最近收录_第710页_生物活性分子
生物活性分子最近更新
Uba1 Mouse Pre
UC
Slc8b1 Rat Pre
TY
HDAC6 ligand
Cremophor EL
MC1
aptTNF
Bcl
N
Ube2o Rat Pre
HDAC3 Human Pre
MCE
2′,7′
hsa
2,3
OSL
hsa
Kieselguhr, soda ash flux
24(28)
3,4
SARS
hsa
MCE
蓝色荧光快速标记试剂盒（AF350） (Blue Fluorescent Rapid Labeling Kit (AF350）)
1,2
Mlh1 Rat Pre
Budesonide oleate (C18 1) (Budesonide 21
double
mmu
亨廷顿舞蹈症
hsa
C12 Mono
3
mmu
Cy5.5
18 1 PE AF 594 triammonium
Mal
Scillascillin 52706
3
YPC
Signal therapy for RAS
IFN
Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation PMID 39298674
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)
non
PARP inhibitor with selectivity toward ADP
14 0 DAP 72719
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers PMID 39630604
PG110
Structural characterization of the papaya cysteine proteinases at low pH PMID 16434027
Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents PMID 40375738
IL24 Human Pre
Preventive Effect of Polysaccharide of Larimichthys crocea Swim Bladder on Reserpine Induced Gastric Ulcer in ICR Mice PMID 24757382
IP
AVN
PM
Modulation of bladder afferent signals in normal and spinal cord
Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress PMID 22783192
Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model PMID 35576719
4'
FAM237A, rather than peptide PEN and proCCK56
Applications of BOP reagent in solid phase synthesis. Advantages of BOP reagent for difficult couplings exemplified by a synthesis of [Ala 15]
PSX
Dye 937 195199
BMS
Triptolide decreases rheumatoid arthritis fibroblast
Hexatriacontane
116
L
Discovery of 8
Sitagliptin impurity 4 486459
NOTCH4 Human Pre
An antidepressant mechanism underlying the allosteric inhibition of GluN2D
GCA
Fmoc
Decreased PD
DZ2002
CXCR4
Discovery of a potent, selective, and orally bioavailable c
Structure
Discovery of stereospecific cytotoxicity of (8R,8'R)
Insights into IrtAB Iron Transport Facilitates Ultrasensitive Detection of Mycobacteria in Both Cellular and Clinical Environments PMID 40028350
Dereplication
BK
Ccl7
Disopyramide phosphate 22059
Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA PMID 39075271
emptying
Discovery of a Potent and Selective Covalent Inhibitor and Activity
Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice PMID 32316544
Chemical genetic discovery of PARP targets reveals a role for PARP
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation PMID 26587712
Sunset Yellow FCF 2783
CP
Isoliquiritigenin inhibits the activation of the ANXA2/STAT3 pathway by down
The effects of P
N
LU
Laninamivir octanoate a new long
IL4R
CCT241161 1163719
Gm2a Rat Pre
MEKK2
Ald
CSBP ligand 1 165806
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation PMID 32634680
Agatharesinol 7288
PteGlu6
Structure
I
OVA
16 0
AVJ
KGP
high throughput
2
NFκB pathway
CDK7
Exploring ND
Trex1 regulates lysosomal biogenesis and interferon
DH
MS 21
Tnfrsf18 Mouse Pre
Azotochelin 23369
Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. ( the Singers' Plant ) Isolation and in Vitro Assays on the Somatosensory and Pain Receptor TRPA1 Channel PMID 30857138
PET/CT imaging of head
Cy5
The third generation AKR1C3
Antiprotozoal Structure
S
Nanoemulsions (NEs), liposomes (LPs) and solid lipid nanoparticles (SLNs) for retinyl palmitate effect on skin permeation PMID 25102113
Antifouling zwitterionic peptide hydrogel based electrochemical biosensor for reliable detection of prostate specific antigen in human serum PMID 36628704
TTP
CQ
m6A
Investigation of C
[Target pharmacology of topiramate, a new antiepileptic drug] PMID 10876816
E7766, a Macrocycle
Calcium Channel antagonist 2
STUDIES ON AN ANTITUMOR ANTIBIOTIC, CERVICARCIN. II. ANTITUMOR ACTIVITY OF CERVICARCIN AND ITS DERIVATIES AGAINST SOME OF TRASPLANTABLE MOUSE TUMORS PMID 14084119
SRP72 Human Pre
Deep learning enables discovery of highly potent anti
1
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects a randomized clinical trial PMID 24118885
Fenofibrate 49562
Identification of volatile emissions from Platypus mutatus (=sulcatus) (Coleoptera Platypodidae) and their behavioral activity PMID 16334317
