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(3S,4R,5S)
CRBN ligand
Benzothiopyranoindole
Mb
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co
2
A near
Toxicokinetics of a developmental toxicity test in zebrafish embryos and larvae Relationship with drug exposure in humans and other mammals PMID 39104612
CRBN ligand
Gpc5 Rat Pre
Saponin QS
Preclinical evaluation of WYE
Bnip3l Rat Pre
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome PMID 31484070
Sustained Release from Ionic
Simultaneous estimation of ZY
Cucurbitacin IIa 58546
Chymase inhibitors for the treatment of cardiac diseases a patent review (2010
Exosome
muscular
N
Targeting Glutamine Metabolism and Redox State for Leukemia Therapy PMID 30940653
Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy PMID 26175929
Gastrodin protects retinal ganglion cells through inhibiting microglial
Minireview Gut peptides targets for antiobesity drug development? PMID 19372201
RANTES/CCL5
toll 样受体 3（TLR3）基因
OTX008 286936
Urocortin participates in LPS
HIF
27
Rorifamide 53078
A Glycyrrhizin Derivative with a More Potent Inhibitory Activity against High
Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug
Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3
Dansyl
Structure
(E)
Natural compound phloretin restores periodontal immune homeostasis via HIF
RA642 54093
白介素 1 受体 1 型（IL1R1）基因
Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling PMID 17052608
DAPD
The inhibition of GLUT1
CRBN ligand
Stereoselective features of (R)
Terpenoids from the root bark of Pterolobium macropterum PMID 25337628
蛋白质精氨酸甲基转移酶1（Prmt1）基因
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists) Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters PMID 28319392
N
Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II
MCE
Trypacidin, a spore
DMTr
Trypsin Acetylated, Bovine
Microwave assisted one
STING agonist
钙网蛋白 3（CALR3）基因
Clerodendrin 119738
Considerations for the discovery and development of 3
Enhancing immunotherapy efficacy in oral cancer through AKB
LB 10517 sodium 175553
(2R,3S)
A possible but unrecognized risk of acceptable daily intake dose triazole pesticides exposure
Ketones 2
Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents PMID 20138519
Quantitation of triacylglycerols in plant oils using HPLC with APCI
Neobavaisoflavone
m
ALDH2 Attenuates Blood
VCP
Activities of new antimicrobial agents (trovafloxacin, moxifloxacin, sanfetrinem, and quinupristin
GPR30
20S,24R
Male SJL mice do not relapse after induction of EAE with PLP 139
Nemorubicin hydrochloride 108943
Gastrodin Protects against Ethanol
Quantitative Structure⁻Activity Relationships for the Flavonoid
Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX
PSB
Kagimminols A and B, Cembrene
MICB Human Pre
Design, synthesis, and biological evaluation of novel capsaicin
Rapid screening and identification of metabolites of murpanicin in rats by UHPLC/Q
Methoxamine
TATA
Inflammation and N
Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1/RAGE/NF
MCE
Highly Modified Lanostane Triterpenes from Fruiting Bodies of the Basidiomycete Tomophagus sp PMID 30983350
Auriculasin 60297
Cynaroside alleviates radiation
Vasopressin analogues and spatial working memory in the 24
Oncogenic KRAS is dependent upon an EFR3A
(Cys47)
Skatole
SELP
MCE
Substrate
uPAR 蛋白, Human (Domain 2&3 , HEK293, His)
Determination of dithiocarbamate fungicide propineb and its main metabolite propylenethiourea in airborne samples PMID 17376506
The Protective Role of Leptin in Neurological Damage Induced by Chronic Intermittent Hypoxia PMID 40335790
Optimal bone fracture repair requires 24R,25
β
Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD
Kv7(KCNQ)
Design, synthesis and anti
Androgen
Glycocinnasperimicin D 99260
Gene expression analysis of oxidative stress
Rb1cc1
Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4
Nanomolar
Erianin Suppresses Pancreatic Cancer Progression by Inducing Cell Cycle Arrest and Ferroptosis PMID 40837329
The PI3K/Akt/GSK
Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF
Cytotoxic and antimalarial azaphilones from Chaetomium longirostre PMID 22004007
Cationic biaryl 1,2,3
