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat PMID 9202059
leptomonads
Enfortumab Vedotin
Fertirelin acetate 66002
D
MLEC Human Pre
ganglionic
Identification of C
Discovery of Novel and Potent Prolyl Hydroxylase Domain
ZINC13466751 (Standard)
CRBN ligand
ML 251
14
Identification of benzofuro[2,3
Targeting the PI3K
CRK12
FICD Human Pre
Mtss1 Mouse Pre
SID 26681509 958772
DSM 265
FANCF Human Pre
rno
Glucose
Setbp1 Mouse Pre
Sf1 Mouse Pre
349C59
COX6C Human Pre
Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice PMID 10397735
The herbicide dinitramine affects the proliferation of murine testicular cells via endoplasmic reticulum stress
B7
Discovery of a Potent RXRγ Degrader WCF
rno
WAY123223
Thalidomide
mmu
β
Jun15716 827034
Fandofloxacin hydrochloride (DW
LY
XCL2
Nat 20(S)
tubulointerstitial
Noninvasive and Precise Transdermal Drug Delivery Using Spatiotemporally Responsive Lipid Vesicles in Conjunction with Ultrasound PMID 40758320
GI tract
RAP2A Human Pre
SM
ABCG4 Human Pre
Zinc borate
Lactate Contributes to Remote Ischemic Preconditioning
MKI 3
Azido
PANK3 Human Pre
MASTL
Palmd Rat Pre
Ifnb1 Mouse Pre
Dimethyl Isophthalate
KLRC2
TG
Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5
F
RPS5 Human Pre
CDK9
Pentamidine dihydrochloride 50357
精子发生相关 13（SPATA13）基因
Antiparasitic agent
silenced
PI
RNA 结合基序蛋白 45（RBM45）基因
Anti
APC 膜募集蛋白 3（AMER3）基因
钙和整合素结合家族成员 3（CIB3）基因
nephrotoxic activity
d
miR
Dimethyl fumarate mitigates kidney injury induced by high
Integrating Bulk and Single
Exosome
Cryoshocked Adipocytes Mediated Dual
Nanoenzyme
Mitochondrial permeability transition mediated by MTCH2 and F
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C PMID 25156254
Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke PMID 38344886
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death PMID 39144257
A requirement for autophagy in HMGA2
Pimelic Diphenylamide 106 937039
Design and Synthesis of sEH/HDAC6 Dual
Shexiang Tongxin Dropping Pills attenuate ischemic microvascular dysfunction via suppressing P66Shc
DX
The synergistic antifungal effects of gypenosides combined with fluconazole against resistant Candida albicans via inhibiting the drug efflux and biofilm formation PMID 32745913
Cinnamaldehyde alleviates doxorubicin
5
Xanthones from the roots of Cudrania fruticosa Wight PMID 17613626
Swertianolin ameliorates immune dysfunction in sepsis em via /em blocking the immunosuppressive function of myeloid
ACETYLCHOLINESTERASE TRIMETHYLAMMONIUM
Ultra
The role of TRPV4 in ferroptosis in MPP+/MPTP
An azido
Piperazine Erastin (Standard)
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma PMID 37172353
Teslexivir
Rhosin hydrochloride 1281870
GRP78 acts as a cAMP/PKA signaling modulator through the MC4R pathway in porcine embryonic development PMID 37917004
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole
A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein
Phenanthrene exposure disrupts puberty onset in SD rats by influencing hypothalamic neural networks PMID 40752717
Scutellaria baicalensis root extract
8,8''
SMARCD1 Human Pre
Peg10 Rat Pre
CRBN ligand
The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity PMID 19447200
mdx mice
LY150378
PF3052334
Microbiota translocation following intestinal barrier disruption promotes Mincle
Benzyl
5
FLI1
MK
AGR2 Human Pre
Sost
KP 1461
J104871
MTSS1 Human Pre
dengue fever
ML213 (Standard)
RP 14539
TRO40303
Boc
Rnf31 Rat Pre
trans
CLT
WAY
c
LNP Lipid26
Antimycobacterial activity of new N(1)
NDUFB9 Human Pre
IPN
PROTAC BET Degrader
Benproperine 2156
ω
The acidic microenvironment promotes pancreatic cancer progression via the lncRNA
Esrp1 Mouse Pre
Y1693 2812381
USP8
Mapt
Klrc2 Rat Pre
The phospholipase D inhibitor FIPI potently blocks EGF
UCM53 2468847
GIMAP2 Human Pre
PAQR7
Setbp1 Rat Pre
PRPF39 Human Pre
SKI2496 1308378
Norfloxacin succinil
VH 101, thiol 2358775
Altered expression of Butyrophilin ( BTN) and BTN
Maternal exposure to Aristolochic Acid I affects meiotic I progression by impairing DNA damage repair in fetal oocytes PMID 40187211
Picropodophyllin
An Exploration of Intervention Augmentation in a Single Case PMID 30136600
hsa
T cell epitopes
FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats evidence that benzodiazepine inverse agonists reduce food palatability PMID 17077811
NS41080
PLAG1 样锌指 2（PLAGL2）基因
MAGE 家族成员 C1（MAGEC1）基因
PRR4
Discovery of novel pyrazolo[3,4
shisa 家族成员 6（SHISA6）基因
Benzyl
含 kelch 结构域 7B（KLHDC7B）基因
Doxorubicinol hydrochloride 63950
Human meprin alpha and beta homo
