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(R)
Polyamine
Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria PMID 6847174
Cadherin
MCE
Pharmacogenomics
Antitumor activity of L
Nav1.7
Gastrodin Pretreatment Alleviates Renal Ischemia
YWHA/14
Geranylamine 6246
Treatment parameters modulating regression of human melanoma xenografts by an antibody
Novel pH
OH
Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID
Morpholino treatment improves muscle function and pathology of Pitx1 transgenic mice PMID 24232919
Type IIA topoisomerase inhibition by a new class of antibacterial agents PMID 20686482
Importance of Indazole against Neurological Disorders PMID 35232360
4
Genistein maintains intestinal homeostasis in colitis mice via activating GPR30
ESCRT requirements for EIAV budding PMID 24107264
Eicosadienoic acid
Rattus norvegicus Glutathione Transferase Omega 1 Localization in Oral Tissues and Interactions with Food Phytochemicals PMID 38441878
YM
Identification and pre
dideoxynucleotide
Peroxy Orange 1 1199576
Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis PMID 27805439
BMY
CP
Targeting of SOS1 from SOS1 Activators to Proteolysis Targeting Chimeras PMID 37073657
N
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging
low
MCE
Transcainide causes two modes of open
Dynasore Suppresses mTORC1 Activity and Induces Autophagy to Regulate the Clearance of Protein Aggregates in Neurodegenerative Diseases PMID 30924108
N
The MHC
Apicidin C 366448
Mezolidon 82697
Growth of respiratory syncytial virus in primary epithelial cells from the human respiratory tract PMID 15956607
Mog Rat Pre
Substituted N
防御素β4A（DEFB4A）基因
SGI1776
A
Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor
Mechanisms of atrial natriuretic peptide secretion from the atrium PMID 15993390
MCE
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand PMID 23651455
Structure
ZD 9379 PMID 10565985
Elastase, Rat
DC20 2892399
rel
Crambene 6071
Targeting PBK in the fibroblast
Atrazine
Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats PMID 23838678
Reaction hijacking of tyrosine tRNA synthetase as a new whole
Studies on the antimycotic activity of 5
Discovery of Selective and Orally Available Galectin
Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative PMID 3076125
BRD5018 2245231
ALP Green
MEMO1 Human Pre
PDGFB
Tetrodecamycin and dihydrotetrodecamycin, new antimicrobial antibiotics against Pasteurella piscicida produced by Streptomyces nashvillensis MJ885
Parathyroid hormone (PTH)
STING agonist
Ginsenoside Re suppresses high glucose
CCR6 Human Pre
表面活性蛋白 B（SFTPB）基因
Synthesis of 5
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo PMID 15956255
JNJ
Unique antiviral mechanism discovered in anti
(R)
The effects of cyclo(leucyl
4
BMS
Khusimol 16223
CRBN ligand
TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma PMID 40473594
Srsf1
B7
Glucuronic acid and the ethanol metabolite ethyl
Pharmacological and Structural Characterizations of Naquotinib, a Novel Third
Alisol B 23
5
Silybin alleviates hepatic lipid accumulation in methionine
PVRIG 蛋白, Human (HEK293, His)
BNIP3 抗体 (YA580)（BNIP3 Antibody (YA580)）
MCE
Therapeutic potential of flavonols in the treatment of JCPyV PMID 40838703
USP1
Benzylmethylether
Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation PMID 40752839
Fluorescent timer protein that changes color with time PMID 11090358
Treatment with 2,4
H
NT
Investigation of the potential role of TGR5 in pancreatic cancer by a comprehensive molecular experiments and the liquid chromatography mass spectrometry (LC
Antibody
LX
Robustaflavone 49620
Synthesis and cytotoxic activity of the heptaphylline and 7
Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections PMID 24731238
2
Design, synthesis and molecular dynamics simulations of thiazole
Sporidesmolide II 3200
Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation PMID 33220272
Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis PMID 35234444
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis
Effects of auriculasin on vascular endothelial growth factor (VEGF)
Carnosol attenuates Ang II
Synergistic effect of gefitinib and rofecoxib in mesothelioma cells PMID 20122271
Fluoroindolocarbazole A
A validated liquid chromatography
Endothelial
CPP9 1831064
Exploring the active site of tripeptidyl
Photophysical Properties of Protoporphyrin IX, Pyropheophorbide