Cholesterol paradox is high total or low HDL cholesterol level a risk for Alzheimer's disease? PMID 12671988
BRN3OMe 188349
Methyl (3S,6R)
9
异质核核糖核蛋白 D 样（HNRNPDL）基因
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux PMID 24291777
L 697661 135525
Antibiofilm agent
Desogestrel down
Anti
Toxicity evolution and control for the UV/H2O2 degradation of nitrogen
D₂
Pan
Fth1 Rat Pre
Structure
MCE
Rho GTPase inhibitor 1 1309252
Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+
A pharmacokinetic interaction study between omeprazole and the H2
MG degrader 3 2413733
5
ret 原癌基因（RET）基因
Protective effect of aldehyde dehydrogenase 2 against rat corneal dysfunction caused by streptozotocin
KLF4 prevented angiotensin II
Discovery of novel pyrrolo[2,1
The mRNA Cap 2'
TRIM24 is an insulin
ITGB1
Balanol 63590
84517
Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity PMID 36479819
LY518674 425671
Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation
Identification of Febuxostat as a New Strong ABCG2 Inhibitor Potential Applications and Risks in Clinical Situations PMID 28082903
A novel intravascular drug delivery method using endothelial biotinylation and avidin
Properties and therapeutic application of bromelain a review PMID 23304525
Topical anti
Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse PMID 2471010
Dacryhainansterone (海南陆均松甾酮)
1,2
Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study PMID 30499424
Drug treatments for metastasis of the Lewis lung carcinoma lack of correlation between inhibition of lung metastasis and survival PMID 2743339
Intratumoral microbiota
Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth PMID 38062013
microRNA
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice PMID 33577983
MBD4 Human Pre
Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation PMID 38663798
Iodomethane
Antidiabetic actions of a non
PX866
Kinmoonosides A
Ionox 330 1709
Veratrum
DR5
Theophylline EP impurity C
Synergistic lethality between PARP
Mixed inhibitors of angiotensin
Discovery of a Novel Mutant
Effect of a specific 5
Discovery of [ cis
ABthrax
3MST
BPDE and B[a]P induce mitochondrial compromise by ROS
Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF
Structure
骨形态发生蛋白 3（BMP3）基因
Proclonol
Ctsh Mouse Pre
RPLP0
Epithelial chloride channel. Development of inhibitory ligands PMID 2450168
Autonomic and antihypertensive activity of oral amosulalol (YM
谷氨酸
A preliminary phytochemical investigation of Digitalis ferruginea PMID 13151981
Reduced amide bond peptidomimetics. (4S)
Combination of microparticles vaccine with MSI
AMPA receptor antagonist
Autophagy inhibition
真核翻译延伸因子 1 alpha 1（EEF1A1）基因
Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species PMID 29107684
Linsitinib 867160
STAT3
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead PMID 36126388
HIV
Telbivudine exhibits no inhibitory activity against HIV
C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1
HY
Therapeutic efficacy of cefpiramide and cefoperazone alone and in combination with gentamicin against pseudomonal infections in neutropenic mice PMID 3698725
Methicillin sodium hydrate 7246
Inhibition of XIST attenuates abdominal aortic aneurysm in mice by regulating apoptosis of vascular smooth muscle cells through miR
HIF
PSN632408 857652
SMC
AR
T 30177
The pharmacology of Ro 64
Development of tolerance to bedaquiline by overexpression of trypanosomal acetate succinate CoA transferase in Mycobacterium smegmatis PMID 39915674
TGF
Loss of PTEN expression is associated with PI3K pathway
Kaolin 1332
Human CST Stimulates Base Excision Repair to Prevent the Accumulation of Oxidative DNA Damage PMID 38908783
Tongmai Yangxin pill alleviates myocardial no
DNA binding, and apoptosis
First report of Candida auris in Guangdong, China clinical and microbiological characteristics of 7 episodes of candidemia PMID 38164742
Development of Thieno[3,2
DOTA
In vivo phenotypic screening for treating chronic neuropathic pain modification of C2
Paclitaxel induces pyroptosis by inhibiting the volume‑sensitive chloride channel leucine‑rich repeat‑containing 8a in ovarian cancer cells PMID 37083067
Chlamydia psittaci plasmid
Off
Flurofamide Prevention and Treatment of Ureaplasma
12
Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects PMID 38687198
Metabolism guided optimization of peptidomimetics as non
D
IGF
N
Alizarin complexone 3952
Vascular smooth muscle
Cyclosporin A Acetate
GV
Aganodine 86696
3',5'
AhR modulator
Antitumor activity of the glutaminase inhibitor CB
Antimycobacterial activities of oxazolidinones a review PMID 17168800
R121919 hydrochloride 195055
Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles PMID 32095934
Discovery of Potent Dual PROTAC Degraders Targeting BET
In vitro and in vivo characterization of a novel CCR3 antagonist, YM
Resistance Analysis of a 3
Neuropeptide W
Optimization of TEAD P
Epirubicin may enhance the inhibition of hepatocellular carcinoma induced by iodine
Elp1
D
Discovery of novel 2
[Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi] PMID 19288919
Synthesis and structure
Substrate stabilization genetically controlled reciprocal relationship of two human enzymes PMID 5410854
Potassium iodate, 99.5% 7758
Antibiofilm agent
MCE
Kelampayoside A 87562
Autologous transplantation of mitochondria/rAAV IGF
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti
无名指蛋白 144A（RNF144A）基因
KRH
7
Oveporexton 2460722
A novel cyclic peptide targeting LAG
Oral phentolamine an alpha
A mechanism for P
HIV
Hel 13
Design, synthesis and biological evaluation of 1,5
Hsa
5,7,3',4'
Antitumor agent
Kmt2c
Effects of an E
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells PMID 30540938
How Rapidly Does the FAPI PET Signal Reverse Following Therapy? Assessing the FAPI PET Signal in Hypertensive Cardiac Injury and Fibrosis in Mice PMID 40935615
(6R,8S,10R,11S,13S,14R)
CGP 53437 150736
Antioxidant activity of different species and varieties of turmeric (Curcuma spp) Isolation of active compounds PMID 30266519
Functional characterization of CFI
Small
Receptor density influences ligand
Design and validation of novel brain
Erythromycin C 1675
Gynosaponin TN
Discovery of JTZ
Dynamic contrast
受体相互作用的丝氨酸
UniPR500
Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells PMID 28395332
VU10010 633283
KP
L
erythro
Nur77 Promotes Inflammation in Cisplatin
Cyclooctyne
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis PMID 31588243
MCE
dATP
CD326
First hydroxamate inhibitors for carboxypeptidase A. N
error
Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis PMID 17520465
serpin 家族成员 12（SERPINA12）基因
Plerixafor 110078
Discovery of a thieno[2,3
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self
In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex PMID 1477384
Glyoxal
Bictegravir
Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX
Leptin signaling, adiposity, and energy balance PMID 12079865
Cer1
脑出血 (Brain Hemorrhage)
Neutrophil
锌和无名指 3（ZNRF3）基因
The antioxidative, non
4SC
Antiproliferative Potential of Gloriosine A Lead for Anticancer Drug Development PMID 36033689
Highly Modified Lanostane Triterpenes from the Wood
The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid PMID 21146550
Double
Losoxantrone 88303
Trixylyl phosphate
Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway PMID 38614041
Ginkgo biloba for cerebral insufficiency PMID 1457269
AMPA
Bis
MCE
Design and synthesis of C
Targeted delivery of ubiquitin
Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination PMID 40048831
Colony
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide
Possible Role of 5
Roluperidone 359625
Aplaviroc hydrochloride 461023
Chicamycin B 89675
FPI1523
Nemorubicin
MCE
Etravirine
Zintevir
GSTO1
Anti
MCE
rac
Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarization PMID 39788632
Sarubicinols A
Netrin
Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein
2
DMT
FLT3LG
GS
Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat PMID 9399638
MCE
Development of LC
Celikalim (Way 120491)
9
Inhibition of SET Domain
Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity PMID 32512613
AZD
Fenbufen
Povovetug 2975573
Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function PMID 29730286
Endothelial
Synthesis and structure
ASB7 Human Pre
Lavandulyl flavanones from Sophora flavescens protect mouse hippocampal cells against glutamate
β
Influence of nucleotide identity on ribose 2'
