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ATTO 740 1188422
Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease PMID 39945752
MC3343 1535187
Anti
PKZ18
Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors PMID 29920191
Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF
HBI
Cavrotolimod
Control of reproduction and of undesirable social and sexual behaviour in dogs and cats PMID 4738952
Salvia miltiorrhiza Bunge aqueous extract inhibits lung metastasis of breast cancer by inhibiting recruitment of M2
Defucogilvocarcin V, a new antibiotic from Streptomyces arenae 2064 isolation, characterization, partial synthesis and biological activity PMID 3917241
Pde3a Mouse Pre
PNR
5
Reducing amyloid
Tumor
ATTO 550 1251752
nuclear factor kappa B
VU6015929 2442597
Overcoming Preclinical Safety Obstacles to Discover ( S)
Qing
U
Probenecid (Standard)
carotid
chromatin damage
Discovery of novel, orally active dual NK1/NK2 antagonists PMID 11591520
Trifloxystrobin induces tumor necrosis factor
Formosanin
Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum PMID 29526485
MEDI
In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection PMID 24128668
PD
Identification of 5,7
pro
Guanine
CP 88059
NUCC390
BX430
c
AK
TTAC
Lidocaine
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway PMID 38868519
Monodemethoxycurcumin (Standard)
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination PMID 34706239
Emodin alleviates severe acute pancreatitis
Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG
Cyclo(Pro
Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers A randomized, open
IPH 5401
Amino
Aleplasinin
GSK
Methyl arachidonate
Research Resource Real
MiR
Synthesis of novel 2, 5
IL
sialoglycans
Ladostigil hemitartrate (Standard)
IDO
1
Systematic investigation of the material basis, effectiveness and safety of Thesium chinense Turcz. and its preparation Bairui Granules against lung inflammation PMID 38720376
Evidence for hypoxia
CB
PNRI
Leucine
Synthesis of 4,5,6,7 and 2,4,5,6,7 Deuterium
SSX 家族成员 2 相互作用蛋白（SSX2IP）基因
Genetic Landscape and Emerging Therapies in Uveal Melanoma PMID 34771666
Bioenergetic suppression by redox
Uptake and metabolism of sulphated steroids by the blood
KT53 1338494
Design, Synthesis, and Evaluation of Selective Ubiquitin
Small molecules targeting c
MAO
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone PMID 30618632
N
The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein PMID 19022239
Investigation of long
Semisynthesis of rosmanol and its derivatives. Easy access to abietatriene diterpenes isolated from the genus Salvia with biological activities PMID 12141857
曲妥单抗
Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL
CD5 蛋白, Human (Biotinylated , HEK293, His
Coro1a Rat Pre
Δ(9)
Preclinical Evaluation of JAB
BODIPY 505/515
Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice PMID 18465074
Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models PMID 36824886
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells PMID 18925943
Aryl Hydrocarbon Receptor Activation Downregulates IL
The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide
Brain microdialysate, CSF and plasma pharmacokinetics of ligustrazine hydrochloride in rats after intranasal and intravenous administration PMID 23868712
Shape
CoQ10 alleviates hepatic ischemia reperfusion injury via inhibiting NLRP3 activity and promoting Tregs infiltration PMID 36640727
Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP
Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate PMID 18775055
Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei PMID 33736972
Pharmacological disruption of insulin
Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor
Synthesis and antitumor effects of novel 18β
Ramp1
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5
CXCL12
Maslinic Acid Attenuates Ischemia/Reperfusion Injury
17(R)
USP21 promotes self
MM
CHIR
Urinary 3
Eribulin induces irreversible mitotic blockade implications of cell
S
Inhibition of shear stress
MCE
Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain PMID 37639183
Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen
左右决定因素 2（LEFTY2）基因
Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis PMID 14506870
Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats PMID 28166749
MMP