In vitro and in vivo formation of two new metabolites of melatonin PMID 4814344
Simultaneous quantification of nine aconitum alkaloids in Aconiti Lateralis Radix Praeparata and related products using UHPLC
Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI
Plasma membrane Ca2+
Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma PMID 32810364
3
Overcoming mTOR resistance mutations with a new
(R)
Design, synthesis, and structure
Csk Mouse Pre
4
Pyrrole An emerging scaffold for construction of valuable therapeutic agents PMID 26807541
(±)8(9)
Anti
Methyl Glycyrrhizate (甘草酸甲酯)
A Novel 2
Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor
Fmoc
Increased CCL19 expression is associated with progression in cervical cancer PMID 29088748
N
Sermetacin 57645
Inhibition of human renin activity by saponins PMID 20460744
PBI
Hydrophobicity
PROTAC BRD4 Degrader
Discovery of potent and orally bioavailable 17β
TGFBR2/TGF
Identification of new small molecule allosteric SHP2 inhibitor through pharmacophore
C12((±)
MCE
CD73 a novel target for cancer immunotherapy PMID 20682793
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice PMID 35325608
4,4'
Wright's stain 68988
Serotonin (5
Effects of aminosalicylates and immunosuppressive agents on nitric oxide
tert
MS
Network pharmacology
Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late
(S)
SGI 1776
A series of case studies practical methodology for identifying antinociceptive multi
HIV
Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells PMID 26401381
Dynamic changes in chemical components, volatile profile and antioxidant properties of Xanthoceras sorbifolium leaf tea during manufacturing process PMID 39671923
MCE
Raspberry Ketone Accumulation in Nicotiana benthamiana and Saccharomyces cerevisiae by Expression of Fused Pathway Genes PMID 37656963
DNP
Transcriptional Intermediary Factor 2 (TIF2) (740
Azlocillin sodium salt 37091
Crisp1
Teratogenic compounds of Veratrum californicum (Durand). VII. The structure of the glycosidic alkaloid cycloposine PMID 4977212
MicroRNA
An investigation on nephrotoxicity of Aristolactam I induced epithelial
CRBN ligand
Antimicrobial activity and stability to beta
Potent immunosuppressive principles, dimeric sesquiterpene thioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum (nymphaeaceae) structure
Discovery of Novel Oxazolo[4,3
Sorafenib impurity 6 1209459
Gynura divaricata rich in 3, 5
Estrogen protects against postpartum Concanavalin A
Short
Vivid COVID
Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression PMID 40070787
Selective targeted delivery of TNFalpha to tumor blood vessels PMID 12933583
INVESTIGATIONS INTO THE MECHANISM OF DEXTRANINDUCED EDEMA IN RATS PMID 14069569
PPARγ inhibition promotes osteogenic differentiation of bone marrow mesenchymal stem cells and fracture healing PMID 38616655
Trifluoromethyl
Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7
The development of HEC
rno
Sirtuin modulator
New Cyclic Lipopeptide Compounds for Efficiently Inhibiting Cellular Inflammation and Collagen
Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety PMID 29601990
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K
N
(S,R,S)
Mechanism
Monolayers of IEC
Leronlimab 674782
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy PMID 28722353
A phase I clinical trial of didemnin B PMID 1933801
Carbohydrate binding module recognition of xyloglucan defined by polar contacts with branching xyloses and CH
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs PMID 8298820
Immunotherapy for brain metastases and primary brain tumors PMID 36521332
CRBN ligand
Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation PMID 38247172
Anthranilic acid amides a novel class of antiangiogenic VEGF receptor kinase inhibitors PMID 12477352
Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor PMID 9353406
Inhibitors on an elastase
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man PMID 8531117
Platinum(IV) complexes as inhibitors of CD47
FGFR
(Rac)
Hypoglaunine D 220751
Biodegradable Cardiac Occluder with Surface Modification by Gelatin
MCE
Towards Personalized Allele
FXR agonist 12 1831862
Ophiopogonin D'
Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL
Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway PMID 31201434
Mordant Black PV
(+)
Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase
