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7
Autotaxin modulator 1 1548743
Evidence that 3
NSC682769 205048
DABCYL
Phosphorylation at Ser²⁶ in the ATP
Nociceptin receptor antagonist JTC
Mechanisms of suppression of nitric oxide production by 3
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals PMID 28495746
PROTAC BRD4
The development of 2
MeOSuc
Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13
CRBN ligand
PD
Discovery of the first nonpeptide agonist of the GPR14/urotensin
Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β
Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2 PMID 27046168
Lingual Denervation Improves the Efficacy of Anti
FGFR4
Gut microbiota
Discovery of PI
5
Glucosamine sulfate 29031
Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model PMID 28314848
9
Next
Hydroxy
Interleukin
Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery PMID 38430853
Discovery of 2
Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells PMID 20978925
Three
In vitro and in vivo pharmacology of trans
2DG
Cimifugin 37921
Discovery of novel 2
An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors PMID 31040156
Tau Peptide (379
1
AT7867 hydrochloride 2624336
Pipoxolan hydrochloride 18174
Finerenone 1050477
Follistatin a multifunctional regulatory protein PMID 9799587
Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines PMID 17120616
Intra
The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration PMID 16492828
Role of P
A recombinant humanized anti
Serratenediol diacetate 27832
The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production PMID 37478173
Evodenoson 844873
Kazinol A 99624
3
A bovine myeloid antimicrobial peptide (BMAP
Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling PMID 26934654
Synthesis and biological evaluation of thioadatanserin and its dialkylated products as partial 5
RTC13 (Standard)
Production of L
MCE
Design, synthesis, in vitro and in silico studies of novel 4
Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation PMID 26208338
葡萄糖依赖性胰岛素多肽/胃抑制肽
Discovery of clinical candidate Sivopixant (S
Anti
Progoitrin 585
The Resurgence of Antibody Drug Conjugates in Cancer Therapeutics Novel Targets and Payloads PMID 32315240
GYY4137, an H2S Slow
Methyl 4
Copper
Flavonoids from Matteuccia struthiopteris and Their Anti
mmu
The cooked meat
Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs PMID 30294258
Kushenol X 254886
Lanthanum hydroxide showed best application potential in La
Stereoselective Degradation of Diacylglycerol Kinases Potentiate T cell Activation and Tumor Cell Cytotoxicity PMID 41427359
Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3
Bile acid profiling in human biological samples comparison of extraction procedures and application to normal and cholestatic patients PMID 22664055
ACT
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity PMID 23108405
Optimization of aqueous two
莱苞迪甙 A (Standard)
Genetic fate
Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons PMID 25937212
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates PMID 40670348
Fmoc
Discovery of Potent and Selective 2
2
2
Doxapram Treatment for Apnea of Prematurity A Systematic Review PMID 27760427
Ac
Otamixaban hydrochloride 409081
Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma Expression, Predictive Value, and Sensitivity to Inhibitors PMID 26769123
VK4
DG
Corosolic acid 4547
Inhibition of alpha
Ursodeoxycholic acid sodium 2898
The discovery of quinoline
Widespread occurrence of norspermidine and norspermine in eukaryotic algae PMID 7096289
Calcitonin gene
Allithiamine ingestion does not enhance isokinetic parameters of muscle performance PMID 9063763
H2TMpyP
XIAP degrader
RS
Insights from atomic
Fmoc
Fumarate induces LncRNA
MCE
In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1 PMID 25986445
Perfluorobutanesulfonic acid 375
MCE
Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells PMID 6310646
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90) Synthesis, biology, and molecular modeling PMID 18571929
Bromhexine 3572
(S)
Phosphate
CDK2
Two new lignans, interiotherins A and B, as anti
Azaphilone
Antitumor agent
Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase PMID 29221146
Comparison of KP1019 and NAMI
1,3'
TIE
Autophagy inducer 2 2684238