Formosanin C inhibits triple
Effect of CSE on M1/M2 polarization in alveolar and peritoneal macrophages at different concentrations and exposure in vitro PMID 31898012
Suppression of ACE2 SUMOylation protects against SARS
IFNA8 Human Pre
NAD+ levels control Ca2+ store replenishment and mitogen
BAFF 抗体 (YA4582)（BAFF Antibody (YA4582)）
Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori PMID 2039199
YAP1 aggravates hyperglycemia
HT
Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin
Dabigatran activates inflammation resolution by promoting fibrinogen
R 29676
Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse PMID 39489186
Saikosaponin A Protects From Pressure Overload
Development of Mithramycin Analogues with Increased Selectivity toward ETS Transcription Factor Expressing Cancers PMID 30114371
5
Thymol improves autism
BMS
Characterization of a potent and selective small
Formoterol
泛素特异性肽酶 13（USP13）基因
TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis PMID 40921878
HA1/Hemagglutinin 蛋白, H1N1 (ACU13097, HEK293, His)
Studies of the extracellular ATP
Simultaneous Quantitation of S(+)
Environmentally realistic dose of tire
Non
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153
Sigma
MK 0686
GIP (3
TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway preliminary evidence PMID 39840833
COX
Active metabolites as antidepressant drugs the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders PMID 24062697
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists PMID 17228869
Curindolizine, an Anti
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia PMID 34798593
Integrated analysis of scRNA
DAGLβ is the principal synthesizing enzyme of 2
Hepatitis B virus X protein promotes the stem
S 33084
(S)
Z
Thermoreversible gel for delivery of activin receptor
Lcn2
NOX4 overexpression is a poor prognostic factor in patients undergoing curative esophagectomy for esophageal squamous cell carcinoma PMID 31889545
Propargyl
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis PMID 35841866
The Cdx transcription factors and retinoic acid play parallel roles in antero
Z
Mal
MRGPRX4 modulator
MCE
NNMT
RP 19583
N
Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities PMID 23327794
Design and Synthesis of New Transient Receptor Potential Vanilloid Type
CG 1521
Pkd2
In vitro and in vivo evaluation of a 64Cu
LLL12 1260247
REGN 5678
Ifnl2
Hal
ATRA Signaling Regulates the Expression of COL9A1 through BMP2
Bioactive Peptide,anti
PhosTAC
A multifunctional transcription factor (A1p145) regulates the smooth muscle phenotype in mesangial cells PMID 9826522
2,5
PF03709270
biliary lipid secretion
Plasma exosomal miRNAs involved in endothelial injury in microscopic polyangiitis patients PMID 32232900
BGN
PD 099560
Diphenyl
Rps10
J
METTL3 aggravates renal fibrogenesis in obstructive nephropathy via the miR
Esters and amides of maslinic acid trigger apoptosis in human tumor cells and alter their mode of action with respect to the substitution pattern at C
EL 222
Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities PMID 22344919
BIBU 52
ICMT
Sitagliptin phosphate
Silencing of PD
Deficiency of canonical Wnt/β
DBP exposure induces thyroid inflammatory impairment through activating AKT/NF
β
Poststatin 135219
IL
ATP Citrate Lyase 抗体 (YA4085)（ATP Citrate Lyase Antibody (YA4085)）
SARS
cardiac stimulating activities
Arbutin Attenuates Isoproterenol
1,1,2,2
17β
Vatalanib (Standard) (瓦他拉尼碱 (标准品))
Gram staining PMID 18770544
Translationally controlled tumor protein exerts a proinflammatory role in acute rejection after liver transplantation PMID 32224126
Cirsimaritin inhibits influenza A virus replication by downregulating the NF
Flavonoids of Tripodanthus acutifolius inhibit TNF
Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs PMID 29091888
PROTAC LRRK2 Degrader
Discovery and biological evaluation of 5
Alpelisib administration reduced lymphatic malformations in a mouse model and in patients PMID 34613809
Bronchial effects of some prostaglandin E and F analogues PMID 888708
Identification of new amine acceptor protein substrate candidates of transglutaminase in rat liver extract use of 5
Postprandial parasympathetic signals promote lung type 2 immunity PMID 39837323
SHP1 and its downstream p38/SP1/PI3K/YAP/Notch
Soyasapogenol B and Genistein Attenuate Lipopolysaccharide