Tk1
C5 Lenalidomide
2’
Hydrogen peroxide
MCE
Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one
Piclozotan 182415
Diperamycin, a new antimicrobial antibiotic produced by Streptomyces griseoaurantiacus MK393
1
GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells PMID 20160501
γ
The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific PMID 1968341
Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains PMID 25694676
DC
Substance P analog, DiMe
Adipose stem cells regulate lipid metabolism by upregulating mitochondrial fatty acid β
Carboxypeptidase E/CPE 蛋白, Human (HEK293 His)
Developmental Exposure to Di
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model PMID 31461309
LY2874455
A novel inhibitor of dengue virus replication that targets the capsid protein PMID 23070172
ELABELA Is an Endogenous Growth Factor that Sustains hESC Self
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy retinal neovascularization in mice and retinal vascular permeability in diabetic rats PMID 18083913
Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function PMID 15661837
Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway PMID 33733293
Determination of amidepin in human plasma by reversed
Metronidazole
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells PMID 17386261
Preclinical pharmacokinetics and metabolism study of SCO
Lamivudine salicylate 173522
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram
Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening PMID 31252285
A Minimally
GLP
Substrate Specificity of Aqualysin I, a Bacterial Thermophilic Alkaline Serine Protease from Thermus aquaticus YT
Down
Oplopanon 1911
2
3
WNT1
HA/Hemagglutinin 蛋白, H1N1 (Y108F, S340Q, I341R, Q342E, S343T, ACP41105, sf9, His)
Targeting Primary Ciliogenesis with Small
(Pyrrolo
Boc
The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β
Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli PMID 4079597
Phosphorylation by Aurora kinase A facilitates cortical
GP1
Analysis of serum lysophosphatidylethanolamine levels in patients with non
6
A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells PMID 28720813
Discovery and characterization of a G protein
Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction PMID 10564041
Proangiogenesis action of the thyroid hormone analog 3,5
Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK
Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice PMID 33039957
BRD4 Inhibitor
Phenolic Constituents Isolated from the Twigs of Cinnamomum cassia and Their Potential Neuroprotective Effects PMID 29883114
Enzymatic conversion of D
MCE
Efficacy and Safety of PF
Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations PMID 30444912
Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity PMID 15844957
3
Electrophysiological consequences of acute mobocertinib exposure in isolated rat and guinea
2
Oxygen Vacancy Formation Energy Determines the Phase
Ginsenoside Rg1 attenuates adjuvant
Pharmacological characterization and CNS effects of a novel highly selective alpha2C
Three
CYP17A1
Inhibition of apical sodium
Firazorexton 2274802
MCE
Fli
α
Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells PMID 20338233
4
The Chinese herbal prescription JZ
PROTAC_ERRα 1801547
Synthesis and structure
Cy5
4
irritable
Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential PMID 7681376
Effect of fenspiride, a non
Crystal Violet 548
Utilizing Epigenetic Regulators to improve HSC
MCE
ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b PMID 31043581
T
Distinct concentration
MCE
Inhibition of phenylethanolamine N
Inhibiting NEDD4 in triple
MCE
Hedgehog inhibitors exert anti
CD160 蛋白, Rhesus Macaque (HEK293)
Selective protection from the inhibition by EEDQ of D1 and D2 dopamine agonist
The crystal structure of a tetrahydrofolate
Paeoniflorigenone 80454
Zapnometinib 303175
Monobenzyl Terephthalate (4
Separation of α
LC3
3’
Danofloxacin
HBx promotes tumorigenicity through RRM2
G3
Puerarin inhibits iNOS, COX
Trimethoprim fumaric acid 1546799
CI936
Discovery of Pre
Identification of PVR (CD155) and Nectin
Methyrapone interaction with Pseudomonas putida cytochrome P
ALB
T
Correlation of anti
A novel inhibitor of plasminogen activator inhibitor
HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis PMID 36462336
N
微甘菊胡椒提取物 (Piper mikanianum (Kunth) Steud.)
