最近收录_第883页_生物活性分子
生物活性分子最近更新
LY255283
FGFR
BRD4097
Pharmacotherapy
XmAb5871
EPH
JTP
LV 320
Kirrel3
EPZ004777
BPRN
NH4CL
Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability PMID 999922
AG2
Nitric oxide synthases
Clenproperol
Haplotoxin
MAP
Y1693
ML218 (Standard)
WCF
Cumin extract
BV2
Val
Apimostinel 1421866
AChE
SUN B8155 (Standard)
Aziprotryne (叠氮津)
Neridronate sodium
NPN12830
MS115 TFA
ML402 (Standard)
Eupatobenzofuran
NAMPT activator
血管活性肠肽受体 2（VIPR2）基因
卷曲类受体 5（FZD5）基因
(R)
Siremadlin succinate (NVP
PTP1B
组蛋白脱乙酰酶 10（Hdac10）基因
6
CTR
TDSP
Mmp19
CD1B
Pla2g15
AMF
异戊酰辅酶 A 脱氢酶（IVD）基因
Cytotoxic antibodies trigger inflammation through Fc receptors PMID 7621075
The TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia Results of the TACL T2009
Emd
Levormeloxifene fumarate 199583
E8L
Folinic acid and 5
Polysucrose 400 26873
Piperazine
Exploring the Immunomodulatory Properties of Red Onion ( Allium cepa L.) Skin Isolation, Structural Elucidation, and Bioactivity Study of Novel Onion Chalcones Targeting the A2A Adenosine Receptor PMID 37931326
CD31/PECAM
New 2
AG
Chymotrypsin molecular and catalytic properties PMID 3555886
Induction of selective autophagy in cells replicating hepatitis C virus genome PMID 30311874
Omalizumab 242138
Substrate preferences of glutamic
DOPE
(S)
CRBN ligand
The three
Pine oil 8000
Selectins interpreters of cell
Synthesis and evaluation of 7
Biosynthetic investigations of lactonamycin and lactonamycin z cloning of the biosynthetic gene clusters and discovery of an unusual starter unit PMID 18070976
GSK 3 Inhibitor IX (Standard)
Chronic cough relief by allosteric modulation of P2X3 without taste disturbance PMID 37730705
Role of IRGM in acute lung injury Inducing mitophagy and inactivating cGAS
Bispyribac 125401
Distribution of methyl and isopropyl N
PTK2
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity PMID 21714126
糖蛋白激素亚基α2（GPHA2）基因
An Autophagy
Design, Synthesis, and Biological Evaluation of Tetrahydropyridine Analogues as Potent Antibiofilm Agents against S. aureus In Vitro and In Silico Studies PMID 41552503
PTK2 protein tyrosine kinase 2
A
STING1 targets MYH9 to drive adipogenesis through the AKT/GSK3β/β
Lcn2 from neutrophil extracellular traps induces astrogliosis and post
Thidiazuron 51707
BRD9539 1374601
Akt plays indispensable roles during the first cell lineage differentiation of mouse PMID 31190160
Focal adhesion kinase
2''
Locomotor activity and tissue levels following acute administration of lambda
Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95
Discovery of First
Antitumor activity of metal
FAK
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites PMID 29397723
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia PMID 33760042
Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions PMID 35231442
Temperature dependence of production of structured triacylglycerols in the alga Trachydiscus minutus PMID 25564261
Thioamides in medicinal chemistry and as small molecule therapeutic agents PMID 39106658
U
Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation PMID 27707539
Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time
Isochlorogenic Acid A Attenuated Periodontitis by Inhibiting Inflammation via ACE/PGK1/STAT1 Signaling PMID 40368646
Pyrrolidine PNA a novel conformationally restricted PNA analogue PMID 11150189
The long
Investigation of the pro
The kappa
breast
(S)
α
Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model PMID 32764214
TAS
Hexanal propylene glycol acetal
Spheroidenone 13836
Protease for flavors 37259
Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG
α
Discovery of GDC
Saripidem 103844
Implications of dibenzyl trisulphide for disease treatment based on its mode of action PMID 20441056
Hypoxia
Sibrafiban PMID 10188763
CL
Cichoriin 531
Multifunctional Arylsulfone and Arylsulfonamide
CALR3
Sch 36605, a novel anti
The antioxidant LY231617 reduces global ischemic neuronal injury in rats PMID 8488528
Zeniplatin 111490
NS4B
Synthesis, Characterization, and Evaluation of the Anxiolytic Activity of Hydrazones Derived from the Drug Isoniazid, Using the Adult Zebrafish (Danio rerio) Model PMID 41078729
Furmecyclox 60568
CCG
MC38
PPL
The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents PMID 25449427
Bioinformatics Identification and Experimental Validation of a Prognostic Model for the Survival of Lung Squamous Cell Carcinoma Patients PMID 38806973
HIFs
Age
Targeting PLOD2 induces epithelioid differentiation and improves therapeutic response in sarcomatoid renal cell carcinoma PMID 41109566
