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Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug
Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers PMID 19185489
28
Bifidobacterium longum Metabolite Indole
An improved assay for platelet
MOTS
Kinetic characterization and molecular docking of a novel, potent, and selective slow
Tph2
7
16 0 Stigmasteryl glucose 59252
hsa
Moenomycin complex 11015
RET
Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia PMID 18434753
TNIK modulator
Network pharmacology combined with molecular docking and experimental validation of the mechanism of action of columbianetin acetate in the treatment of ovarian cancer PMID 40071097
Comparison of Zaire and Bundibugyo Ebolavirus Polymerase Complexes and Susceptibility to Antivirals through a Newly Developed Bundibugyo Minigenome System PMID 34379503
Druggable epigenetic suppression of interferon
Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima PMID 11835991
MHI
MCE
The role of ladderlectin in spermatogenesis and ovarian sperm storage in the black rockfish (Sebastes schlegelii) PMID 40247087
Pathogenesis of chronic lymphocytic leukemia and the development of novel therapeutic strategies PMID 33148933
Evaluating the Mechanism and Therapeutic Potential of PTC
Targeting glutaminase C, a splice variant of glutaminase 1, suppresses smooth muscle cell phenotypic modulation and neointimal hyperplasia PMID 41016577
3’
Spinal anesthesia with diphenhydramine and pheniramine in rats PMID 22044917
TDG
CD1B 蛋白, Human (HEK293, Fc)
Potent humanin analog increases glucose
Developing novel antiepileptic drugs characterization of NAX 5055, a systemically
Crenulatin 63026
Targeting protein biotinylation enhances tuberculosis chemotherapy PMID 29695454
Soluble or insoluble prussian blue for radiocesium and thallium poisoning? PMID 15252192
YCH3292 3049753
Unifying principles of bifunctional, proximity
FTI
[Anthraquinones from the roots of Knoxia valerianoides] PMID 22308688
Discovery of a mu
Actions and mechanisms of action of novel analogues of sotalol on guinea
Ecdysterone Alleviates Atherosclerosis by Inhibiting NCF2 and Inhibiting Ferroptosis Mediated by the PI3K/Akt/Nrf2 Pathway PMID 40045169
Antipseudomonal penicillins PMID 7791416
Structure
Identification of the first noncompetitive SARM1 inhibitors PMID 32828421
D
Pharmacologic characterization of the cloned human trace amine
Dual function of protein phosphatase 5 (PPP5C) An emerging therapeutic target for drug discovery PMID 37054560
Neuroprotective effect of 3
Discovery and structure of the antimicrobial lasso peptide citrocin PMID 30846564
Covalent Guanosine Mimetic Inhibitors of G12C KRAS PMID 28105276
Interaction between the Neuroprotective and Hyperglycemia Mitigation Effects of Walnut
The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine
Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge PMID 10608745
An exaggerated epinephrine
Readily functionalizable phosphonium
CRBN ligand
CRBN ligand
Endo
CRBN ligand
Design of Novel 2
Promising New Inhibitors of Tyrosyl
Tilfrinib 1600515
Tilnoprofenic acid 52549
Talsupram 21489
D
cis
Novel vanilloid receptor
Utilization of iPSC
CRBN ligand
DMAPP triammonium 1186
Antiflammin 3 118850
RyRs activator 1 2571579
Nr0b1
MCE
Discovery of In Vivo Active Sphingosine
MCE
CRBN ligand
Oleoylestrone
BCR
Design, synthesis, and structure
Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae PMID 11860083
Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat PMID 23406008
Chronic d
pTH
Peptide Stereocomplexation Orchestrates Supramolecular Assembly of Hydrogel Biomaterials PMID 37566784
CP 226269 220941
Exploratory Studies With BT
Linogliride fumarate 78782
The antidepressant
Imidacloprid 138261
6,2′,4′
A potent PGK1 antagonist reveals PGK1 regulates the production of IL
Boc
Oxyntomodulin (human, mouse, rat) 159002
Tumor inhibitors. XXII. Senecionine and senecionine N
Amfenac sodium 61941
Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics PMID 40890445
Medicinal chemistry strategies targeting PRMT5 for cancer therapy PMID 36274274
Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer PMID 37390491
Candida parapsilosis and echinocandins should the clinical laboratory drop anidulafungin Etest from the susceptibility testing panel? PMID 40590712
Meclonazepam 58662
MCE
Protein kinase inhibitor 10 871317
TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity PMID 24379686
GK718 3032392
Inhibition of peptide BF
Ro 23
CRBN ligand
CRBN ligand
A metabolomic profile is associated with the risk of incident coronary heart disease PMID 24952859
CDK8
Kp7