AChE
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility PMID 31353221
New role of calcium
ZnAF
DPhPC
Focusing on new monoamine oxidase inhibitors differently substituted coumarins as an interesting scaffold PMID 23231397
Indoline derivatives as 5
Conversion of a tumor
NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells PMID 10359120
Elf3
JHU395 2079938
DIM
Conformation
Distinction of microsomal prostaglandin E synthase
BRM/BRG1 ATP
Hirudin Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats via Regulating NLRP3 Inflammasome
2
A secreted effector with a dual role as a toxin and as a transcriptional factor PMID 36522324
trans
Metabolic fate of newly developed nondigestible oligosaccharide, maltobionic acid, in rats and humans PMID 32724623
Azide
Carbonic anhydrase inhibitor 9 3033042
Big Endothelin
Protective effects of whey protein hydrolysate on Bifidobacterium animalis ssp. lactis Probio
Recombinant human GLP
INCB159020 2923669
Blood
Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease PMID 21073971
CRBN ligand
Identification of Antiviral Drug Candidates against SARS
Chemokine
The effect of docarpamine, a dopamine pro
Phase II study of iproplatin in advanced ovarian carcinoma PMID 3335895
SLV313 (1
Iqcb1
Propargyl
Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin PMID 27713531
Identification of astrocyte regulators by nucleic acid cytometry PMID 36599367
GPRC5A/CXCL8/NLRP3
Proclonol 14088
Synthesis and biological activity of naphthyl
Antiviral activities of 4H
Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor
Identification of 2,4
Maltobionic acid 534
Antiviral activity of scillarenin, a plant bufadienolide PMID 4375728
Gluco
Itaconic acid prodrug
Discovery of BAY 94
Stilbene
Maleimide activation of photon upconverting nanoparticles for bioconjugation PMID 23128671
Role of galanin in stimulation of pituitary luteinizing hormone secretion as revealed by a specific receptor antagonist, galantide PMID 7507825
Sulfaquinoxaline
Recombinant enterokinase 9014
CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism PMID 24950000
3,4
Boosting RNA nanotherapeutics with V
Synthesis and the 5
Trapping biosynthetic acyl
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity PMID 19877647
A novel strategy for designing irreversible inhibitors of metalloproteases acetals as latent electrophiles that interact with catalytic nucleophile at the active site PMID 11009368
Antioxidant and renoprotective effects of paricalcitol on experimental contrast
FPPS ligand 3 51527
M6A
Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α
Spiramide 510
CCL17/TARC and CCR4 expression in Merkel cell carcinoma PMID 30140381
Novel non
The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species PMID 11717389
(21R)
Hibarimicin G 208588
MK
Design, synthesis, and biological evaluation of new 5
Discovery of highly potent and selective KRASG12C degraders by VHL
Systemic administration of thrombin peptide TP508 enhances VEGF
Anti
Pyridazinopsoralens of wide chemotherapeutic interest PMID 20615713
Bicyclo[3.2.1]octane and 6
NPPB
H
MCE
DTPA
Enniatin F 144446
LHRH free acid 35263
Bromodomain inhibitor
Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production PMID 20515062
Synthesis and evaluation of beta
CRBN ligand
3
L
[Chemical constituents from Clausena excavata and their inhibitory activities against proliferation of synoviocytes] PMID 34581048
Protective effects of Araloside C against myocardial ischaemia/reperfusion injury potential involvement of heat shock protein 90 PMID 28225183
The biology and pharmacology of PGD2 PMID 3283848
DC
Actinine
Sodium tyropanoate, a new oral cholecystographic agent PMID 5458405
Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against Candida albicans PMID 37672929
MCE
Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation Identification of Quinazolin
MCE
Forsythoside B alleviates osteoarthritis through the HMGB1/TLR4/NF
Flexible bioelectronic nose based on olfactory receptor/hydrogel hybrid nanostructures for the direct detection of odorants in both the gas and liquid phases PMID 40445130
Fangchinoline alleviates the progression of osteoarthritis through the nuclear factor kappa B signaling pathway PMID 39894170
Distinctive Immune Signatures Driven by Structural Alterations in Desmuramylpeptide NOD2 Agonists PMID 39344184