LG
MCOPPB 1028969
PRR4
G 蛋白信号调节因子 3（GPSM3）基因
2
Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis PMID 40216205
Xanthone glycosides from Polygala tenuifolia and their conformational analyses PMID 15974611
Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ PMID 40369665
In vitro efficacy of tyrosine kinase inhibitors SYK and BCR
Regulation of cholesterol metabolism during high fatty acid
Effects of CSTB on in vitro maturation of ovine oocytes PMID 40252273
Laccaridione B 320369
C6(6
1,3,5,6
LB 46
Low
Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups PMID 35063733
1,2,5
TCMDC
Triptolide
Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition PMID 31337841
Blocking LFA
The selective cyclooxygenase
Surfactin C1 24730
Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials PMID 22564140
Potablan
Spcs3 Mouse Pre
HIP1
Mg anode
Monalide
Benzo[h]quinoline 230
Monoclonal anti
WDR91 Human Pre
Cad
CGS 24012
17
The major metabolite of dipeptide piracetam analogue GVS
Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer's Disease Based on Network Pharmacology and Experimental Validation PMID 35656471
MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program PMID 27462455
RyRs activator2
HDAC
GLP Receptor
Antiarrhythmic agent 3
F
Apoptosis inducer42
C3H mice
5'
µ
L 649923
GBR 830, an anti
Cryptomoscatone D2
Peritassine A
Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel PMID 21934630
Hypoxia
CIAO1 Human Pre
BMS 566419
Daucosterin
Agomir
synergism
Rucaparib phosphate 459868
Munc13 Is a Molecular Target of Bryostatin 1 PMID 31243993
SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators PMID 31227344
Design, synthesis and biological evaluation of imidazopyridine
Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin PMID 29115558
Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9
Isoquinoline
Abeta
TBC1 domain family member 23 interacts with Ras
HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru
A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death PMID 23445405
A therapeutic approach to pantothenate kinase associated neurodegeneration PMID 30352999
Quantitatively Dissecting Triple Roles of Dynactin in Dynein
Synthesis of novel triazole/isoxazole functionalized 7
Nephroprotective role of resveratrol in renal ischemia
Bremelanotide 189691
Pioglitazone Attenuates Experimental Colitis
Evaluation of the protective role of resveratrol on LPS
Characterization of new PPARgamma agonists benzimidazole derivatives
Design, synthesis and docking studies of novel 1,2
Design, Synthesis, and Biological Activity of l
Nocodazole is a high
Ketoconazole potentiates the antitumor effects of nocodazole In vivo therapy for human tumor xenografts in nude mice PMID 12203371
HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis PMID 39862081
TIM
Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression PMID 39964130
Imipramine
CDK2
Zampilimab 2098280
Flavonoid GL
Azide
PEG
Polysaccharides extracted from Cassia seeds protect against high glucose
Breviscapine alleviates podocyte injury by inhibiting NF
Ganglioside GM3
Tetracosactide 16960
RGS3 Human Pre
PNU
Viteralone
ALK
NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS PMID 34949550
Gpha2
Interorgan communication in neurogenic heterotopic ossification the role of brain
2
Tipiracil hydrochloride 183204
NMR for screening and a biochemical assay Identification of new FPPS inhibitors exerting anticancer activity PMID 32057422
Baoyuan Jiedu Decoction Alleviates Cancer
MCE
Monocarboxylate transporter 1 promotes classical microglial activation and pro
Identifying potential anti
LINC00174 promotes cell proliferation and metastasis in renal clear cell carcinoma by regulating miR
Transglutaminase 2 Inhibitor KCC009 Induces p53
Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease PMID 38730470
Azimilide dihydrochloride 149888
Synthesis and anti
Rational development of Stafib
[3H]RS79948
Unveiling the inequivalent biochemical functions of OsSMO2
Jun15716
Dihydroquercetin (DHQ) ameliorates LPS
Enc1 Mouse Pre
AG 2
Discovery of nonpungent Transient Receptor Potential Vanilloid (TRPV1) agonist antedrugs for treatment of dysphagia PMID 40412447
8
Discovery of Dihydropyrrolo[1,2
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers PMID 36042463
Design, synthesis and bioactivity evaluation of phosphinanes as potential anticancer agents PMID 40753097
TBBPA induced hepatocyte ferroptosis by PCBP1
Pinus pinaster bark extract 90082
Yuanhuacine 60195
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