HIF/HIF Prolyl
IGF
Fosaprepitant 172673
4
Protein kinase inhibitor 7 84478
Management of systemic fungal infections alternatives to itraconazole PMID 16120633
Effects of an eosinophil chemotaxis inhibitor, TAK
Dimethenamide
Methyl 4
Cone snails
Bis
Gabaculine
HIF
LY231617 free base 93811
Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium PMID 11473127
N
Flavodilol
TP0472993 2126874
Novel androgen receptor antagonist identified by structure
Discovery of a new class of glucosylceramide synthase inhibitors PMID 21974949
R55104
YYSW001 2763672
4
PSFL
SB290157 trifluoroacetate 1140525
C19 Benzylisoquinoline Alkaloid with Unprecedented Architecture from Hypecoum erectum PMID 34723525
Synthesis, solution structure and biological action of PACAP
3
Polysucrose70
Ligustroflavone 260413
Haliangicin D 661466
GSTO1
CAY10471 627865
MPPEE acid
Anti
bEnd.3 cells
GNKG168
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation PMID 26540348
Metabolic activation of TM5441 in vitro and in vivo Formation of reactive metabolites and human enzymes involved PMID 31852629
Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47
ZINC13466751 117953
Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF
In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates PMID 17307977
Anti
A69024
Pyrazole
GDF9 Human Pre
EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF
LXR
Elsulfavirine sodium 867365
Design and Discovery of Novel Selective RET Inhibitors with High Central Nervous System Penetration, Enhanced Pharmacokinetics, and Pharmacodynamics PMID 40556477
γ
Design and synthesis of novel soluble 2,5
A luciferin analogue generating near
Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape PMID 32213632
Beta3
Structure
MiR
2,4,6
The Development of a Highly Potent and Selective Human Toll
ZINC000028464438 866123
Haliangicin C 661466
Repurposing ketotifen as a therapeutic strategy for neuroendocrine prostate cancer by targeting the IL
Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low
The protective effect of HET0016 on brain edema and blood
Ala
Dimethyl biphenyl
3
chromosome
A molecular dynamics study of catestatin docked on nicotinic acetylcholine receptors to identify amino acids potentially involved in the binding of chromogranin A fragments PMID 26079001
MCE
TASIN
MCE
Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists PMID 12605028
A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip
MUC21 controls melanoma progression via regulating SLITRK5 and hedgehog signaling pathway PMID 35579188
Long
NCC
SANT1
High salt diet induces cognitive impairment and is linked to the activation of IGF1R/mTOR/p70S6K signaling PMID 38771412
Cationic dendronization of amylose via click chemistry for complexation and transfection of plasmid DNA PMID 25944369
MCE
Gc
Curcuminoids Inhibit Angiogenic Behaviors of Human Umbilical Vein Endothelial Cells via Endoglin/Smad1 Signaling PMID 35409247
NME/NM23 家族成员 5（NME5）基因
Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats PMID 40216110
Discovery of citrinin derivatives with SIRT1 agonist activity from Penicillium citrinum TJ507 PMID 41512353
Antioxidative glucosides from the fruits of Ligustrum lucidum PMID 11411539
Monactin 7182
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension PMID 37467498
The effect of strontium ranelate on titanium particle
Stem cell factor receptor/c
2,3,5
SC
Randomised clinical trial safety, efficacy and pharmacokinetics of HS
A new diterpene from the leaves of Andrographis paniculata Nees PMID 22574448
SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases PMID 34509861
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway PMID 39551239
Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis
Proteasome
Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway PMID 28702312
tert
Small molecule inhibitors of HCV replication from pomegranate PMID 24958333
Esflurbiprofen exerts a fast
Fe65L2 a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity PMID 26916555
Lipid 7
Flavivirus
Nano
Inhibition of Activated Coagulation Factor XII by the Phosphodiesterase
G194
AChE
Tuberculosis inhibitor 8
解整合素和金属肽酶结构域 17（Adam17）基因
Dengue Virus
Fmoc
链条 1（ARCN1）基因
DENV
Deunirmatrelvir 2861202
NOS
MicroRNA‑433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK PMID 30272334
NO Synthase
Spiroxatrine 1054
Ziyuglycoside I Inhibits the Proliferation of MDA
PF
In
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin
A murine Niemann