ELGV
Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)
Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long
Herbicide applications increase greenhouse gas emissions of alfalfa pasture in the inland arid region of northwest China PMID 32509469
OMDM 4
Determination of protein
Neutrophil Extracellular Traps may be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage PMID 33852132
Discovery of an Orally Active Small
Autophagy inducer 7 944159
Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen
Search for lipidized PrRP analogs with strong anorexigenic effect In vitro and in vivo studies PMID 36669365
Discovery of TAK
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus PMID 30392371
Direct inhibition of oncogenic KRAS by hydrocarbon
Tetrahydroimidazo[1,2
Ethyl
Sydnone Reporters for Highly Fluorogenic Copper
Bufotalin
Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis PMID 30021909
Targeting Lipocalin
articular
TCF3 Human Pre
Antifungal spectrum, in vivo efficacy, and structure
Raphin
A prolonged nitric oxide
MMV03
The m6A RNA demethylase FTO promotes radioresistance and stemness maintenance of glioma stem cells PMID 40185350
Discovery of Novel Diaryl
3'
(R)
Root bark of Sambucus Williamsii Hance promotes rat femoral fracture healing by the BMP
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy PMID 22039576
Probing the early stages of solvation of cis
The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing PMID 18996007
UAE
Nocistatin, a peptide that blocks nociceptin action in pain transmission PMID 9521323
grains
Cellular chromium enhances activation of insulin receptor kinase PMID 15924436
Ginsenoside Rg1 Downregulates miR
6
Paliperidone 144598
OTUD6A in tubular epithelial cells mediates Angiotensin II
Investigation of the mechanistic basis of N,N
HA
Sarsasapogenin Inhibits HCT116 and Caco
C4
Effect of locked
Identification and regulation of EMT cells in vivo by laser stimulation PMID 40438388
Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells PMID 28032588
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders PMID 24102928
Anxiolytic
Acetamide
CMP
Chemical synthesis, growth
An HECT domain ubiquitin ligase CgWWP1 regulates granulocytes proliferation in oyster Crassostrea gigas PMID 34097916
Copper sulfate anhydrous, 99% 7758
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild
Artemether
OX01914 49676
m
Harnessing TGF
chitin
15(S)
Inhibitory effects of anti
PS 220
23
2,4
Levomilnacipran 96847
Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations PMID 38372272
The selective cyclooxygenase
Dose and duration
SC65872
CSF1R
Recognition of double
Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces PMID 29767975
PDE4A
Bikaverin production and applications PMID 20376635
Cyclization Synthetic Methodologies for Triphenylene Derivatives PMID 41088542
Pre
Zinc
MMP
Oxysophocarpine Retards the Growth and Metastasis of Oral Squamous Cell Carcinoma by Targeting the Nrf2/HO
Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching PMID 29364918
Identification of potent BRD4
The recycling collagen receptor uPARAP is a unique mediator of stromal drug delivery to carcinoma cells PMID 40665797
CEBPG
Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis PMID 12950080
Pharmacokinetics of 6
Coumarin 6 38215
NSD3 Advances in cancer therapeutic potential and inhibitors research PMID 37182335
Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1 PMID 27049670
Scyliorhinin II 112748
Hexanoic acid
SI
Studies on the chemotherapy of viral infections. II. The effect of caprochlorone on influenza virus infections in mice PMID 13429090
Naftoxate 28820
PI3K
Antiviral agent 34 945152
Sebacic acid binding to human plasma albumin PMID 8442769
CPF
The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes PMID 34863038
Broussonin B 73731
Bonducellpin C 197781
RAB21 Human Pre
Trans
NSC1746
Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity PMID 40310691
Sulforaphane Suppresses Hepatitis C Virus Replication by Up
Amph Rat Pre
Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus
W12
Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B
Mitochondrial stress induces hepatic stellate cell activation in response to the ATF4/TRIB3 pathway stimulation PMID 37150773
1
孪蛋白 DNA 复制抑制因子（GMNN）基因
A novel chemiluminescent ELISA for detecting furaltadone metabolite, 3
NSC
A1480LS
pithelial
MY
TP0586352
OC90 Human Pre
Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)
DFN
2
ZSA215
CCOE5
Lenvervimab 2055006
Hsd17b12 Mouse Pre
Crystallization and preliminary X
Glb1 Rat Pre
CCL
Analogues of cyclic adenosine 5'
JNJ16259685 409345
Discovery of ABBV
ABT450
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation PMID 38956039
Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells PMID 27416805
4ME 16 0 Diether PC 200715
Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis PMID 18347017
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry PMID 16134928
ACP
Small molecules restore mutant mitochondrial DNA polymerase activity PMID 40205042
sec
Fragment
Cytochrome P450
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone
[Functional implications of single nucleotide polymorphisms (SNPs) in protein
DFL23448, A Novel Transient Receptor Potential Melastin 8
N
EGM1
FSHRs
Effects of halopemide on GABA receptor binding, uptake and release PMID 6261878
DW71177
Concurrent blockade of free radical and microsomal prostaglandin E synthase
Regioselective synthesis and evaluation of 2
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism PMID 35259044
2B1
Inhibition of allergen
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral PMID 18160521
The Beneficial Effects of Pine Nuts and Its Major Fatty Acid, Pinolenic Acid, on Inflammation and Metabolic Perturbations in Inflammatory Disorders PMID 36674687
ADS
GSK2656157 1337532
Napyradiomycin B1 103106
Inhibition of cyclin
Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice relationship to capillary degeneration and permeability PMID 25667222
Efna2 Rat Pre
Cy5.5 hydrazide
Tracking fructose 1,6
Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke A Retrospective Pooled Analysis PMID 27032444
HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines PMID 26917266
Discovery of 5
Protective effects of bendazac lysine on early experimental diabetic nephropathy in rats PMID 15916739
Synthesis, bioevaluation and molecular dynamics of pyrrolo
CLG promotes mTOR/ULK1 pathway
Coenzyme Q10
CRBN ligand
OGR1
Interiorin D 133360
Psmd14
VSIG2
Norstictic Acid Is a Selective Allosteric Transcriptional Regulator PMID 34137598
FOXN1 Human Pre
Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3
BLOC1S2
VARS2 Human Pre
AHR
Taxinine A (紫杉宁A)
Effect of temperature on cell division in the cultured rabbit lens PMID 5130523
Complanatoside A 146501
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines PMID 38228616
TGN
S15535
4
HLY78 protects blood
β
Screening of drugs for thermogenic anti
[SER140]
Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds PMID 28595837
BMS
Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes PMID 28241436
4'
Polθ inhibitors elicit BRCA
Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model A First Report PMID 34455974
Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA PMID 28394340
miR
Undecane 1120
CDK2 inhibitors rationally directed discovery of a novel potent lead derived from cyclohepta[ e]thieno[2,3
Cell
L
Synthesis and antiproliferative activity of 6BrCaQ
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide
S
GEM231
Ispinesib 336113
SMCC
BPI
Stigmasterol exerts antiglioma effects by regulating lipid metabolism PMID 39364731
SMAD2
Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum PMID 8393943
o,p'
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone PMID 9275080
BPN
D
PEG 25 cetostearyl ether 874945
Hypoxanthine as an indicator of hypoxia its role in health and disease through free radical production PMID 3281119
dBAZ 2
Infection detection in mice using 99mTc
Drug action of benzocaine on the sarcoplasmic reticulum Ca
2
Cilnidipine is a novel slow
BET bromodomain
miR
GGTI
荧光成像
Testosterone Sulfate
A stable and highly sensitive 3,3',5,5'