Effects of febuxostat on metabolic and renal alterations in rats with fructose
Oxychlordane and trans
Xylose
Antidepressant properties of rotigotine in experimental models of depression PMID 16959244
Development of a Competitive Enzyme
Sifuvirtide, a potent HIV fusion inhibitor peptide PMID 19289098
R
Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206
Complexes of plasmid DNA with basic domain 47
Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel PMID 2448164
AKT inhibitor VIII 612847
Cannabinol methyl ether 41935
A 7
Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism PMID 34800643
Species
Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra
BMS
Identification of a selective pyruvate dehydrogenase kinase 1 (PDHK1) chemical probe by virtual screening PMID 39742699
MCE
Differential requirement for IL
CD52
Anticancer and antiangiogenic activity of HPMA copolymer
Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa PMID 19214944
(rel)
Calcium influx promotes PLEKHG4B localization to cell
7,4'
Nefopam
In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5
Structure
A novel N(alpha)
4'
BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation PMID 11782431
Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads PMID 29163463
Maritoclax (Marinopyrrole A)
NCDM
PT
HMC
Clarithromycin impurity 7 127140
D
Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells PMID 11385076
Biological activity and brain actions of recombinant rat interleukin
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis PMID 18284588
Expanding the toolbox to develop IAP
Maurocalcine 269745
Intestinal Anti
Gallotannins are non
Mps1
2,5
Activation of Cdk2
Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis PMID 26188915
TG101209 936091
Improved PIEZO1 agonism through 4
Estrogen receptor α aggravates intestinal inflammation via promoting the activation of NLRP3 inflammasome PMID 39426237
Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2 PMID 11278893
Allicin
Tamsulosin
SMARCA2
6
CRBN ligand
3
L
5
Trimethyl chitosan and its applications in drug delivery PMID 19112609
Comparative pharmacology of human dopamine D(2)
Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC PMID 9349436
Cloprostenol isopropyl ester 157283
DS68591889 2488609
Thymic stromal lymphopoietin
Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA
Salsolinol modulation of dopamine neurons PMID 23745110
Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish PMID 26034134
Penicillin acylases revisited importance beyond their industrial utility PMID 25430891
Trimazosin in normotensive subjects PMID 6141018
rel
E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance PMID 36198264
6,6'
Search for Shorter Portions of the Proline
Ethyl 4
HAT
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti
NP
Juncuenin B 1161681
CRBN ligand
MCE
Excitatory action of some aspartate
Dieicosanoin 60586
Phf24
AY 29315 114394
The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'
Optimization of biotinyl
Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice PMID 22617756
CRBN ligand
The effects of PRX
(S,R,S)
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis PMID 34015269
AL
DC260126 346692
Discovery of 1
Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant
Transition of a solitary to a biofilm community life style in bacteria a survival strategy with division of labour PMID 32427342
Anti
Structural basis for the highly selective inhibition of MMP
A series of 4
Role of protein farnesylation in burn
Protostemotinine 169534
HBED dihydrochloride 35369
Biotinylated
Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8 PMID 16221874
Protective effect of Cupressus sempervirens extract against indomethacin
Carzinophillin A 106486
Protein kinase G inhibitor
Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF
Biosynthesis of the cancer
Reduction of Abeta42 in brains of transgenic APPswe mice by 2
Antipyrine
UCM
Anemonin 508
Insights into the binding specificity and catalytic mechanism of N
DITMD
Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells PMID 21199801
BNP 抗体 (YA1001)（BNP Antibody (YA1001)）
Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage PMID 36805606
Pre
Kisspeptin
A simple and rapid method for the preparation of gram
Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus PMID 33888802
Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan PMID 22314317
Leukotriene B4 ethanolamide 877459
Linavonkibart 2640981
Leonoside F
Fascin 抗体 (YA445)（Fascin Antibody (YA445)）
CRBN ligand
Core regulatory RNA molecules identified in articular cartilage stem/progenitor cells during osteoarthritis progression PMID 30775942