Retinol Binding Protein 4 reactivates latent HIV
Carbidopa 28860
Prostaglandin E3 attenuates macrophage
Reaction of irofulven with zinc and acid PMID 12608875
Activity of irofulven (6
JS007
TSC1 Affects the Process of Renal Ischemia
HJURP 蛋白, Human (His
Atf4 Mouse Pre
PROTAC IKKβ degrader
Transforming growth factor
Ravenelin 479
The effect of anti
MAO
Discovery of methoxy
Repurposing the FDA
Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti
Effect of Selected Anionic and Cationic Drugs Affecting the Central Nervous System on Electrical Properties of Phosphatidylcholine Liposomes Experiment and Theory PMID 33668791
Insights into the accumulation and hepatobiliary transport of bisphenols (BPs) in liver and bile PMID 39476930
Acid
CXCL7 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)
BLK 蛋白, Human (Active, Sf9)
Developing Subcutaneous Formulations for Irisin as a Potential Therapeutic PMID 41126008
A novel class of Hsp90 inhibitors isolated by structure
The anti
BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models PMID 24009722
KRT86 Human Pre
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens PMID 9847399
Inhibition of FOXO3 ameliorates ropivacaine
Structural insights into hydroxycoumarin
Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB PMID 38640354
Pharmacokinetics and Pharmacodynamics of Temocillin PMID 28849402
Bio
Identification of a transcytosis epitope on staphylococcal enterotoxins PMID 11895985
1
Reaction products of gamma
The antibacterial and pharmacological activity of oxolinic acid (Prodoxol) PMID 810473
含 GTF2I 重复结构域 1（GTF2IRD1）基因
IL
(R)
Gga3 Rat Pre
Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer PMID 40280967
MCE
Ethyl 2
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 PMID 21087210
INHBB Human Pre
Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues PMID 37522336
Saponin Formosanin C
Daporinad in vitro metabolite profiling via rat, dog, monkey and human liver microsomes by liquid chromatography/quadrupole
ASIC1a regulates airway epithelial cell pyroptosis in acute lung injury by NLRP3
Therapeutic effects of an anti
Gc Rat Pre
INSIG2 Human Pre
N
Reprogramming of DNA methylation patterns mediates perfluorooctane sulfonate
An orally available small
Development of a new isogenic cell
Phytoecdysteroids from the stem bark of Vitex doniana and their anti
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation PMID 37597514
Deletional tolerance prevents AQP4
Radiosensitization of solid tumors by Z
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo PMID 28106668
Identification of a Potent Human Trace Amine
The 6
Carcinine has 4
Identification and functional analysis of transforming growth factor
5'
Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome
Pharmacological inhibition of SUMO
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair PMID 36475791
Targeting Lewis X oligosaccharide
N
CD58 蛋白, Human (HEK293, His)
The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia
KP
Mitigation of cardiovascular toxicity in a series of CSF
Piperonylic acid, a selective, mechanism
Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549
Microglia regulate central nervous system myelin growth and integrity PMID 36517604
Protective Effects of Reduced Glutathione and Ulinastatin on Xeno
Homoplantaginin alleviates intervertebral disc degeneration by blocking the NF
Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF
Tonabersat 175013
Vitamin D alleviates silica
Discovery of N
Zhilong Huoxue Tongyu Capsule attenuates hemorrhagic transformation through the let
Phillyrin promotes autophagosome formation in A53T
Isovitexin 7
Pragliflozin
Itaconic acid production in microorganisms PMID 29299715
Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells PMID 37833712
Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38
Hyperprolactinaemia PMID 17889620
BZAD 01
NEt
Alpha
NSC 260179
AG
Emerging Paradigms in Immune
bacteria infecting
Cyanine
Orticumab 1314241
SP3
structure
Pacanalotamab 2251756
Immunomodulatory effects of Inonotus obliquus polysaccharide on splenic lymphocytes infected with Toxoplasma gondii via NF
Indole
hsa
Human IL27 mRNA
CGA 154281
sEH inhibitor
Lucialdehyde B suppresses proliferation and induces mitochondria
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA
Botryodiplodia spp.