Prostate cancer diagnosis among men with isolated high
A novel piperidine identified by stem cell
Ac2
Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth Anti
Dactolisib
RIPK3
In silico evaluation of S
RG
Anti
A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium
PATU
Three
The Highly Potent AhR Agonist Picoberin Modulates Hh
UPR
PI3K
Classes of sigma2 (σ2) receptor ligands structure affinity relationship (SAfiR) studies and antiproliferative activity PMID 22288411
Cellular spermine targets JAK signaling to restrain cytokine
Hippo pathway
Two
strain
Acute drug
Synthesis and biological evaluation of (6
Cytoplasmic Clusterin Suppresses Lung Cancer Metastasis by Inhibiting the ROCK1
Synthesis and biological evaluation of novel aliphatic amido
Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cells PMID 37959792
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice PMID 34089617
IMR
8
Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat PMID 30891022
MBL regulates phagocytosis and bactericidal activity of macrophages by triggering AKT/NF
Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty A network meta
Cypate
Lcz696 Alleviates Myocardial Fibrosis After Myocardial Infarction Through the sFRP
Aspinonene 157676
Disperse red 151 70210
The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small
Structural basis of Nav1.7 inhibition by an isoform
Novel amide
Pirozadil 54110
Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A PMID 10559474
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP
α5IA 215874
Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo PMID 26525771
Rabdoserrin A 96685
MDR
C.I. Acid black 60
Upregulation of IL
P388
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T
Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c
Mosapride in gastrointestinal disorders PMID 18457463
Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells PMID 28638477
Koenigicine 24123
Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders PMID 1715267
Sophocarpine alleviates doxorubicin
Induction of GLI1 by miR
Combined effect of gene dosage and process optimization strategies on high
Hydrophobic Tagging
Selective mechanism
SBP1
LYRM7 Human Pre
PRN1371
Biophysical characterization of styryl dye
AF 698
SCH 23390 the first selective dopamine D1
Capsaicin ameliorates cholestasis through modulation of the FXR
Reversible male contraception by targeted inhibition of serine/threonine kinase 33 PMID 38781365
Development of a copper
DiOC5(3) 53213
Poly(ADP
recombination
De novo identification of toxicants that cause irreparable damage to parasitic nematode intestinal cells PMID 32453724
Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life PMID 31541821
Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist PMID 10454481
Methotrexate disodium 7413
G
Neuroprotective Effect of a Novel Soluble Guanylate Cyclase Activator (sGCa) Runcaciguat in Diabetes and Ischemic Retinopathy PMID 40249725
THP
3
Enhanced production of 24S
Targeting Hsp90α to inhibit HMGB1
Butoconazole nitrate 64872
Phase Ib Study of the BET Inhibitor GS
Geraniol (GER) attenuated chronic sleep restriction (CSR)
KCA
New tirucallane
Nanoparticles with ultrasound
Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture PMID 25118903
NSC689857 241127
Increased ten
Dimethyl octadecanedioate 1472
Isolation of 2,5
oleanolic acid
Use of co
Solid chip
Isoerysenegalensein E 478158
Molecular docking guided 3D
CBX1 Human Pre
Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure
Peripheral cannabinoid
HSD17B13
A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease PMID 28451363
Iridium Catalyst
GA
EED226
LQFM
Megastigmane
HDAC
AQP
H
Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye PMID 20505203
Fluorochrome
An increase in side
Hydrogen ion buffers for biological research PMID 5942950
Comparison of corneal thickness after the instillation of topical anesthetics proparacaine versus oxybuprocaine PMID 16331042
共989页
首页
上一页
715
714
713
712
711
710
709
708
707
706
705
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新