Chromatin
LGR5/mTORC2 axis regulates cellular metabolic plasticity to maintain tumorigenesis in hepatocellular carcinoma PMID 40796068
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti
Methodological improvements for fluorescence recordings in Xenopus laevis oocytes PMID 30606741
Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain
CRBN ligand
A Menin
Pathogenic TDP
The use of zebrafish model in prostate cancer therapeutic development and discovery PMID 33392639
LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30
A synthetic pregnenolone analog promotes microtubule dynamics and neural development PMID 36456994
Aquaporin
CRBN ligand
The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole PMID 15696328
Ephrin
Echihumiline 174285
ELND 006 1333990
CG 858
CRBN ligand
Cyclotraxin
Discovery of 3
ATR
Tyrosinase
Ametryn
Bacterial
CRBN ligand
Poloppin 683808
L 373890 187162
CRBN ligand
Desmethylcyclobenzaprine
Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion PMID 30626681
WRN
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor PMID 40529099
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury PMID 24633426
Phase I study of safety and pharmacokinetics of the anti
Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3
Tilbroquinol 7175
Mdivi
Tebipenem pivoxil 161715
TRPM4
CHD1L
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo PMID 24516202
Radequinil 219846
Methylmalonic acid
Synthesis and in vivo validation of [O
Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity
In vitro and in vivo testing of nanofibrous membranes doped with alaptide and L
Oxyclozanide 2277
(Leu31,Pro34)
S
CRBN ligand
Upregulation of KCNMA1 facilitates the reversal effect of verapamil on the chemoresistance to cisplatin of esophageal squamous cell carcinoma cells PMID 33660797
Next
Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata PMID 8984148
Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311 in vivo pulmonary studies PMID 10763854
Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR
Inhibitors of acetylcholine esterase in vitro
Trijugin D 1233534
D&C Red No. 31 6371
Penetratin
Ala5
Effects of 8
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis PMID 40739373
Hippocampal synaptic plasticity is impaired in the Mecp2
Epothilone D, a microtubule
The ACAT inhibitor CP
DJ
Everninomicin D 39340
hsa
CYR61 regulates BMP
VASN Human Pre
Netupitant Exhibits Potent Activity on Mycobacterium tuberculosis Persisters PMID 39554043
Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells PMID 27036311
Indoramin
CRBN ligand
Cucumegastigmane I 929881
RH 421 107610
Increased expression of dystrophin, beta
Myostatin inhibitory peptide 7 1621169
Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens PMID 23627380
Suppression by orally
Kinetic analyses of Keap1
JY
Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines PMID 17296291
Melatonin enhances NK cell function in aged mice by increasing T
GPR34 agonist 1 2459994
Myr
MCE
Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors PMID 38316369
Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4 PMID 21940714
Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2 PMID 27382052
PAD4
Isocaproic acid, a metabolite of 20 alpha
In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin PMID 27933947
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth PMID 34168367
Mogroside III 130567
Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress PMID 36842710
Penamecillin
αvβ6
Cyclin E 蛋白, Human (sf9, His
Flavonoid inhibition of aromatase enzyme activity in human preadipocytes PMID 9831487
Cholera toxin an intracellular journey into the cytosol by way of the endoplasmic reticulum PMID 22069586
Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice PMID 27180983
Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice PMID 27622015
Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P
CHO
2
501A054 3080980
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition PMID 28255082
MMPIP hydrochloride 1215566
Identification of naphthalimide
Ac
In vitro antibacterial activity of cefoperazone (T
CP 53631 79836
Expression, purification and characterisation of two variant cysteine peptidases from Trypanosoma congolense with active site substitutions PMID 20609389
MCE
B
DNA Electrophoresis Using Thiazole Orange Instead of Ethidium Bromide or Alternative Dyes PMID 30985761
Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel
Structural studies on pyrrolomycins C, D and E PMID 6654758
Total Flavones of Rhododendron Protect Against Ischemic Cerebral Injury by Regulating the Phosphorylation of the RhoA