Activation of the SIRT1/PGC
Quinacrine attenuates cyclosporine
ERK/PKM2 Is Mediated in the Warburg Effect and Cell Proliferation in Arsenic
Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4 PMID 30741931
Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection PMID 33301709
Tnfrsf1b
GN44028 1421448
poly ADP ribose polymerase
Ancistrosecolines A
Development of Lipopeptides as Orthoflavivirin Inhibitors with Low Micromolar Broad
Substituted 1,3
Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats PMID 29679880
Synthesis of urea analogues bearing N
Progesterone pharmacokinetics in the mouse implications for potential stroke therapy PMID 23058048
Antimicrobial blue light inactivation of Pseudomonas aeruginosa Unraveling the multifaceted impact of wavelength, growth stage, and medium composition PMID 39241393
MCE
Discovery and structure
NPI
Diterpenoids from Salvia miltiorrhiza and Their Immune
Discovery of BW710 as a potent, selective and orally bioavailable fibroblast growth factor receptor 2 (FGFR2) inhibitor PMID 39908791
Excretory/secretory products from Hymenolepis nana adult worms alleviate ulcerative colitis in mice via tuft/IL
DI
An investigation into the formation of N
skeletal myoblasts
P7C3
Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase
De
VEGFR2
Nor
5
Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases PMID 22726684
Effects of inhalation or incubation of oxitropium bromide on diaphragm muscle contractility in mice PMID 21593578
Formulation of microencapsulated rutin and evaluation of bioactivity and stability upon in vitro digestive and dialysis conditions PMID 32417545
E17241 as a Novel ABCA1 (ATP
Effect of crop residue ashes on sorption behavior of herbicides used in the succeeding crop in Indian soils PMID 32338140
Tracheomalacia in bronchopulmonary dysplasia Trachealis hyper
Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti
P2X3 antagonist 34 2417288
Fluorophore
(Rac)
Mesaconitine
RyRs activator 2 2408415
Synthesis and biological evaluation of gamma
钙/钙调蛋白依赖性蛋白激酶 IV（CAMK4）基因
MCE
EOC317 939805
General synthesis of meso
Preparative isolation and purification of four compounds from the Chinese medicinal herb rhizoma Anemarrhenae by high
Suclofenide 30279
Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption PMID 29981360
In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP
锯齿状，RNA 效应分子（SRRT）基因
A Novel NADP
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N
FXR antagonist 3 3024652
4,4',4'',4'''
Direct brown 95 16071
Neocyclomorusin 62596
First Cdc7 kinase inhibitors pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery PMID 19115845
Camk4
3',4',7
Vilastobart 2760549
BPR5K230 3029897
Modulation of proteasome subunit selectivity of syringolins PMID 38704960
羧肽酶 A1（CPA1）基因
Nsun2
LncRNA HOTTIP promotes the proliferation and invasion of ovarian cancer cells by activating the MEK/ERK pathway PMID 33000231
PPFIA 结合蛋白 1（PPFIBP1）基因
In
Systemic CI
Binding ability of Cu2+ ions by opiate
富半胱氨酸和甘氨酸的蛋白质 3（CSRP3）基因
Cryo
AT1R antagonist 4 2982582
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist PMID 23134120
Ddx3x
A brain
A Novel Acetyl
NAD+ and NADH in cellular functions and cell death PMID 16720381
Trierucin 2752
Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues PMID 6206315
Suppression of IgE
5’
Antitumor agent
1,5
MSAB 173436
Specific activation of insulin
Enhanced binding of radioligands to receptors of gamma
Chrysene contribution to bronchial asthma Activation of TRPA1 disrupts bronchial epithelial barrier via ERK pathway PMID 39395376
Anti
BLK degrader 1 3049215
D
Di
Influence of cinaciguat on gastrointestinal motility in apo
DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25
Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos PMID 30954817
CRBN
Inhibitors of acyl
Identification of Novel Fused Heteroaromatics
Profluralin 26399
Design and synthesis of a novel series of N
Parental exposure to Cypermethrin causes intergenerational toxicity in zebrafish offspring PMID 38788937
Enhanced Antitumor Efficacy through an AND gate Reactive Oxygen
A molecular mechanism of action of theophylline Induction of histone deacetylase activity to decrease inflammatory gene expression PMID 12070353
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer PMID 32516590
Palazestrant (OP
Influence of Rifampin
Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine
Ganoderic acid Df 1352033
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats PMID 27821712
Petasin 26577
Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity PMID 28595013
Riviciclib hydrochloride 920113
[Studies on the alkaloids of Cephalotaxus. IX. Semi
Danoprevir (Standard) (丹诺普韦 (标准品))
Natural Prenylflavones from the Stem Bark of Artocarpus altilis Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT
Cyclic hydroxyamidines as amide isosteres discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ
The nitric oxide synthase inhibitor and serotonin
Photoclick myristic acid 2707485
Novel 1,2,4
Inhibitory effect of phenothiazine
Development of pyrrolo[2,1
In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands PMID 34443366
Gene expression within cell
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn's Disease Network Pharmacology, Molecular Docking and Experiment Validation PMID 39081706
Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism PMID 12767282
Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer's Disease PMID 39009798
Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer PMID 39515174
RR
CSP
MDI
(3S)
Targeting TRAF6 E3 ligase activity with a small
84
Synthesis and pharmacological evaluation of 5
Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin
The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux PMID 30890728
Quantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112 PMID 7606467
Design, synthesis, and biological evaluation of 8
3
Simultaneous determination of four sesquiterpenoids in Atractylodes Macrocephala Rhizoma by GC
EMICORON A multi
Asparagoside A 14835
Transforming growth factor beta receptors
Sinensetin Induces Autophagic Cell Death through p53
NG25 1315355
(Rac)
GW
2
那明特罗
PFM39 1310744
Chaperone
Ergothioneine mitigates cisplatin
SLSLSPG 943235
Targeted potent antimicrobial and antitumor oxygen
MCE
Novel Plasminogen Activator Inhibitor
双特异性磷酸酶 18（DUSP18）基因
CRBN ligand
The keratin 17/YAP/IL6 axis contributes to E
TGF
BCL
Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase PMID 2485065
Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum PMID 26287548
METTL3
YL93 2771313
Synergy of Ginkgetin and Resveratrol in Suppressing VEGF
Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A3 receptor in complete Freund's adjuvant
LINC01711 modulates proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by targeting miR
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor PMID 26824386
2
C1q/tumor necrosis factor
Role of phospholipase A2 activation and calcium in CYP2E1
Targeting of Lung Cancer Stem Cell Self
Meclizine
Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase PMID 41329866
C6(6
FASN
Polyamidoamine Dendron
Charge
2'
Phenyl 4
DSPE
New imidazole
SIK inhibition in human myeloid cells modulates TLR and IL
TFAP2B governs the regulation of SIRT1 to inhibit osteoclast
Necrotic cell death induced by dithianon on Saccharomyces cerevisiae PMID 30033009
Effects of 4
Atriopeptin II elevates cyclic GMP, activates cyclic GMP
AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog PMID 20386458
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase
Acetylation of TIR domains in the TLR4
Discovery of Bicyclo[1.1.1]pentane
DU
Bioinspired 3D hydrogel scaffold to mimic tumor microenvironment for investigating into the anoikis resistance mechanisms in colorectal cancer PMID 40697318
Ponatinib Acid 2748500
Promacyl 34264
NAD+
Chain
The Snf5
LTB4 antagonist 3 2929239
Structure
The anti
Discovery of TYRA
VAPB depletion alters neuritogenesis and phosphoinositide balance in motoneuron
Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth PMID 38187734
Thalidomide
Coenzyme Q10
Gut
Asimilobine and lirinidine, serotonergic receptor antagonists, from Nelumbo nucifera PMID 3430176
Terrein is an inhibitor of quorum sensing and c
Multitargeted drugs discovery balancing anti
Angiotensin
Design, Synthesis, and Bioactivity of Novel 2
Sesquiterpenes and butenolides, natural anti
Effects of protein kinase inhibitors on the cell motility stimulated by autocrine motility factor PMID 8038208
(3S,6Z,9Z,12Z,15Z,18Z,21Z)
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling PMID 29426911
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1 PMID 8455624
Design, Synthesis, Pharmacology, and In Silico Studies of (1 S,2 S,3 S)
Aspartyl
Hypertension is a major contributor to 20
Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS
SARS
Decarestrictin A
RNA
AMG28 1202764
18 1 1,3
YZL
共941页
首页
上一页
888
887
886
885
884
883
882
881
880
879
878
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新