DS44470011 1192586
Mesp1
VV261 3003864
PDDHV 179469
Burapitant 537034
Design, synthesis and evaluation of MCH receptor 1 antagonists
Application of lanthanide luminescence in probing enzyme activity PMID 29790500
1
An original pronucleotide strategy for the simultaneous delivery of two bioactive drugs PMID 33711763
(
BRM/BRG1 ATP degrader
DDR1/2 inhibitor
Lars1
L 796568
TFB
Differential profile of antipsychotics at serotonin 5
CRBN ligand
Leucine zipper protein 1 attenuates pressure overload
Laquinimod sodium 248282
MCE
Gallopamil 16662
Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice PMID 16467389
Cross
BAY 1892005 2036352
2'
Macarangin 129385
MCE
Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes PMID 9871775
Prostaglandin K1 69413
Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous
Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1 PMID 22763201
Current Experimental Methods for Characterizing Protein
MCE
THZ1 suppresses human non
A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism PMID 39211182
Proteomics
Lead Optimization of 5
Mus81
Plantainoside D protects adriamycin
Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC PMID 40731028
JTK
Functional characterization of a partial loss
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2
Discovery of Potent Myeloid Cell Leukemia
Activity of biphenyl matrix metalloproteinase inhibitor BAY 12
A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth PMID 30293939
hCAIX
SNF 9007 137415
3
Effect of ASP2205 fumarate, a novel 5
N
Antimycobacterial cycloartanes from Borrichia frutescens PMID 8988597
PLX7922 1638772
Olendalizumab 2210314
MCE
MCE
Structure
A Fluorogenic RNA
Terazosin
Discovery of novel benzimidazoles as potent inhibitors of TIE
[DArg10, DAla20] TLQP
Pentagalloylglucose 14937
Does Cisapride, as a 5HT(4) Receptor Agonist, Aggravate the Severity of TNBS
The complex effects of the slow
Plitidepsin 137219
Emerging glucagon
Structure
HIV
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog
Cbl
Neuroprotective Activities of Constituents from Phyllosticta capitalensis, an Endophyte Fungus of Loropetalum chinense var. rubrum PMID 34101351
Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa PMID 31068610
Amonafide L
Cholestenone
Pregnancy outcome after first trimester exposure to bisoprolol an observational cohort study PMID 29985206
Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK
ML162 1035072
L
S3D5 3033746
Tiragolumab Impresses in Multiple Trials PMID 32576590
Inhibition of GGTase
Toxicity studies on mephenoxalone in rats and dogs PMID 13867249
Preparation of fluorescently
TPP@CUR 3032193
TCL1(10
INVA8001 1312993
ZD
Fluorogenic peptide
Site
Neuromedin U
RAD21 (356–395), biotin labeled
In vitro pharmacological characterization of the bispyridinium non
Naphthalenyl derivatives for hitting P
MCE
CRBN ligand
Development and Validation of a Stability
Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics PMID 28087808
Kinetics of the inhibition of plasminogen activators by the plasminogen
The identification of potent and selective imidazole
Orexin
Mivotilate 130112
8
Teprotumumab 1036734
Factor B
VSIG1 蛋白, Human (HEK293, His)
PCSK9
CRBN ligand
CCL25
AQP4 (201
Arzoxifene the evidence for its development in the management of breast cancer PMID 21221190
Metabolism of 7
Adenosine
FGFR
rel
MP
Ep300/CREBBP
Design and Synthesis of Bitopic 2
Olezarsen sodium 2298451
In vivo effects of propyl gallate, a novel Ca(2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation PMID 24931907
Hydrophilic and lipophilic colchicinoid formulations for therapy of liver fibrosis in murine model PMID 41411690
Cyanine3 hydrazide dichloride 2695564
Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes
Multiscale Simulations of the Covalent Inhibition of the SARS
Selective 5
Evaluating the antidiabetic effects of R
Corisin 2651277
Foropafant 136468
CAY10734 635701
Identification of important odorants derived from phosphatidylethanolamine species in steamed male Eriocheir sinensis hepatopancreas in model systems PMID 30827637
The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity in rats and dogs PMID 12383719
REV
Development of novel S
Y
Rilonacept 501081
Design of the naphthyl
Liquiritigenin attenuates alcohol