Cyclic amide derivatives as potential prodrugs II N
Pharmacology of the new reversible inhibitor of monoamine oxidase A, RS
JG
Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model PMID 41208336
Oxazine drug
Nrf2 activator
1,2,3,4,6,7,8
Quaternary diamines as mass spectrometry cleavable crosslinkers for protein interactions PMID 22131227
Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas PMID 25838390
Ubiquitin
Exendin
Studies on the mechanism of spasmolytic activity of (O
2
UK
DNMT3A
Discovery of a potent, Highly selective, and In vivo anti
Discovery of Novel Hydroxyimine
Advances in the management of non
Discovery of imidazo[1,2
Hirsutine 7729
A simple and sensitive analytical method for the determination of antimony in environmental and biological samples PMID 16512419
Inhibition of the central melanocortin system decreases brown adipose tissue activity PMID 25016380
Mal
RMI2
Adrafinil 63547
SB2960 3111225
In situ administration of STING
Fabrications and applications of hemicellulose
Silencing of epidermal growth factor, latrophilin and seven transmembrane domain
Bis(4
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families PMID 28137884
Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents PMID 28012840
Bicyclic Boronate VNRX
Asenapine hydrochloride 1412458
Determination of henatinib in human plasma and urine by liquid chromatography
Pemafibrate 848259
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo PMID 16829954
Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin
KRAS G12C inhibitor 57 2821863
Clenpenterol
JBJ
Boc
DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor PMID 31312405
Presence of a thapsigargin
c
HA1/Hemagglutinin 蛋白, H6N6 (AEF59343, HEK293, His)
Auristatin S An Auristatin Payload with Improved Tolerability and Modified Bystander Activity PMID 40666458
KRA
Bio
MCE
BNP 抗体 (YA4756)（BNP Antibody (YA4756)）
Carcinogenicity of the antineoplastic agent, 5
CRBN ligand
EPZ
Discovery and Optimization of Dihydroquinolin
碳酸酐酶
MCE
WJ
Caryophyllene Oxide, the Active Compound Isolated from Leaves of Hymenaea courbaril L. (Fabaceae) with Antiproliferative and Apoptotic Effects on PC
Exploring the role of iNOS in HFpEF
Tenoxicam exerts a neuroprotective action after cerebral ischemia in rats PMID 15756931
Boc
4
伴侣介导的自噬
Cronidipine 113759
Employing splice
Inhibition of AKT enhances the anti
Structure
CDD
Determination of Bupropion and Its Impurities via a Chaotropic Chromatography Method Following Analytical Quality
Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co
H2
NPM
Indolepropionic acid modulates the immune response in allergic rhinitis through the AKT/CEBPB/IL‑10 signaling pathway PMID 40417918
Discovery of covalent prolyl oligopeptidase boronic ester inhibitors PMID 31732257
The Role of DPO
WRN helicase safeguards deprotected replication forks in BRCA2
RS
Alofanib 1612888
N,N
SsPtc3 Modulating SsSmk1
Jujuboside B 55466
Fibrillarin 抗体 (YA437)（Fibrillarin Antibody (YA437)）
Regulation of T cell development by the deubiquitinating enzyme CYLD PMID 16501569
A randomized, placebo
Hirudin promotes cerebral angiogenesis and exerts neuroprotective effects in MCAO/R rats by activating the Wnt/β
COQ7
Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time PMID 7716176
Plitidepsin has potent preclinical efficacy against SARS
Esculentoside H 66656
8
Synthesis of willardiine and 6
SIRT2
Abiesadine I
Design, synthesis, and antiviral evaluation of 2
IACS
PH
Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP
Preparation and anti
5
TcNTPDase1
Imidazole
L3mbtl1
Prevention of the development of murine systemic lupus erythematosus (SLE)
ASARM
Propiomazine maleate 3568
NSC 194308 90379
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress
CRBN ligand
Isoform selectivity of adenylyl cyclase inhibitors characterization of known and novel compounds PMID 24006339
Amb123203 956571
3
Deoxybrevianamide E 34610
Gpr37
The Deubiquitinating Enzyme USP4 Promotes Trophoblast Dysfunction by Stabilizing RYBP PMID 39405024
TCO
Steroid sulfatase
Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) PMID 23762934
The complement receptor 3 (CD11b/CD18) agonist Leukadherin
Sparticolins A
A novel receptor for Apo2L/TRAIL contains a truncated death domain PMID 9382840
5
Kinetics and metabolism of fomepizole in healthy humans PMID 22554311
Mybl2
Fmoc
The effects of non
Effects of a fluoro substituent on the fungal metabolism of 1
Effect of metoprolol on myocardial apoptosis and caspase
Cdkn3
S
Ombrabulin hydrochloride 253426
Active components with inhibitory activities on IFN
Small
The toll
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