人 iPSC/ESC 皮质脑成熟培养基 (Human iPSC/ESC Cortical Brain Organoid Maturation Medium)
Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1
Synthesis of the Pitstop family of clathrin inhibitors PMID 24922269
(Z)
3,5
异质核核糖核蛋白 A/B（HNRNPAB）基因
MCE
Effects of EGIS
Regulation of glial ApoE secretion by the mevalonate pathway is independent of ApoE isoform PMID 39994996
Diversity
Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF
[Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)] PMID 18536375
Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM
HY
tri
NRP1
Immunoprecipitation Strategies to Isolate RIPK1/RIPK3 Complexes in Mouse Macrophages PMID 34106523
Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid PMID 40138412
MCE
Gut
Edoxaban impurity 14 ((1R,2S,5S)
Shank3
MCE
The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV
glycan arrays
Wt1 Rat Pre
Efficacy of SPK
KIR2DL4 (CD158d), an NK cell
Methyl 2
FITC
Sodium 1H,1H,2H,2H
plakophilin 3（PKP3）基因
Antibiofilm agent
Xamoterol hemifumarate (Standard)
Kushenol Q (苦参醇 Q)
Gamma
ABCG2
Development of inhibitors of heterotrimeric Gαi subunits PMID 24818958
E3 Ligase Ligand
JAK1
Pharmacokinetics and metabolism of metioprim in pigs and goats PMID 3438229
Invobenitug 3034173
ADAM17 is an essential attachment factor for classical swine fever virus PMID 33684175
Antimycobacterial activity a facile three
New Agents in Development for Sepsis Any Reason for Hope? PMID 32951149
CRBN ligand
Regulation of inflammatory responses by pH
Bis
Synthesis and in vitro antimycobacterial activity of novel 3
Silencing of ALOX15 reduces ferroptosis and inflammation induced by cerebral ischemia
(R,S,S)
Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane
Eugenol works synergistically with colistin against colistin
Restoration of HMGCS2
Cyclizine dihydrochloride 5897
AMPA receptor antagonist
Cimifugin Inhibits Inflammatory Responses of RAW264.7 Cells Induced by Lipopolysaccharide PMID 30638197
Alpha
Single‑Dose Pharmacokinetics and Safety of the Oral Galectin‑3 Inhibitor, Selvigaltin (GB1211), in Participants with Hepatic Impairment PMID 39358661
Tazarotenic acid (Standard) (AGN 190299 (Standard))
Multi
Rational drug design based synthesis of novel arylquinolines as anti
The effect of dexrazoxane on myocardial injury in doxorubicin
S
Crilvastatin 120551
Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb PMID 17497420
The anti
Comparison of cell
1,3
Repurposing a Cardiovascular Disease Drug of Cloridarol as hIAPP Inhibitor PMID 33780229
动力蛋白轻链 Tctex
Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T
3'
Biosensing methods for determination of creatinine A review PMID 30551062
Delmopinol
Phanquinone (11925 C)
Amidepin
Effects of vitexin
Pulmonary surfactant
Targeting SHP
N
SH3 和 PX 域 2A（SH3PXD2A）基因
Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha PMID 34709688
Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS PMID 38531462
Lipid Tail Length Determines Nano
Discovery of pyrrolo[2,3
Biguanide
Modulation of sexual behaviour in the rat by a potent and selective alpha 2
Sobetirome 211110
Purification and biochemical characterization of pyruvate oxidase from Lactobacillus plantarum PMID 6480556
Isoglobotetraose 75645
AS2521780 1214726
Neuroprotective and anti
PD
Saroglitazar magnesium 1639792
Sigma
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors PMID 23731016
(±)7(S),8(R)
MCE
The oncoprotein SET promotes serine
Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP
ADP 核糖基化因子样 GTPase 16（ARL16）基因
MCE
Ciclopirox olamine 41621
MS8815 2855085
Regulation of HDL metabolism in alcohol
AR expression
Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS
Effects of TNFalpha
MTOR 复合物 1 的调节相关蛋白（RPTOR）基因
Vilazodone HCl (Viibryd) A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder PMID 22346333
ret 原癌基因（Ret）基因
Gclc
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor PMID 35931745
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector PMID 22508309
The newly identified K+ channel blocker talatisamine attenuates beta
Chicken Ovomucoid (卵类粘蛋白)
Vectofusin1
Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin
C2
rel
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