Sulfanylbenzamides with Unique Side Chains to Improve Metabolic Stability, Pharmacokinetics, and Anti
Identification of diagnostic biomarkers and mitochondrial metabolic characteristics in sepsis
GRM2 Regulates Functional Integration of Adult
Effects of hibarimicins and hibarimicin
Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO
Retro
Dual targeting of transformed and untransformed HTLV
Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β
ARN16186 2320555
S
Lewis
Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells PMID 32245484
Exploring Fatty Acid Mimetics as NR4A Ligands PMID 37918435
Psmd3
3
CD74
In vivo depletion of O6
Cholesteryl 4,7,10,13,16
The adhesion molecule P
Identification of a small
MCE
A low molecular weight mimic of the Toll/IL
GNF
(S,R,S)
Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism A Novel Class of 2
Ultrasound
Discovery of novel fructose
Fidaxomicin
IL
Simlukafusp alfa (FAP
Dissipation and safety evaluation of afidopyropen and its metabolite residues in supervised cotton field PMID 31100589
ATPase
GSK484 hydrochloride (Standard)
Cd84
9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells PMID 33398364
Oleocanthal Modulates LPS
Blubber Thickening Driven by UCP1 Inactivation Insights from a Cetacean
Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+
NT
RNA 结合基序蛋白 26（RBM26）基因
IRF2
Denotivir 51287
Targeting USP7
Lobophorin CR
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation PMID 37028404
chemo
Eugenol protects against Aspergillus fumigatus keratitis by inhibiting inflammatory response and reducing fungal load PMID 35436473
Sodium 1H,1H,2H,2H
MSX2 Human Pre
Mizagliflozin 666843
Development of Prostate
Tph1
Canthaxanthin 514
Structure
PI4P5K
Tissue
Y 9000 53944
Ebola virus Glycoprotein/GP1 蛋白 (AHX24649, sf9, His)
Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation PMID 21147071
尿路上皮癌 (Urothelial Cancer)
Activities of the microtubule
Synthesis of benzo[ d]thiazole
Fluorescence lifetime characterization of novel low
S 38093 862896
Silencing of long non
Menin
(3β,5α,8α,22E,24ξ)
Clathrin
Adm
Ursodeoxycholic acid Mechanism of action and novel clinical applications PMID 18034825
Novel aspects of cellular action of dipeptidyl peptidase IV/CD26 PMID 21194362
Pathways in the activation of human coagulation factor X PMID 6770848
2
DDO
Antidepressant
MCE
Accumbal D2R
TMZ
[Glp5,(Me)Phe8,Sar9] Substance P (5
D
(
SLC7A11
In vitro antiplasmodial activity of Central American medicinal plants PMID 10540301
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule PMID 33838082
microRNA
Evolution of function in the crotonase superfamily (3S)
长春西汀 d<sub>5</sub>
MK
Carviolin
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta
Lanuginosine 23740
Calycosin
Design, synthesis and biological evaluation of [1,2,3]triazolo[4,5
DMTr
Isoxepac
Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide
Solanthrene
Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis PMID 40168988
Houpo Paiqi Mixture Promotes Intestinal Motility in Constipated Rats by Modulating Gut Microbiota and Activating 5
mmu
GPR55
Formation and persistence of DNA adducts of 2
Lead exposure induced lipid metabolism disorders by regulating the lipophagy process in microglia PMID 38008839
Fomepizole in the treatment of poisoning PMID 11134450
6
Synthesis and analgesic activity of 2
Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation PMID 21577096
Regulatory effect of sericin protein in inflammatory pathways; A comprehensive review PMID 36812737
MCE
Design of MKC
Tyrosinase
Lmtk2 Rat Pre
Effects of adenosine and 2'
Discovery of novel 2,4
Niruriside 173268
Opposite Roles of RNase and Kinase Activities of Inositol
GDF15 negatively regulates chemosensitivity via TGFBR2
HKPerox
ARN 19689
hAChE
Pharmacological targeting of MTHFD2 suppresses NSCLC via the regulation of ILK signaling pathway PMID 36827714
MAT2A
Suppression of hypoxia
A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis PMID 36394649
CRBN ligand
Anti
Anti
Daphnetin Preconditioning Decreases Cardiac Injury and Susceptibility to Ventricular Arrhythmia following Ischaemia
Endosulfan promotes cell growth, migration and invasion via CCL5/CCR5 axis in MCF
Effects of differential modulation of mu
Synthesis of 8
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP
Alstoniaphyllines A
Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives PMID 29626797
NH
Diastereomer
Prosapogenin A induces GSDME
MCE
PSP
Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma PMID 27085251
The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside
Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors PMID 38744169
MCE
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