Als2 Mouse Pre
Pif1 Rat Pre
Ssbp1 Rat Pre
Dapagliflozin ((2S)
Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS
Y 15
PK4C9
LY228729
P2X3 receptor
Brief Report A Randomized, Double
IEM 1754
LDN
YJZ5118 3031861
2X
Pyroglutamylleucine
neutrophil elastase
Celsr1
METTL3
SLC44A4 抗体 (YA7065)（SLC44A4 Antibody (YA7065)）
SR
SNX11 Human Pre
Dolastatinol
Gdf2 Mouse Pre
KU1257
CDH5
Initial evaluation of Cu
SAR247799
MDGA2
IL
Pteleine
Synthesis of N
MRTX849
MCE
Inhibition of the aryl hydrocarbon receptor prevents Western diet
Decoding dengue's neurological assault insights from single
The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin
Pseudostellarin E
Menthone inhibits type
PKN1/PRK1
Mouse Immunoglobulin G1 (小鼠免疫球蛋白G1)
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration PMID 33824228
Antiviral effects and mechanism of Qi pi pill against influenza viruses PMID 39865580
Chalcomycin 20283
BMS 189664
Thalidomide
MK 647
A375 cell
Y641N
PKM2 modulator 2
AZD7648 is a potent and selective DNA
Dioctyl
AHR
taurine
GNKG168 sodium
SRI 31255
Caspase
Zometapine
Stereodifferentiation of 3
Heme oxygenase
GNQWFI
Anti
(+)
SJF 620
CD80 抗体 (YA5496)（CD80 Antibody (YA5496)）
luteum
J 14
Monobehenin
Pyrene
MEDI 528
Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune
2
SJ995973
1
1
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage PMID 39924585
Insulin
Cavrotolimod sodium scrambled negative control
Frizzled
IL
HY
NKG2C/CD159c 蛋白, Human (Biotinylated, HEK293, His
磷脂酶 C delta 1（PLCD1）基因
The role of linagliptin, a selective dipeptidyl peptidase
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis PMID 22430489
GLP
Tumor
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1
Ibandronate pharmacology and preclinical studies PMID 16531132
Efficacy of nemadectin, a new broad
EGFR Ligand
Pharmacokinetics of triamterene after i.v. administration to man determination of bioavailability PMID 6628507
HDAC inhibitor
IL
Active mitochondria support osteogenic differentiation by stimulating β
IL
IL
MAF Human Pre
STAM Human Pre
A molecular chaperone inducer protects neurons from ER stress PMID 18049481
HB9 抗体 (YA2415)（HB9 Antibody (YA2415)）
Lactobacillus rhamnosus ameliorates experimental autoimmune neuritis via modulation of gut microbiota and metabolites PMID 39524841
Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4 PMID 31346987
Benzyl 2
(±)
Levobetaxolol hydrochloride a review of its pharmacology and use in the treatment of chronic open
Inhibitory properties and X
Contrasting effects of DOI and lisuride on impulsive decision
Receptor binding and membrane fusion in virus entry the influenza hemagglutinin PMID 10966468
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS
β
KAT6A Human Pre
Novel Indoleamine
Activin isoforms signal through type I receptor serine/threonine kinase ALK7 PMID 15196700
USP25 Human Pre
GTSE1 Human Pre
Erythromycin PMID 3320616
Maslinic Acid Inhibits Myocardial Ischemia
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia PMID 27157927
Ergosterol Attenuates LPS
Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK PMID 41060807
SEPTIN7 Human Pre
Tox Mouse Pre
Ester and amide prodrugs of ibuprofen and naproxen synthesis, anti
SB
Dimemorfan prevents seizures induced by the L
Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression PMID 25364207
Soyasapogenol B exhibits anti
The Carthamus tinctorius L. and Lepidium apetalum Willd. Drug Pair Inhibits EndMT through the TGF β 1/Snail Signaling Pathway in the Treatment of Myocardial Fibrosis PMID 36686974
Doxapram metabolism in human fetal hepatic organ culture PMID 1855351
Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases PMID 26164127
HY
Application of Non
PYGM downregulates necroptosis signaling to attenuate sodium iodate
Identification of a novel series of BET family bromodomain inhibitors binding mode and profile of I
Pixantrone free base 144510
Zoligratinib 1265229
22828
CRBN ligand
Metconazole
N6
p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke PMID 39981897
PDIA2 抗体 (YA238)（PDIA2 Antibody (YA238)）
Cross
mmu
Loading of doxorubicin on poly(methyl methacrylate
Pao Pereira Extract Attenuates Testosterone
A Frog
Talabostat Alleviates Obesity and Associated Metabolic Dysfunction via Suppression of Macrophage
Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin
2',4'
Phospholipase A2 Activator Protein 抗体 (YA2834)（Phospholipase A2 Activator Protein Antibody (YA2834)）
Quinapril
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