Discovery of potential dual
Oxazolone
Hsp90
Muscimol as an ionotropic GABA receptor agonist PMID 24473816
3
Y207–5465 667404
Design and synthesis of novel 4
Anivamersen sodium 959716
Characterization and Regulation of Alpha
AP736 1365531
L
Allele
ACAT
17
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro PMID 38385556
1
A Novel Selective PPARα Modulator (SPPARMα), K
D
Drychampones A
Real
Alisol
PTGR2
[Clinical effects of biapenem on febrile neutropenia in patients with hematological malignancy] PMID 18814798
Discovery of Novel Small
Modulating cholesteryl ester transfer protein activity maintains efficient pre
Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD
The efficiency of dihydroxy aluminum aminoacetate in phosphate insolubilization PMID 13162897
ATTO 590 639065
Lumefantrine
CP 154526 157286
N1,N11
谷胱甘肽过氧化物酶
HDAC6
Pigment Yellow 14 5468
Divarasib 2417987
Synthesis and Preclinical Evaluation of Fluorinated 5
Synthesis and evaluation of 1,2,3,4
DSPS
Ferulic acid methylester improves the comorbidity of insomnia and anxiety in a rat model of PCPA
Detection, accumulation, distribution, and depletion of furaltadone and nifursol residues in poultry muscle, liver, and gizzard PMID 22011291
Design, Synthesis, and Evaluation of the Selective and Orally Active LSD1 Inhibitor with the Potential of Treating Heart Failure PMID 39036880
MCE
A novel selective androgen receptor modulator (SARM) MK
Exploration of substituted arylpiperazine
HDAC
Avibactam sodium dihydrate
Synthesis of Isosteviol derivatives as potential anticancer agents, especially for ovarian Cancer In vitro cytotoxicity, cell cycle arrest, network pharmacology and molecular docking study PMID 40311784
Renal protective effects of N
N
MRT
LY450108 376594
(R)
MCE
Soyasaponin IV 108906
Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy PMID 40355412
[3H]Spiperone binding sites in brain autoradiographic localization of multiple receptors PMID 7248759
Substrate specificity of a recombinant D
Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts PMID 18029185
TMI
Preferred Conformation
Anti HIV
Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H
Fosfluconazole 194798
RCOR1 Human Pre
RA
Three
YY1 (Yin
2
Dynorphin A(1
Boc
Antileukemic Effects of Novel First
Therapeutic approach of histamine H3 receptors in obesity PMID 18221234
New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors Synthesis and in
Tyropanoate sodium 7246
ML10375 174008
Hexacyclinol 903574
5
甘氨酸受体
(S)
Chronological development of functional fluorophores for bio
3,3'
Corthrombin (CVS 995)
gamma
Hydrouracil
ASP
Injection of an aromatase inhibitor after the critical period of sexual differentiation PMID 8115420
LNK4
MSA
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone PMID 19442525
白细胞免疫球蛋白样受体 A5（LILRA5）基因
Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor 4
N,N'
Overview of SIRT5 as a potential therapeutic target Structure, function and inhibitors PMID 35436671
Inhibition of phosphodiesterase 4 by FCPR16 protects SH
Mal
3'
Exploration of anti
EphB1 promotes the differentiation and maturation of dendritic cells in non
An integrated computational, in vitro and metabolomics approach to the discovery of novel aromatase inhibitors with anti
1
Ticagrelor impurity 11 220352
Citral protects against LPS
Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat PMID 17597600
Non
Reaction kinetics and mechanisms of organosilicon fungicide flusilazole with sulfate and hydroxyl radicals PMID 28992485
Vielanin K enhances doxorubicin
Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up
MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression PMID 15757975
Scillarenin 465
Dual
Bilayer lipid membrane formation on a chemically modified S
CRBN ligand
6
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri
Thalidomide
Microbial
Antiviral agent 6 2847129
(R)
DL
Agathisflavone 28441
Trpvicin 2019994
CRBN ligand
Inhibition of TNF
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch
Distearoylphosphatidylserine
Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst PMID 30881626
Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury PMID 23871054
A phase I and pharmacokinetic study of LAF389 administered to patients with advanced cancer PMID 17159608
α
GNE
TAK
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